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Protein

Transmembrane protein 45B

Gene

TMEM45B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 45B
Gene namesi
Name:TMEM45B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000151715.7
HGNCiHGNC:25194 TMEM45B
neXtProtiNX_Q96B21

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi120224
OpenTargetsiENSG00000151715
PharmGKBiPA134909603

Polymorphism and mutation databases

BioMutaiTMEM45B
DMDMi74731190

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002711991 – 275Transmembrane protein 45BAdd BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphoserineBy similarity1
Modified residuei272PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96B21
PaxDbiQ96B21
PeptideAtlasiQ96B21
PRIDEiQ96B21
ProteomicsDBi76035

PTM databases

iPTMnetiQ96B21
PhosphoSitePlusiQ96B21

Expressioni

Gene expression databases

BgeeiENSG00000151715
CleanExiHS_TMEM45B
GenevisibleiQ96B21 HS

Organism-specific databases

HPAiHPA015878

Interactioni

Protein-protein interaction databases

BioGridi125675, 6 interactors
IntActiQ96B21, 2 interactors
STRINGi9606.ENSP00000281441

Structurei

3D structure databases

ProteinModelPortaliQ96B21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM45 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG9I Eukaryota
ENOG410ZTA1 LUCA
GeneTreeiENSGT00530000063088
HOGENOMiHOG000136727
HOVERGENiHBG008722
InParanoidiQ96B21
OMAiLTYLVTH
OrthoDBiEOG091G0GQ9
PhylomeDBiQ96B21
TreeFamiTF328673

Family and domain databases

InterProiView protein in InterPro
IPR006904 DUF716_TMEM45
PANTHERiPTHR16007 PTHR16007, 1 hit
PfamiView protein in Pfam
PF04819 DUF716, 1 hit

Sequencei

Sequence statusi: Complete.

Q96B21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANFKGHALP GSFFLIIGLC WSVKYPLKYF SHTRKNSPLH YYQRLEIVEA
60 70 80 90 100
AIRTLFSVTG ILAEQFVPDG PHLHLYHENH WIKLMNWQHS TMYLFFAVSG
110 120 130 140 150
IVDMLTYLVS HVPLGVDRLV MAVAVFMEGF LFYYHVHNRP PLDQHIHSLL
160 170 180 190 200
LYALFGGCVS ISLEVIFRDH IVLELFRTSL IILQGTWFWQ IGFVLFPPFG
210 220 230 240 250
TPEWDQKDDA NLMFITMCFC WHYLAALSIV AVNYSLVYCL LTRMKRHGRG
260 270
EIIGIQKLNS DDTYQTALLS GSDEE
Length:275
Mass (Da):31,826
Last modified:December 1, 2001 - v1
Checksum:iDB8514C1E5005216
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02986659T → I. Corresponds to variant dbSNP:rs558813Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098106 mRNA Translation: BAC05235.1
AK290283 mRNA Translation: BAF82972.1
AK292058 mRNA Translation: BAF84747.1
BC016153 mRNA Translation: AAH16153.1
CCDSiCCDS8482.1
RefSeqiNP_001318139.1, NM_001331210.1
NP_001318140.1, NM_001331211.1
NP_001318141.1, NM_001331212.1
NP_620143.1, NM_138788.4
XP_016872677.1, XM_017017188.1
XP_016872678.1, XM_017017189.1
UniGeneiHs.504301

Genome annotation databases

EnsembliENST00000281441; ENSP00000281441; ENSG00000151715
ENST00000524567; ENSP00000436293; ENSG00000151715
GeneIDi120224
KEGGihsa:120224
UCSCiuc001qfe.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM45B_HUMAN
AccessioniPrimary (citable) accession number: Q96B21
Secondary accession number(s): A8K2L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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