ID TTC28_HUMAN Reviewed; 2481 AA. AC Q96AY4; K7ZRV2; O95928; O95929; Q5W189; Q9NTE4; Q9UG31; Q9UGG5; Q9UPV8; AC Q9Y3S5; DT 28-NOV-2002, integrated into UniProtKB/Swiss-Prot. DT 16-DEC-2008, sequence version 4. DT 27-MAR-2024, entry version 199. DE RecName: Full=Tetratricopeptide repeat protein 28; DE Short=TPR repeat protein 28; DE AltName: Full=TPR repeat-containing big gene cloned at Keio; GN Name=TTC28; Synonyms=KIAA1043, TPRBK; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH AURKB, AND TISSUE RP SPECIFICITY. RX PubMed=23036704; DOI=10.1016/j.gene.2012.09.061; RA Izumiyama T., Minoshima S., Yoshida T., Shimizu N.; RT "A novel big protein TPRBK possessing 25 units of TPR motif is essential RT for the progress of mitosis and cytokinesis."; RL Gene 511:202-217(2012). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10591208; DOI=10.1038/990031; RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C., RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., RA Wright H.; RT "The DNA sequence of human chromosome 22."; RL Nature 402:489-495(1999). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-97. RA Kim M.K., Kim Y.H., Suh J.M., Lee H.M., Hwang S.Y., Sohn M.Y., Im S.U., RA Chung E.J., Cha S.Y., Park M.K., Kim J.O., Kim J.A., Yang J.O., Sung Y.K., RA Kim J.C.; RT "KNU hair EST project."; RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-292. RA Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., RA Bye J.M., Beare D.M., Dunham I.; RT "Re-evaluating human gene annotation: a second generation analysis of RT chromosome 22."; RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 356-2481. RC TISSUE=Brain; RX PubMed=10470851; DOI=10.1093/dnares/6.3.197; RA Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., RA Kotani H., Nomura N., Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. XIV. The RT complete sequences of 100 new cDNA clones from brain which code for large RT proteins in vitro."; RL DNA Res. 6:197-205(1999). RN [6] RP SEQUENCE REVISION. RX PubMed=12168954; DOI=10.1093/dnares/9.3.99; RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.; RT "Construction of expression-ready cDNA clones for KIAA genes: manual RT curation of 330 KIAA cDNA clones."; RL DNA Res. 9:99-106(2002). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1106-2481. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1914-2481. RC TISSUE=Testis; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2398, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007; RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., RA Greff Z., Keri G., Stemmann O., Mann M.; RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the RT kinome across the cell cycle."; RL Mol. Cell 31:438-448(2008). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-2104 AND SER-2398, RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [11] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a RT refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [12] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19369195; DOI=10.1074/mcp.m800588-mcp200; RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., RA Mann M., Daub H.; RT "Large-scale proteomics analysis of the human kinome."; RL Mol. Cell. Proteomics 8:1751-1764(2009). RN [13] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2393 AND SER-2398, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [14] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [15] RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22814378; DOI=10.1073/pnas.1210303109; RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.; RT "N-terminal acetylome analyses and functional insights of the N-terminal RT acetyltransferase NatB."; RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012). RN [16] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2251 AND SER-2398, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [17] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28 AND SER-2224, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: During mitosis, may be involved in the condensation of CC spindle midzone microtubules, leading to the formation of midbody. CC {ECO:0000269|PubMed:23036704}. CC -!- SUBUNIT: Interacts with AURKB. {ECO:0000269|PubMed:23036704}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, CC cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. CC Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, CC cytoskeleton, spindle pole {ECO:0000250}. Midbody {ECO:0000250}. CC Note=At interphase, localizes to centrosomes. At prometaphase and CC metaphase, associated with spindle microtubules and spindle poles. At CC anaphase, accumulates in the spindle midzone. At telophase, condensed CC on central spindles. During cytokinesis, condensed on the midbody where CC it colocalizes with AURKB (By similarity). {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Widely expressed in fetal tissues. In adult CC tissues, expressed in testis and ovary and, at much lower levels, in CC kidney and pancreas. {ECO:0000269|PubMed:23036704}. CC -!- SEQUENCE CAUTION: CC Sequence=AAH16465.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=CAB62963.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=CAB62964.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB665284; BAM66822.1; -; mRNA. DR EMBL; AL008724; CAB62963.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL008724; CAB62964.1; ALT_SEQ; Genomic_DNA. DR EMBL; AL121825; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL023281; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL050313; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL035453; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL035397; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL033538; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; ES313581; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; BU584912; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AB028966; BAA82995.3; -; mRNA. DR EMBL; BC016465; AAH16465.1; ALT_INIT; mRNA. DR EMBL; AL080174; CAB45760.2; -; mRNA. DR EMBL; AL137328; CAB70697.1; -; mRNA. DR CCDS; CCDS46678.1; -. DR PIR; T12496; T12496. DR RefSeq; NP_001138890.1; NM_001145418.1. DR AlphaFoldDB; Q96AY4; -. DR SMR; Q96AY4; -. DR BioGRID; 116918; 105. DR IntAct; Q96AY4; 35. DR MINT; Q96AY4; -. DR STRING; 9606.ENSP00000381003; -. DR GlyCosmos; Q96AY4; 2 sites, 1 glycan. DR GlyGen; Q96AY4; 3 sites, 1 O-linked glycan (3 sites). DR iPTMnet; Q96AY4; -. DR PhosphoSitePlus; Q96AY4; -. DR BioMuta; TTC28; -. DR DMDM; 218512146; -. DR EPD; Q96AY4; -. DR jPOST; Q96AY4; -. DR MassIVE; Q96AY4; -. DR MaxQB; Q96AY4; -. DR PaxDb; 9606-ENSP00000381003; -. DR PeptideAtlas; Q96AY4; -. DR ProteomicsDB; 76021; -. DR Pumba; Q96AY4; -. DR Antibodypedia; 5496; 10 antibodies from 6 providers. DR DNASU; 23331; -. DR Ensembl; ENST00000397906.7; ENSP00000381003.2; ENSG00000100154.15. DR GeneID; 23331; -. DR KEGG; hsa:23331; -. DR MANE-Select; ENST00000397906.7; ENSP00000381003.2; NM_001145418.2; NP_001138890.1. DR UCSC; uc003adp.4; human. DR AGR; HGNC:29179; -. DR CTD; 23331; -. DR