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Protein

Dapper homolog 3

Gene

DACT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Dapper homolog 3
Alternative name(s):
Antagonist of beta-catenin Dapper homolog 3
Arginine-rich region 1 protein
Dapper antagonist of catenin 3
Gene namesi
Name:DACT3
Synonyms:RRR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30745. DACT3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162383145.

Polymorphism and mutation databases

BioMutaiDACT3.
DMDMi119368655.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 629629Dapper homolog 3PRO_0000264616Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei165 – 1651PhosphoserineBy similarity
Modified residuei239 – 2391PhosphoserineBy similarity
Modified residuei478 – 4781PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96B18.
PRIDEiQ96B18.

PTM databases

iPTMnetiQ96B18.
PhosphoSiteiQ96B18.

Expressioni

Gene expression databases

BgeeiQ96B18.
CleanExiHS_DACT3.
ExpressionAtlasiQ96B18. baseline and differential.
GenevisibleiQ96B18. HS.

Organism-specific databases

HPAiHPA043053.

Interactioni

Subunit structurei

Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, DVL1, DVL3, VANGL1, VANGL2 and CTNND1 (By similarity). Interacts with DVL2.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127095. 3 interactions.
STRINGi9606.ENSP00000375783.

Structurei

3D structure databases

ProteinModelPortaliQ96B18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili63 – 8725Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi626 – 6294PDZ-bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi258 – 2636Poly-Arg
Compositional biasi368 – 498131Arg-richAdd
BLAST

Domaini

The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.By similarity

Sequence similaritiesi

Belongs to the dapper family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J2VF. Eukaryota.
ENOG4111AXJ. LUCA.
GeneTreeiENSGT00730000111567.
HOGENOMiHOG000112139.
HOVERGENiHBG081403.
InParanoidiQ96B18.
OMAiVAMRSPR.
OrthoDBiEOG7MKW6J.
PhylomeDBiQ96B18.
TreeFamiTF331300.

Family and domain databases

InterProiIPR024844. Dact3.
IPR024843. Dapper.
[Graphical view]
PANTHERiPTHR15919. PTHR15919. 1 hit.
PTHR15919:SF1. PTHR15919:SF1. 1 hit.
PfamiPF15268. Dapper. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96B18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRAFSFPVS PERGRLRGWL EGSLAGLCEL HWLRERQEYR VQQALRLAQP
60 70 80 90 100
GMGGAEAEDE EDADEDEDAA AARRAAAALE EQLEALPGLV WDLGQQLGDL
110 120 130 140 150
SLESGGLEQE SGRSSGFYED PSSTGGPDSP PSTFCGDSGF SGSSSYGRLG
160 170 180 190 200
PSEPRGIYAS ERPKSLGDAS PSAPEVVGAR AAVPRSFSAP YPTAGGSAGP
210 220 230 240 250
EACSSAERRA RAGPFLTPSP LHAVAMRSPR PCGRPPTDSP DAGGAGRPLD
260 270 280 290 300
GYISALLRRR RRRGAGQPRT SPGGADGGPR RQNSVRQRPP DASPSPGSAR
310 320 330 340 350
PAREPSLERV GGHPTSPAAL SRAWASSWES EAAPEPAAPP AAPSPPDSPA
360 370 380 390 400
EGRLVKAQYI PGAQAATRGL PGRAARRKPP PLTRGRSVEQ SPPRERPRAA
410 420 430 440 450
GRRGRMAEAS GRRGSPRARK ASRSQSETSL LGRASAVPSG PPKYPTAERE
460 470 480 490 500
EPRPPRPRRG PAPTLAAQAA GSCRRWRSTA EIDAADGRRV RPRAPAARVP
510 520 530 540 550
GPGPSPSAPQ RRLLYGCAGS DSECSAGRLG PLGRRGPAGG VGGGYGESES
560 570 580 590 600
SASEGESPAF SSASSDSDGS GGLVWPQQLV AATAASGGGA GAGAPAGPAK
610 620
VFVKIKASHA LKKKILRFRS GSLKVMTTV
Length:629
Mass (Da):64,949
Last modified:December 12, 2006 - v2
Checksum:i916CAA2AA9370497
GO

