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Q96AY4 (TTC28_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetratricopeptide repeat protein 28

Short name=TPR repeat protein 28
Alternative name(s):
TPR repeat-containing big gene cloned at Keio
Gene names
Name:TTC28
Synonyms:KIAA1043, TPRBK
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2481 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody. Ref.1

Subunit structure

Interacts with AURKB. Ref.1

Subcellular location

Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Midbody By similarity. Note: At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB By similarity.

Tissue specificity

Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas. Ref.1

Sequence similarities

Contains 28 TPR repeats.

Sequence caution

The sequence AAH16465.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAB62963.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAB62964.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Cellular componentCytoplasm
Cytoskeleton
   DomainRepeat
TPR repeat
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmitotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

midbody

Inferred from electronic annotation. Source: UniProtKB-SubCell

spindle pole

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 24812481Tetratricopeptide repeat protein 28
PRO_0000106427

Regions

Repeat58 – 9134TPR 1
Repeat93 – 12533TPR 2
Repeat126 – 15934TPR 3
Repeat196 – 22934TPR 4
Repeat234 – 26734TPR 5
Repeat274 – 30734TPR 6
Repeat314 – 34734TPR 7
Repeat354 – 38734TPR 8
Repeat394 – 42734TPR 9
Repeat434 – 46734TPR 10
Repeat474 – 50734TPR 11
Repeat514 – 54734TPR 12
Repeat554 – 58734TPR 13
Repeat594 – 62734TPR 14
Repeat634 – 66734TPR 15
Repeat674 – 70734TPR 16
Repeat714 – 74734TPR 17
Repeat754 – 78734TPR 18
Repeat794 – 82734TPR 19
Repeat834 – 86734TPR 20
Repeat877 – 91034TPR 21
Repeat917 – 95034TPR 22
Repeat957 – 99034TPR 23
Repeat997 – 103034TPR 24
Repeat1037 – 107034TPR 25
Repeat1077 – 111034TPR 26
Repeat1117 – 115034TPR 27
Repeat1169 – 120234TPR 28
Compositional bias1948 – 200659Ser-rich
Compositional bias2201 – 2335135Ser-rich

Amino acid modifications

Modified residue11N-acetylmethionine Ref.15
Modified residue281Phosphoserine Ref.10 Ref.12
Modified residue21041Phosphoserine Ref.10
Modified residue23931Phosphoserine Ref.13
Modified residue23981Phosphoserine Ref.9 Ref.10 Ref.13

Sequences

Sequence LengthMass (Da)Tools
Q96AY4 [UniParc].

Last modified December 16, 2008. Version 4.
Checksum: D646D744EBFCFE35

FASTA2,481270,884
        10         20         30         40         50         60 
MEQSPPPAPE PTQGPTPARS RRRREPESPP ASAPIPLFGA DTIGQRSPDG PVLSKAEFVE 

        70         80         90        100        110        120 
KVRQSNQACH DGDFHTAIVL YNEALAVDPQ NCILYSNRSA AYMKIQQYDK ALDDAIKARL 

       130        140        150        160        170        180 
LNPKWPKAYF RQGVALQYLG RHADALAAFA SGLAQDPKSL QLLVGMVEAA MKSPMRDSLE 

       190        200        210        220        230        240 
PTYQQLQKMK LDKSPFVVVS VVGQELLTAG HHGASVVVLE AALKIGTCSL KLRGSVFSAL 

       250        260        270        280        290        300 
SSAYWSLGNT EKSTGYMQQD LDVAKTLGDQ TGECRAHGNL GSAFFSKGNY REALTNHRHQ 

       310        320        330        340        350        360 
LVLAMKLKDR EAASSALSSL GHVYTAIGDY PNALASHKQC VLLAKQSKDE LSEARELGNM 

       370        380        390        400        410        420 
GAVYIAMGDF ENAVQCHEQH LKIAKDLGNK REEARAYSNL GSAYHYRRNF DKAMSYHNYV 

       430        440        450        460        470        480 
LELAQELMEK AIEMRAYAGL GHAARCMQDL ERAKQYHEQQ LGIAEDLKDR AAEGRASSNL 

       490        500        510        520        530        540 
GIIHQMKGDY DTALKLHKTH LCIAQELSDY AAQGRAYGNM GNAYNALGMY DQAVKYHRQE 

       550        560        570        580        590        600 
LQISMEVNDR ASQASTHGNL AVAYQALGAH DRALQHYQNH LNIARELRDI QSEARALSNL 

       610        620        630        640        650        660 
GNFHCSRGEY VQAAPYYEQY LRLAPDLQDM EGEGKVCHNL GYAHYCLGNY QEAVKYYEQD 

       670        680        690        700        710        720 
LALAKDLHDK LSQAKAYCNL GLAFKALLNF SKAEECQKYL LSLAQSLNNS QAKFRALGNL 

       730        740        750        760        770        780 
GDIFICKKDI NGAIKFYEQQ LGLAHQVKDR RLEASAYAAL GTAYRMIQKY DKALGYHTQE 

