Q96AX9 (MIB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
E3 ubiquitin-protein ligase MIB2
EC=6.3.2.-

Alternative name(s):
Mind bomb homolog 2
Novel zinc finger protein
Short name=Novelzin
Putative NF-kappa-B-activating protein 002N
Skeletrophin
Zinc finger ZZ type with ankyrin repeat domain protein 1

Gene names

Name:	MIB2
Synonyms:	SKD, ZZANK1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1013 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors By similarity.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with actin monomer. Ref.1
Subcellular location	Cytoplasm. Endosome. Note: Colocalizes with endosomal compartments. Ref.1
Tissue specificity	Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney. Ref.1
Induction	Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene. Ref.1
Post-translational modification	Ubiquitinated. Possibly via autoubiquitination By similarity.
Sequence similarities	Contains 9 ANK repeats. Contains 2 MIB/HERC2 domains. Contains 2 RING-type zinc fingers. Contains 1 ZZ-type zinc finger.
Sequence caution	The sequence AAH16490.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB82979.1 differs from that shown. Reason: Frameshift at positions 193 and 205. The sequence BAC03707.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC04646.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC04752.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC04952.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Notch signaling pathway Ubl conjugation pathway
Cellular component	Cytoplasm Endosome
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Repeat Zinc-finger
Ligand	Actin-binding Metal-binding Zinc
Molecular function	Ligase
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Notch signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype Ref.3. Source: UniProtKB
Cellular_component	endosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	signal transducer activity Inferred from mutant phenotype Ref.3. Source: UniProtKB ubiquitin-protein ligase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TBK1	Q9UHD2	2	EBI-2130249,EBI-356402

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96AX9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96AX9-2)

Also known as: Alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     37-50: Missing.

Isoform 3 (identifier: Q96AX9-3)

Also known as: Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     347-350: Missing.

Isoform 4 (identifier: Q96AX9-4)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     234-298: Missing.

Isoform 5 (identifier: Q96AX9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     383-417: Missing.

Note: No experimental confirmation available.

Isoform 10 (identifier: Q96AX9-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.
     234-298: Missing.
     853-1013: ERQAGGGAAP...PIRDRIQIFV → VRAQDEEVHQVPGGRQQETAPRRL

Note: No experimental confirmation available.

Isoform 7 (identifier: Q96AX9-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.

Isoform 8 (identifier: Q96AX9-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.
     858-860: GGA → RGR
     861-1013: Missing.

Note: No experimental confirmation available.

Isoform 9 (identifier: Q96AX9-9)

The sequence of this isoform differs from the canonical sequence as follows:
     673-1013: Missing.

Isoform 6 (identifier: Q96AX9-6)

The sequence of this isoform differs from the canonical sequence as follows:
     347-382: Missing.

Note: No experimental confirmation available.

