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Q96AY4

- TTC28_HUMAN

UniProt

Q96AY4 - TTC28_HUMAN

Protein

Tetratricopeptide repeat protein 28

Gene

TTC28

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 4 (16 Dec 2008)
      Previous versions | rss
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    Functioni

    During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.1 Publication

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. regulation of mitotic cell cycle Source: InterPro

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetratricopeptide repeat protein 28
    Short name:
    TPR repeat protein 28
    Alternative name(s):
    TPR repeat-containing big gene cloned at Keio
    Gene namesi
    Name:TTC28
    Synonyms:KIAA1043, TPRBK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:29179. TTC28.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Midbody By similarity
    Note: At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB By similarity.By similarity

    GO - Cellular componenti

    1. centrosome Source: InterPro
    2. cytoplasm Source: UniProtKB-KW
    3. midbody Source: UniProtKB-SubCell
    4. spindle pole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145147752.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 24812481Tetratricopeptide repeat protein 28PRO_0000106427Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei28 – 281Phosphoserine2 Publications
    Modified residuei2104 – 21041Phosphoserine1 Publication
    Modified residuei2393 – 23931Phosphoserine1 Publication
    Modified residuei2398 – 23981Phosphoserine3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ96AY4.
    PaxDbiQ96AY4.
    PRIDEiQ96AY4.

    Expressioni

    Tissue specificityi

    Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ96AY4.
    BgeeiQ96AY4.
    CleanExiHS_TTC28.
    GenevestigatoriQ96AY4.

    Organism-specific databases

    HPAiHPA003099.

    Interactioni

    Subunit structurei

    Interacts with AURKB.1 Publication

    Protein-protein interaction databases

    BioGridi116918. 4 interactions.
    IntActiQ96AY4. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96AY4.
    SMRiQ96AY4. Positions 60-185, 199-1231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati58 – 9134TPR 1Add
    BLAST
    Repeati93 – 12533TPR 2Add
    BLAST
    Repeati126 – 15934TPR 3Add
    BLAST
    Repeati196 – 22934TPR 4Add
    BLAST
    Repeati234 – 26734TPR 5Add
    BLAST
    Repeati274 – 30734TPR 6Add
    BLAST
    Repeati314 – 34734TPR 7Add
    BLAST
    Repeati354 – 38734TPR 8Add
    BLAST
    Repeati394 – 42734TPR 9Add
    BLAST
    Repeati434 – 46734TPR 10Add
    BLAST
    Repeati474 – 50734TPR 11Add
    BLAST
    Repeati514 – 54734TPR 12Add
    BLAST
    Repeati554 – 58734TPR 13Add
    BLAST
    Repeati594 – 62734TPR 14Add
    BLAST
    Repeati634 – 66734TPR 15Add
    BLAST
    Repeati674 – 70734TPR 16Add
    BLAST
    Repeati714 – 74734TPR 17Add
    BLAST
    Repeati754 – 78734TPR 18Add
    BLAST
    Repeati794 – 82734TPR 19Add
    BLAST
    Repeati834 – 86734TPR 20Add
    BLAST
    Repeati877 – 91034TPR 21Add
    BLAST
    Repeati917 – 95034TPR 22Add
    BLAST
    Repeati957 – 99034TPR 23Add
    BLAST
    Repeati997 – 103034TPR 24Add
    BLAST
    Repeati1037 – 107034TPR 25Add
    BLAST
    Repeati1077 – 111034TPR 26Add
    BLAST
    Repeati1117 – 115034TPR 27Add
    BLAST
    Repeati1169 – 120234TPR 28Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1948 – 200659Ser-richAdd
    BLAST
    Compositional biasi2201 – 2335135Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 28 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG4995.
    HOVERGENiHBG052194.
    InParanoidiQ96AY4.
    OMAiSYYSRAC.
    OrthoDBiEOG7D2FCR.
    PhylomeDBiQ96AY4.
    TreeFamiTF328344.