       790        800        810        820        830        840 
LEVYQELSDL PGECRAHGHL AAVYMALGKY TMAFKCYEEQ LDLGQKLKDP SLEAQVYGNM 

       850        860        870        880        890        900 
GITKMNMNVM EEAIGYFEQQ LAMLQQLSGN ESVLDRGRAY GNLGDCYEAL GDYEEAIKYY 

       910        920        930        940        950        960 
EQYLSVAQSL NRMQDQAKAY RGLGNGHRAM GSLQQALVCF EKRLVVAHEL GEAFNKAQAY 

       970        980        990       1000       1010       1020 
GELGSLHSQL GNYEQAISCL ERQLNIARDM KDRALESDAA CGLGGVYQQM GEYDTALQYH 

      1030       1040       1050       1060       1070       1080 
QLDLQIAEET NNPTCQGRAY GNLGLTYESL GTFERAVVYQ EQHLSIAAQM NDLAAKTVSY 

      1090       1100       1110       1120       1130       1140 
SSLGRTHHAL QNYSQAVMYL QEGLRLAEQL GRREDEAKIR HGLGLSLWAS GNLEEAQHQL 

      1150       1160       1170       1180       1190       1200 
YRASALFETI RHEAQLSTDY KLSLFDLQTS SYQALQRVLV SLGHHDEALA VAERGRTRAF 

      1210       1220       1230       1240       1250       1260 
ADLLVERQTG QQDSDPYSPV TIDQILEMVN GQRGLVLYYS LAAGYLYSWL LAPGAGIVKF 

      1270       1280       1290       1300       1310       1320 
HEHYLGENTV ENSSDFQASS SVTLPTATGS ALEQHIASVR EALGVESHYS RACASSETES 

      1330       1340       1350       1360       1370       1380 
EAGDIMDQQF EEMNNKLNSV TDPTGFLRMV RRNNLFNRSC QSMTSLFSNT VSPTQDGTSS 

      1390       1400       1410       1420       1430       1440 
LPRRQSSFAK PPLRALYDLL IAPMEGGLMH SSGPVGRHRQ LILVLEGELY LIPFALLKGS 

      1450       1460       1470       1480       1490       1500 
SSNEYLYERF GLLAVPSIRS LSVQSKSHLR KNPPTYSSST SMAAVIGNPK LPSAVMDRWL 

      1510       1520       1530       1540       1550       1560 
WGPMPSAEEE AYMVSELLGC QPLVGSVATK ERVMSALTQA ECVHFATHIS WKLSALVLTP 

      1570       1580       1590       1600       1610       1620 
SMDGNPASSK SSFGHPYTIP ESLRVQDDAS DGESISDCPP LQELLLTAAD VLDLQLPVKL 

      1630       1640       1650       1660       1670       1680 
VVLGSSQESN SKVTADGVIA LTRAFLAAGA QCVLVSLWPV PVAASKMFIH AFYSSLLNGL 

      1690       1700       1710       1720       1730       1740 
KASAALGEAM KVVQSSKAFS HPSNWAGFML IGSDVKLNSP SSLIGQALTE ILQHPERARD 

      1750       1760       1770       1780       1790       1800 
ALRVLLHLVE KSLQRIQNGQ RNAMYTSQQS VENKVGGIPG WQALLTAVGF RLDPPTSGLP 

      1810       1820       1830       1840       1850       1860 
AAVFFPTSDP GDRLQQCSST LQSLLGLPNP ALQALCKLIT ASETGEQLIS RAVKNMVGML 

      1870       1880       1890       1900       1910       1920 
HQVLVQLQAG EKEQDLASAP IQVSISVQLW RLPGCHEFLA ALGFDLCEVG QEEVILKTGK 

      1930       1940       1950       1960       1970       1980 
QANRRTVHFA LQSLLSLFDS TELPKRLSLD SSSSLESLAS AQSVSNALPL GYQQPPFSPT 

      1990       2000       2010       2020       2030       2040 
GADSIASDAI SVYSLSSIAS SMSFVSKPEG GSEGGGPGGR QDHDRSKNAY LQRSTLPRSQ 

      2050       2060       2070       2080       2090       2100 
LPPQTRPAGN KDEEEYEGFS IISNEPLATY QENRNTCFSP DHKQPQPGTA GGMRVSVSSK 

      2110       2120       2130       2140       2150       2160 
GSISTPNSPV KMTLIPSPNS PFQKVGKLAS SDTGESDQSS TETDSTVKSQ EESNPKLDPQ 

      2170       2180       2190       2200       2210       2220 
ELAQKILEET QSHLIAVERL QRSGGQVSKS NNPEDGVQAP SSTAVFRASE TSAFSRPVLS 

      2230       2240       2250       2260       2270       2280 
HQKSQPSPVT VKPKPPARSS SLPKVSSGYS SPTTSEMSIK DSPSQHSGRP SPGCDSQTSQ 

      2290       2300       2310       2320       2330       2340 
LDQPLFKLKY PSSPYSAHIS KSPRNMSPSS GHQSPAGSAP SPALSYSSAG SARSSPADAP 

