Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase MIB2

Gene

MIB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri143 – 190ZZ-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri890 – 925RING-type 1PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri969 – 1002RING-type 2PROSITE-ProRule annotationAdd BLAST34

GO - Molecular functioni

GO - Biological processi

  • Notch signaling pathway Source: UniProtKB-KW
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • protein polyubiquitination Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Notch signaling pathway, Ubl conjugation pathway

Keywords - Ligandi

Actin-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-HSA-2644606. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
R-HSA-2691232. Constitutive Signaling by NOTCH1 HD Domain Mutants.
R-HSA-2894862. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
R-HSA-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ96AX9.
SIGNORiQ96AX9.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MIB2 (EC:6.3.2.-)
Alternative name(s):
Mind bomb homolog 2
Novel zinc finger protein
Short name:
Novelzin
Putative NF-kappa-B-activating protein 002N
Skeletrophin
Zinc finger ZZ type with ankyrin repeat domain protein 1
Gene namesi
Name:MIB2
Synonyms:SKD, ZZANK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30577. MIB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi142678.
OpenTargetsiENSG00000197530.
PharmGKBiPA134924284.

Polymorphism and mutation databases

BioMutaiMIB2.
DMDMi209572707.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559471 – 1013E3 ubiquitin-protein ligase MIB2Add BLAST1013

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei309PhosphoserineCombined sources1
Isoform 10 (identifier: Q96AX9-10)
Modified residuei1N-acetylmethionineCombined sources1
Isoform 8 (identifier: Q96AX9-8)
Modified residuei1N-acetylmethionineCombined sources1

Post-translational modificationi

Ubiquitinated. Possibly via autoubiquitination (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ96AX9.
PaxDbiQ96AX9.
PeptideAtlasiQ96AX9.
PRIDEiQ96AX9.

PTM databases

iPTMnetiQ96AX9.
PhosphoSitePlusiQ96AX9.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.1 Publication

Inductioni

Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene.1 Publication

Gene expression databases

BgeeiENSG00000197530.
ExpressionAtlasiQ96AX9. baseline and differential.
GenevisibleiQ96AX9. HS.

Organism-specific databases

HPAiCAB037055.
HPA027871.

Interactioni

Subunit structurei

Interacts with actin monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TBK1Q9UHD22EBI-2130249,EBI-356402

Protein-protein interaction databases

BioGridi126769. 22 interactors.
IntActiQ96AX9. 11 interactors.
MINTiMINT-3050933.
STRINGi9606.ENSP00000426103.

Structurei

3D structure databases

ProteinModelPortaliQ96AX9.
SMRiQ96AX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 138MIB/HERC2 1PROSITE-ProRule annotationAdd BLAST80
Domaini207 – 285MIB/HERC2 2PROSITE-ProRule annotationAdd BLAST79
Repeati522 – 551ANK 1Add BLAST30
Repeati555 – 584ANK 2Add BLAST30
Repeati588 – 617ANK 3Add BLAST30
Repeati621 – 653ANK 4Add BLAST33
Repeati657 – 686ANK 5Add BLAST30
Repeati691 – 721ANK 6Add BLAST31
Repeati725 – 754ANK 7Add BLAST30
Repeati758 – 786ANK 8Add BLAST29
Repeati827 – 856ANK 9Add BLAST30

Sequence similaritiesi

Contains 9 ANK repeats.PROSITE-ProRule annotation
Contains 2 MIB/HERC2 domains.PROSITE-ProRule annotation
Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri143 – 190ZZ-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri890 – 925RING-type 1PROSITE-ProRule annotationAdd BLAST36
Zinc fingeri969 – 1002RING-type 2PROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

ANK repeat, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4582. Eukaryota.
ENOG410XP18. LUCA.
GeneTreeiENSGT00790000122981.
HOGENOMiHOG000231158.
HOVERGENiHBG068386.
InParanoidiQ96AX9.
KOiK10645.
OMAiATCGGHY.
OrthoDBiEOG091G00Z0.
PhylomeDBiQ96AX9.
TreeFamiTF324147.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
3.30.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR010606. Mib_Herc2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF06701. MIB_HERC2. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
SM00184. RING. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS51416. MIB_HERC2. 2 hits.
PS50089. ZF_RING_2. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequences (14)i

Sequence statusi: Complete.

