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Q96AY4

- TTC28_HUMAN

UniProt

Q96AY4 - TTC28_HUMAN

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Protein
Tetratricopeptide repeat protein 28
Gene
TTC28, KIAA1043, TPRBK
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.1 Publication

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. regulation of mitotic cell cycle Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 28
Short name:
TPR repeat protein 28
Alternative name(s):
TPR repeat-containing big gene cloned at Keio
Gene namesi
Name:TTC28
Synonyms:KIAA1043, TPRBK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:29179. TTC28.

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Midbody By similarity
Note: At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB By similarity.

GO - Cellular componenti

  1. centrosome Source: InterPro
  2. cytoplasm Source: UniProtKB-KW
  3. midbody Source: UniProtKB-SubCell
  4. spindle pole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147752.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24812481Tetratricopeptide repeat protein 28
PRO_0000106427Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei28 – 281Phosphoserine2 Publications
Modified residuei2104 – 21041Phosphoserine1 Publication
Modified residuei2393 – 23931Phosphoserine1 Publication
Modified residuei2398 – 23981Phosphoserine3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96AY4.
PaxDbiQ96AY4.
PRIDEiQ96AY4.

Expressioni

Tissue specificityi

Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas.1 Publication

Gene expression databases

ArrayExpressiQ96AY4.
BgeeiQ96AY4.
CleanExiHS_TTC28.
GenevestigatoriQ96AY4.

Organism-specific databases

HPAiHPA003099.

Interactioni

Subunit structurei

Interacts with AURKB.1 Publication

Protein-protein interaction databases

BioGridi116918. 4 interactions.
IntActiQ96AY4. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ96AY4.
SMRiQ96AY4. Positions 60-185, 199-1231.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 9134TPR 1
Add
BLAST
Repeati93 – 12533TPR 2
Add
BLAST
Repeati126 – 15934TPR 3
Add
BLAST
Repeati196 – 22934TPR 4
Add
BLAST
Repeati234 – 26734TPR 5
Add
BLAST
Repeati274 – 30734TPR 6
Add
BLAST
Repeati314 – 34734TPR 7
Add
BLAST
Repeati354 – 38734TPR 8
Add
BLAST
Repeati394 – 42734TPR 9
Add
BLAST
Repeati434 – 46734TPR 10
Add
BLAST
Repeati474 – 50734TPR 11
Add
BLAST
Repeati514 – 54734TPR 12
Add
BLAST
Repeati554 – 58734TPR 13
Add
BLAST
Repeati594 – 62734TPR 14
Add
BLAST
Repeati634 – 66734TPR 15
Add
BLAST
Repeati674 – 70734TPR 16
Add
BLAST
Repeati714 – 74734TPR 17
Add
BLAST
Repeati754 – 78734TPR 18
Add
BLAST
Repeati794 – 82734TPR 19
Add
BLAST
Repeati834 – 86734TPR 20
Add
BLAST
Repeati877 – 91034TPR 21
Add
BLAST
Repeati917 – 95034TPR 22
Add
BLAST
Repeati957 – 99034TPR 23
Add
BLAST
Repeati997 – 103034TPR 24
Add
BLAST
Repeati1037 – 107034TPR 25
Add
BLAST
Repeati1077 – 111034TPR 26
Add
BLAST
Repeati1117 – 115034TPR 27
Add
BLAST
Repeati1169 – 120234TPR 28
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1948 – 200659Ser-rich
Add
BLAST
Compositional biasi2201 – 2335135Ser-rich
Add
BLAST

Sequence similaritiesi

Contains 28 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG4995.
HOVERGENiHBG052194.
InParanoidiQ96AY4.
OMAiSYYSRAC.
OrthoDBiEOG7D2FCR.
PhylomeDBiQ96AY4.
TreeFamiTF328344.

