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Q96AY3

- FKB10_HUMAN

UniProt

Q96AY3 - FKB10_HUMAN

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Protein

Peptidyl-prolyl cis-trans isomerase FKBP10

Gene

FKBP10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin, but not by cyclosporin A.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi510 – 521121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi555 – 566122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. FK506 binding Source: RefGenome
  3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

GO - Biological processi

  1. chaperone-mediated protein folding Source: RefGenome
  2. protein peptidyl-prolyl isomerization Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP10 (EC:5.2.1.8)
Short name:
PPIase FKBP10
Alternative name(s):
65 kDa FK506-binding protein
Short name:
65 kDa FKBP
Short name:
FKBP-65
FK506-binding protein 10
Short name:
FKBP-10
Immunophilin FKBP65
Rotamase
Gene namesi
Name:FKBP10
Synonyms:FKBP65
ORF Names:PSEC0056
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:18169. FKBP10.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Involvement in diseasei

Osteogenesis imperfecta 11 (OI11) [MIM:610968]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI11 is an autosomal recessive form.3 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 11711Missing in OI11.
VAR_063601Add
BLAST
Bruck syndrome 1 (BRKS1) [MIM:259450]: A disease characterized by generalized osteopenia, congenital joint contractures, fragile bones with onset of fractures in infancy or early childhood, short stature, severe limb deformity, progressive scoliosis, and pterygia.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131E → K in BRKS1. 1 Publication
VAR_069902
Natural varianti115 – 1151R → Q in BRKS1. 2 Publications
VAR_069903
Natural varianti136 – 1361P → L in BRKS1. 1 Publication
VAR_069904

Keywords - Diseasei

Disease mutation, Osteogenesis imperfecta

Organism-specific databases

MIMi259450. phenotype.
610968. phenotype.
Orphaneti1149. Arthrogryposis-like syndrome.
2771. Bruck syndrome.
216828. Osteogenesis imperfecta type 5.
PharmGKBiPA28152.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 582556Peptidyl-prolyl cis-trans isomerase FKBP10PRO_0000025517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi182 – 1821N-linked (GlcNAc...)2 Publications
Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi407 – 4071N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Glycosylated and phosphorylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ96AY3.
PaxDbiQ96AY3.
PeptideAtlasiQ96AY3.
PRIDEiQ96AY3.

PTM databases

PhosphoSiteiQ96AY3.

Expressioni

Gene expression databases

BgeeiQ96AY3.
CleanExiHS_FKBP10.
ExpressionAtlasiQ96AY3. baseline and differential.
GenevestigatoriQ96AY3.

Organism-specific databases

HPAiHPA051171.

Interactioni

Protein-protein interaction databases

BioGridi121955. 20 interactions.
IntActiQ96AY3. 3 interactions.
STRINGi9606.ENSP00000317232.