Isoform 11 (identifier: Q96AX9-11)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGALRRGRALGSRPSGPTVSSRRSPQCPVAQEGLGARSRPRVAPRSLARCGPSSRLM
     42-55: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1013	1013	E3 ubiquitin-protein ligase MIB2		PRO_0000055947
Regions
	Domain	59 – 138	80	MIB/HERC2 1
	Domain	207 – 285	79	MIB/HERC2 2
	Repeat	522 – 551	30	ANK 1
	Repeat	555 – 584	30	ANK 2
	Repeat	588 – 617	30	ANK 3
	Repeat	621 – 653	33	ANK 4
	Repeat	657 – 686	30	ANK 5
	Repeat	691 – 721	31	ANK 6
	Repeat	725 – 754	30	ANK 7
	Repeat	758 – 786	29	ANK 8
	Repeat	827 – 856	30	ANK 9
	Zinc finger	143 – 190	48	ZZ-type
	Zinc finger	890 – 925	36	RING-type 1
	Zinc finger	969 – 1002	34	RING-type 2
Amino acid modifications
	Modified residue	309	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 159	159	Missing in isoform 7.		VSP_035508
	Alternative sequence	1 – 58	58	Missing in isoform 8 and isoform 10.		VSP_035509
	Alternative sequence	1	1	M → MAGALRRGRALGSRPSGPTV SSRRSPQCPVAQEGLGARSR PRVAPRSLARCGPSSRLM in isoform 11.		VSP_046405
	Alternative sequence	37 – 50	14	Missing in isoform 2.		VSP_014392
	Alternative sequence	42 – 55	14	Missing in isoform 11.		VSP_046406
	Alternative sequence	234 – 298	65	Missing in isoform 4 and isoform 10.		VSP_014393
	Alternative sequence	347 – 382	36	Missing in isoform 6.		VSP_014394
	Alternative sequence	347 – 350	4	Missing in isoform 3.		VSP_014395
	Alternative sequence	383 – 417	35	Missing in isoform 5.		VSP_014396
	Alternative sequence	673 – 1013	341	Missing in isoform 9.		VSP_035510
	Alternative sequence	853 – 1013	161	ERQAG…IQIFV → VRAQDEEVHQVPGGRQQETA PRRL in isoform 10.		VSP_045186
	Alternative sequence	858 – 860	3	GGA → RGR in isoform 8.		VSP_035511
	Alternative sequence	861 – 1013	153	Missing in isoform 8.		VSP_035512
	Natural variant	15	1	F → L. Ref.3 Ref.4 Corresponds to variant rs7418389 [ dbSNP | Ensembl ].		VAR_046668
	Natural variant	45	1	M → T. Ref.1 Ref.2 Ref.4 Corresponds to variant rs12755088 [ dbSNP | Ensembl ].		VAR_046669
Experimental info
	Sequence conflict	80	1	K → N in AAH16490. Ref.6
	Sequence conflict	176 – 177	2	CY → SN in BAB82979. Ref.2
	Sequence conflict	221	1	V → A in BAB82979. Ref.2
	Sequence conflict	226	1	D → F in BAC77353. Ref.3
	Sequence conflict	235	1	G → R in BAG63969. Ref.4
	Sequence conflict	273	1	H → Y in AAH37542. Ref.6
	Sequence conflict	375	1	F → L in BAC04646. Ref.4
	Sequence conflict	508	1	D → G in AAH37542. Ref.6
	Sequence conflict	637	1	S → G in AAH37542. Ref.6
	Sequence conflict	689	1	K → E in BAC04752. Ref.4
	Sequence conflict	692	1	G → D in BAG53705. Ref.4
	Sequence conflict	937	1	S → F in BAC04646. Ref.4
	Sequence conflict	975	1	S → R in BAC77353. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 14, 2008. Version 3. Checksum: 737BA12300091C70	FASTA	1,013	109,939
	10 20 30 40 50 60 MGWKPSEARG QSQSFQASGL QPRSLKAARR ATGRPDRSRA ARPTMDPSAH RSRAAPPNMD 70 80 90 100 110 120 PDPQAGVQVG MRVVRGVDWK WGQQDGGEGG VGTVVELGRH GSPSTPDRTV VVQWDQGTRT 130 140 150 160 170 180 NYRAGYQGAH DLLLYDNAQI GVRHPNIICD CCKKHGLRGM RWKCRVCLDY DLCTQCYMHN 190 200 210 220 230 240 KHELAHAFDR YETAHSRPVT LSPRQGLPRI PLRGIFQGAK VVRGPDWEWG SQDGGEGKPG 250 260 270 280 290 300 RVVDIRGWDV ETGRSVASVT WADGTTNVYR VGHKGKVDLK CVGEAAGGFY YKDHLPRLGK 310 320 330 340 350 360 PAELQRRVSA DSQPFQHGDK VKCLLDTDVL