Q96B18 (DACT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dapper homolog 3

Alternative name(s):
Antagonist of beta-catenin Dapper homolog 3
Arginine-rich region 1 protein

Gene names

Name:	DACT3
Synonyms:	RRR1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	629 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Domain	The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins By similarity.
Sequence similarities	Belongs to the dapper family.
Sequence caution	The sequence AAH16161.1 differs from that shown. Reason: Frameshift at position 119.

Ontologies

Keywords
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 629	629	Dapper homolog 3		PRO_0000264616
Regions
	Coiled coil	63 – 87	25	Potential
	Motif	626 – 629	4	PDZ-binding By similarity
	Compositional bias	258 – 263	6	Poly-Arg
	Compositional bias	368 – 498	131	Arg-rich

Sequences

	Sequence		Length	Mass (Da)
	Q96B18 [UniParc]. Last modified December 12, 2006. Version 2. Checksum: 916CAA2AA9370497	FASTA	629	64,949
	10 20 30 40 50 60 MIRAFSFPVS PERGRLRGWL EGSLAGLCEL HWLRERQEYR VQQALRLAQP GMGGAEAEDE 70 80 90 100 110 120 EDADEDEDAA AARRAAAALE EQLEALPGLV WDLGQQLGDL SLESGGLEQE SGRSSGFYED 130 140 150 160 170 180 PSSTGGPDSP PSTFCGDSGF SGSSSYGRLG PSEPRGIYAS ERPKSLGDAS PSAPEVVGAR 190 200 210 220 230 240 AAVPRSFSAP YPTAGGSAGP EACSSAERRA RAGPFLTPSP LHAVAMRSPR PCGRPPTDSP 250 260 270 280 290 300 DAGGAGRPLD GYISALLRRR RRRGAGQPRT SPGGADGGPR RQNSVRQRPP DASPSPGSAR 310 320 330 340 350 360 PAREPSLERV GGHPTSPAAL SRAWASSWES EAAPEPAAPP AAPSPPDSPA EGRLVKAQYI 370 380 390 400 410 420 PGAQAATRGL PGRAARRKPP PLTRGRSVEQ SPPRERPRAA GRRGRMAEAS GRRGSPRARK 430 440 450 460 470 480 ASRSQSETSL LGRASAVPSG PPKYPTAERE EPRPPRPRRG PAPTLAAQAA GSCRRWRSTA 490 500 510 520 530 540 EIDAADGRRV RPRAPAARVP GPGPSPSAPQ RRLLYGCAGS DSECSAGRLG PLGRRGPAGG 550 560 570 580 590 600 VGGGYGESES SASEGESPAF SSASSDSDGS GGLVWPQQLV AATAASGGGA GAGAPAGPAK 610 620 VFVKIKASHA LKKKILRFRS GSLKVMTTV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[2]	"Three Dact gene family members are expressed during embryonic development and in the adult brains of mice." Fisher D.A., Kivimaee S., Hoshino J., Suriben R., Martin P.-M., Baxter N., Cheyette B.N.R. Dev. Dyn. 235:2620-2630(2006) [PubMed: 16881060] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC016161 mRNA. Translation: AAH16161.1. Sequence problems. BI603646 mRNA. No translation available.
IPI	IPI00059662.
RefSeq	NP_659493.2. NM_145056.2.
UniGene	Hs.515490.
3D structure databases
ProteinModelPortal	Q96B18.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96B18.
PTM databases
PhosphoSite	Q96B18.
Polymorphism databases
DMDM	119368655.
Proteomic databases
PRIDE	Q96B18.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000391916; ENSP00000375783; ENSG00000197380.
GeneID	147906.
KEGG	hsa:147906.
UCSC	uc010ekq.1. human.
Organism-specific databases
CTD	147906.
GeneCards	GC19M047150.
H-InvDB	HIX0022841.
HGNC	HGNC:30745. DACT3.
HPA	HPA043053.
MIM	611112. gene.
neXtProt	NX_Q96B18.
PharmGKB	PA162383145.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG21802.
GeneTree	ENSGT00530000063890.
HOGENOM	HBG283341.
HOVERGEN	HBG081403.
InParanoid	Q96B18.
OMA	GAGQPRT.
OrthoDB	EOG4H9XMQ.
Gene expression databases
ArrayExpress	Q96B18.
Bgee	Q96B18.
CleanEx	HS_DACT3.
Genevestigator	Q96B18.
GermOnline	ENSG00000197380. Homo sapiens.
Family and domain databases
InterPro	IPR024844. Dact3. IPR024843. Dapper. [Graphical view]
PANTHER	PTHR15919. PTHR15919. 1 hit. PTHR15919:SF1. PTHR15919:SF1. 1 hit.
ProtoNet	Search...
Other
NextBio	85754.
SOURCE	Search...

Entry information

Entry name

DACT3_HUMAN

Accession

Primary (citable) accession number: Q96B18

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	January 25, 2012
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.