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Protein

Vacuolar protein sorting-associated protein 33A

Gene

VPS33A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).3 Publications2 Publications

GO - Biological processi

  • autophagosome maturation Source: UniProtKB
  • endosome to lysosome transport Source: UniProtKB
  • lysosome localization Source: UniProtKB
  • melanosome localization Source: UniProtKB
  • platelet formation Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of developmental pigmentation Source: UniProtKB
  • vesicle docking involved in exocytosis Source: InterPro
  • vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 33A
Short name:
hVPS33A
Gene namesi
Name:VPS33A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:18179. VPS33A.

Subcellular locationi

GO - Cellular componenti

  • autophagosome Source: UniProtKB-SubCell
  • clathrin-coated vesicle Source: UniProtKB-SubCell
  • early endosome Source: UniProtKB
  • HOPS complex Source: UniProtKB
  • late endosome Source: UniProtKB
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi429 – 4291K → D: Disrupts interaction with VPS16. Disrupts interaction with VPS18 and impairs endosome-lysosome fusion; when associated with K-438. Disrupts interaction with VPS18 and impairs endosome-lysosome fusion; when associated with K-441. 2 Publications
Mutagenesisi438 – 4381Y → D: Disrupts interaction with VPS16. Disrupts interaction with VPS18 and impairs endosome-lysosome fusion; when associated with D-429. Disrupts interaction with VPS18 and impairs endosome-lysosome fusion; when associated with K-441. 2 Publications
Mutagenesisi441 – 4411I → K: Disrupts interaction with VPS16. Disrupts interaction with VPS18 and impairs endosome-lysosome fusion; when associated with D-429. Disrupts interaction with VPS18 and impairs endosome-lysosome fusion; when associated with D-438. 2 Publications

Organism-specific databases

PharmGKBiPA38306.

Polymorphism and mutation databases

BioMutaiVPS33A.
DMDMi23396917.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Vacuolar protein sorting-associated protein 33APRO_0000206302Add
BLAST

Proteomic databases

EPDiQ96AX1.
MaxQBiQ96AX1.
PaxDbiQ96AX1.
PeptideAtlasiQ96AX1.
PRIDEiQ96AX1.
TopDownProteomicsiQ96AX1.

PTM databases

iPTMnetiQ96AX1.
PhosphoSiteiQ96AX1.

Expressioni

Gene expression databases

BgeeiQ96AX1.
CleanExiHS_VPS33A.
ExpressionAtlasiQ96AX1. baseline and differential.
GenevisibleiQ96AX1. HS.

Organism-specific databases

HPAiHPA038701.
HPA038702.
HPA053209.

Interactioni

Subunit structurei

Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuaole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, which in HOPS further associates with VPS39 and VPS41 and in CORVET with VPS8 and TGFBRAP1 (PubMed:23351085, PubMed:25783203, PubMed:25266290 PubMed:23901104). Interacts with RAB5C (By similarity). Interacts with UVRAG, STX17, MON1A and MON1B (PubMed:18552835, PubMed:20434987, PubMed:24554770). Interacts with VIPAS39; however, this interaction is debated (PubMed:19109425, PubMed:23901104). Associates with adaptor protein complex 3 (AP-3) and clathrin (PubMed:21411634).By similarity2 Publications6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
STX17P569624EBI-2527283,EBI-2797775
UVRAGQ9P2Y54EBI-2527283,EBI-2952704
VPS16Q9H26913EBI-2527283,EBI-2655929
VPS18Q9P2536EBI-2527283,EBI-1053363

Protein-protein interaction databases

BioGridi122390. 26 interactions.
IntActiQ96AX1. 12 interactions.
MINTiMINT-2813690.
STRINGi9606.ENSP00000267199.