Family and domain databases

Gene3Di1.25.40.10. 5 hits.
InterProiIPR024983. CHAT_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
IPR028833. TTC28.
[Graphical view]
PANTHERiPTHR10098:SF106. PTHR10098:SF106. 1 hit.
PfamiPF12770. CHAT. 1 hit.
PF00515. TPR_1. 3 hits.
PF07719. TPR_2. 2 hits.
PF13176. TPR_7. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 25 hits.
[Graphical view]
PROSITEiPS50005. TPR. 25 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96AY4-1 [UniParc]FASTAAdd to Basket

« Hide

MEQSPPPAPE PTQGPTPARS RRRREPESPP ASAPIPLFGA DTIGQRSPDG     50
PVLSKAEFVE KVRQSNQACH DGDFHTAIVL YNEALAVDPQ NCILYSNRSA 100
AYMKIQQYDK ALDDAIKARL LNPKWPKAYF RQGVALQYLG RHADALAAFA 150
SGLAQDPKSL QLLVGMVEAA MKSPMRDSLE PTYQQLQKMK LDKSPFVVVS 200
VVGQELLTAG HHGASVVVLE AALKIGTCSL KLRGSVFSAL SSAYWSLGNT 250
EKSTGYMQQD LDVAKTLGDQ TGECRAHGNL GSAFFSKGNY REALTNHRHQ 300
LVLAMKLKDR EAASSALSSL GHVYTAIGDY PNALASHKQC VLLAKQSKDE 350
LSEARELGNM GAVYIAMGDF ENAVQCHEQH LKIAKDLGNK REEARAYSNL 400
GSAYHYRRNF DKAMSYHNYV LELAQELMEK AIEMRAYAGL GHAARCMQDL 450
ERAKQYHEQQ LGIAEDLKDR AAEGRASSNL GIIHQMKGDY DTALKLHKTH 500
LCIAQELSDY AAQGRAYGNM GNAYNALGMY DQAVKYHRQE LQISMEVNDR 550
ASQASTHGNL AVAYQALGAH DRALQHYQNH LNIARELRDI QSEARALSNL 600
GNFHCSRGEY VQAAPYYEQY LRLAPDLQDM EGEGKVCHNL GYAHYCLGNY 650
QEAVKYYEQD LALAKDLHDK LSQAKAYCNL GLAFKALLNF SKAEECQKYL 700
LSLAQSLNNS QAKFRALGNL GDIFICKKDI NGAIKFYEQQ LGLAHQVKDR 750
RLEASAYAAL GTAYRMIQKY DKALGYHTQE LEVYQELSDL PGECRAHGHL 800
AAVYMALGKY TMAFKCYEEQ LDLGQKLKDP SLEAQVYGNM GITKMNMNVM 850
EEAIGYFEQQ LAMLQQLSGN ESVLDRGRAY GNLGDCYEAL GDYEEAIKYY 900
EQYLSVAQSL NRMQDQAKAY RGLGNGHRAM GSLQQALVCF EKRLVVAHEL 950
GEAFNKAQAY GELGSLHSQL GNYEQAISCL ERQLNIARDM KDRALESDAA 1000
CGLGGVYQQM GEYDTALQYH QLDLQIAEET NNPTCQGRAY GNLGLTYESL 1050
GTFERAVVYQ EQHLSIAAQM NDLAAKTVSY SSLGRTHHAL QNYSQAVMYL 1100
QEGLRLAEQL GRREDEAKIR HGLGLSLWAS GNLEEAQHQL YRASALFETI 1150
RHEAQLSTDY KLSLFDLQTS SYQALQRVLV SLGHHDEALA VAERGRTRAF 1200
ADLLVERQTG QQDSDPYSPV TIDQILEMVN GQRGLVLYYS LAAGYLYSWL 1250
LAPGAGIVKF HEHYLGENTV ENSSDFQASS SVTLPTATGS ALEQHIASVR 1300
EALGVESHYS RACASSETES EAGDIMDQQF EEMNNKLNSV TDPTGFLRMV 1350
RRNNLFNRSC QSMTSLFSNT VSPTQDGTSS LPRRQSSFAK PPLRALYDLL 1400
IAPMEGGLMH SSGPVGRHRQ LILVLEGELY LIPFALLKGS SSNEYLYERF 1450
GLLAVPSIRS LSVQSKSHLR KNPPTYSSST SMAAVIGNPK LPSAVMDRWL 1500
WGPMPSAEEE AYMVSELLGC QPLVGSVATK ERVMSALTQA ECVHFATHIS 1550
WKLSALVLTP SMDGNPASSK SSFGHPYTIP ESLRVQDDAS DGESISDCPP 1600
LQELLLTAAD VLDLQLPVKL VVLGSSQESN SKVTADGVIA LTRAFLAAGA 1650
QCVLVSLWPV PVAASKMFIH AFYSSLLNGL KASAALGEAM KVVQSSKAFS 1700
HPSNWAGFML IGSDVKLNSP SSLIGQALTE ILQHPERARD ALRVLLHLVE 1750
KSLQRIQNGQ RNAMYTSQQS VENKVGGIPG WQALLTAVGF RLDPPTSGLP 1800
AAVFFPTSDP GDRLQQCSST LQSLLGLPNP ALQALCKLIT ASETGEQLIS 1850
RAVKNMVGML HQVLVQLQAG EKEQDLASAP IQVSISVQLW RLPGCHEFLA 1900
ALGFDLCEVG QEEVILKTGK QANRRTVHFA LQSLLSLFDS TELPKRLSLD 1950
SSSSLESLAS AQSVSNALPL GYQQPPFSPT GADSIASDAI SVYSLSSIAS 2000
SMSFVSKPEG GSEGGGPGGR QDHDRSKNAY LQRSTLPRSQ LPPQTRPAGN 2050
KDEEEYEGFS IISNEPLATY QENRNTCFSP DHKQPQPGTA GGMRVSVSSK 2100
GSISTPNSPV KMTLIPSPNS PFQKVGKLAS SDTGESDQSS TETDSTVKSQ 2150
EESNPKLDPQ ELAQKILEET QSHLIAVERL QRSGGQVSKS NNPEDGVQAP 2200
SSTAVFRASE TSAFSRPVLS HQKSQPSPVT VKPKPPARSS SLPKVSSGYS 2250
SPTTSEMSIK DSPSQHSGRP SPGCDSQTSQ LDQPLFKLKY PSSPYSAHIS 2300
KSPRNMSPSS GHQSPAGSAP SPALSYSSAG SARSSPADAP DIDKLKMAAI 2350
DEKVQAVHNL KMFWQSTPQH STGPMKIFRG APGTMTSKRD VLSLLNLSPR 2400
HNKKEEGVDK LELKELSLQQ HDGAPPKAPP NGHWRTETTS LGSLPLPAGP 2450
PATAPARPLR LPSGNGYKFL SPGRFFPSSK C 2481
Length:2,481
Mass (Da):270,884
Last modified:December 16, 2008 - v4
Checksum:iD646D744EBFCFE35
GO