    Family and domain databases

    Gene3Di1.25.40.10. 5 hits.
    InterProiIPR024983. CHAT_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    IPR028833. TTC28.
    [Graphical view]
    PANTHERiPTHR10098:SF106. PTHR10098:SF106. 1 hit.
    PfamiPF12770. CHAT. 1 hit.
    PF00515. TPR_1. 3 hits.
    PF07719. TPR_2. 2 hits.
    PF13176. TPR_7. 1 hit.
    [Graphical view]
    SMARTiSM00028. TPR. 25 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 25 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96AY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQSPPPAPE PTQGPTPARS RRRREPESPP ASAPIPLFGA DTIGQRSPDG     50
    PVLSKAEFVE KVRQSNQACH DGDFHTAIVL YNEALAVDPQ NCILYSNRSA 100
    AYMKIQQYDK ALDDAIKARL LNPKWPKAYF RQGVALQYLG RHADALAAFA 150
    SGLAQDPKSL QLLVGMVEAA MKSPMRDSLE PTYQQLQKMK LDKSPFVVVS 200
    VVGQELLTAG HHGASVVVLE AALKIGTCSL KLRGSVFSAL SSAYWSLGNT 250
    EKSTGYMQQD LDVAKTLGDQ TGECRAHGNL GSAFFSKGNY REALTNHRHQ 300
    LVLAMKLKDR EAASSALSSL GHVYTAIGDY PNALASHKQC VLLAKQSKDE 350
    LSEARELGNM GAVYIAMGDF ENAVQCHEQH LKIAKDLGNK REEARAYSNL 400
    GSAYHYRRNF DKAMSYHNYV LELAQELMEK AIEMRAYAGL GHAARCMQDL 450
    ERAKQYHEQQ LGIAEDLKDR AAEGRASSNL GIIHQMKGDY DTALKLHKTH 500
    LCIAQELSDY AAQGRAYGNM GNAYNALGMY DQAVKYHRQE LQISMEVNDR 550
    ASQASTHGNL AVAYQALGAH DRALQHYQNH LNIARELRDI QSEARALSNL 600
    GNFHCSRGEY VQAAPYYEQY LRLAPDLQDM EGEGKVCHNL GYAHYCLGNY 650
    QEAVKYYEQD LALAKDLHDK LSQAKAYCNL GLAFKALLNF SKAEECQKYL 700
    LSLAQSLNNS QAKFRALGNL GDIFICKKDI NGAIKFYEQQ LGLAHQVKDR 750
    RLEASAYAAL GTAYRMIQKY DKALGYHTQE LEVYQELSDL PGECRAHGHL 800
    AAVYMALGKY TMAFKCYEEQ LDLGQKLKDP SLEAQVYGNM GITKMNMNVM 850
    EEAIGYFEQQ LAMLQQLSGN ESVLDRGRAY GNLGDCYEAL GDYEEAIKYY 900
    EQYLSVAQSL NRMQDQAKAY RGLGNGHRAM GSLQQALVCF EKRLVVAHEL 950
    GEAFNKAQAY GELGSLHSQL GNYEQAISCL ERQLNIARDM KDRALESDAA 1000
    CGLGGVYQQM GEYDTALQYH QLDLQIAEET NNPTCQGRAY GNLGLTYESL 1050
    GTFERAVVYQ EQHLSIAAQM NDLAAKTVSY SSLGRTHHAL QNYSQAVMYL 1100
    QEGLRLAEQL GRREDEAKIR HGLGLSLWAS GNLEEAQHQL YRASALFETI 1150
    RHEAQLSTDY KLSLFDLQTS SYQALQRVLV SLGHHDEALA VAERGRTRAF 1200
    ADLLVERQTG QQDSDPYSPV TIDQILEMVN GQRGLVLYYS LAAGYLYSWL 1250
    LAPGAGIVKF HEHYLGENTV ENSSDFQASS SVTLPTATGS ALEQHIASVR 1300
    EALGVESHYS RACASSETES EAGDIMDQQF EEMNNKLNSV TDPTGFLRMV 1350
    RRNNLFNRSC QSMTSLFSNT VSPTQDGTSS LPRRQSSFAK PPLRALYDLL 1400
    IAPMEGGLMH SSGPVGRHRQ LILVLEGELY LIPFALLKGS SSNEYLYERF 1450
    GLLAVPSIRS LSVQSKSHLR KNPPTYSSST SMAAVIGNPK LPSAVMDRWL 1500
    WGPMPSAEEE AYMVSELLGC QPLVGSVATK ERVMSALTQA ECVHFATHIS 1550
    WKLSALVLTP SMDGNPASSK SSFGHPYTIP ESLRVQDDAS DGESISDCPP 1600
    LQELLLTAAD VLDLQLPVKL VVLGSSQESN SKVTADGVIA LTRAFLAAGA 1650
    QCVLVSLWPV PVAASKMFIH AFYSSLLNGL KASAALGEAM KVVQSSKAFS 1700
    HPSNWAGFML IGSDVKLNSP SSLIGQALTE ILQHPERARD ALRVLLHLVE 1750
    KSLQRIQNGQ RNAMYTSQQS VENKVGGIPG WQALLTAVGF RLDPPTSGLP 1800
    AAVFFPTSDP GDRLQQCSST LQSLLGLPNP ALQALCKLIT ASETGEQLIS 1850
    RAVKNMVGML HQVLVQLQAG EKEQDLASAP IQVSISVQLW RLPGCHEFLA 1900
    ALGFDLCEVG QEEVILKTGK QANRRTVHFA LQSLLSLFDS TELPKRLSLD 1950
    SSSSLESLAS AQSVSNALPL GYQQPPFSPT GADSIASDAI SVYSLSSIAS 2000
    SMSFVSKPEG GSEGGGPGGR QDHDRSKNAY LQRSTLPRSQ LPPQTRPAGN 2050
    KDEEEYEGFS IISNEPLATY QENRNTCFSP DHKQPQPGTA GGMRVSVSSK 2100
    GSISTPNSPV KMTLIPSPNS PFQKVGKLAS SDTGESDQSS TETDSTVKSQ 2150
    EESNPKLDPQ ELAQKILEET QSHLIAVERL QRSGGQVSKS NNPEDGVQAP 2200
    SSTAVFRASE TSAFSRPVLS HQKSQPSPVT VKPKPPARSS SLPKVSSGYS 2250
    SPTTSEMSIK DSPSQHSGRP SPGCDSQTSQ LDQPLFKLKY PSSPYSAHIS 2300
    KSPRNMSPSS GHQSPAGSAP SPALSYSSAG SARSSPADAP DIDKLKMAAI 2350
    DEKVQAVHNL KMFWQSTPQH STGPMKIFRG APGTMTSKRD VLSLLNLSPR 2400
    HNKKEEGVDK LELKELSLQQ HDGAPPKAPP NGHWRTETTS LGSLPLPAGP 2450
    PATAPARPLR LPSGNGYKFL SPGRFFPSSK C 2481
    Length:2,481
    Mass (Da):270,884
    Last modified:December 16, 2008 - v4
    Checksum:iD646D744EBFCFE35
    GO

