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Q96AX1

- VP33A_HUMAN

UniProt

Q96AX1 - VP33A_HUMAN

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Protein

Vacuolar protein sorting-associated protein 33A

Gene
VPS33A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes By similarity.

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. lysosome localization Source: UniProtKB
  2. melanosome localization Source: UniProtKB
  3. platelet formation Source: UniProtKB
  4. protein transport Source: UniProtKB-KW
  5. regulation of developmental pigmentation Source: UniProtKB
  6. vesicle docking involved in exocytosis Source: InterPro
  7. vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 33A
Short name:
hVPS33A
Gene namesi
Name:VPS33A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:18179. VPS33A.

Subcellular locationi

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes By similarity.

GO - Cellular componenti

  1. early endosome Source: UniProtKB
  2. late endosome Source: UniProtKB
  3. late endosome membrane Source: UniProtKB-SubCell
  4. lysosomal membrane Source: UniProtKB
  5. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38306.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Vacuolar protein sorting-associated protein 33APRO_0000206302Add
BLAST

Proteomic databases

MaxQBiQ96AX1.
PaxDbiQ96AX1.
PRIDEiQ96AX1.

PTM databases

PhosphoSiteiQ96AX1.

Expressioni

Gene expression databases

ArrayExpressiQ96AX1.
BgeeiQ96AX1.
CleanExiHS_VPS33A.
GenevestigatoriQ96AX1.

Organism-specific databases

HPAiHPA038701.

Interactioni

Subunit structurei

Large heterooligomeric complex together with VPS11, VPS16 and VPS18. Interacts with STX7 By similarity. Interacts with VIPAS39.1 Publication

Protein-protein interaction databases

BioGridi122390. 14 interactions.
IntActiQ96AX1. 7 interactions.
MINTiMINT-2813690.
STRINGi9606.ENSP00000267199.

Structurei

Secondary structure

1
596
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53
Beta strandi7 – 104
Helixi13 – 2917
Beta strandi34 – 385
Helixi40 – 423
Helixi43 – 464
Turni47 – 493
Helixi52 – 576
Beta strandi60 – 656
Beta strandi68 – 703
Beta strandi77 – 837
Helixi87 – 9812
Beta strandi102 – 1043
Beta strandi108 – 1158
Helixi119 – 12810
Helixi130 – 1334
Beta strandi134 – 1396
Beta strandi144 – 1485
Beta strandi151 – 1533
Helixi159 – 1657
Helixi170 – 18617
Beta strandi190 – 1967
Helixi197 – 21115
Beta strandi225 – 2317
Helixi232 – 2343
Helixi238 – 2403
Helixi246 – 2538
Beta strandi260 – 2634
Beta strandi285 – 2884
Helixi294 – 2996
Helixi304 – 3063
Helixi307 – 32620
Helixi337 – 36529
Helixi368 – 38114
Helixi391 – 3988
Helixi403 – 41715
Helixi422 – 43615
Helixi440 – 44910
Helixi463 – 4697
Beta strandi479 – 4813
Helixi485 – 4895
Helixi495 – 50410
Helixi508 – 5114
Helixi512 – 5165
Beta strandi518 – 5203
Beta strandi522 – 5265
Beta strandi543 – 5519
Helixi555 – 56511
Beta strandi568 – 5703
Beta strandi572 – 5798
Helixi584 – 5896

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BX8X-ray2.40A/B1-596[»]
4BX9X-ray2.60A/B1-596[»]
ProteinModelPortaliQ96AX1.
SMRiQ96AX1. Positions 2-596.

Family & Domainsi

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.

Phylogenomic databases

eggNOGiCOG5158.
HOGENOMiHOG000166771.
HOVERGENiHBG054244.
InParanoidiQ96AX1.
OMAiLRFLSQM.
OrthoDBiEOG722J85.
PhylomeDBiQ96AX1.
TreeFamiTF315126.

Family and domain databases

Gene3Di3.40.50.1910. 2 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
SUPFAMiSSF56815. SSF56815. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96AX1-1 [UniParc]FASTAAdd to Basket