Sequence cautioni

The sequence AAH16161.1 differs from that shown. Reason: Frameshift at position 119. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016161 mRNA. Translation: AAH16161.1. Sequence problems.
BI603646 mRNA. No translation available.
CCDSiCCDS12688.2.
RefSeqiNP_001287975.1. NM_001301046.1.
NP_659493.2. NM_145056.2.
XP_011524800.1. XM_011526498.1.
XP_011524801.1. XM_011526499.1.
XP_011524802.1. XM_011526500.1.
UniGeneiHs.515490.

Genome annotation databases

EnsembliENST00000391916; ENSP00000375783; ENSG00000197380.
GeneIDi147906.
KEGGihsa:147906.
UCSCiuc010ekq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016161 mRNA. Translation: AAH16161.1. Sequence problems.
BI603646 mRNA. No translation available.
CCDSiCCDS12688.2.
RefSeqiNP_001287975.1. NM_001301046.1.
NP_659493.2. NM_145056.2.
XP_011524800.1. XM_011526498.1.
XP_011524801.1. XM_011526499.1.
XP_011524802.1. XM_011526500.1.
UniGeneiHs.515490.

3D structure databases

ProteinModelPortaliQ96B18.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127095. 3 interactions.
STRINGi9606.ENSP00000375783.

PTM databases

iPTMnetiQ96B18.
PhosphoSiteiQ96B18.

Polymorphism and mutation databases

BioMutaiDACT3.
DMDMi119368655.

Proteomic databases

PaxDbiQ96B18.
PRIDEiQ96B18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391916; ENSP00000375783; ENSG00000197380.
GeneIDi147906.
KEGGihsa:147906.
UCSCiuc010ekq.3. human.

Organism-specific databases

CTDi147906.
GeneCardsiDACT3.
H-InvDBHIX0022841.
HGNCiHGNC:30745. DACT3.
HPAiHPA043053.
MIMi611112. gene.
neXtProtiNX_Q96B18.
PharmGKBiPA162383145.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2VF. Eukaryota.
ENOG4111AXJ. LUCA.
GeneTreeiENSGT00730000111567.
HOGENOMiHOG000112139.
HOVERGENiHBG081403.
InParanoidiQ96B18.
OMAiVAMRSPR.
OrthoDBiEOG7MKW6J.
PhylomeDBiQ96B18.
TreeFamiTF331300.

Miscellaneous databases

GenomeRNAii147906.
NextBioi85754.
PROiQ96B18.
SOURCEiSearch...

Gene expression databases

BgeeiQ96B18.
CleanExiHS_DACT3.
ExpressionAtlasiQ96B18. baseline and differential.
GenevisibleiQ96B18. HS.

Family and domain databases

InterProiIPR024844. Dact3.
IPR024843. Dapper.
[Graphical view]
PANTHERiPTHR15919. PTHR15919. 1 hit.
PTHR15919:SF1. PTHR15919:SF1. 1 hit.
PfamiPF15268. Dapper. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  2. "Three Dact gene family members are expressed during embryonic development and in the adult brains of mice."
    Fisher D.A., Kivimaee S., Hoshino J., Suriben R., Martin P.-M., Baxter N., Cheyette B.N.R.
    Dev. Dyn. 235:2620-2630(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  3. "DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications."
    Jiang X., Tan J., Li J., Kivimae S., Yang X., Zhuang L., Lee P.L., Chan M.T., Stanton L.W., Liu E.T., Cheyette B.N., Yu Q.
    Cancer Cell 13:529-541(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DVL2.

Entry informationi

Entry nameiDACT3_HUMAN
AccessioniPrimary (citable) accession number: Q96B18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: January 20, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.