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Protein

Transmembrane protein 45B

Gene

TMEM45B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151715-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 45B
Gene namesi
Name:TMEM45B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25194. TMEM45B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi120224.
OpenTargetsiENSG00000151715.
PharmGKBiPA134909603.

Polymorphism and mutation databases

BioMutaiTMEM45B.
DMDMi74731190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002711991 – 275Transmembrane protein 45BAdd BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphoserineBy similarity1
Modified residuei272PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96B21.
PaxDbiQ96B21.
PeptideAtlasiQ96B21.
PRIDEiQ96B21.

PTM databases

iPTMnetiQ96B21.
PhosphoSitePlusiQ96B21.

Expressioni

Gene expression databases

BgeeiENSG00000151715.
CleanExiHS_TMEM45B.
GenevisibleiQ96B21. HS.

Organism-specific databases

HPAiHPA015878.

Interactioni

Protein-protein interaction databases

BioGridi125675. 3 interactors.
IntActiQ96B21. 2 interactors.
STRINGi9606.ENSP00000281441.

Structurei

3D structure databases

ProteinModelPortaliQ96B21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM45 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG9I. Eukaryota.
ENOG410ZTA1. LUCA.
GeneTreeiENSGT00530000063088.
HOGENOMiHOG000136727.
HOVERGENiHBG008722.
InParanoidiQ96B21.
OMAiQWVKLMN.
OrthoDBiEOG091G0GQ9.
PhylomeDBiQ96B21.
TreeFamiTF328673.

Family and domain databases

InterProiIPR006904. DUF716_TMEM45.
[Graphical view]
PANTHERiPTHR16007. PTHR16007. 1 hit.
PfamiPF04819. DUF716. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96B21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANFKGHALP GSFFLIIGLC WSVKYPLKYF SHTRKNSPLH YYQRLEIVEA
60 70 80 90 100
AIRTLFSVTG ILAEQFVPDG PHLHLYHENH WIKLMNWQHS TMYLFFAVSG
110 120 130 140 150
IVDMLTYLVS HVPLGVDRLV MAVAVFMEGF LFYYHVHNRP PLDQHIHSLL
160 170 180 190 200
LYALFGGCVS ISLEVIFRDH IVLELFRTSL IILQGTWFWQ IGFVLFPPFG
210 220 230 240 250
TPEWDQKDDA NLMFITMCFC WHYLAALSIV AVNYSLVYCL LTRMKRHGRG
260 270
EIIGIQKLNS DDTYQTALLS GSDEE
Length:275
Mass (Da):31,826
Last modified:December 1, 2001 - v1
Checksum:iDB8514C1E5005216
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02986659T → I.Corresponds to variant rs558813dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098106 mRNA. Translation: BAC05235.1.
AK290283 mRNA. Translation: BAF82972.1.
AK292058 mRNA. Translation: BAF84747.1.
BC016153 mRNA. Translation: AAH16153.1.
CCDSiCCDS8482.1.
RefSeqiNP_620143.1. NM_138788.4.
XP_016872677.1. XM_017017188.1.
XP_016872678.1. XM_017017189.1.
UniGeneiHs.504301.

Genome annotation databases

EnsembliENST00000281441; ENSP00000281441; ENSG00000151715.
ENST00000524567; ENSP00000436293; ENSG00000151715.
GeneIDi120224.
KEGGihsa:120224.
UCSCiuc001qfe.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098106 mRNA. Translation: BAC05235.1.
AK290283 mRNA. Translation: BAF82972.1.
AK292058 mRNA. Translation: BAF84747.1.
BC016153 mRNA. Translation: AAH16153.1.
CCDSiCCDS8482.1.
RefSeqiNP_620143.1. NM_138788.4.
XP_016872677.1. XM_017017188.1.
XP_016872678.1. XM_017017189.1.
UniGeneiHs.504301.

3D structure databases

ProteinModelPortaliQ96B21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125675. 3 interactors.
IntActiQ96B21. 2 interactors.
STRINGi9606.ENSP00000281441.

PTM databases

iPTMnetiQ96B21.
PhosphoSitePlusiQ96B21.

Polymorphism and mutation databases

BioMutaiTMEM45B.
DMDMi74731190.

Proteomic databases

MaxQBiQ96B21.
PaxDbiQ96B21.
PeptideAtlasiQ96B21.
PRIDEiQ96B21.

Protocols and materials databases

DNASUi120224.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281441; ENSP00000281441; ENSG00000151715.
ENST00000524567; ENSP00000436293; ENSG00000151715.
GeneIDi120224.
KEGGihsa:120224.
UCSCiuc001qfe.2. human.

Organism-specific databases

CTDi120224.
DisGeNETi120224.
GeneCardsiTMEM45B.
HGNCiHGNC:25194. TMEM45B.
HPAiHPA015878.
neXtProtiNX_Q96B21.
OpenTargetsiENSG00000151715.
PharmGKBiPA134909603.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG9I. Eukaryota.
ENOG410ZTA1. LUCA.
GeneTreeiENSGT00530000063088.
HOGENOMiHOG000136727.
HOVERGENiHBG008722.
InParanoidiQ96B21.
OMAiQWVKLMN.
OrthoDBiEOG091G0GQ9.
PhylomeDBiQ96B21.
TreeFamiTF328673.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151715-MONOMER.

Miscellaneous databases

GenomeRNAii120224.
PROiQ96B21.

Gene expression databases

BgeeiENSG00000151715.
CleanExiHS_TMEM45B.
GenevisibleiQ96B21. HS.

Family and domain databases

InterProiIPR006904. DUF716_TMEM45.
[Graphical view]
PANTHERiPTHR16007. PTHR16007. 1 hit.
PfamiPF04819. DUF716. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM45B_HUMAN
AccessioniPrimary (citable) accession number: Q96B21
Secondary accession number(s): A8K2L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.