This entry describes 14 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96AX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGWKPSEARG QSQSFQASGL QPRSLKAARR ATGRPDRSRA ARPTMDPSAH
60 70 80 90 100
RSRAAPPNMD PDPQAGVQVG MRVVRGVDWK WGQQDGGEGG VGTVVELGRH
110 120 130 140 150
GSPSTPDRTV VVQWDQGTRT NYRAGYQGAH DLLLYDNAQI GVRHPNIICD
160 170 180 190 200
CCKKHGLRGM RWKCRVCLDY DLCTQCYMHN KHELAHAFDR YETAHSRPVT
210 220 230 240 250
LSPRQGLPRI PLRGIFQGAK VVRGPDWEWG SQDGGEGKPG RVVDIRGWDV
260 270 280 290 300
ETGRSVASVT WADGTTNVYR VGHKGKVDLK CVGEAAGGFY YKDHLPRLGK
310 320 330 340 350
PAELQRRVSA DSQPFQHGDK VKCLLDTDVL REMQEGHGGW NPRMAEFIGQ
360 370 380 390 400
TGTVHRITDR GDVRVQFNHE TRWTFHPGAL TKHHSFWVGD VVRVIGDLDT
410 420 430 440 450
VKRLQAGHGE WTDDMAPALG RVGKVVKVFG DGNLRVAVAG QRWTFSPSCL
460 470 480 490 500
VAYRPEEDAN LDVAERAREN KSSLSVALDK LRAQKSDPEH PGRLVVEVAL
510 520 530 540 550
GNAARALDLL RRRPEQVDTK NQGRTALQVA AYLGQVELIR LLLQARAGVD
560 570 580 590 600
LPDDEGNTAL HYAALGNQPE ATRVLLSAGC RADAINSTQS TALHVAVQRG
610 620 630 640 650
FLEVVRALCE RGCDVNLPDA HSDTPLHSAI SAGTGASGIV EVLTEVPNID
660 670 680 690 700
VTATNSQGFT LLHHASLKGH ALAVRKILAR ARQLVDAKKE DGFTALHLAA
710 720 730 740 750
LNNHREVAQI LIREGRCDVN VRNRKLQSPL HLAVQQAHVG LVPLLVDAGC
760 770 780 790 800
SVNAEDEEGD TALHVALQRH QLLPLVADGA GGDPGPLQLL SRLQASGLPG
810 820 830 840 850
SAELTVGAAV ACFLALEGAD VSYTNHRGRS PLDLAAEGRV LKALQGCAQR
860 870 880 890 900
FRERQAGGGA APGPRQTLGT PNTVTNLHVG AAPGPEAAEC LVCSELALLV
910 920 930 940 950
LFSPCQHRTV CEECARRMKK CIRCQVVVSK KLRPDGSEVA SAAPAPGPPR
960 970 980 990 1000
QLVEELQSRY RQMEERITCP ICIDSHIRLV FQCGHGACAP CGSALSACPI
1010
CRQPIRDRIQ IFV
Length:1,013
Mass (Da):109,939
Last modified:October 14, 2008 - v3
Checksum:i737BA12300091C70
GO
Isoform 2 (identifier: Q96AX9-2) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     37-50: Missing.

Show »
Length:999
Mass (Da):108,404
Checksum:i37BC32E3C342FC75
GO
Isoform 3 (identifier: Q96AX9-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     347-350: Missing.

Show »
Length:1,009
Mass (Da):109,493
Checksum:i6A16B37089CF3538
GO
Isoform 4 (identifier: Q96AX9-4) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     234-298: Missing.

Show »
Length:948
Mass (Da):102,967
Checksum:iDDC32F6A7743A6E3
GO
Isoform 5 (identifier: Q96AX9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-417: Missing.

Note: No experimental confirmation available.
Show »
Length:978
Mass (Da):106,011
Checksum:i211C2E732319290D
GO
Isoform 10 (identifier: Q96AX9-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.
     234-298: Missing.
     853-1013: ERQAGGGAAP...PIRDRIQIFV → VRAQDEEVHQVPGGRQQETAPRRL

Note: No experimental confirmation available.Combined sources
Show »
Length:753
Mass (Da):82,129
Checksum:i9447C993AF8726DC
GO
Isoform 7 (identifier: Q96AX9-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.