REMQEGHGGW NPRMAEFIGQ TGTVHRITDR 370 380 390 400 410 420 GDVRVQFNHE TRWTFHPGAL TKHHSFWVGD VVRVIGDLDT VKRLQAGHGE WTDDMAPALG 430 440 450 460 470 480 RVGKVVKVFG DGNLRVAVAG QRWTFSPSCL VAYRPEEDAN LDVAERAREN KSSLSVALDK 490 500 510 520 530 540 LRAQKSDPEH PGRLVVEVAL GNAARALDLL RRRPEQVDTK NQGRTALQVA AYLGQVELIR 550 560 570 580 590 600 LLLQARAGVD LPDDEGNTAL HYAALGNQPE ATRVLLSAGC RADAINSTQS TALHVAVQRG 610 620 630 640 650 660 FLEVVRALCE RGCDVNLPDA HSDTPLHSAI SAGTGASGIV EVLTEVPNID VTATNSQGFT 670 680 690 700 710 720 LLHHASLKGH ALAVRKILAR ARQLVDAKKE DGFTALHLAA LNNHREVAQI LIREGRCDVN 730 740 750 760 770 780 VRNRKLQSPL HLAVQQAHVG LVPLLVDAGC SVNAEDEEGD TALHVALQRH QLLPLVADGA 790 800 810 820 830 840 GGDPGPLQLL SRLQASGLPG SAELTVGAAV ACFLALEGAD VSYTNHRGRS PLDLAAEGRV 850 860 870 880 890 900 LKALQGCAQR FRERQAGGGA APGPRQTLGT PNTVTNLHVG AAPGPEAAEC LVCSELALLV 910 920 930 940 950 960 LFSPCQHRTV CEECARRMKK CIRCQVVVSK KLRPDGSEVA SAAPAPGPPR QLVEELQSRY 970 980 990 1000 1010 RQMEERITCP ICIDSHIRLV FQCGHGACAP CGSALSACPI CRQPIRDRIQ IFV
	Isoform 2 (Alpha) [UniParc]. Checksum: 37BC32E3C342FC75	FASTA	999	108,404
	10 20 30 40 50 60 MGWKPSEARG QSQSFQASGL QPRSLKAARR ATGRPDRSRA APPNMDPDPQ AGVQVGMRVV 70 80 90 100 110 120 RGVDWKWGQQ DGGEGGVGTV VELGRHGSPS TPDRTVVVQW DQGTRTNYRA GYQGAHDLLL 130 140 150 160 170 180 YDNAQIGVRH PNIICDCCKK HGLRGMRWKC RVCLDYDLCT QCYMHNKHEL AHAFDRYETA 190 200 210 220 230 240 HSRPVTLSPR QGLPRIPLRG IFQGAKVVRG PDWEWGSQDG GEGKPGRVVD IRGWDVETGR 250 260 270 280 290 300 SVASVTWADG TTNVYRVGHK GKVDLKCVGE AAGGFYYKDH LPRLGKPAEL QRRVSADSQP 310 320 330 340 350 360 FQHGDKVKCL LDTDVLREMQ EGHGGWNPRM AEFIGQTGTV HRITDRGDVR VQFNHETRWT 370 380 390 400 410 420 FHPGALTKHH SFWVGDVVRV IGDLDTVKRL QAGHGEWTDD MAPALGRVGK VVKVFGDGNL 430 440 450 460 470 480 RVAVAGQRWT FSPSCLVAYR PEEDANLDVA ERARENKSSL SVALDKLRAQ KSDPEHPGRL 490 500 510 520 530 540 VVEVALGNAA RALDLLRRRP EQVDTKNQGR TALQVAAYLG QVELIRLLLQ ARAGVDLPDD 550 560 570 580 590 600 EGNTALHYAA LGNQPEATRV LLSAGCRADA INSTQSTALH VAVQRGFLEV VRALCERGCD 610 620 630 640 650 660 VNLPDAHSDT PLHSAISAGT GASGIVEVLT EVPNIDVTAT NSQGFTLLHH ASLKGHALAV 670 680 690 700 710 720 RKILARARQL VDAKKEDGFT ALHLAALNNH REVAQILIRE GRCDVNVRNR KLQSPLHLAV 730 740 750 760 770 780 QQAHVGLVPL LVDAGCSVNA EDEEGDTALH VALQRHQLLP LVADGAGGDP GPLQLLSRLQ 790 800 810 820 830 840 ASGLPGSAEL TVGAAVACFL ALEGADVSYT NHRGRSPLDL AAEGRVLKAL QGCAQRFRER 850 860 870 880 890 900 QAGGGAAPGP RQTLGTPNTV TNLHVGAAPG PEAAECLVCS ELALLVLFSP CQHRTVCEEC 910 920 930 940 950 960 ARRMKKCIRC QVVVSKKLRP DGSEVASAAP APGPPRQLVE ELQSRYRQME ERITCPICID 970 980 990 SHIRLVFQCG HGACAPCGSA LSACPICRQP IRDRIQIFV
	Isoform 3 (Gamma) [UniParc]. Checksum: 6A16B37089CF3538	FASTA	1,009	109,493
	10 20 30 40 50 60 MGWKPSEARG QSQSFQASGL QPRSLKAARR ATGRPDRSRA ARPTMDPSAH RSRAAPPNMD 70 80 90 100 110 120 PDPQAGVQVG MRVVRGVDWK WGQQDGGEGG VGTVVELGRH GSPSTPDRTV VVQWDQGTRT 130 140 150 160 170 180 NYRAGYQGAH DLLLYDNAQI GVRHPNIICD CCKKHGLRGM RWKCRVCLDY DLCTQCYMHN 190 200 210 220 230 240 KHELAHAFDR YETAHSRPVT LSPRQGLPRI PLRGIFQGAK VVRGPDWEWG SQDGGEGKPG 250 260 270 280 290 300 RVVDIRGWDV ETGRSVASVT WADGTTNVYR VGHKGKVDLK CVGEAAGGFY YKDHLPRLGK 310 320 330 340 350 360 PAELQRRVSA DSQPFQHGDK VKCLLDTDVL REMQEGHGGW NPRMAETGTV HRITDRGDVR 370 380 390 400 410 420 VQFNHETRWT FHPGALTKHH SFWVGDVVRV IGDLDTVKRL QAGHGEWTDD MAPALGRVGK 