    Sequence cautioni

    The sequence AAH16465.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAB62963.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB62964.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB665284 mRNA. Translation: BAM66822.1.
    AL008724 Genomic DNA. Translation: CAB62963.1. Sequence problems.
    AL008724 Genomic DNA. Translation: CAB62964.1. Sequence problems.
    AL121825
    , AL023281, AL033538, AL035397, AL035453, AL050313 Genomic DNA. Translation: CAH73824.1.
    AL023281
    , AL033538, AL035397, AL035453, AL050313, AL121825 Genomic DNA. Translation: CAI17985.1.
    AL050313
    , AL023281, AL033538, AL035397, AL035453, AL121825 Genomic DNA. Translation: CAI17993.1.
    AL035453
    , AL023281, AL033538, AL035397, AL050313, AL121825 Genomic DNA. Translation: CAI18760.1.
    AL035397
    , AL023281, AL033538, AL035453, AL050313, AL121825 Genomic DNA. Translation: CAI18818.1.
    AL033538
    , AL023281, AL035397, AL035453, AL050313, AL121825 Genomic DNA. Translation: CAI21502.1.
    ES313581 mRNA. No translation available.
    BU584912 mRNA. No translation available.
    AB028966 mRNA. Translation: BAA82995.3.
    BC016465 mRNA. Translation: AAH16465.1. Different initiation.
    AL080174 mRNA. Translation: CAB45760.2.
    AL137328 mRNA. Translation: CAB70697.1.
    CCDSiCCDS46678.1.
    PIRiT12496.
    RefSeqiNP_001138890.1. NM_001145418.1.
    UniGeneiHs.387856.

    Genome annotation databases

    EnsembliENST00000397906; ENSP00000381003; ENSG00000100154.
    GeneIDi23331.
    KEGGihsa:23331.
    UCSCiuc003adp.4. human.