Show »
Length:854
Mass (Da):92,680
Checksum:iC8390208E6E8CFDF
GO
Isoform 8 (identifier: Q96AX9-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.
     858-860: GGA → RGR
     861-1013: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:802
Mass (Da):87,273
Checksum:i9142D07056C27DBE
GO
Isoform 9 (identifier: Q96AX9-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     673-1013: Missing.

Show »
Length:672
Mass (Da):73,542
Checksum:i1257E008401D9FF9
GO
Isoform 6 (identifier: Q96AX9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-382: Missing.

Note: No experimental confirmation available.
Show »
Length:977
Mass (Da):105,777
Checksum:i80A370887F8655CE
GO
Isoform 11 (identifier: Q96AX9-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGALRRGRALGSRPSGPTVSSRRSPQCPVAQEGLGARSRPRVAPRSLARCGPSSRLM
     42-55: Missing.

Note: No experimental confirmation available.
Show »
Length:1,056
Mass (Da):114,326
Checksum:iCF351D9EC0CF7592
GO
Isoform 12 (identifier: Q96AX9-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGALRRGRALGSRPSGPTVSSRRSPQCPVAQEGLGARSRPRVAPRSLARCGPSSRLM
     234-298: Missing.

Note: No experimental confirmation available.
Show »
Length:1,005
Mass (Da):108,889
Checksum:i1DFA3D2E0A3ADDAE
GO
Isoform 13 (identifier: Q96AX9-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGALRRGRALGSRPSGPTVSSRRSPQCPVAQEGLGARSRPRVAPRSLARCGPSSRLM
     347-350: Missing.

Note: No experimental confirmation available.
Show »
Length:1,066
Mass (Da):115,415
Checksum:i5A269C248614C73A
GO
Isoform 14 (identifier: Q96AX9-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGALRRGRALGSRPSGPTVSSRRSPQCPVAQEGLGARSRPRVAPRSLARCGPSSRLM

Note: No experimental confirmation available.
Show »
Length:1,070
Mass (Da):115,861
Checksum:i7A4B6B4050393324
GO