430 440 450 460 470 480 VVKVFGDGNL RVAVAGQRWT FSPSCLVAYR PEEDANLDVA ERARENKSSL SVALDKLRAQ 490 500 510 520 530 540 KSDPEHPGRL VVEVALGNAA RALDLLRRRP EQVDTKNQGR TALQVAAYLG QVELIRLLLQ 550 560 570 580 590 600 ARAGVDLPDD EGNTALHYAA LGNQPEATRV LLSAGCRADA INSTQSTALH VAVQRGFLEV 610 620 630 640 650 660 VRALCERGCD VNLPDAHSDT PLHSAISAGT GASGIVEVLT EVPNIDVTAT NSQGFTLLHH 670 680 690 700 710 720 ASLKGHALAV RKILARARQL VDAKKEDGFT ALHLAALNNH REVAQILIRE GRCDVNVRNR 730 740 750 760 770 780 KLQSPLHLAV QQAHVGLVPL LVDAGCSVNA EDEEGDTALH VALQRHQLLP LVADGAGGDP 790 800 810 820 830 840 GPLQLLSRLQ ASGLPGSAEL TVGAAVACFL ALEGADVSYT NHRGRSPLDL AAEGRVLKAL 850 860 870 880 890 900 QGCAQRFRER QAGGGAAPGP RQTLGTPNTV TNLHVGAAPG PEAAECLVCS ELALLVLFSP 910 920 930 940 950 960 CQHRTVCEEC ARRMKKCIRC QVVVSKKLRP DGSEVASAAP APGPPRQLVE ELQSRYRQME 970 980 990 1000 ERITCPICID SHIRLVFQCG HGACAPCGSA LSACPICRQP IRDRIQIFV
	Isoform 4 (Beta) [UniParc]. Checksum: DDC32F6A7743A6E3	FASTA	948	102,967
	10 20 30 40 50 60 MGWKPSEARG QSQSFQASGL QPRSLKAARR ATGRPDRSRA ARPTMDPSAH RSRAAPPNMD 70 80 90 100 110 120 PDPQAGVQVG MRVVRGVDWK WGQQDGGEGG VGTVVELGRH GSPSTPDRTV VVQWDQGTRT 130 140 150 160 170 180 NYRAGYQGAH DLLLYDNAQI GVRHPNIICD CCKKHGLRGM RWKCRVCLDY DLCTQCYMHN 190 200 210 220 230 240 KHELAHAFDR YETAHSRPVT LSPRQGLPRI PLRGIFQGAK VVRGPDWEWG SQDGKPAELQ 250 260 270 280 290 300 RRVSADSQPF QHGDKVKCLL DTDVLREMQE GHGGWNPRMA EFIGQTGTVH RITDRGDVRV 310 320 330 340 350 360 QFNHETRWTF HPGALTKHHS FWVGDVVRVI GDLDTVKRLQ AGHGEWTDDM APALGRVGKV 370 380 390 400 410 420 VKVFGDGNLR VAVAGQRWTF SPSCLVAYRP EEDANLDVAE RARENKSSLS VALDKLRAQK 430 440 450 460 470 480 SDPEHPGRLV VEVALGNAAR ALDLLRRRPE QVDTKNQGRT ALQVAAYLGQ VELIRLLLQA 490 500 510 520 530 540 RAGVDLPDDE GNTALHYAAL GNQPEATRVL LSAGCRADAI NSTQSTALHV AVQRGFLEVV 550 560 570 580 590 600 RALCERGCDV NLPDAHSDTP LHSAISAGTG ASGIVEVLTE VPNIDVTATN SQGFTLLHHA 610 620 630 640 650 660 SLKGHALAVR KILARARQLV DAKKEDGFTA LHLAALNNHR EVAQILIREG RCDVNVRNRK 670 680 690 700 710 720 LQSPLHLAVQ QAHVGLVPLL VDAGCSVNAE DEEGDTALHV ALQRHQLLPL VADGAGGDPG 730 740 750 760 770 780 PLQLLSRLQA SGLPGSAELT VGAAVACFLA LEGADVSYTN HRGRSPLDLA AEGRVLKALQ 790 800 810 820 830 840 GCAQRFRERQ AGGGAAPGPR QTLGTPNTVT NLHVGAAPGP EAAECLVCSE LALLVLFSPC 850 860 870 880 890 900 QHRTVCEECA RRMKKCIRCQ VVVSKKLRPD GSEVASAAPA PGPPRQLVEE LQSRYRQMEE 910 920 930 940 RITCPICIDS HIRLVFQCGH GACAPCGSAL SACPICRQPI RDRIQIFV
	Isoform 5 [UniParc]. Checksum: 211C2E732319290D	FASTA	978	106,011
	10 20 30 40 50 60 MGWKPSEARG QSQSFQASGL QPRSLKAARR ATGRPDRSRA ARPTMDPSAH RSRAAPPNMD 70 80 90 100 110 120 PDPQAGVQVG MRVVRGVDWK WGQQDGGEGG VGTVVELGRH GSPSTPDRTV VVQWDQGTRT 130 140 150 160 170 180 NYRAGYQGAH DLLLYDNAQI GVRHPNIICD CCKKHGLRGM RWKCRVCLDY DLCTQCYMHN 190 200 210 220 230 240 KHELAHAFDR YETAHSRPVT LSPRQGLPRI PLRGIFQGAK VVRGPDWEWG SQDGGEGKPG 250 260 270 280 290 300 RVVDIRGWDV ETGRSVASVT WADGTTNVYR VGHKGKVDLK CVGEAAGGFY YKDHLPRLGK 310 320 330 340 350 360 PAELQRRVSA DSQPFQHGDK VKCLLDTDVL REMQEGHGGW NPRMAEFIGQ TGTVHRITDR 370 380 390 400 410 420 GDVRVQFNHE TRWTFHPGAL TKALGRVGKV VKVFGDGNLR VAVAGQRWTF SPSCLVAYRP 430 440 450 460 470 480 EEDANLDVAE RARENKSSLS VALDKLRAQK SDPEHPGRLV VEVALGNAAR ALDLLRRRPE 490 500 510 520 530 540 QVDTKNQGRT ALQVAAYLGQ VELIRLLLQA RAGVDLPDDE GNTALHYAAL GNQPEATRVL 550 560 570 580 590 600 LSAGCRADAI NSTQSTALHV