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Q96AY4

- TTC28_HUMAN

UniProt

Q96AY4 - TTC28_HUMAN

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Protein

Tetratricopeptide repeat protein 28

Gene

TTC28

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.1 Publication

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. regulation of mitotic cell cycle Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 28
Short name:
TPR repeat protein 28
Alternative name(s):
TPR repeat-containing big gene cloned at Keio
Gene namesi
Name:TTC28
Synonyms:KIAA1043, TPRBK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:29179. TTC28.

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Midbody By similarity
Note: At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity).By similarity

GO - Cellular componenti

  1. centrosome Source: InterPro
  2. cytoplasm Source: UniProtKB-KW
  3. midbody Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147752.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24812481Tetratricopeptide repeat protein 28PRO_0000106427Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei28 – 281Phosphoserine2 Publications
Modified residuei2104 – 21041Phosphoserine1 Publication
Modified residuei2393 – 23931Phosphoserine1 Publication
Modified residuei2398 – 23981Phosphoserine3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96AY4.
PaxDbiQ96AY4.
PRIDEiQ96AY4.

Expressioni

Tissue specificityi

Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas.1 Publication

Gene expression databases

BgeeiQ96AY4.
CleanExiHS_TTC28.
ExpressionAtlasiQ96AY4. baseline and differential.
GenevestigatoriQ96AY4.

Organism-specific databases

HPAiHPA003099.

Interactioni

Subunit structurei

Interacts with AURKB.1 Publication

Protein-protein interaction databases

BioGridi116918. 9 interactions.
IntActiQ96AY4. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ96AY4.
SMRiQ96AY4. Positions 60-166, 199-1231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 9134TPR 1Add
BLAST
Repeati93 – 12533TPR 2Add
BLAST
Repeati126 – 15934TPR 3Add
BLAST
Repeati196 – 22934TPR 4Add
BLAST
Repeati234 – 26734TPR 5Add
BLAST
Repeati274 – 30734TPR 6Add
BLAST
Repeati314 – 34734TPR 7Add
BLAST
Repeati354 – 38734TPR 8Add
BLAST
Repeati394 – 42734TPR 9Add
BLAST
Repeati434 – 46734TPR 10Add
BLAST
Repeati474 – 50734TPR 11Add
BLAST
Repeati514 – 54734TPR 12Add
BLAST
Repeati554 – 58734TPR 13Add
BLAST
Repeati594 – 62734TPR 14Add
BLAST
Repeati634 – 66734TPR 15Add
BLAST
Repeati674 – 70734TPR 16Add
BLAST
Repeati714 – 74734TPR 17Add
BLAST
Repeati754 – 78734TPR 18Add
BLAST
Repeati794 – 82734TPR 19Add
BLAST
Repeati834 – 86734TPR 20Add
BLAST
Repeati877 – 91034TPR 21Add
BLAST
Repeati917 – 95034TPR 22Add
BLAST
Repeati957 – 99034TPR 23Add
BLAST
Repeati997 – 103034TPR 24Add
BLAST
Repeati1037 – 107034TPR 25Add
BLAST
Repeati1077 – 111034TPR 26Add
BLAST
Repeati1117 – 115034TPR 27Add
BLAST
Repeati1169 – 120234TPR 28Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1948 – 200659Ser-richAdd
BLAST
Compositional biasi2201 – 2335135Ser-richAdd
BLAST

Sequence similaritiesi

Contains 28 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG4995.
GeneTreeiENSGT00530000063126.
HOVERGENiHBG052194.
InParanoidiQ96AY4.
OMAiSYYSRAC.
OrthoDBiEOG7D2FCR.
PhylomeDBiQ96AY4.
TreeFamiTF328344.

