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Q96AY3

- FKB10_HUMAN

UniProt

Q96AY3 - FKB10_HUMAN

Protein

Peptidyl-prolyl cis-trans isomerase FKBP10

Gene

FKBP10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins during protein synthesis.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Inhibited by both FK506 and rapamycin, but not by cyclosporin A.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi510 – 521121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi555 – 566122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. FK506 binding Source: RefGenome
    3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

    GO - Biological processi

    1. chaperone-mediated protein folding Source: RefGenome
    2. protein peptidyl-prolyl isomerization Source: RefGenome

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP10 (EC:5.2.1.8)
    Short name:
    PPIase FKBP10
    Alternative name(s):
    65 kDa FK506-binding protein
    Short name:
    65 kDa FKBP
    Short name:
    FKBP-65
    FK506-binding protein 10
    Short name:
    FKBP-10
    Immunophilin FKBP65
    Rotamase
    Gene namesi
    Name:FKBP10
    Synonyms:FKBP65
    ORF Names:PSEC0056
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:18169. FKBP10.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    2. endoplasmic reticulum membrane Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Involvement in diseasei

    Osteogenesis imperfecta 11 (OI11) [MIM:610968]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI11 is an autosomal recessive form.3 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti107 – 11711Missing in OI11.
    VAR_063601Add
    BLAST
    Bruck syndrome 1 (BRKS1) [MIM:259450]: A disease characterized by generalized osteopenia, congenital joint contractures, fragile bones with onset of fractures in infancy or early childhood, short stature, severe limb deformity, progressive scoliosis, and pterygia.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti113 – 1131E → K in BRKS1. 1 Publication
    VAR_069902
    Natural varianti115 – 1151R → Q in BRKS1. 2 Publications
    VAR_069903
    Natural varianti136 – 1361P → L in BRKS1. 1 Publication
    VAR_069904

    Keywords - Diseasei

    Disease mutation, Osteogenesis imperfecta

    Organism-specific databases

    MIMi259450. phenotype.
    610968. phenotype.
    Orphaneti1149. Arthrogryposis-like syndrome.
    2771. Bruck syndrome.
    216828. Osteogenesis imperfecta type 5.
    PharmGKBiPA28152.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 582556Peptidyl-prolyl cis-trans isomerase FKBP10PRO_0000025517Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi182 – 1821N-linked (GlcNAc...)2 Publications
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi407 – 4071N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Glycosylated and phosphorylated.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ96AY3.
    PaxDbiQ96AY3.
    PeptideAtlasiQ96AY3.
    PRIDEiQ96AY3.

    PTM databases

    PhosphoSiteiQ96AY3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96AY3.
    BgeeiQ96AY3.
    CleanExiHS_FKBP10.
    GenevestigatoriQ96AY3.

    Organism-specific databases

    HPAiHPA051171.