AVQRGFLEVV RALCERGCDV NLPDAHSDTP LHSAISAGTG 610 620 630 640 650 660 ASGIVEVLTE VPNIDVTATN SQGFTLLHHA SLKGHALAVR KILARARQLV DAKKEDGFTA 670 680 690 700 710 720 LHLAALNNHR EVAQILIREG RCDVNVRNRK LQSPLHLAVQ QAHVGLVPLL VDAGCSVNAE 730 740 750 760 770 780 DEEGDTALHV ALQRHQLLPL VADGAGGDPG PLQLLSRLQA SGLPGSAELT VGAAVACFLA 790 800 810 820 830 840 LEGADVSYTN HRGRSPLDLA AEGRVLKALQ GCAQRFRERQ AGGGAAPGPR QTLGTPNTVT 850 860 870 880 890 900 NLHVGAAPGP EAAECLVCSE LALLVLFSPC QHRTVCEECA RRMKKCIRCQ VVVSKKLRPD 910 920 930 940 950 960 GSEVASAAPA PGPPRQLVEE LQSRYRQMEE RITCPICIDS HIRLVFQCGH GACAPCGSAL 970 SACPICRQPI RDRIQIFV
	Isoform 10 [UniParc]. Checksum: 9447C993AF8726DC	FASTA	753	82,129
	10 20 30 40 50 60 MDPDPQAGVQ VGMRVVRGVD WKWGQQDGGE GGVGTVVELG RHGSPSTPDR TVVVQWDQGT 70 80 90 100 110 120 RTNYRAGYQG AHDLLLYDNA QIGVRHPNII CDCCKKHGLR GMRWKCRVCL DYDLCTQCYM 130 140 150 160 170 180 HNKHELAHAF DRYETAHSRP VTLSPRQGLP RIPLRGIFQG AKVVRGPDWE WGSQDGKPAE 190 200 210 220 230 240 LQRRVSADSQ PFQHGDKVKC LLDTDVLREM QEGHGGWNPR MAEFIGQTGT VHRITDRGDV 250 260 270 280 290 300 RVQFNHETRW TFHPGALTKH HSFWVGDVVR VIGDLDTVKR LQAGHGEWTD DMAPALGRVG 310 320 330 340 350 360 KVVKVFGDGN LRVAVAGQRW TFSPSCLVAY RPEEDANLDV AERARENKSS LSVALDKLRA 370 380 390 400 410 420 QKSDPEHPGR LVVEVALGNA ARALDLLRRR PEQVDTKNQG RTALQVAAYL GQVELIRLLL 430 440 450 460 470 480 QARAGVDLPD DEGNTALHYA ALGNQPEATR VLLSAGCRAD AINSTQSTAL HVAVQRGFLE 490 500 510 520 530 540 VVRALCERGC DVNLPDAHSD TPLHSAISAG TGASGIVEVL TEVPNIDVTA TNSQGFTLLH 550 560 570 580 590 600 HASLKGHALA VRKILARARQ LVDAKKEDGF TALHLAALNN HREVAQILIR EGRCDVNVRN 610 620 630 640 650 660 RKLQSPLHLA VQQAHVGLVP LLVDAGCSVN AEDEEGDTAL HVALQRHQLL PLVADGAGGD 670 680 690 700 710 720 PGPLQLLSRL QASGLPGSAE LTVGAAVACF LALEGADVSY TNHRGRSPLD LAAEGRVLKA 730 740 750 LQGCAQRFRV RAQDEEVHQV PGGRQQETAP RRL
	Isoform 7 [UniParc]. Checksum: C8390208E6E8CFDF	FASTA	854	92,680
	10 20 30 40 50 60 MRWKCRVCLD YDLCTQCYMH NKHELAHAFD RYETAHSRPV TLSPRQGLPR IPLRGIFQGA 70 80 90 100 110 120 KVVRGPDWEW GSQDGGEGKP GRVVDIRGWD VETGRSVASV TWADGTTNVY RVGHKGKVDL 130 140 150 160 170 180 KCVGEAAGGF YYKDHLPRLG KPAELQRRVS ADSQPFQHGD KVKCLLDTDV LREMQEGHGG 190 200 210 220 230 240 WNPRMAEFIG QTGTVHRITD RGDVRVQFNH ETRWTFHPGA LTKHHSFWVG DVVRVIGDLD 250 260 270 280 290 300 TVKRLQAGHG EWTDDMAPAL GRVGKVVKVF GDGNLRVAVA GQRWTFSPSC LVAYRPEEDA 310 320 330 340 350 360 NLDVAERARE NKSSLSVALD KLRAQKSDPE HPGRLVVEVA LGNAARALDL LRRRPEQVDT 370 380 390 400 410 420 KNQGRTALQV AAYLGQVELI RLLLQARAGV DLPDDEGNTA LHYAALGNQP EATRVLLSAG 430 440 450 460 470 480 CRADAINSTQ STALHVAVQR GFLEVVRALC ERGCDVNLPD AHSDTPLHSA ISAGTGASGI 490 500 510 520 530 540 VEVLTEVPNI DVTATNSQGF TLLHHASLKG HALAVRKILA RARQLVDAKK EDGFTALHLA 550 560 570 580 590 600 ALNNHREVAQ ILIREGRCDV NVRNRKLQSP LHLAVQQAHV GLVPLLVDAG CSVNAEDEEG 610 620 630 640 650 660 DTALHVALQR HQLLPLVADG AGGDPGPLQL LSRLQASGLP GSAELTVGAA VACFLALEGA 670 680 690 700 710 720 DVSYTNHRGR SPLDLAAEGR VLKALQGCAQ RFRERQAGGG AAPGPRQTLG TPNTVTNLHV 730 740 750 760 770 780 GAAPGPEAAE CLVCSELALL VLFSPCQHRT VCEECARRMK KCIRCQVVVS KKLRPDGSEV 790 800 810 820 830 840 ASAAPAPGPP RQLVEELQSR YRQMEERITC PICIDSHIRL VFQCGHGACA PCGSALSACP 850 ICRQPIRDRI QIFV
	Isoform 8 [UniParc]. Checksum: 9142D07056C27DBE	FASTA	802	87,273