DisGeNET; 23331; -. DR GeneCards; TTC28; -. DR HGNC; HGNC:29179; TTC28. DR HPA; ENSG00000100154; Low tissue specificity. DR MIM; 615098; gene. DR neXtProt; NX_Q96AY4; -. DR OpenTargets; ENSG00000100154; -. DR PharmGKB; PA145147752; -. DR VEuPathDB; HostDB:ENSG00000100154; -. DR eggNOG; KOG0548; Eukaryota. DR eggNOG; KOG1130; Eukaryota. DR GeneTree; ENSGT00940000156428; -. DR InParanoid; Q96AY4; -. DR OMA; FHAARID; -. DR OrthoDB; 2963601at2759; -. DR PhylomeDB; Q96AY4; -. DR TreeFam; TF328344; -. DR PathwayCommons; Q96AY4; -. DR SignaLink; Q96AY4; -. DR BioGRID-ORCS; 23331; 26 hits in 1145 CRISPR screens. DR ChiTaRS; TTC28; human. DR GenomeRNAi; 23331; -. DR Pharos; Q96AY4; Tdark. DR PRO; PR:Q96AY4; -. DR Proteomes; UP000005640; Chromosome 22. DR RNAct; Q96AY4; Protein. DR Bgee; ENSG00000100154; Expressed in ganglionic eminence and 198 other cell types or tissues. DR ExpressionAtlas; Q96AY4; baseline and differential. DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0030496; C:midbody; IDA:UniProtKB. DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell. DR GO; GO:0019900; F:kinase binding; IPI:UniProtKB. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:UniProtKB. DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 6. DR InterPro; IPR024983; CHAT_dom. DR InterPro; IPR011990; TPR-like_helical_dom_sf. DR InterPro; IPR019734; TPR_repeat. DR PANTHER; PTHR10098; RAPSYN-RELATED; 1. DR PANTHER; PTHR10098:SF106; TETRATRICOPEPTIDE REPEAT PROTEIN 28; 1. DR Pfam; PF12770; CHAT; 1. DR Pfam; PF13424; TPR_12; 10. DR Pfam; PF13176; TPR_7; 2. DR SMART; SM00028; TPR; 25. DR SUPFAM; SSF48452; TPR-like; 7. DR PROSITE; PS50005; TPR; 25. DR PROSITE; PS50293; TPR_REGION; 1. DR Genevisible; Q96AY4; HS. PE 1: Evidence at protein level; KW Acetylation; Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis; KW Phosphoprotein; Reference proteome; Repeat; TPR repeat. FT CHAIN 1..2481 FT /note="Tetratricopeptide repeat protein 28" FT /id="PRO_0000106427" FT REPEAT 58..91 FT /note="TPR 1" FT REPEAT 93..125 FT /note="TPR 2" FT REPEAT 126..159 FT /note="TPR 3" FT REPEAT 196..229 FT /note="TPR 4" FT REPEAT 234..267 FT /note="TPR 5" FT REPEAT 274..307 FT /note="TPR 6" FT REPEAT 314..347 FT /note="TPR 7" FT REPEAT 354..387 FT /note="TPR 8" FT REPEAT 394..427 FT /note="TPR 9" FT REPEAT 434..467 FT /note="TPR 10" FT REPEAT 474..507 FT /note="TPR 11" FT REPEAT 514..547 FT /note="TPR 12" FT REPEAT 554..587 FT /note="TPR 13" FT REPEAT 594..627 FT /note="TPR 14" FT REPEAT 634..667 FT /note="TPR 15" FT REPEAT 674..707 FT /note="TPR 16" FT REPEAT 714..747 FT /note="TPR 17" FT REPEAT 754..787 FT /note="TPR 18" FT REPEAT 794..827 FT /note="TPR 19" FT REPEAT 834..867 FT /note="TPR 20" FT REPEAT 877..910 FT /note="TPR 21" FT REPEAT 917..950 FT /note="TPR 22" FT REPEAT 957..990 FT /note="TPR 23" FT REPEAT 997..1030 FT /note="TPR 24" FT REPEAT 1037..1070 FT /note="TPR 25" FT REPEAT 1077..1110 FT /note="TPR 26" FT REPEAT 1117..1150 FT /note="TPR 27" FT REPEAT 1169..1202 FT /note="TPR 28" FT REGION 1..48 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2004..2055 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2075..2161 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2176..2339 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2420..2467 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2030..2046 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2091..2148 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2183..2228 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2240..2286 