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Protein

Protein FAM131C

Gene

FAM131C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM131C
Gene namesi
Name:FAM131C
Synonyms:C1orf117
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26717. FAM131C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386082.

Polymorphism and mutation databases

BioMutaiFAM131C.
DMDMi134035394.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Protein FAM131CPRO_0000280401Add
BLAST

Proteomic databases

PaxDbiQ96AQ9.
PRIDEiQ96AQ9.

PTM databases

iPTMnetiQ96AQ9.

Expressioni

Gene expression databases

BgeeiQ96AQ9.
CleanExiHS_FAM131C.
GenevisibleiQ96AQ9. HS.

Organism-specific databases

HPAiHPA031046.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HPCAL4Q9UM193EBI-741921,EBI-744820
LMO3Q8TAP43EBI-741921,EBI-742259
VSNL1P627604EBI-741921,EBI-740943

Protein-protein interaction databases

BioGridi131523. 11 interactions.
IntActiQ96AQ9. 7 interactions.
STRINGi9606.ENSP00000364814.

Structurei

3D structure databases

ProteinModelPortaliQ96AQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi214 – 26451Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM131 family.Curated

Phylogenomic databases

eggNOGiENOG410IKD9. Eukaryota.
ENOG41120RD. LUCA.
GeneTreeiENSGT00390000015421.
HOGENOMiHOG000231296.
HOVERGENiHBG080216.
InParanoidiQ96AQ9.
OMAiHPENSPQ.
OrthoDBiEOG76473D.
PhylomeDBiQ96AQ9.
TreeFamiTF331537.

Family and domain databases

InterProiIPR026782. FAM131.
[Graphical view]
PANTHERiPTHR15736. PTHR15736. 1 hit.
PfamiPF15010. FAM131. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96AQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSCVSRDLF TSAHKNCPMP QGADPLNPDL PSGRTPTVAP DCVIGKDKQM
60 70 80 90 100
DFCWDPWQRC FQTTNGYLSD SRSRPGNYNV AALATSSLVG VVQSIKDHIT
110 120 130 140 150
KPTAMARGRV AHLIEWKGWS AQPAGWELSP AEDEHYCCLP DELREARFAA
160 170 180 190 200
GVAEQFAITE ATLSAWSSLD EEELHPENSP QGIVQLQDLE SIYLQDSLPS
210 220 230 240 250
GPSQDDSLQA FSSPSPSPDS CPSPEEPPST AGIPQPPSPE LQHRRRLPGA
260 270 280
QGPEGGTHPP GSLPSMDSGS LWEEDEVFYN
Length:280
Mass (Da):30,351
Last modified:March 20, 2007 - v2
Checksum:i674631222FA8095C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191M → I in BAC04282 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481K → E.2 Publications
Corresponds to variant rs2863458 [ dbSNP | Ensembl ].
VAR_031130
Natural varianti107 – 1071R → Q.1 Publication
Corresponds to variant rs71510977 [ dbSNP | Ensembl ].
VAR_031131
Natural varianti123 – 1231P → R.2 Publications
Corresponds to variant rs11576236 [ dbSNP | Ensembl ].
VAR_031132
Natural varianti215 – 2151S → I.
Corresponds to variant rs1832151 [ dbSNP | Ensembl ].
VAR_031133
Natural varianti226 – 2261E → D.1 Publication
Corresponds to variant rs17853749 [ dbSNP | Ensembl ].
VAR_031134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094085 mRNA. Translation: BAC04282.1.
AL355994 Genomic DNA. Translation: CAI16143.1.
BC016848 mRNA. Translation: AAH16848.1.
BC037394 mRNA. Translation: AAH37394.1.
CCDSiCCDS41270.1.
RefSeqiNP_872429.2. NM_182623.2.
UniGeneiHs.126825.

Genome annotation databases

EnsembliENST00000375662; ENSP00000364814; ENSG00000185519.
GeneIDi348487.
KEGGihsa:348487.
UCSCiuc001axz.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094085 mRNA. Translation: BAC04282.1.
AL355994 Genomic DNA. Translation: CAI16143.1.
BC016848 mRNA. Translation: AAH16848.1.
BC037394 mRNA. Translation: AAH37394.1.
CCDSiCCDS41270.1.
RefSeqiNP_872429.2. NM_182623.2.
UniGeneiHs.126825.

3D structure databases

ProteinModelPortaliQ96AQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131523. 11 interactions.
IntActiQ96AQ9. 7 interactions.
STRINGi9606.ENSP00000364814.

PTM databases

iPTMnetiQ96AQ9.

Polymorphism and mutation databases

BioMutaiFAM131C.
DMDMi134035394.

Proteomic databases

PaxDbiQ96AQ9.
PRIDEiQ96AQ9.

Protocols and materials databases

DNASUi348487.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375662; ENSP00000364814; ENSG00000185519.
GeneIDi348487.
KEGGihsa:348487.
UCSCiuc001axz.5. human.

Organism-specific databases

CTDi348487.
GeneCardsiFAM131C.
HGNCiHGNC:26717. FAM131C.
HPAiHPA031046.
neXtProtiNX_Q96AQ9.
PharmGKBiPA162386082.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKD9. Eukaryota.
ENOG41120RD. LUCA.
GeneTreeiENSGT00390000015421.
HOGENOMiHOG000231296.
HOVERGENiHBG080216.
InParanoidiQ96AQ9.
OMAiHPENSPQ.
OrthoDBiEOG76473D.
PhylomeDBiQ96AQ9.
TreeFamiTF331537.

Miscellaneous databases

GenomeRNAii348487.
PROiQ96AQ9.

Gene expression databases

BgeeiQ96AQ9.
CleanExiHS_FAM131C.
GenevisibleiQ96AQ9. HS.

Family and domain databases

InterProiIPR026782. FAM131.
[Graphical view]
PANTHERiPTHR15736. PTHR15736. 1 hit.
PfamiPF15010. FAM131. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-48 AND ARG-123.
    Tissue: Neuroblastoma.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-48; GLN-107; ARG-123 AND ASP-226.
    Tissue: Brain and Uterus.

Entry informationi

Entry nameiF131C_HUMAN
AccessioniPrimary (citable) accession number: Q96AQ9
Secondary accession number(s): Q5T5Q5, Q8N3X3, Q8N9P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: June 8, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.