	10 20 30 40 50 60 MDPDPQAGVQ VGMRVVRGVD WKWGQQDGGE GGVGTVVELG RHGSPSTPDR TVVVQWDQGT 70 80 90 100 110 120 RTNYRAGYQG AHDLLLYDNA QIGVRHPNII CDCCKKHGLR GMRWKCRVCL DYDLCTQCYM 130 140 150 160 170 180 HNKHELAHAF DRYETAHSRP VTLSPRQGLP RIPLRGIFQG AKVVRGPDWE WGSQDGGEGK 190 200 210 220 230 240 PGRVVDIRGW DVETGRSVAS VTWADGTTNV YRVGHKGKVD LKCVGEAAGG FYYKDHLPRL 250 260 270 280 290 300 GKPAELQRRV SADSQPFQHG DKVKCLLDTD VLREMQEGHG GWNPRMAEFI GQTGTVHRIT 310 320 330 340 350 360 DRGDVRVQFN HETRWTFHPG ALTKHHSFWV GDVVRVIGDL DTVKRLQAGH GEWTDDMAPA 370 380 390 400 410 420 LGRVGKVVKV FGDGNLRVAV AGQRWTFSPS CLVAYRPEED ANLDVAERAR ENKSSLSVAL 430 440 450 460 470 480 DKLRAQKSDP EHPGRLVVEV ALGNAARALD LLRRRPEQVD TKNQGRTALQ VAAYLGQVEL 490 500 510 520 530 540 IRLLLQARAG VDLPDDEGNT ALHYAALGNQ PEATRVLLSA GCRADAINST QSTALHVAVQ 550 560 570 580 590 600 RGFLEVVRAL CERGCDVNLP DAHSDTPLHS AISAGTGASG IVEVLTEVPN IDVTATNSQG 610 620 630 640 650 660 FTLLHHASLK GHALAVRKIL ARARQLVDAK KEDGFTALHL AALNNHREVA QILIREGRCD 670 680 690 700 710 720 VNVRNRKLQS PLHLAVQQAH VGLVPLLVDA GCSVNAEDEE GDTALHVALQ RHQLLPLVAD 730 740 750 760 770 780 GAGGDPGPLQ LLSRLQASGL PGSAELTVGA AVACFLALEG ADVSYTNHRG RSPLDLAAEG 790 800 RVLKALQGCA QRFRERQAGR GR
	Isoform 9 [UniParc]. Checksum: 1257E008401D9FF9	FASTA	672	73,542
	10 20 30 40 50 60 MGWKPSEARG QSQSFQASGL QPRSLKAARR ATGRPDRSRA ARPTMDPSAH RSRAAPPNMD 70 80 90 100 110 120 PDPQAGVQVG MRVVRGVDWK WGQQDGGEGG VGTVVELGRH GSPSTPDRTV VVQWDQGTRT 130 140 150 160 170 180 NYRAGYQGAH DLLLYDNAQI GVRHPNIICD CCKKHGLRGM RWKCRVCLDY DLCTQCYMHN 190 200 210 220 230 240 KHELAHAFDR YETAHSRPVT LSPRQGLPRI PLRGIFQGAK VVRGPDWEWG SQDGGEGKPG 250 260 270 280 290 300 RVVDIRGWDV ETGRSVASVT WADGTTNVYR VGHKGKVDLK CVGEAAGGFY YKDHLPRLGK 310 320 330 340 350 360 PAELQRRVSA DSQPFQHGDK VKCLLDTDVL REMQEGHGGW NPRMAEFIGQ TGTVHRITDR 370 380 390 400 410 420 GDVRVQFNHE TRWTFHPGAL TKHHSFWVGD VVRVIGDLDT VKRLQAGHGE WTDDMAPALG 430 440 450 460 470 480 RVGKVVKVFG DGNLRVAVAG QRWTFSPSCL VAYRPEEDAN LDVAERAREN KSSLSVALDK 490 500 510 520 530 540 LRAQKSDPEH PGRLVVEVAL GNAARALDLL RRRPEQVDTK NQGRTALQVA AYLGQVELIR 550 560 570 580 590 600 LLLQARAGVD LPDDEGNTAL HYAALGNQPE ATRVLLSAGC RADAINSTQS TALHVAVQRG 610 620 630 640 650 660 FLEVVRALCE RGCDVNLPDA HSDTPLHSAI SAGTGASGIV EVLTEVPNID VTATNSQGFT 670 LLHHASLKGH AL
	Isoform 6 [UniParc]. Checksum: 80A370887F8655CE	FASTA	977	105,777
	10 20 30 40 50 60 MGWKPSEARG QSQSFQASGL QPRSLKAARR ATGRPDRSRA ARPTMDPSAH RSRAAPPNMD 70 80 90 100 110 120 PDPQAGVQVG MRVVRGVDWK WGQQDGGEGG VGTVVELGRH GSPSTPDRTV VVQWDQGTRT 130 140 150 160 170 180 NYRAGYQGAH DLLLYDNAQI GVRHPNIICD CCKKHGLRGM RWKCRVCLDY DLCTQCYMHN 190 200 210 220 230 240 KHELAHAFDR YETAHSRPVT LSPRQGLPRI PLRGIFQGAK VVRGPDWEWG SQDGGEGKPG 250 260 270 280 290 300 RVVDIRGWDV ETGRSVASVT WADGTTNVYR VGHKGKVDLK CVGEAAGGFY YKDHLPRLGK 310 320 330 340 350 360 PAELQRRVSA DSQPFQHGDK VKCLLDTDVL REMQEGHGGW NPRMAEHHSF WVGDVVRVIG 370 380 390 400 410 420 DLDTVKRLQA GHGEWTDDMA PALGRVGKVV KVFGDGNLRV AVAGQRWTFS PSCLVAYRPE 430 440 450 460 470 480 EDANLDVAER ARENKSSLSV ALDKLRAQKS DPEHPGRLVV EVALGNAARA LDLLRRRPEQ 490 500 510 520 530 540 VDTKNQGRTA LQVAAYLGQV ELIRLLLQAR AGVDLPDDEG NTALHYAALG NQPEATRVLL 550 560 570 580 590 600 SAGCRADAIN STQSTALHVA VQRGFLEVVR ALCERGCDVN LPDAHSDTPL HSAISAGTGA 610 620 630 640 650 660 SGIVEVLTEV PNIDVTATNS QGFTLLHHAS LKGHALAVRK ILARARQLVD AKKEDGFTAL 670 680 690 700 710 720 HLAALNNHRE VAQILIREGR CDVNVRNRKL QSPLHLAVQQ AHVGLVPLLV DAGCSVNAED 730 740 750 760 770 780 EEGDTALHVA LQRHQLLPLV ADGAGGDPGP LQLLSRLQAS GLPGSAELTV GAAVACFLAL 790 800 810 820 830 840 EGADVSYTNH RGRSPLDLAA EGRVLKALQG CAQRFRERQA GGGAAPGPRQ TLGTPNTVTN 850 860 870 880 890 900 LHVGAAPGPE AAECLVCSEL ALLVLFSPCQ HRTVCEECAR RMKKCIRCQV VVSKKLRPDG 910 920 930 940 950 960 SEVASAAPAP GPPRQLVEEL QSRYRQMEER ITCPICIDSH IRLVFQCGHG ACAPCGSALS 970 ACPICRQPIR DRIQIFV