Structurei

3D structure databases

ProteinModelPortaliQ96AY3.
SMRiQ96AY3. Positions 22-573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 15089PPIase FKBP-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini174 – 26289PPIase FKBP-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini286 – 37489PPIase FKBP-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini399 – 48688PPIase FKBP-type 4PROSITE-ProRule annotationAdd
BLAST
Domaini497 – 53236EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini542 – 57736EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi579 – 5824Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 4 PPIase FKBP-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG0545.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000230960.
HOVERGENiHBG051620.
InParanoidiQ96AY3.
KOiK09575.
PhylomeDBiQ96AY3.
TreeFamiTF105296.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13202. EF-hand_5. 2 hits.
PF00254. FKBP_C. 4 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96AY3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPAGPPSHS LLRLPLLQLL LLVVQAVGRG LGRASPAGGP LEDVVIERYH
60 70 80 90 100
IPRACPREVQ MGDFVRYHYN GTFEDGKKFD SSYDRNTLVA IVVGVGRLIT
110 120 130 140 150
GMDRGLMGMC VNERRRLIVP PHLGYGSIGL AGLIPPDATL YFDVVLLDVW
160 170 180 190 200
NKEDTVQVST LLRPPHCPRM VQDGDFVRYH YNGTLLDGTS FDTSYSKGGT
210 220 230 240 250
YDTYVGSGWL IKGMDQGLLG MCPGERRKII IPPFLAYGEK GYGTVIPPQA
260 270 280 290 300
SLVFHVLLID VHNPKDAVQL ETLELPPGCV RRAGAGDFMR YHYNGSLMDG
310 320 330 340 350
TLFDSSYSRN HTYNTYIGQG YIIPGMDQGL QGACMGERRR ITIPPHLAYG
360 370 380 390 400
ENGTGDKIPG SAVLIFNVHV IDFHNPADVV EIRTLSRPSE TCNETTKLGD
410 420 430 440 450
FVRYHYNCSL LDGTQLFTSH DYGAPQEATL GANKVIEGLD TGLQGMCVGE
460 470 480 490 500
RRQLIVPPHL AHGESGARGV PGSAVLLFEV ELVSREDGLP TGYLFVWHKD
510 520 530 540 550
PPANLFEDMD LNKDGEVPPE EFSTFIKAQV SEGKGRLMPG QDPEKTIGDM
560 570 580
FQNQDRNQDG KITVDELKLK SDEDEERVHE EL
Length:582
Mass (Da):64,245
Last modified:December 1, 2001 - v1
Checksum:i98257459158407C2
GO
Isoform 2 (identifier: Q96AY3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-177: Missing.
     184-212: TLLDGTSFDTSYSKGGTYDTYVGSGWLIK → SLMDGTLFDSSYSRNHTYNTYIGQGYIIP
     219-303: LGMCPGERRK...NGSLMDGTLF → QGACMGERRR...VKWASHADPQ
     304-354: Missing.

Note: No experimental confirmation available.

Show »
Length:355
Mass (Da):38,950
Checksum:iDBECF4B8618BF54F
GO

Sequence cautioni

The sequence BAB15220.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAD97695.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti190 – 1901S → F in BAB20974. (PubMed:16303743)Curated
Sequence conflicti456 – 4561V → L in CAD97695. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 11711Missing in OI11.
VAR_063601Add
BLAST
Natural varianti113 – 1131E → K in BRKS1. 1 Publication
VAR_069902
Natural varianti115 – 1151R → Q in BRKS1. 2 Publications
VAR_069903
Natural varianti136 – 1361P → L in BRKS1. 1 Publication
VAR_069904
Natural varianti197 – 1971K → R.
Corresponds to variant rs34764749 [ dbSNP | Ensembl ].
VAR_050625

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 177176Missing in isoform 2. 1 PublicationVSP_056425Add
BLAST
Alternative sequencei184 – 21229TLLDG…GWLIK → SLMDGTLFDSSYSRNHTYNT YIGQGYIIP in isoform 2. 1 PublicationVSP_056426Add
BLAST
Alternative sequencei219 – 30385LGMCP…DGTLF → QGACMGERRRITIPPHLAYG ENGTDSIGFLQGSAPLRPFR SGEGQPSLGREGGYGKTEPA YPQDPAVLGASVSSPVKWAS HADPQ in isoform 2. 1 PublicationVSP_056427Add
BLAST
Alternative sequencei304 – 35451Missing in isoform 2. 1 PublicationVSP_056428Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF337909 mRNA. Translation: AAM15770.1.
AK025694 mRNA. Translation: BAB15220.1. Different initiation.
AK025874 mRNA. Translation: BAB15266.1.
AB045981 mRNA. Translation: BAB20974.1.
BX537452 mRNA. Translation: CAD97695.1. Different initiation.
AL133116 mRNA. Translation: CAB61418.1.
AC091172 Genomic DNA. No translation available.
BC016467 mRNA. Translation: AAH16467.1.
CCDSiCCDS11409.1. [Q96AY3-1]
PIRiT42709.
RefSeqiNP_068758.3. NM_021939.3.
UniGeneiHs.463035.