Sequence cautioni

The sequence AAH16490 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB82979 differs from that shown. Reason: Frameshift at positions 193 and 205.Curated
The sequence BAC03707 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04646 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04752 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04952 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80K → N in AAH16490 (PubMed:15489334).Curated1
Sequence conflicti176 – 177CY → SN in BAB82979 (Ref. 2) Curated2
Sequence conflicti221V → A in BAB82979 (Ref. 2) Curated1
Sequence conflicti226D → F in BAC77353 (PubMed:12761501).Curated1
Sequence conflicti235G → R in BAG63969 (PubMed:14702039).Curated1
Sequence conflicti273H → Y in AAH37542 (PubMed:15489334).Curated1
Sequence conflicti375F → L in BAC04646 (PubMed:14702039).Curated1
Sequence conflicti508D → G in AAH37542 (PubMed:15489334).Curated1
Sequence conflicti637S → G in AAH37542 (PubMed:15489334).Curated1
Sequence conflicti689K → E in BAC04752 (PubMed:14702039).Curated1
Sequence conflicti692G → D in BAG53705 (PubMed:14702039).Curated1
Sequence conflicti937S → F in BAC04646 (PubMed:14702039).Curated1
Sequence conflicti975S → R in BAC77353 (PubMed:12761501).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04666815F → L.2 PublicationsCorresponds to variant rs7418389dbSNPEnsembl.1
Natural variantiVAR_04666945M → T.3 PublicationsCorresponds to variant rs12755088dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0355081 – 159Missing in isoform 7. 1 PublicationAdd BLAST159
Alternative sequenceiVSP_0355091 – 58Missing in isoform 8 and isoform 10. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_0464051M → MAGALRRGRALGSRPSGPTV SSRRSPQCPVAQEGLGARSR PRVAPRSLARCGPSSRLM in isoform 11, isoform 12, isoform 13 and isoform 14. 1 Publication1
Alternative sequenceiVSP_01439237 – 50Missing in isoform 2. 3 PublicationsAdd BLAST14
Alternative sequenceiVSP_04640642 – 55Missing in isoform 11. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_014393234 – 298Missing in isoform 4, isoform 10 and isoform 12. 2 PublicationsAdd BLAST65
Alternative sequenceiVSP_014394347 – 382Missing in isoform 6. CuratedAdd BLAST36
Alternative sequenceiVSP_014395347 – 350Missing in isoform 3 and isoform 13. 1 Publication4
Alternative sequenceiVSP_014396383 – 417Missing in isoform 5. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_035510673 – 1013Missing in isoform 9. 1 PublicationAdd BLAST341
Alternative sequenceiVSP_045186853 – 1013ERQAG…IQIFV → VRAQDEEVHQVPGGRQQETA PRRL in isoform 10. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_035511858 – 860GGA → RGR in isoform 8. 1 Publication3
Alternative sequenceiVSP_035512861 – 1013Missing in isoform 8. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074480 mRNA. Translation: BAB92950.1.
AB064367 mRNA. Translation: BAB82979.1. Frameshift.
AB076691 mRNA. Translation: BAC00992.1.
AB076692 mRNA. Translation: BAC00993.1.
AB076693 mRNA. Translation: BAC00994.1.
AB097000 mRNA. Translation: BAC77353.1.
AK091610 mRNA. Translation: BAC03707.1. Different initiation.
AK095914 mRNA. Translation: BAC04646.1. Different initiation.
AK096295 mRNA. Translation: BAC04752.1. Different initiation.
AK097106 mRNA. Translation: BAC04952.1. Different initiation.
AK098785 mRNA. Translation: BAC05413.1.
AK122751 mRNA. Translation: BAG53705.1.
AK122863 mRNA. Translation: BAG53766.1.
AK128167 mRNA. Translation: BAG54643.1.
AK302757 mRNA. Translation: BAG63969.1.
AL691432 Genomic DNA. No translation available.
BC016490 mRNA. Translation: AAH16490.1. Different initiation.
BC037542 mRNA. Translation: AAH37542.1.
AL834527 mRNA. Translation: CAD39183.1.
CCDSiCCDS41224.2. [Q96AX9-14]
CCDS53261.1. [Q96AX9-13]
CCDS53262.1. [Q96AX9-12]
CCDS53263.1. [Q96AX9-11]
CCDS53264.1. [Q96AX9-10]
RefSeqiNP_001164157.1. NM_001170686.1. [Q96AX9-13]
NP_001164158.1. NM_001170687.1. [Q96AX9-11]
NP_001164159.1. NM_001170688.1. [Q96AX9-12]
NP_001164160.1. NM_001170689.1. [Q96AX9-10]
NP_543151.2. NM_080875.2. [Q96AX9-14]
UniGeneiHs.135805.
Hs.593430.

Genome annotation databases

EnsembliENST00000355826; ENSP00000348081; ENSG00000197530. [Q96AX9-11]
ENST00000378712; ENSP00000367984; ENSG00000197530. [Q96AX9-10]
ENST00000505820; ENSP00000426103; ENSG00000197530. [Q96AX9-14]
ENST00000518681; ENSP00000428264; ENSG00000197530. [Q96AX9-12]
ENST00000520777; ENSP00000428660; ENSG00000197530. [Q96AX9-13]
GeneIDi142678.
KEGGihsa:142678.
UCSCiuc001agg.4. human. [Q96AX9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074480 mRNA. Translation: BAB92950.1.
AB064367 mRNA. Translation: BAB82979.1. Frameshift.
AB076691 mRNA. Translation: BAC00992.1.
AB076692 mRNA. Translation: BAC00993.1.
AB076693 mRNA. Translation: BAC00994.1.
AB097000 mRNA. Translation: BAC77353.1.
AK091610 mRNA. Translation: BAC03707.1. Different initiation.
AK095914 mRNA. Translation: BAC04646.1. Different initiation.
AK096295 mRNA. Translation: BAC04752.1. Different initiation.
AK097106 mRNA. Translation: BAC04952.1. Different initiation.
AK098785 mRNA. Translation: BAC05413.1.
AK122751 mRNA. Translation: BAG53705.1.
AK122863 mRNA. Translation: BAG53766.1.
AK128167 mRNA. Translation: BAG54643.1.
AK302757 mRNA. Translation: BAG63969.1.
AL691432 Genomic DNA. No translation available.
BC016490 mRNA. Translation: AAH16490.1. Different initiation.
BC037542 mRNA. Translation: AAH37542.1.
AL834527 mRNA. Translation: CAD39183.1.
CCDSiCCDS41224.2. [Q96AX9-14]
CCDS53261.1. [Q96AX9-13]
CCDS53262.1. [Q96AX9-12]
CCDS53263.1. [Q96AX9-11]
CCDS53264.1. [Q96AX9-10]
RefSeqiNP_001164157.1. NM_001170686.1. [Q96AX9-13]
NP_001164158.1. NM_001170687.1. [Q96AX9-11]
NP_001164159.1. NM_001170688.1. [Q96AX9-12]
NP_001164160.1. NM_001170689.1. [Q96AX9-10]
NP_543151.2. NM_080875.2. [Q96AX9-14]
UniGeneiHs.135805.
Hs.593430.