Family and domain databases

Gene3Di1.25.40.10. 5 hits.
InterProiIPR024983. CHAT_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
IPR028833. TTC28.
[Graphical view]
PANTHERiPTHR10098:SF106. PTHR10098:SF106. 1 hit.
PfamiPF12770. CHAT. 1 hit.
PF00515. TPR_1. 3 hits.
PF07719. TPR_2. 2 hits.
PF13176. TPR_7. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 25 hits.
[Graphical view]
PROSITEiPS50005. TPR. 25 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96AY4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQSPPPAPE PTQGPTPARS RRRREPESPP ASAPIPLFGA DTIGQRSPDG
60 70 80 90 100
PVLSKAEFVE KVRQSNQACH DGDFHTAIVL YNEALAVDPQ NCILYSNRSA
110 120 130 140 150
AYMKIQQYDK ALDDAIKARL LNPKWPKAYF RQGVALQYLG RHADALAAFA
160 170 180 190 200
SGLAQDPKSL QLLVGMVEAA MKSPMRDSLE PTYQQLQKMK LDKSPFVVVS
210 220 230 240 250
VVGQELLTAG HHGASVVVLE AALKIGTCSL KLRGSVFSAL SSAYWSLGNT
260 270 280 290 300
EKSTGYMQQD LDVAKTLGDQ TGECRAHGNL GSAFFSKGNY REALTNHRHQ
310 320 330 340 350
LVLAMKLKDR EAASSALSSL GHVYTAIGDY PNALASHKQC VLLAKQSKDE
360 370 380 390 400
LSEARELGNM GAVYIAMGDF ENAVQCHEQH LKIAKDLGNK REEARAYSNL
410 420 430 440 450
GSAYHYRRNF DKAMSYHNYV LELAQELMEK AIEMRAYAGL GHAARCMQDL
460 470 480 490 500
ERAKQYHEQQ LGIAEDLKDR AAEGRASSNL GIIHQMKGDY DTALKLHKTH
510 520 530 540 550
LCIAQELSDY AAQGRAYGNM GNAYNALGMY DQAVKYHRQE LQISMEVNDR
560 570 580 590 600
ASQASTHGNL AVAYQALGAH DRALQHYQNH LNIARELRDI QSEARALSNL
610 620 630 640 650
GNFHCSRGEY VQAAPYYEQY LRLAPDLQDM EGEGKVCHNL GYAHYCLGNY
660 670 680 690 700
QEAVKYYEQD LALAKDLHDK LSQAKAYCNL GLAFKALLNF SKAEECQKYL
710 720 730 740 750
LSLAQSLNNS QAKFRALGNL GDIFICKKDI NGAIKFYEQQ LGLAHQVKDR
760 770 780 790 800
RLEASAYAAL GTAYRMIQKY DKALGYHTQE LEVYQELSDL PGECRAHGHL
810 820 830 840 850
AAVYMALGKY TMAFKCYEEQ LDLGQKLKDP SLEAQVYGNM GITKMNMNVM
860 870 880 890 900
EEAIGYFEQQ LAMLQQLSGN ESVLDRGRAY GNLGDCYEAL GDYEEAIKYY
910 920 930 940 950
EQYLSVAQSL NRMQDQAKAY RGLGNGHRAM GSLQQALVCF EKRLVVAHEL
960 970 980 990 1000
GEAFNKAQAY GELGSLHSQL GNYEQAISCL ERQLNIARDM KDRALESDAA
1010 1020 1030 1040 1050
CGLGGVYQQM GEYDTALQYH QLDLQIAEET NNPTCQGRAY GNLGLTYESL
1060 1070 1080 1090 1100
GTFERAVVYQ EQHLSIAAQM NDLAAKTVSY SSLGRTHHAL QNYSQAVMYL
1110 1120 1130 1140 1150
QEGLRLAEQL GRREDEAKIR HGLGLSLWAS GNLEEAQHQL YRASALFETI
1160 1170 1180 1190 1200
RHEAQLSTDY KLSLFDLQTS SYQALQRVLV SLGHHDEALA VAERGRTRAF
1210 1220 1230 1240 1250
ADLLVERQTG QQDSDPYSPV TIDQILEMVN GQRGLVLYYS LAAGYLYSWL
1260 1270 1280 1290 1300
LAPGAGIVKF HEHYLGENTV ENSSDFQASS SVTLPTATGS ALEQHIASVR
1310 1320 1330 1340 1350
EALGVESHYS RACASSETES EAGDIMDQQF EEMNNKLNSV TDPTGFLRMV
1360 1370 1380 1390 1400
RRNNLFNRSC QSMTSLFSNT VSPTQDGTSS LPRRQSSFAK PPLRALYDLL
1410 1420 1430 1440 1450
IAPMEGGLMH SSGPVGRHRQ LILVLEGELY LIPFALLKGS SSNEYLYERF
1460 1470 1480 1490 1500
GLLAVPSIRS LSVQSKSHLR KNPPTYSSST SMAAVIGNPK LPSAVMDRWL
1510 1520 1530 1540 1550
WGPMPSAEEE AYMVSELLGC QPLVGSVATK ERVMSALTQA ECVHFATHIS
1560 1570 1580 1590 1600
WKLSALVLTP SMDGNPASSK SSFGHPYTIP ESLRVQDDAS DGESISDCPP
1610 1620 1630 1640 1650
LQELLLTAAD VLDLQLPVKL VVLGSSQESN SKVTADGVIA LTRAFLAAGA
1660 1670 1680 1690 1700
QCVLVSLWPV PVAASKMFIH AFYSSLLNGL KASAALGEAM KVVQSSKAFS
1710 1720 1730 1740 1750
HPSNWAGFML IGSDVKLNSP SSLIGQALTE ILQHPERARD ALRVLLHLVE
1760 1770 1780 1790 1800
KSLQRIQNGQ RNAMYTSQQS VENKVGGIPG WQALLTAVGF RLDPPTSGLP
1810 1820 1830 1840 1850
AAVFFPTSDP GDRLQQCSST LQSLLGLPNP ALQALCKLIT ASETGEQLIS
1860 1870 1880 1890 1900
RAVKNMVGML HQVLVQLQAG EKEQDLASAP IQVSISVQLW RLPGCHEFLA
1910 1920 1930 1940 1950
ALGFDLCEVG QEEVILKTGK QANRRTVHFA LQSLLSLFDS TELPKRLSLD
1960 1970 1980 1990 2000
SSSSLESLAS AQSVSNALPL GYQQPPFSPT GADSIASDAI SVYSLSSIAS
2010 2020 2030 2040 2050
SMSFVSKPEG GSEGGGPGGR QDHDRSKNAY LQRSTLPRSQ LPPQTRPAGN
2060 2070 2080 2090 2100
KDEEEYEGFS IISNEPLATY QENRNTCFSP DHKQPQPGTA GGMRVSVSSK
2110 2120 2130 2140 2150
GSISTPNSPV KMTLIPSPNS PFQKVGKLAS SDTGESDQSS TETDSTVKSQ
2160 2170 2180 2190 2200
EESNPKLDPQ ELAQKILEET QSHLIAVERL QRSGGQVSKS NNPEDGVQAP
2210 2220 2230 2240 2250
SSTAVFRASE TSAFSRPVLS HQKSQPSPVT VKPKPPARSS SLPKVSSGYS
2260 2270 2280 2290 2300
SPTTSEMSIK DSPSQHSGRP SPGCDSQTSQ LDQPLFKLKY PSSPYSAHIS
2310 2320 2330 2340 2350
KSPRNMSPSS GHQSPAGSAP SPALSYSSAG SARSSPADAP DIDKLKMAAI
2360 2370 2380 2390 2400
DEKVQAVHNL KMFWQSTPQH STGPMKIFRG APGTMTSKRD VLSLLNLSPR
2410 2420 2430 2440 2450
HNKKEEGVDK LELKELSLQQ HDGAPPKAPP NGHWRTETTS LGSLPLPAGP
2460 2470 2480
PATAPARPLR LPSGNGYKFL SPGRFFPSSK C
Length:2,481
Mass (Da):270,884
Last modified:December 16, 2008 - v4
Checksum:iD646D744EBFCFE35
GO