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2295..2334 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 1 FT /note="N-acetylmethionine" FT /evidence="ECO:0007744|PubMed:22814378" FT MOD_RES 28 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:24275569" FT MOD_RES 1590 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q80XJ3" FT MOD_RES 2104 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648" FT MOD_RES 2224 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:24275569" FT MOD_RES 2251 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 2393 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:20068231" FT MOD_RES 2398 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, FT ECO:0007744|PubMed:23186163" SQ SEQUENCE 2481 AA; 270884 MW; D646D744EBFCFE35 CRC64; MEQSPPPAPE PTQGPTPARS RRRREPESPP ASAPIPLFGA DTIGQRSPDG PVLSKAEFVE KVRQSNQACH DGDFHTAIVL YNEALAVDPQ NCILYSNRSA AYMKIQQYDK ALDDAIKARL LNPKWPKAYF RQGVALQYLG RHADALAAFA SGLAQDPKSL QLLVGMVEAA MKSPMRDSLE PTYQQLQKMK LDKSPFVVVS VVGQELLTAG HHGASVVVLE AALKIGTCSL KLRGSVFSAL SSAYWSLGNT EKSTGYMQQD LDVAKTLGDQ TGECRAHGNL GSAFFSKGNY REALTNHRHQ LVLAMKLKDR EAASSALSSL GHVYTAIGDY PNALASHKQC VLLAKQSKDE LSEARELGNM GAVYIAMGDF ENAVQCHEQH LKIAKDLGNK REEARAYSNL GSAYHYRRNF DKAMSYHNYV LELAQELMEK AIEMRAYAGL GHAARCMQDL ERAKQYHEQQ LGIAEDLKDR AAEGRASSNL GIIHQMKGDY DTALKLHKTH LCIAQELSDY AAQGRAYGNM GNAYNALGMY DQAVKYHRQE LQISMEVNDR ASQASTHGNL AVAYQALGAH DRALQHYQNH LNIARELRDI QSEARALSNL GNFHCSRGEY VQAAPYYEQY LRLAPDLQDM EGEGKVCHNL GYAHYCLGNY QEAVKYYEQD LALAKDLHDK LSQAKAYCNL GLAFKALLNF SKAEECQKYL LSLAQSLNNS QAKFRALGNL GDIFICKKDI NGAIKFYEQQ LGLAHQVKDR RLEASAYAAL GTAYRMIQKY DKALGYHTQE LEVYQELSDL PGECRAHGHL AAVYMALGKY TMAFKCYEEQ LDLGQKLKDP SLEAQVYGNM GITKMNMNVM EEAIGYFEQQ LAMLQQLSGN ESVLDRGRAY GNLGDCYEAL GDYEEAIKYY EQYLSVAQSL NRMQDQAKAY RGLGNGHRAM GSLQQALVCF EKRLVVAHEL GEAFNKAQAY GELGSLHSQL GNYEQAISCL ERQLNIARDM KDRALESDAA CGLGGVYQQM GEYDTALQYH QLDLQIAEET NNPTCQGRAY GNLGLTYESL GTFERAVVYQ EQHLSIAAQM NDLAAKTVSY SSLGRTHHAL QNYSQAVMYL QEGLRLAEQL GRREDEAKIR HGLGLSLWAS GNLEEAQHQL YRASALFETI RHEAQLSTDY KLSLFDLQTS SYQALQRVLV SLGHHDEALA VAERGRTRAF ADLLVERQTG QQDSDPYSPV TIDQILEMVN GQRGLVLYYS LAAGYLYSWL LAPGAGIVKF HEHYLGENTV ENSSDFQASS SVTLPTATGS ALEQHIASVR EALGVESHYS RACASSETES EAGDIMDQQF EEMNNKLNSV TDPTGFLRMV RRNNLFNRSC QSMTSLFSNT VSPTQDGTSS LPRRQSSFAK PPLRALYDLL IAPMEGGLMH SSGPVGRHRQ LILVLEGELY LIPFALLKGS SSNEYLYERF GLLAVPSIRS LSVQSKSHLR KNPPTYSSST SMAAVIGNPK LPSAVMDRWL WGPMPSAEEE AYMVSELLGC QPLVGSVATK ERVMSALTQA ECVHFATHIS WKLSALVLTP SMDGNPASSK SSFGHPYTIP ESLRVQDDAS DGESISDCPP LQELLLTAAD VLDLQLPVKL VVLGSSQESN SKVTADGVIA LTRAFLAAGA QCVLVSLWPV PVAASKMFIH AFYSSLLNGL KASAALGEAM KVVQSSKAFS HPSNWAGFML IGSDVKLNSP SSLIGQALTE ILQHPERARD ALRVLLHLVE KSLQRIQNGQ RNAMYTSQQS VENKVGGIPG WQALLTAVGF RLDPPTSGLP AAVFFPTSDP GDRLQQCSST LQSLLGLPNP ALQALCKLIT ASETGEQLIS RAVKNMVGML HQVLVQLQAG EKEQDLASAP IQVSISVQLW RLPGCHEFLA ALGFDLCEVG QEEVILKTGK QANRRTVHFA LQSLLSLFDS TELPKRLSLD SSSSLESLAS AQSVSNALPL GYQQPPFSPT GADSIASDAI SVYSLSSIAS SMSFVSKPEG GSEGGGPGGR QDHDRSKNAY LQRSTLPRSQ LPPQTRPAGN KDEEEYEGFS IISNEPLATY QENRNTCFSP DHKQPQPGTA GGMRVSVSSK GSISTPNSPV KMTLIPSPNS PFQKVGKLAS SDTGESDQSS TETDSTVKSQ EESNPKLDPQ ELAQKILEET QSHLIAVERL QRSGGQVSKS NNPEDGVQAP SSTAVFRASE TSAFSRPVLS HQKSQPSPVT VKPKPPARSS SLPKVSSGYS SPTTSEMSIK DSPSQHSGRP SPGCDSQTSQ LDQPLFKLKY PSSPYSAHIS KSPRNMSPSS GHQSPAGSAP SPALSYSSAG SARSSPADAP DIDKLKMAAI DEKVQAVHNL KMFWQSTPQH STGPMKIFRG APGTMTSKRD VLSLLNLSPR HNKKEEGVDK LELKELSLQQ HDGAPPKAPP NGHWRTETTS LGSLPLPAGP PATAPARPLR LPSGNGYKFL SPGRFFPSSK C //