      2350       2360       2370       2380       2390       2400 
DIDKLKMAAI DEKVQAVHNL KMFWQSTPQH STGPMKIFRG APGTMTSKRD VLSLLNLSPR 

      2410       2420       2430       2440       2450       2460 
HNKKEEGVDK LELKELSLQQ HDGAPPKAPP NGHWRTETTS LGSLPLPAGP PATAPARPLR 

      2470       2480 
LPSGNGYKFL SPGRFFPSSK C 

« Hide

References

« Hide 'large scale' references
[1]"A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis."
Izumiyama T., Minoshima S., Yoshida T., Shimizu N.
Gene 511:202-217(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH AURKB, TISSUE SPECIFICITY.
[2]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"KNU hair EST project."
Kim M.K., Kim Y.H., Suh J.M., Lee H.M., Hwang S.Y., Sohn M.Y., Im S.U., Chung E.J., Cha S.Y., Park M.K., Kim J.O., Kim J.A., Yang J.O., Sung Y.K., Kim J.C.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-97.
[4]"Re-evaluating human gene annotation: a second generation analysis of chromosome 22."
Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-292.
[5]"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 356-2481.
Tissue: Brain.
[6]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1106-2481.
Tissue: Brain.
[8]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1914-2481.
Tissue: Testis.
[9]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-2104 AND SER-2398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2393 AND SER-2398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB665284 mRNA. Translation: BAM66822.1.
AL008724 Genomic DNA. Translation: CAB62963.1. Sequence problems.
AL008724 Genomic DNA. Translation: CAB62964.1. Sequence problems.
AL121825 expand/collapse EMBL AC list , AL023281, AL033538, AL035397, AL035453, AL050313 Genomic DNA. Translation: CAH73824.1.
AL023281 expand/collapse EMBL AC list , AL033538, AL035397, AL035453, AL050313, AL121825 Genomic DNA. Translation: CAI17985.1.
AL050313 expand/collapse EMBL AC list , AL023281, AL033538, AL035397, AL035453, AL121825 Genomic DNA. Translation: CAI17993.1.
AL035453 expand/collapse EMBL AC list , AL023281, AL033538, AL035397, AL050313, AL121825 Genomic DNA. Translation: CAI18760.1.
AL035397 expand/collapse EMBL AC list , AL023281, AL033538, AL035453, AL050313, AL121825 Genomic DNA. Translation: CAI18818.1.
AL033538 expand/collapse EMBL AC list , AL023281, AL035397, AL035453, AL050313, AL121825 Genomic DNA. Translation: CAI21502.1.
ES313581 mRNA. No translation available.
BU584912 mRNA. No translation available.
AB028966 mRNA. Translation: BAA82995.3.
BC016465 mRNA. Translation: AAH16465.1. Different initiation.
AL080174 mRNA. Translation: CAB45760.2.
AL137328 mRNA. Translation: CAB70697.1.
CCDSCCDS46678.1.
PIRT12496.
RefSeqNP_001138890.1. NM_001145418.1.
UniGeneHs.387856.

3D structure databases

ProteinModelPortalQ96AY4.
SMRQ96AY4. Positions 60-185, 199-1231.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116918. 4 interactions.
IntActQ96AY4. 3 interactions.

Polymorphism databases

DMDM218512146.

Proteomic databases

MaxQBQ96AY4.
PaxDbQ96AY4.
PRIDEQ96AY4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000397906; ENSP00000381003; ENSG00000100154.
GeneID23331.
KEGGhsa:23331.
UCSCuc003adp.4. human.

Organism-specific databases

CTD23331.
GeneCardsGC22M028374.
H-InvDBHIX0016336.
HGNCHGNC:29179. TTC28.
HPAHPA003099.
MIM615098. gene.
neXtProtNX_Q96AY4.
PharmGKBPA145147752.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4995.
HOVERGENHBG052194.
InParanoidQ96AY4.
OMASYYSRAC.
OrthoDBEOG7D2FCR.
PhylomeDBQ96AY4.
TreeFamTF328344.

Gene expression databases

ArrayExpressQ96AY4.
BgeeQ96AY4.
CleanExHS_TTC28.
GenevestigatorQ96AY4.

Family and domain databases

Gene3D1.25.40.10. 5 hits.
InterProIPR024983. CHAT_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
IPR028833. TTC28.
[Graphical view]
PANTHERPTHR10098:SF106. PTHR10098:SF106. 1 hit.
PfamPF12770. CHAT. 1 hit.
PF00515. TPR_1. 3 hits.
PF07719. TPR_2. 2 hits.
PF13176. TPR_7. 1 hit.
[Graphical view]
SMARTSM00028. TPR. 25 hits.
[Graphical view]
PROSITEPS50005. TPR. 25 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTTC28. human.
GenomeRNAi23331.
NextBio45253.
PROQ96AY4.
SOURCESearch...

Entry information

Entry nameTTC28_HUMAN
AccessionPrimary (citable) accession number: Q96AY4
Secondary accession number(s): K7ZRV2 expand/collapse secondary AC list , O95928, O95929, Q5W189, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: December 16, 2008
Last modified: July 9, 2014
This is version 130 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM