Q96B21 (TM45B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 45B

Gene names

Name:

TMEM45B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TMEM45 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Transmembrane protein 45B		PRO_0000271199
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	47 – 67	21	Helical; Potential
	Transmembrane	94 – 114	21	Helical; Potential
	Transmembrane	116 – 136	21	Helical; Potential
	Transmembrane	146 – 166	21	Helical; Potential
	Transmembrane	180 – 200	21	Helical; Potential
	Transmembrane	212 – 232	21	Helical; Potential
Amino acid modifications
	Modified residue	270	1	Phosphoserine By similarity
	Modified residue	272	1	Phosphoserine By similarity
Natural variations
	Natural variant	59	1	T → I. Corresponds to variant rs558813 [ dbSNP | Ensembl ].		VAR_029866

Sequences

	Sequence		Length	Mass (Da)
	Q96B21 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: DB8514C1E5005216	FASTA	275	31,826
	10 20 30 40 50 60 MANFKGHALP GSFFLIIGLC WSVKYPLKYF SHTRKNSPLH YYQRLEIVEA AIRTLFSVTG 70 80 90 100 110 120 ILAEQFVPDG PHLHLYHENH WIKLMNWQHS TMYLFFAVSG IVDMLTYLVS HVPLGVDRLV 130 140 150 160 170 180 MAVAVFMEGF LFYYHVHNRP PLDQHIHSLL LYALFGGCVS ISLEVIFRDH IVLELFRTSL 190 200 210 220 230 240 IILQGTWFWQ IGFVLFPPFG TPEWDQKDDA NLMFITMCFC WHYLAALSIV AVNYSLVYCL 250 260 270 LTRMKRHGRG EIIGIQKLNS DDTYQTALLS GSDEE

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Trachea.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK098106 mRNA. Translation: BAC05235.1. AK290283 mRNA. Translation: BAF82972.1. AK292058 mRNA. Translation: BAF84747.1. BC016153 mRNA. Translation: AAH16153.1.
IPI	IPI00059683.
RefSeq	NP_620143.1. NM_138788.3.
UniGene	Hs.504301.
3D structure databases
ProteinModelPortal	Q96B21.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96B21. 2 interactions.
STRING	9606.ENSP00000281441.
PTM databases
PhosphoSite	Q96B21.
Polymorphism databases
DMDM	74731190.
Proteomic databases
PaxDb	Q96B21.
PRIDE	Q96B21.
Protocols and materials databases
DNASU	120224.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000281441; ENSP00000281441; ENSG00000151715. ENST00000524567; ENSP00000436293; ENSG00000151715.
GeneID	120224.
KEGG	hsa:120224.
UCSC	uc001qfe.1. human.
Organism-specific databases
CTD	120224.
GeneCards	GC11P129688.
HGNC	HGNC:25194. TMEM45B.
HPA	HPA015878.
neXtProt	NX_Q96B21.
PharmGKB	PA134909603.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG80677.
HOGENOM	HOG000136727.
HOVERGEN	HBG008722.
InParanoid	Q96B21.
OMA	LMFITMC.
OrthoDB	EOG412M6D.
PhylomeDB	Q96B21.
Gene expression databases
Bgee	Q96B21.
CleanEx	HS_TMEM45B.
Genevestigator	Q96B21.
Family and domain databases
InterPro	IPR006904. DUF716_TMEM45. [Graphical view]
PANTHER	PTHR16007. PTHR16007. 1 hit.
Pfam	PF04819. DUF716. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	120224.
NextBio	80545.

Entry information

Entry name

TM45B_HUMAN

Accession

Primary (citable) accession number: Q96B21
Secondary accession number(s): A8K2L8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.