Genome annotation databases

EnsembliENST00000321562; ENSP00000317232; ENSG00000141756. [Q96AY3-1]
GeneIDi60681.
KEGGihsa:60681.
UCSCiuc002hxv.2. human. [Q96AY3-1]

Polymorphism databases

DMDMi23396594.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Osteogenesis imperfecta variant database

Peptidyl-prolyl cis-trans isomerase FKBP10

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF337909 mRNA. Translation: AAM15770.1 .
AK025694 mRNA. Translation: BAB15220.1 . Different initiation.
AK025874 mRNA. Translation: BAB15266.1 .
AB045981 mRNA. Translation: BAB20974.1 .
BX537452 mRNA. Translation: CAD97695.1 . Different initiation.
AL133116 mRNA. Translation: CAB61418.1 .
AC091172 Genomic DNA. No translation available.
BC016467 mRNA. Translation: AAH16467.1 .
CCDSi CCDS11409.1. [Q96AY3-1 ]
PIRi T42709.
RefSeqi NP_068758.3. NM_021939.3.
UniGenei Hs.463035.

3D structure databases

ProteinModelPortali Q96AY3.
SMRi Q96AY3. Positions 22-573.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121955. 20 interactions.
IntActi Q96AY3. 3 interactions.
STRINGi 9606.ENSP00000317232.

PTM databases

PhosphoSitei Q96AY3.

Polymorphism databases

DMDMi 23396594.

Proteomic databases

MaxQBi Q96AY3.
PaxDbi Q96AY3.
PeptideAtlasi Q96AY3.
PRIDEi Q96AY3.

Protocols and materials databases

DNASUi 60681.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000321562 ; ENSP00000317232 ; ENSG00000141756 . [Q96AY3-1 ]
GeneIDi 60681.
KEGGi hsa:60681.
UCSCi uc002hxv.2. human. [Q96AY3-1 ]

Organism-specific databases

CTDi 60681.
GeneCardsi GC17P039968.
HGNCi HGNC:18169. FKBP10.
HPAi HPA051171.
MIMi 259450. phenotype.
607063. gene.
610968. phenotype.
neXtProti NX_Q96AY3.
Orphaneti 1149. Arthrogryposis-like syndrome.
2771. Bruck syndrome.
216828. Osteogenesis imperfecta type 5.
PharmGKBi PA28152.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0545.
GeneTreei ENSGT00530000062784.
HOGENOMi HOG000230960.
HOVERGENi HBG051620.
InParanoidi Q96AY3.
KOi K09575.
PhylomeDBi Q96AY3.
TreeFami TF105296.

Miscellaneous databases

ChiTaRSi FKBP10. human.
GenomeRNAii 60681.
NextBioi 65504.
PROi Q96AY3.
SOURCEi Search...

Gene expression databases

Bgeei Q96AY3.
CleanExi HS_FKBP10.
ExpressionAtlasi Q96AY3. baseline and differential.
Genevestigatori Q96AY3.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF13202. EF-hand_5. 2 hits.
PF00254. FKBP_C. 4 hits.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human FK506-binding protein repertoire."
    Rulten S., Kinloch R.A., Robinson C., Gettins L., Kay J.E.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-582 (ISOFORM 1).
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Endometrial tumor and Uterus.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
    Zhang H., Li X.-J., Martin D.B., Aebersold R.
    Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-182 AND ASN-407.
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-182.
    Tissue: Liver.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: VARIANT OI11 MET-107--117-LEU DEL.
  12. Cited for: VARIANT BRKS1 GLN-115, INVOLVEMENT IN OI11.
  13. Cited for: VARIANTS BRKS1 LYS-113; GLN-115 AND LEU-136, INVOLVEMENT IN OI11.

Entry informationi

Entry nameiFKB10_HUMAN
AccessioniPrimary (citable) accession number: Q96AY3
Secondary accession number(s): Q7Z3R4
, Q9H3N3, Q9H6J3, Q9H6N5, Q9UF89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3