    Interactioni

    Protein-protein interaction databases

    BioGridi121955. 20 interactions.
    IntActiQ96AY3. 3 interactions.
    STRINGi9606.ENSP00000317232.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96AY3.
    SMRiQ96AY3. Positions 22-573.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 15089PPIase FKBP-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini174 – 26289PPIase FKBP-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini286 – 37489PPIase FKBP-type 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini399 – 48688PPIase FKBP-type 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini497 – 53236EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini542 – 57736EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi579 – 5824Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 4 PPIase FKBP-type domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000230960.
    HOVERGENiHBG051620.
    InParanoidiQ96AY3.
    KOiK09575.
    PhylomeDBiQ96AY3.
    TreeFamiTF105296.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF13202. EF-hand_5. 2 hits.
    PF00254. FKBP_C. 4 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96AY3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFPAGPPSHS LLRLPLLQLL LLVVQAVGRG LGRASPAGGP LEDVVIERYH    50
    IPRACPREVQ MGDFVRYHYN GTFEDGKKFD SSYDRNTLVA IVVGVGRLIT 100
    GMDRGLMGMC VNERRRLIVP PHLGYGSIGL AGLIPPDATL YFDVVLLDVW 150
    NKEDTVQVST LLRPPHCPRM VQDGDFVRYH YNGTLLDGTS FDTSYSKGGT 200
    YDTYVGSGWL IKGMDQGLLG MCPGERRKII IPPFLAYGEK GYGTVIPPQA 250
    SLVFHVLLID VHNPKDAVQL ETLELPPGCV RRAGAGDFMR YHYNGSLMDG 300
    TLFDSSYSRN HTYNTYIGQG YIIPGMDQGL QGACMGERRR ITIPPHLAYG 350
    ENGTGDKIPG SAVLIFNVHV IDFHNPADVV EIRTLSRPSE TCNETTKLGD 400
    FVRYHYNCSL LDGTQLFTSH DYGAPQEATL GANKVIEGLD TGLQGMCVGE 450
    RRQLIVPPHL AHGESGARGV PGSAVLLFEV ELVSREDGLP TGYLFVWHKD 500
    PPANLFEDMD LNKDGEVPPE EFSTFIKAQV SEGKGRLMPG QDPEKTIGDM 550
    FQNQDRNQDG KITVDELKLK SDEDEERVHE EL 582
    Length:582
    Mass (Da):64,245
    Last modified:December 1, 2001 - v1
    Checksum:i98257459158407C2
    GO
    Isoform 2 (identifier: Q96AY3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-177: Missing.
         184-212: TLLDGTSFDTSYSKGGTYDTYVGSGWLIK → SLMDGTLFDSSYSRNHTYNTYIGQGYIIP
         219-303: LGMCPGERRK...NGSLMDGTLF → QGACMGERRR...VKWASHADPQ
         304-354: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:355
    Mass (Da):38,950
    Checksum:iDBECF4B8618BF54F
    GO

    Sequence cautioni

    The sequence BAB15220.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAD97695.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti190 – 1901S → F in BAB20974. (PubMed:16303743)Curated
    Sequence conflicti456 – 4561V → L in CAD97695. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti107 – 11711Missing in OI11.
    VAR_063601Add
    BLAST
    Natural varianti113 – 1131E → K in BRKS1. 1 Publication
    VAR_069902
    Natural varianti115 – 1151R → Q in BRKS1. 2 Publications
    VAR_069903
    Natural varianti136 – 1361P → L in BRKS1. 1 Publication
    VAR_069904
    Natural varianti197 – 1971K → R.
    Corresponds to variant rs34764749 [ dbSNP | Ensembl ].
    VAR_050625

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 177176Missing in isoform 2. 1 PublicationVSP_056425Add
    BLAST
    Alternative sequencei184 – 21229TLLDG…GWLIK → SLMDGTLFDSSYSRNHTYNT YIGQGYIIP in isoform 2. 1 PublicationVSP_056426Add
    BLAST
    Alternative sequencei219 – 30385LGMCP…DGTLF → QGACMGERRRITIPPHLAYG ENGTDSIGFLQGSAPLRPFR SGEGQPSLGREGGYGKTEPA YPQDPAVLGASVSSPVKWAS HADPQ in isoform 2. 1 PublicationVSP_056427Add
    BLAST
    Alternative sequencei304 – 35451Missing in isoform 2. 1 PublicationVSP_056428Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF337909 mRNA. Translation: AAM15770.1.
    AK025694 mRNA. Translation: BAB15220.1. Different initiation.
    AK025874 mRNA. Translation: BAB15266.1.
    AB045981 mRNA. Translation: BAB20974.1.
    BX537452 mRNA. Translation: CAD97695.1. Different initiation.
    AL133116 mRNA. Translation: CAB61418.1.
    AC091172 Genomic DNA. No translation available.
    BC016467 mRNA. Translation: AAH16467.1.
    CCDSiCCDS11409.1.
    PIRiT42709.
    RefSeqiNP_068758.3. NM_021939.3.
    UniGeneiHs.463035.