Structurei

Secondary structure

1
596
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53Combined sources
Beta strandi7 – 104Combined sources
Helixi13 – 2917Combined sources
Beta strandi34 – 385Combined sources
Helixi40 – 423Combined sources
Helixi43 – 464Combined sources
Turni47 – 493Combined sources
Helixi52 – 576Combined sources
Beta strandi60 – 656Combined sources
Beta strandi68 – 703Combined sources
Beta strandi77 – 837Combined sources
Helixi87 – 9812Combined sources
Beta strandi102 – 1043Combined sources
Beta strandi108 – 1158Combined sources
Helixi119 – 12810Combined sources
Helixi130 – 1334Combined sources
Beta strandi134 – 1396Combined sources
Beta strandi144 – 1485Combined sources
Beta strandi151 – 1533Combined sources
Helixi159 – 1657Combined sources
Helixi170 – 18617Combined sources
Beta strandi190 – 1967Combined sources
Helixi197 – 21115Combined sources
Beta strandi225 – 2317Combined sources
Helixi232 – 2343Combined sources
Helixi238 – 2403Combined sources
Helixi246 – 2538Combined sources
Beta strandi260 – 2634Combined sources
Beta strandi274 – 2763Combined sources
Beta strandi285 – 2884Combined sources
Helixi294 – 2996Combined sources
Helixi304 – 3063Combined sources
Helixi307 – 32620Combined sources
Helixi337 – 36529Combined sources
Helixi368 – 38114Combined sources
Helixi391 – 3988Combined sources
Helixi403 – 41715Combined sources
Helixi422 – 43615Combined sources
Helixi440 – 44910Combined sources
Helixi463 – 4697Combined sources
Beta strandi479 – 4813Combined sources
Helixi485 – 4895Combined sources
Helixi495 – 50410Combined sources
Helixi508 – 5114Combined sources
Helixi512 – 5165Combined sources
Beta strandi518 – 5203Combined sources
Beta strandi522 – 5265Combined sources
Beta strandi543 – 5519Combined sources
Helixi555 – 56511Combined sources
Beta strandi568 – 5703Combined sources
Beta strandi572 – 5798Combined sources
Helixi584 – 5896Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BX8X-ray2.40A/B1-596[»]
4BX9X-ray2.60A/B1-596[»]
ProteinModelPortaliQ96AX1.
SMRiQ96AX1. Positions 2-596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGiKOG1302. Eukaryota.
COG5158. LUCA.
GeneTreeiENSGT00530000063488.
HOGENOMiHOG000166771.
HOVERGENiHBG054244.
InParanoidiQ96AX1.
KOiK20182.
OMAiRHVANMM.
OrthoDBiEOG722J85.
PhylomeDBiQ96AX1.
TreeFamiTF315126.

Family and domain databases

Gene3Di3.40.50.1910. 2 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
SUPFAMiSSF56815. SSF56815. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96AX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHLSYGRV NLNVLREAVR RELREFLDKC AGSKAIVWDE YLTGPFGLIA
60 70 80 90 100
QYSLLKEHEV EKMFTLKGNR LPAADVKNII FFVRPRLELM DIIAENVLSE
110 120 130 140 150
DRRGPTRDFH ILFVPRRSLL CEQRLKDLGV LGSFIHREEY SLDLIPFDGD
160 170 180 190 200
LLSMESEGAF KECYLEGDQT SLYHAAKGLM TLQALYGTIP QIFGKGECAR
210 220 230 240 250
QVANMMIRMK REFTGSQNSI FPVFDNLLLL DRNVDLLTPL ATQLTYEGLI
260 270 280 290 300
DEIYGIQNSY VKLPPEKFAP KKQGDGGKDL PTEAKKLQLN SAEELYAEIR
310 320 330 340 350
DKNFNAVGSV LSKKAKIISA AFEERHNAKT VGEIKQFVSQ LPHMQAARGS
360 370 380 390 400
LANHTSIAEL IKDVTTSEDF FDKLTVEQEF MSGIDTDKVN NYIEDCIAQK
410 420 430 440 450
HSLIKVLRLV CLQSVCNSGL KQKVLDYYKR EILQTYGYEH ILTLHNLEKA
460 470 480 490 500
GLLKPQTGGR NNYPTIRKTL RLWMDDVNEQ NPTDISYVYS GYAPLSVRLA
510 520 530 540 550
QLLSRPGWRS IEEVLRILPG PHFEERQPLP TGLQKKRQPG ENRVTLIFFL
560 570 580 590
GGVTFAEIAA LRFLSQLEDG GTEYVIATTK LMNGTSWIEA LMEKPF
Length:596
Mass (Da):67,611
Last modified:December 1, 2001 - v1
Checksum:i12442A1D9A223F56
GO

Sequence cautioni

The sequence BAB15570.1 differs from that shown. Reason: Frameshift at position 140. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti256 – 2561I → L.
Corresponds to variant rs34996966 [ dbSNP | Ensembl ].
VAR_052471

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439857 mRNA. Translation: AAL33577.1.
AK026840 mRNA. Translation: BAB15570.1. Frameshift.
CH471054 Genomic DNA. Translation: EAW98319.1.
BC016617 mRNA. Translation: AAH16617.1.
CCDSiCCDS9231.1.
RefSeqiNP_075067.2. NM_022916.4.
UniGeneiHs.592009.

Genome annotation databases

EnsembliENST00000267199; ENSP00000267199; ENSG00000139719.
GeneIDi65082.
KEGGihsa:65082.
UCSCiuc001ucd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439857 mRNA. Translation: AAL33577.1.
AK026840 mRNA. Translation: BAB15570.1. Frameshift.
CH471054 Genomic DNA. Translation: EAW98319.1.
BC016617 mRNA. Translation: AAH16617.1.
CCDSiCCDS9231.1.
RefSeqiNP_075067.2. NM_022916.4.
UniGeneiHs.592009.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BX8X-ray2.40A/B1-596[»]
4BX9X-ray2.60A/B1-596[»]
ProteinModelPortaliQ96AX1.
SMRiQ96AX1. Positions 2-596.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122390. 26 interactions.
IntActiQ96AX1. 12 interactions.
MINTiMINT-2813690.
STRINGi9606.ENSP00000267199.

