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Protein

Transmembrane protein 45B

Gene

TMEM45B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 45B
Gene namesi
Name:TMEM45B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25194. TMEM45B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence analysisAdd
BLAST
Transmembranei47 – 6721HelicalSequence analysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence analysisAdd
BLAST
Transmembranei212 – 23221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134909603.

Polymorphism and mutation databases

BioMutaiTMEM45B.
DMDMi74731190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Transmembrane protein 45BPRO_0000271199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701PhosphoserineBy similarity
Modified residuei272 – 2721PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96B21.
PaxDbiQ96B21.
PRIDEiQ96B21.

PTM databases

iPTMnetiQ96B21.
PhosphoSiteiQ96B21.

Expressioni

Gene expression databases

BgeeiQ96B21.
CleanExiHS_TMEM45B.
GenevisibleiQ96B21. HS.

Organism-specific databases

HPAiHPA015878.

Interactioni

Protein-protein interaction databases

BioGridi125675. 3 interactions.
IntActiQ96B21. 2 interactions.
STRINGi9606.ENSP00000281441.

Structurei

3D structure databases

ProteinModelPortaliQ96B21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM45 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG9I. Eukaryota.
ENOG410ZTA1. LUCA.
GeneTreeiENSGT00530000063088.
HOGENOMiHOG000136727.
HOVERGENiHBG008722.
InParanoidiQ96B21.
OMAiQWVKLMN.
OrthoDBiEOG7288SZ.
PhylomeDBiQ96B21.
TreeFamiTF328673.

Family and domain databases

InterProiIPR006904. DUF716_TMEM45.
[Graphical view]
PANTHERiPTHR16007. PTHR16007. 1 hit.
PfamiPF04819. DUF716. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96B21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANFKGHALP GSFFLIIGLC WSVKYPLKYF SHTRKNSPLH YYQRLEIVEA
60 70 80 90 100
AIRTLFSVTG ILAEQFVPDG PHLHLYHENH WIKLMNWQHS TMYLFFAVSG
110 120 130 140 150
IVDMLTYLVS HVPLGVDRLV MAVAVFMEGF LFYYHVHNRP PLDQHIHSLL
160 170 180 190 200
LYALFGGCVS ISLEVIFRDH IVLELFRTSL IILQGTWFWQ IGFVLFPPFG
210 220 230 240 250
TPEWDQKDDA NLMFITMCFC WHYLAALSIV AVNYSLVYCL LTRMKRHGRG
260 270
EIIGIQKLNS DDTYQTALLS GSDEE
Length:275
Mass (Da):31,826
Last modified:December 1, 2001 - v1
Checksum:iDB8514C1E5005216
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591T → I.
Corresponds to variant rs558813 [ dbSNP | Ensembl ].
VAR_029866

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098106 mRNA. Translation: BAC05235.1.
AK290283 mRNA. Translation: BAF82972.1.
AK292058 mRNA. Translation: BAF84747.1.
BC016153 mRNA. Translation: AAH16153.1.
CCDSiCCDS8482.1.
RefSeqiNP_620143.1. NM_138788.3.
XP_005271457.1. XM_005271400.3.
XP_011540888.1. XM_011542586.1.
XP_011540889.1. XM_011542587.1.
XP_011540890.1. XM_011542588.1.
UniGeneiHs.504301.

Genome annotation databases

EnsembliENST00000281441; ENSP00000281441; ENSG00000151715.
ENST00000524567; ENSP00000436293; ENSG00000151715.
GeneIDi120224.
KEGGihsa:120224.
UCSCiuc001qfe.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098106 mRNA. Translation: BAC05235.1.
AK290283 mRNA. Translation: BAF82972.1.
AK292058 mRNA. Translation: BAF84747.1.
BC016153 mRNA. Translation: AAH16153.1.
CCDSiCCDS8482.1.
RefSeqiNP_620143.1. NM_138788.3.
XP_005271457.1. XM_005271400.3.
XP_011540888.1. XM_011542586.1.
XP_011540889.1. XM_011542587.1.
XP_011540890.1. XM_011542588.1.
UniGeneiHs.504301.

3D structure databases

ProteinModelPortaliQ96B21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125675. 3 interactions.
IntActiQ96B21. 2 interactions.
STRINGi9606.ENSP00000281441.

PTM databases

iPTMnetiQ96B21.
PhosphoSiteiQ96B21.

Polymorphism and mutation databases

BioMutaiTMEM45B.
DMDMi74731190.

Proteomic databases

MaxQBiQ96B21.
PaxDbiQ96B21.
PRIDEiQ96B21.

Protocols and materials databases

DNASUi120224.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281441; ENSP00000281441; ENSG00000151715.
ENST00000524567; ENSP00000436293; ENSG00000151715.
GeneIDi120224.
KEGGihsa:120224.
UCSCiuc001qfe.2. human.

Organism-specific databases

CTDi120224.
GeneCardsiTMEM45B.
HGNCiHGNC:25194. TMEM45B.
HPAiHPA015878.
neXtProtiNX_Q96B21.
PharmGKBiPA134909603.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG9I. Eukaryota.
ENOG410ZTA1. LUCA.
GeneTreeiENSGT00530000063088.
HOGENOMiHOG000136727.
HOVERGENiHBG008722.
InParanoidiQ96B21.
OMAiQWVKLMN.
OrthoDBiEOG7288SZ.
PhylomeDBiQ96B21.
TreeFamiTF328673.

Miscellaneous databases

GenomeRNAii120224.
NextBioi80545.
PROiQ96B21.

Gene expression databases

BgeeiQ96B21.
CleanExiHS_TMEM45B.
GenevisibleiQ96B21. HS.

Family and domain databases

InterProiIPR006904. DUF716_TMEM45.
[Graphical view]
PANTHERiPTHR16007. PTHR16007. 1 hit.
PfamiPF04819. DUF716. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Trachea.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTM45B_HUMAN
AccessioniPrimary (citable) accession number: Q96B21
Secondary accession number(s): A8K2L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.