Sequence cautioni

The sequence AAH16465.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAB62963.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAB62964.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB665284 mRNA. Translation: BAM66822.1.
AL008724 Genomic DNA. Translation: CAB62963.1. Sequence problems.
AL008724 Genomic DNA. Translation: CAB62964.1. Sequence problems.
AL121825
, AL023281, AL033538, AL035397, AL035453, AL050313 Genomic DNA. Translation: CAH73824.1.
AL023281
, AL033538, AL035397, AL035453, AL050313, AL121825 Genomic DNA. Translation: CAI17985.1.
AL050313
, AL023281, AL033538, AL035397, AL035453, AL121825 Genomic DNA. Translation: CAI17993.1.
AL035453
, AL023281, AL033538, AL035397, AL050313, AL121825 Genomic DNA. Translation: CAI18760.1.
AL035397
, AL023281, AL033538, AL035453, AL050313, AL121825 Genomic DNA. Translation: CAI18818.1.
AL033538
, AL023281, AL035397, AL035453, AL050313, AL121825 Genomic DNA. Translation: CAI21502.1.
ES313581 mRNA. No translation available.
BU584912 mRNA. No translation available.
AB028966 mRNA. Translation: BAA82995.3.
BC016465 mRNA. Translation: AAH16465.1. Different initiation.
AL080174 mRNA. Translation: CAB45760.2.
AL137328 mRNA. Translation: CAB70697.1.
CCDSiCCDS46678.1.
PIRiT12496.
RefSeqiNP_001138890.1. NM_001145418.1.
UniGeneiHs.387856.

Genome annotation databases

EnsembliENST00000397906; ENSP00000381003; ENSG00000100154.
GeneIDi23331.
KEGGihsa:23331.
UCSCiuc003adp.4. human.