3D structure databases

ProteinModelPortaliQ96AX9.
SMRiQ96AX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126769. 22 interactors.
IntActiQ96AX9. 11 interactors.
MINTiMINT-3050933.
STRINGi9606.ENSP00000426103.

PTM databases

iPTMnetiQ96AX9.
PhosphoSitePlusiQ96AX9.

Polymorphism and mutation databases

BioMutaiMIB2.
DMDMi209572707.

Proteomic databases

MaxQBiQ96AX9.
PaxDbiQ96AX9.
PeptideAtlasiQ96AX9.
PRIDEiQ96AX9.

Protocols and materials databases

DNASUi142678.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355826; ENSP00000348081; ENSG00000197530. [Q96AX9-11]
ENST00000378712; ENSP00000367984; ENSG00000197530. [Q96AX9-10]
ENST00000505820; ENSP00000426103; ENSG00000197530. [Q96AX9-14]
ENST00000518681; ENSP00000428264; ENSG00000197530. [Q96AX9-12]
ENST00000520777; ENSP00000428660; ENSG00000197530. [Q96AX9-13]
GeneIDi142678.
KEGGihsa:142678.
UCSCiuc001agg.4. human. [Q96AX9-1]

Organism-specific databases

CTDi142678.
DisGeNETi142678.
GeneCardsiMIB2.
HGNCiHGNC:30577. MIB2.
HPAiCAB037055.
HPA027871.
MIMi611141. gene.
neXtProtiNX_Q96AX9.
OpenTargetsiENSG00000197530.
PharmGKBiPA134924284.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
KOG4582. Eukaryota.
ENOG410XP18. LUCA.
GeneTreeiENSGT00790000122981.
HOGENOMiHOG000231158.
HOVERGENiHBG068386.
InParanoidiQ96AX9.
KOiK10645.
OMAiATCGGHY.
OrthoDBiEOG091G00Z0.
PhylomeDBiQ96AX9.
TreeFamiTF324147.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-HSA-2644606. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
R-HSA-2691232. Constitutive Signaling by NOTCH1 HD Domain Mutants.
R-HSA-2894862. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
R-HSA-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ96AX9.
SIGNORiQ96AX9.

Miscellaneous databases

ChiTaRSiMIB2. human.
GeneWikiiMIB2_(gene).
GenomeRNAii142678.
PROiQ96AX9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197530.
ExpressionAtlasiQ96AX9. baseline and differential.
GenevisibleiQ96AX9. HS.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
3.30.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR010606. Mib_Herc2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF06701. MIB_HERC2. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
SM00184. RING. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS51416. MIB_HERC2. 2 hits.
PS50089. ZF_RING_2. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIB2_HUMAN
AccessioniPrimary (citable) accession number: Q96AX9
Secondary accession number(s): A2AGM5
, A2AGM6, B3KV93, B3KVF4, B3KXY1, B4DZ57, E9PGU1, E9PHQ1, F8WA73, J3KNZ7, Q7Z437, Q8IY62, Q8N786, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 14, 2008
Last modified: November 30, 2016
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.