	Isoform 11 [UniParc]. Checksum: CF351D9EC0CF7592	FASTA	1,056	114,326
	10 20 30 40 50 60 MAGALRRGRA LGSRPSGPTV SSRRSPQCPV AQEGLGARSR PRVAPRSLAR CGPSSRLMGW 70 80 90 100 110 120 KPSEARGQSQ SFQASGLQPR SLKAARRATG RPDRSRAAPP NMDPDPQAGV QVGMRVVRGV 130 140 150 160 170 180 DWKWGQQDGG EGGVGTVVEL GRHGSPSTPD RTVVVQWDQG TRTNYRAGYQ GAHDLLLYDN 190 200 210 220 230 240 AQIGVRHPNI ICDCCKKHGL RGMRWKCRVC LDYDLCTQCY MHNKHELAHA FDRYETAHSR 250 260 270 280 290 300 PVTLSPRQGL PRIPLRGIFQ GAKVVRGPDW EWGSQDGGEG KPGRVVDIRG WDVETGRSVA 310 320 330 340 350 360 SVTWADGTTN VYRVGHKGKV DLKCVGEAAG GFYYKDHLPR LGKPAELQRR VSADSQPFQH 370 380 390 400 410 420 GDKVKCLLDT DVLREMQEGH GGWNPRMAEF IGQTGTVHRI TDRGDVRVQF NHETRWTFHP 430 440 450 460 470 480 GALTKHHSFW VGDVVRVIGD LDTVKRLQAG HGEWTDDMAP ALGRVGKVVK VFGDGNLRVA 490 500 510 520 530 540 VAGQRWTFSP SCLVAYRPEE DANLDVAERA RENKSSLSVA LDKLRAQKSD PEHPGRLVVE 550 560 570 580 590 600 VALGNAARAL DLLRRRPEQV DTKNQGRTAL QVAAYLGQVE LIRLLLQARA GVDLPDDEGN 610 620 630 640 650 660 TALHYAALGN QPEATRVLLS AGCRADAINS TQSTALHVAV QRGFLEVVRA LCERGCDVNL 670 680 690 700 710 720 PDAHSDTPLH SAISAGTGAS GIVEVLTEVP NIDVTATNSQ GFTLLHHASL KGHALAVRKI 730 740 750 760 770 780 LARARQLVDA KKEDGFTALH LAALNNHREV AQILIREGRC DVNVRNRKLQ SPLHLAVQQA 790 800 810 820 830 840 HVGLVPLLVD AGCSVNAEDE EGDTALHVAL QRHQLLPLVA DGAGGDPGPL QLLSRLQASG 850 860 870 880 890 900 LPGSAELTVG AAVACFLALE GADVSYTNHR GRSPLDLAAE GRVLKALQGC AQRFRERQAG 910 920 930 940 950 960 GGAAPGPRQT LGTPNTVTNL HVGAAPGPEA AECLVCSELA LLVLFSPCQH RTVCEECARR 970 980 990 1000 1010 1020 MKKCIRCQVV VSKKLRPDGS EVASAAPAPG PPRQLVEELQ SRYRQMEERI TCPICIDSHI 1030 1040 1050 RLVFQCGHGA CAPCGSALSA CPICRQPIRD RIQIFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma." Takeuchi T., Heng H.H.Q., Ye C.J., Liang S.-B., Iwata J., Sonobe H., Ohtsuki Y. Am. J. Pathol. 163:1395-1404(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, INTERACTION WITH ACTIN, VARIANT THR-45.
[2]	"A novel zinc finger protein." Takeuchi T. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), VARIANT THR-45.
[3]	"Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways." Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S. Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LEU-15. Tissue: Lung fibroblast.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7; 8; 9; 10 AND 11), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 151-1013 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-1013 (ISOFORMS 1/2/6/7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 327-1013 (ISOFORM 4), VARIANTS LEU-15 AND THR-45. Tissue: Brain, Heart, Spleen, Teratocarcinoma, Testis and Tongue.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain and Lymph.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 252-1013 (ISOFORMS 1/2). Tissue: Testis.