PTM databases

iPTMnetiQ96AX1.
PhosphoSiteiQ96AX1.

Polymorphism and mutation databases

BioMutaiVPS33A.
DMDMi23396917.

Proteomic databases

EPDiQ96AX1.
MaxQBiQ96AX1.
PaxDbiQ96AX1.
PeptideAtlasiQ96AX1.
PRIDEiQ96AX1.
TopDownProteomicsiQ96AX1.

Protocols and materials databases

DNASUi65082.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267199; ENSP00000267199; ENSG00000139719.
GeneIDi65082.
KEGGihsa:65082.
UCSCiuc001ucd.4. human.

Organism-specific databases

CTDi65082.
GeneCardsiVPS33A.
H-InvDBHIX0079486.
HGNCiHGNC:18179. VPS33A.
HPAiHPA038701.
HPA038702.
HPA053209.
MIMi610034. gene.
neXtProtiNX_Q96AX1.
PharmGKBiPA38306.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1302. Eukaryota.
COG5158. LUCA.
GeneTreeiENSGT00530000063488.
HOGENOMiHOG000166771.
HOVERGENiHBG054244.
InParanoidiQ96AX1.
KOiK20182.
OMAiRHVANMM.
OrthoDBiEOG722J85.
PhylomeDBiQ96AX1.
TreeFamiTF315126.

Miscellaneous databases

GeneWikiiVPS33A.
GenomeRNAii65082.
PROiQ96AX1.
SOURCEiSearch...

Gene expression databases

BgeeiQ96AX1.
CleanExiHS_VPS33A.
ExpressionAtlasiQ96AX1. baseline and differential.
GenevisibleiQ96AX1. HS.

Family and domain databases

Gene3Di3.40.50.1910. 2 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
SUPFAMiSSF56815. SSF56815. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse organellar biogenesis mutant buff results from a mutation in Vps33a, a homologue of yeast vps33 and Drosophila carnation."
    Suzuki T., Oiso N., Gautam R., Novak E.K., Panthier J.J., Suprabha P.G., Vida T., Swank R.T., Spritz R.A.
    Proc. Natl. Acad. Sci. U.S.A. 100:1146-1150(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  5. "Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking."
    Liang C., Lee J.S., Inn K.S., Gack M.U., Li Q., Roberts E.A., Vergne I., Deretic V., Feng P., Akazawa C., Jung J.U.
    Nat. Cell Biol. 10:776-787(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UVRAG.
  6. "SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery."
    Zhu G.D., Salazar G., Zlatic S.A., Fiza B., Doucette M.M., Heilman C.J., Levey A.I., Faundez V., L'hernault S.W.
    Mol. Biol. Cell 20:1223-1240(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VIPAS39.
  7. "Identification of the switch in early-to-late endosome transition."
    Poteryaev D., Datta S., Ackema K., Zerial M., Spang A.
    Cell 141:497-508(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MON1A AND MON1B.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells."
    Zlatic S.A., Tornieri K., L'Hernault S.W., Faundez V.
    Mol. Biol. Cell 22:1699-1715(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AP-3 COMPLEX AND CLATHRIN.
  10. "Tethering complexes in the endocytic pathway: CORVET and HOPS."
    Solinger J.A., Spang A.
    FEBS J. 280:2743-2757(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON THE HOPS AND CORVET COMPLEXES.
  11. "The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17."
    Jiang P., Nishimura T., Sakamaki Y., Itakura E., Hatta T., Natsume T., Mizushima N.
    Mol. Biol. Cell 25:1327-1337(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, FUNCTION OF THE HOPS COMPLEX, INTERACTION WITH STX17, SUBCELLULAR LOCATION.
  12. "Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations."
    Perini E.D., Schaefer R., Stoeter M., Kalaidzidis Y., Zerial M.
    Traffic 15:1366-1389(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE CORVET COMPLEX, SUBUNIT.
  13. "Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes."
    Wartosch L., Guenesdogan U., Graham S.C., Luzio J.P.
    Traffic 16:727-742(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, FUNCTION OF THE HOPS COMPLEX, INTERACTION WITH VPS18 AND VPS16, MUTAGENESIS OF LYS-429; TYR-438 AND ILE-441.
  14. Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS), X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH VPS16, INTERACTION WITH VPS16, MUTAGENESIS OF LYS-429; TYR-438 AND ILE-441.

Entry informationi

Entry nameiVP33A_HUMAN
AccessioniPrimary (citable) accession number: Q96AX1
Secondary accession number(s): Q547V4, Q9H5Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.