« Hide

MAAHLSYGRV NLNVLREAVR RELREFLDKC AGSKAIVWDE YLTGPFGLIA    50
QYSLLKEHEV EKMFTLKGNR LPAADVKNII FFVRPRLELM DIIAENVLSE 100
DRRGPTRDFH ILFVPRRSLL CEQRLKDLGV LGSFIHREEY SLDLIPFDGD 150
LLSMESEGAF KECYLEGDQT SLYHAAKGLM TLQALYGTIP QIFGKGECAR 200
QVANMMIRMK REFTGSQNSI FPVFDNLLLL DRNVDLLTPL ATQLTYEGLI 250
DEIYGIQNSY VKLPPEKFAP KKQGDGGKDL PTEAKKLQLN SAEELYAEIR 300
DKNFNAVGSV LSKKAKIISA AFEERHNAKT VGEIKQFVSQ LPHMQAARGS 350
LANHTSIAEL IKDVTTSEDF FDKLTVEQEF MSGIDTDKVN NYIEDCIAQK 400
HSLIKVLRLV CLQSVCNSGL KQKVLDYYKR EILQTYGYEH ILTLHNLEKA 450
GLLKPQTGGR NNYPTIRKTL RLWMDDVNEQ NPTDISYVYS GYAPLSVRLA 500
QLLSRPGWRS IEEVLRILPG PHFEERQPLP TGLQKKRQPG ENRVTLIFFL 550
GGVTFAEIAA LRFLSQLEDG GTEYVIATTK LMNGTSWIEA LMEKPF 596
Length:596
Mass (Da):67,611
Last modified:December 1, 2001 - v1
Checksum:i12442A1D9A223F56
GO

Sequence cautioni

The sequence BAB15570.1 differs from that shown. Reason: Frameshift at position 140.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti256 – 2561I → L.
Corresponds to variant rs34996966 [ dbSNP | Ensembl ].
VAR_052471

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF439857 mRNA. Translation: AAL33577.1.
AK026840 mRNA. Translation: BAB15570.1. Frameshift.
CH471054 Genomic DNA. Translation: EAW98319.1.
BC016617 mRNA. Translation: AAH16617.1.
CCDSiCCDS9231.1.
RefSeqiNP_075067.2. NM_022916.4.
UniGeneiHs.592009.

Genome annotation databases

EnsembliENST00000267199; ENSP00000267199; ENSG00000139719.
GeneIDi65082.
KEGGihsa:65082.
UCSCiuc001ucd.3. human.

Polymorphism databases

DMDMi23396917.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF439857 mRNA. Translation: AAL33577.1 .
AK026840 mRNA. Translation: BAB15570.1 . Frameshift.
CH471054 Genomic DNA. Translation: EAW98319.1 .
BC016617 mRNA. Translation: AAH16617.1 .
CCDSi CCDS9231.1.
RefSeqi NP_075067.2. NM_022916.4.
UniGenei Hs.592009.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BX8 X-ray 2.40 A/B 1-596 [» ]
4BX9 X-ray 2.60 A/B 1-596 [» ]
ProteinModelPortali Q96AX1.
SMRi Q96AX1. Positions 2-596.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122390. 14 interactions.
IntActi Q96AX1. 7 interactions.
MINTi MINT-2813690.
STRINGi 9606.ENSP00000267199.

PTM databases

PhosphoSitei Q96AX1.

Polymorphism databases

DMDMi 23396917.

Proteomic databases

MaxQBi Q96AX1.
PaxDbi Q96AX1.
PRIDEi Q96AX1.

Protocols and materials databases

DNASUi 65082.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000267199 ; ENSP00000267199 ; ENSG00000139719 .
GeneIDi 65082.
KEGGi hsa:65082.
UCSCi uc001ucd.3. human.

Organism-specific databases

CTDi 65082.
GeneCardsi GC12M122716.
H-InvDB HIX0079486.
HGNCi HGNC:18179. VPS33A.
HPAi HPA038701.
MIMi 610034. gene.
neXtProti NX_Q96AX1.
PharmGKBi PA38306.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5158.
HOGENOMi HOG000166771.
HOVERGENi HBG054244.
InParanoidi Q96AX1.
OMAi LRFLSQM.
OrthoDBi EOG722J85.
PhylomeDBi Q96AX1.
TreeFami TF315126.

Miscellaneous databases

ChiTaRSi VPS33A. human.
GeneWikii VPS33A.
GenomeRNAii 65082.
NextBioi 67276.
PROi Q96AX1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96AX1.
Bgeei Q96AX1.
CleanExi HS_VPS33A.
Genevestigatori Q96AX1.

Family and domain databases

Gene3Di 3.40.50.1910. 2 hits.
InterProi IPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view ]
PANTHERi PTHR11679. PTHR11679. 1 hit.
Pfami PF00995. Sec1. 1 hit.
[Graphical view ]
SUPFAMi SSF56815. SSF56815. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse organellar biogenesis mutant buff results from a mutation in Vps33a, a homologue of yeast vps33 and Drosophila carnation."
    Suzuki T., Oiso N., Gautam R., Novak E.K., Panthier J.J., Suprabha P.G., Vida T., Swank R.T., Spritz R.A.
    Proc. Natl. Acad. Sci. U.S.A. 100:1146-1150(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  5. "SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery."
    Zhu G.D., Salazar G., Zlatic S.A., Fiza B., Doucette M.M., Heilman C.J., Levey A.I., Faundez V., L'hernault S.W.
    Mol. Biol. Cell 20:1223-1240(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VIPAS39.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVP33A_HUMAN
AccessioniPrimary (citable) accession number: Q96AX1
Secondary accession number(s): Q547V4, Q9H5Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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