Polymorphism databases

DMDMi218512146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB665284 mRNA. Translation: BAM66822.1 .
AL008724 Genomic DNA. Translation: CAB62963.1 . Sequence problems.
AL008724 Genomic DNA. Translation: CAB62964.1 . Sequence problems.
AL121825
, AL023281 , AL033538 , AL035397 , AL035453 , AL050313 Genomic DNA. Translation: CAH73824.1 .
AL023281
, AL033538 , AL035397 , AL035453 , AL050313 , AL121825 Genomic DNA. Translation: CAI17985.1 .
AL050313
, AL023281 , AL033538 , AL035397 , AL035453 , AL121825 Genomic DNA. Translation: CAI17993.1 .
AL035453
, AL023281 , AL033538 , AL035397 , AL050313 , AL121825 Genomic DNA. Translation: CAI18760.1 .
AL035397
, AL023281 , AL033538 , AL035453 , AL050313 , AL121825 Genomic DNA. Translation: CAI18818.1 .
AL033538
, AL023281 , AL035397 , AL035453 , AL050313 , AL121825 Genomic DNA. Translation: CAI21502.1 .
ES313581 mRNA. No translation available.
BU584912 mRNA. No translation available.
AB028966 mRNA. Translation: BAA82995.3 .
BC016465 mRNA. Translation: AAH16465.1 . Different initiation.
AL080174 mRNA. Translation: CAB45760.2 .
AL137328 mRNA. Translation: CAB70697.1 .
CCDSi CCDS46678.1.
PIRi T12496.
RefSeqi NP_001138890.1. NM_001145418.1.
UniGenei Hs.387856.

3D structure databases

ProteinModelPortali Q96AY4.
SMRi Q96AY4. Positions 60-185, 199-1231.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116918. 4 interactions.
IntActi Q96AY4. 3 interactions.

Polymorphism databases

DMDMi 218512146.

Proteomic databases

MaxQBi Q96AY4.
PaxDbi Q96AY4.
PRIDEi Q96AY4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397906 ; ENSP00000381003 ; ENSG00000100154 .
GeneIDi 23331.
KEGGi hsa:23331.
UCSCi uc003adp.4. human.

Organism-specific databases

CTDi 23331.
GeneCardsi GC22M028374.
H-InvDB HIX0016336.
HGNCi HGNC:29179. TTC28.
HPAi HPA003099.
MIMi 615098. gene.
neXtProti NX_Q96AY4.
PharmGKBi PA145147752.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4995.
HOVERGENi HBG052194.
InParanoidi Q96AY4.
OMAi SYYSRAC.
OrthoDBi EOG7D2FCR.
PhylomeDBi Q96AY4.
TreeFami TF328344.

Miscellaneous databases

ChiTaRSi TTC28. human.
GenomeRNAii 23331.
NextBioi 45253.
PROi Q96AY4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96AY4.
Bgeei Q96AY4.
CleanExi HS_TTC28.
Genevestigatori Q96AY4.

Family and domain databases

Gene3Di 1.25.40.10. 5 hits.
InterProi IPR024983. CHAT_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
IPR028833. TTC28.
[Graphical view ]
PANTHERi PTHR10098:SF106. PTHR10098:SF106. 1 hit.
Pfami PF12770. CHAT. 1 hit.
PF00515. TPR_1. 3 hits.
PF07719. TPR_2. 2 hits.
PF13176. TPR_7. 1 hit.
[Graphical view ]
SMARTi SM00028. TPR. 25 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 25 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis."
    Izumiyama T., Minoshima S., Yoshida T., Shimizu N.
    Gene 511:202-217(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH AURKB, TISSUE SPECIFICITY.
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "KNU hair EST project."
    Kim M.K., Kim Y.H., Suh J.M., Lee H.M., Hwang S.Y., Sohn M.Y., Im S.U., Chung E.J., Cha S.Y., Park M.K., Kim J.O., Kim J.A., Yang J.O., Sung Y.K., Kim J.C.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-97.
  4. "Re-evaluating human gene annotation: a second generation analysis of chromosome 22."
    Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-292.
  5. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 356-2481.
    Tissue: Brain.
  6. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1106-2481.
    Tissue: Brain.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1914-2481.
    Tissue: Testis.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-2104 AND SER-2398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2393 AND SER-2398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTTC28_HUMAN
AccessioniPrimary (citable) accession number: Q96AY4
Secondary accession number(s): K7ZRV2
, O95928, O95929, Q5W189, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: December 16, 2008
Last modified: September 3, 2014
This is version 131 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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