    Polymorphism databases

    DMDMi218512146.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB665284 mRNA. Translation: BAM66822.1 .
    AL008724 Genomic DNA. Translation: CAB62963.1 . Sequence problems.
    AL008724 Genomic DNA. Translation: CAB62964.1 . Sequence problems.
    AL121825
    , AL023281 , AL033538 , AL035397 , AL035453 , AL050313 Genomic DNA. Translation: CAH73824.1 .
    AL023281
    , AL033538 , AL035397 , AL035453 , AL050313 , AL121825 Genomic DNA. Translation: CAI17985.1 .
    AL050313
    , AL023281 , AL033538 , AL035397 , AL035453 , AL121825 Genomic DNA. Translation: CAI17993.1 .
    AL035453
    , AL023281 , AL033538 , AL035397 , AL050313 , AL121825 Genomic DNA. Translation: CAI18760.1 .
    AL035397
    , AL023281 , AL033538 , AL035453 , AL050313 , AL121825 Genomic DNA. Translation: CAI18818.1 .
    AL033538
    , AL023281 , AL035397 , AL035453 , AL050313 , AL121825 Genomic DNA. Translation: CAI21502.1 .
    ES313581 mRNA. No translation available.
    BU584912 mRNA. No translation available.
    AB028966 mRNA. Translation: BAA82995.3 .
    BC016465 mRNA. Translation: AAH16465.1 . Different initiation.
    AL080174 mRNA. Translation: CAB45760.2 .
    AL137328 mRNA. Translation: CAB70697.1 .
    CCDSi CCDS46678.1.
    PIRi T12496.
    RefSeqi NP_001138890.1. NM_001145418.1.
    UniGenei Hs.387856.

    3D structure databases

    ProteinModelPortali Q96AY4.
    SMRi Q96AY4. Positions 60-185, 199-1231.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116918. 4 interactions.
    IntActi Q96AY4. 3 interactions.

    Polymorphism databases

    DMDMi 218512146.

    Proteomic databases

    MaxQBi Q96AY4.
    PaxDbi Q96AY4.
    PRIDEi Q96AY4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397906 ; ENSP00000381003 ; ENSG00000100154 .
    GeneIDi 23331.
    KEGGi hsa:23331.
    UCSCi uc003adp.4. human.

    Organism-specific databases

    CTDi 23331.
    GeneCardsi GC22M028374.
    H-InvDB HIX0016336.
    HGNCi HGNC:29179. TTC28.
    HPAi HPA003099.
    MIMi 615098. gene.
    neXtProti NX_Q96AY4.
    PharmGKBi PA145147752.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4995.
    HOVERGENi HBG052194.
    InParanoidi Q96AY4.
    OMAi SYYSRAC.
    OrthoDBi EOG7D2FCR.
    PhylomeDBi Q96AY4.
    TreeFami TF328344.

    Miscellaneous databases

    ChiTaRSi TTC28. human.
    GenomeRNAii 23331.
    NextBioi 45253.
    PROi Q96AY4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96AY4.
    Bgeei Q96AY4.
    CleanExi HS_TTC28.
    Genevestigatori Q96AY4.

    Family and domain databases

    Gene3Di 1.25.40.10. 5 hits.
    InterProi IPR024983. CHAT_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR013105. TPR_2.
    IPR019734. TPR_repeat.
    IPR028833. TTC28.
    [Graphical view ]
    PANTHERi PTHR10098:SF106. PTHR10098:SF106. 1 hit.
    Pfami PF12770. CHAT. 1 hit.
    PF00515. TPR_1. 3 hits.
    PF07719. TPR_2. 2 hits.
    PF13176. TPR_7. 1 hit.
    [Graphical view ]
    SMARTi SM00028. TPR. 25 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 25 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis."
      Izumiyama T., Minoshima S., Yoshida T., Shimizu N.
      Gene 511:202-217(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH AURKB, TISSUE SPECIFICITY.
    2. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "KNU hair EST project."
      Kim M.K., Kim Y.H., Suh J.M., Lee H.M., Hwang S.Y., Sohn M.Y., Im S.U., Chung E.J., Cha S.Y., Park M.K., Kim J.O., Kim J.A., Yang J.O., Sung Y.K., Kim J.C.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-97.
    4. "Re-evaluating human gene annotation: a second generation analysis of chromosome 22."
      Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-292.
    5. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 356-2481.
      Tissue: Brain.
    6. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1106-2481.
      Tissue: Brain.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1914-2481.
      Tissue: Testis.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-2104 AND SER-2398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2393 AND SER-2398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTTC28_HUMAN
    AccessioniPrimary (citable) accession number: Q96AY4
    Secondary accession number(s): K7ZRV2
    , O95928, O95929, Q5W189, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: December 16, 2008
    Last modified: October 1, 2014
    This is version 132 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3