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB074480 mRNA. Translation: BAB92950.1. AB064367 mRNA. Translation: BAB82979.1. Frameshift. AB076691 mRNA. Translation: BAC00992.1. AB076692 mRNA. Translation: BAC00993.1. AB076693 mRNA. Translation: BAC00994.1. AB097000 mRNA. Translation: BAC77353.1. AK091610 mRNA. Translation: BAC03707.1. Different initiation. AK095914 mRNA. Translation: BAC04646.1. Different initiation. AK096295 mRNA. Translation: BAC04752.1. Different initiation. AK097106 mRNA. Translation: BAC04952.1. Different initiation. AK098785 mRNA. Translation: BAC05413.1. AK122751 mRNA. Translation: BAG53705.1. AK122863 mRNA. Translation: BAG53766.1. AK128167 mRNA. Translation: BAG54643.1. AK302757 mRNA. Translation: BAG63969.1. AL691432 Genomic DNA. No translation available. BC016490 mRNA. Translation: AAH16490.1. Different initiation. BC037542 mRNA. Translation: AAH37542.1. AL834527 mRNA. Translation: CAD39183.1.
IPI	IPI00059796. IPI00383255. IPI00386276. IPI00414714. IPI00477349. IPI00607637. IPI00658021. IPI00914018. IPI00914032. IPI00914066.
RefSeq	NP_001164157.1. NM_001170686.1. NP_001164158.1. NM_001170687.1. NP_001164159.1. NM_001170688.1. NP_001164160.1. NM_001170689.1. NP_543151.2. NM_080875.2.
UniGene	Hs.135805. Hs.593430.
3D structure databases
ProteinModelPortal	Q96AX9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96AX9. 7 interactions.
PTM databases
PhosphoSite	Q96AX9.
Polymorphism databases
DMDM	209572707.
Proteomic databases
PaxDb	Q96AX9.
PRIDE	Q96AX9.
Protocols and materials databases
DNASU	142678.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000355826; ENSP00000348081; ENSG00000197530. ENST00000357210; ENSP00000349741; ENSG00000197530. ENST00000360522; ENSP00000353713; ENSG00000197530. ENST00000378710; ENSP00000367982; ENSG00000197530. ENST00000378712; ENSP00000367984; ENSG00000197530.
GeneID	142678.
KEGG	hsa:142678.
UCSC	uc001agj.3. human. uc009vkh.3. human.
Organism-specific databases
CTD	142678.
GeneCards	GC01P001540.
HGNC	HGNC:30577. MIB2.
HPA	HPA027871.
MIM	611141. gene.
neXtProt	NX_Q96AX9.
PharmGKB	PA134924284.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0666.
HOVERGEN	HBG068386.
InParanoid	Q96AX9.
KO	K10645.
OrthoDB	EOG4Z62MV.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	Q96AX9.
Bgee	Q96AX9.
Genevestigator	Q96AX9.
GermOnline	ENSG00000197530. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 4 hits. 3.30.40.10. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR010606. Mib_Herc2. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR000433. Znf_ZZ. [Graphical view]
Pfam	PF12796. Ank_2. 2 hits. PF06701. MIB_HERC2. 2 hits. PF00569. ZZ. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 9 hits. SM00184. RING. 2 hits. SM00291. ZnF_ZZ. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. PS51416. MIB_HERC2. 2 hits. PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. 2 hits. PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	142678.
NextBio	84589.
SOURCE	Search...

Entry information

Entry name

MIB2_HUMAN

Accession

Primary (citable) accession number: Q96AX9
Secondary accession number(s): A2AGM5 , A2AGM6, B3KV93, B3KVF4, B3KXY1, B4DZ57, J3KNZ7, Q7Z437, Q8IY62, Q8N786, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	October 14, 2008
Last modified:	May 1, 2013
This is version 109 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.