    Genome annotation databases

    EnsembliENST00000321562; ENSP00000317232; ENSG00000141756.
    ENST00000544340; ENSP00000442009; ENSG00000141756.
    GeneIDi60681.
    KEGGihsa:60681.
    UCSCiuc002hxv.2. human.

    Polymorphism databases

    DMDMi23396594.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Osteogenesis imperfecta variant database

    Peptidyl-prolyl cis-trans isomerase FKBP10

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF337909 mRNA. Translation: AAM15770.1 .
    AK025694 mRNA. Translation: BAB15220.1 . Different initiation.
    AK025874 mRNA. Translation: BAB15266.1 .
    AB045981 mRNA. Translation: BAB20974.1 .
    BX537452 mRNA. Translation: CAD97695.1 . Different initiation.
    AL133116 mRNA. Translation: CAB61418.1 .
    AC091172 Genomic DNA. No translation available.
    BC016467 mRNA. Translation: AAH16467.1 .
    CCDSi CCDS11409.1.
    PIRi T42709.
    RefSeqi NP_068758.3. NM_021939.3.
    UniGenei Hs.463035.

    3D structure databases

    ProteinModelPortali Q96AY3.
    SMRi Q96AY3. Positions 22-573.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121955. 20 interactions.
    IntActi Q96AY3. 3 interactions.
    STRINGi 9606.ENSP00000317232.

    PTM databases

    PhosphoSitei Q96AY3.

    Polymorphism databases

    DMDMi 23396594.

    Proteomic databases

    MaxQBi Q96AY3.
    PaxDbi Q96AY3.
    PeptideAtlasi Q96AY3.
    PRIDEi Q96AY3.

    Protocols and materials databases

    DNASUi 60681.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321562 ; ENSP00000317232 ; ENSG00000141756 .
    ENST00000544340 ; ENSP00000442009 ; ENSG00000141756 .
    GeneIDi 60681.
    KEGGi hsa:60681.
    UCSCi uc002hxv.2. human.

    Organism-specific databases

    CTDi 60681.
    GeneCardsi GC17P039968.
    HGNCi HGNC:18169. FKBP10.
    HPAi HPA051171.
    MIMi 259450. phenotype.
    607063. gene.
    610968. phenotype.
    neXtProti NX_Q96AY3.
    Orphaneti 1149. Arthrogryposis-like syndrome.
    2771. Bruck syndrome.
    216828. Osteogenesis imperfecta type 5.
    PharmGKBi PA28152.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000230960.
    HOVERGENi HBG051620.
    InParanoidi Q96AY3.
    KOi K09575.
    PhylomeDBi Q96AY3.
    TreeFami TF105296.

    Miscellaneous databases

    ChiTaRSi FKBP10. human.
    GenomeRNAii 60681.
    NextBioi 65504.
    PROi Q96AY3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96AY3.
    Bgeei Q96AY3.
    CleanExi HS_FKBP10.
    Genevestigatori Q96AY3.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF13202. EF-hand_5. 2 hits.
    PF00254. FKBP_C. 4 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human FK506-binding protein repertoire."
      Rulten S., Kinloch R.A., Robinson C., Gettins L., Kay J.E.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-582 (ISOFORM 1).
    3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Teratocarcinoma.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Endometrial tumor and Uterus.
    5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H., Li X.-J., Martin D.B., Aebersold R.
      Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-182 AND ASN-407.
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-182.
      Tissue: Liver.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: VARIANT OI11 MET-107--117-LEU DEL.
    12. Cited for: VARIANT BRKS1 GLN-115, INVOLVEMENT IN OI11.
    13. Cited for: VARIANTS BRKS1 LYS-113; GLN-115 AND LEU-136, INVOLVEMENT IN OI11.

    Entry informationi

    Entry nameiFKB10_HUMAN
    AccessioniPrimary (citable) accession number: Q96AY3
    Secondary accession number(s): Q7Z3R4
    , Q9H3N3, Q9H6J3, Q9H6N5, Q9UF89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3