Sequence cautioni

The sequence AAH16465.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB62963.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAB62964.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB665284 mRNA. Translation: BAM66822.1.
AL008724 Genomic DNA. Translation: CAB62963.1. Sequence problems.
AL008724 Genomic DNA. Translation: CAB62964.1. Sequence problems.
AL121825
, AL023281, AL033538, AL035397, AL035453, AL050313 Genomic DNA. Translation: CAH73824.1.
AL023281
, AL033538, AL035397, AL035453, AL050313, AL121825 Genomic DNA. Translation: CAI17985.1.
AL050313
, AL023281, AL033538, AL035397, AL035453, AL121825 Genomic DNA. Translation: CAI17993.1.
AL035453
, AL023281, AL033538, AL035397, AL050313, AL121825 Genomic DNA. Translation: CAI18760.1.
AL035397
, AL023281, AL033538, AL035453, AL050313, AL121825 Genomic DNA. Translation: CAI18818.1.
AL033538
, AL023281, AL035397, AL035453, AL050313, AL121825 Genomic DNA. Translation: CAI21502.1.
ES313581 mRNA. No translation available.
BU584912 mRNA. No translation available.
AB028966 mRNA. Translation: BAA82995.3.
BC016465 mRNA. Translation: AAH16465.1. Different initiation.
AL080174 mRNA. Translation: CAB45760.2.
AL137328 mRNA. Translation: CAB70697.1.
CCDSiCCDS46678.1.
PIRiT12496.
RefSeqiNP_001138890.1. NM_001145418.1.
UniGeneiHs.387856.

Genome annotation databases

EnsembliENST00000397906; ENSP00000381003; ENSG00000100154.
GeneIDi23331.
KEGGihsa:23331.
UCSCiuc003adp.4. human.

Polymorphism databases

DMDMi218512146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB665284 mRNA. Translation: BAM66822.1 .
AL008724 Genomic DNA. Translation: CAB62963.1 . Sequence problems.
AL008724 Genomic DNA. Translation: CAB62964.1 . Sequence problems.
AL121825
, AL023281 , AL033538 , AL035397 , AL035453 , AL050313 Genomic DNA. Translation: CAH73824.1 .
AL023281
, AL033538 , AL035397 , AL035453 , AL050313 , AL121825 Genomic DNA. Translation: CAI17985.1 .
AL050313
, AL023281 , AL033538 , AL035397 , AL035453 , AL121825 Genomic DNA. Translation: CAI17993.1 .
AL035453
, AL023281 , AL033538 , AL035397 , AL050313 , AL121825 Genomic DNA. Translation: CAI18760.1 .
AL035397
, AL023281 , AL033538 , AL035453 , AL050313 , AL121825 Genomic DNA. Translation: CAI18818.1 .
AL033538
, AL023281 , AL035397 , AL035453 , AL050313 , AL121825 Genomic DNA. Translation: CAI21502.1 .
ES313581 mRNA. No translation available.
BU584912 mRNA. No translation available.
AB028966 mRNA. Translation: BAA82995.3 .
BC016465 mRNA. Translation: AAH16465.1 . Different initiation.
AL080174 mRNA. Translation: CAB45760.2 .
AL137328 mRNA. Translation: CAB70697.1 .
CCDSi CCDS46678.1.
PIRi T12496.
RefSeqi NP_001138890.1. NM_001145418.1.
UniGenei Hs.387856.

3D structure databases

ProteinModelPortali Q96AY4.
SMRi Q96AY4. Positions 60-166, 199-1231.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116918. 9 interactions.
IntActi Q96AY4. 3 interactions.

Polymorphism databases

DMDMi 218512146.

Proteomic databases

MaxQBi Q96AY4.
PaxDbi Q96AY4.
PRIDEi Q96AY4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397906 ; ENSP00000381003 ; ENSG00000100154 .
GeneIDi 23331.
KEGGi hsa:23331.
UCSCi uc003adp.4. human.

Organism-specific databases

CTDi 23331.
GeneCardsi GC22M028374.
H-InvDB HIX0016336.
HGNCi HGNC:29179. TTC28.
HPAi HPA003099.
MIMi 615098. gene.
neXtProti NX_Q96AY4.
PharmGKBi PA145147752.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4995.
GeneTreei ENSGT00530000063126.
HOVERGENi HBG052194.
InParanoidi Q96AY4.
OMAi SYYSRAC.
OrthoDBi EOG7D2FCR.
PhylomeDBi Q96AY4.
TreeFami TF328344.

Miscellaneous databases

ChiTaRSi TTC28. human.
GenomeRNAii 23331.
NextBioi 45253.
PROi Q96AY4.
SOURCEi Search...

Gene expression databases

Bgeei Q96AY4.
CleanExi HS_TTC28.
ExpressionAtlasi Q96AY4. baseline and differential.
Genevestigatori Q96AY4.

Family and domain databases

Gene3Di 1.25.40.10. 5 hits.
InterProi IPR024983. CHAT_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
IPR028833. TTC28.
[Graphical view ]
PANTHERi PTHR10098:SF106. PTHR10098:SF106. 1 hit.
Pfami PF12770. CHAT. 1 hit.
PF00515. TPR_1. 3 hits.
PF07719. TPR_2. 2 hits.
PF13176. TPR_7. 1 hit.
[Graphical view ]
SMARTi SM00028. TPR. 25 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 25 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis."
    Izumiyama T., Minoshima S., Yoshida T., Shimizu N.
    Gene 511:202-217(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH AURKB, TISSUE SPECIFICITY.
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "KNU hair EST project."
    Kim M.K., Kim Y.H., Suh J.M., Lee H.M., Hwang S.Y., Sohn M.Y., Im S.U., Chung E.J., Cha S.Y., Park M.K., Kim J.O., Kim J.A., Yang J.O., Sung Y.K., Kim J.C.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-97.
  4. "Re-evaluating human gene annotation: a second generation analysis of chromosome 22."
    Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-292.
  5. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 356-2481.
    Tissue: Brain.
  6. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1106-2481.
    Tissue: Brain.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1914-2481.
    Tissue: Testis.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-2104 AND SER-2398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2393 AND SER-2398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTTC28_HUMAN
AccessioniPrimary (citable) accession number: Q96AY4
Secondary accession number(s): K7ZRV2
, O95928, O95929, Q5W189, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3