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Q96AQ2

- TM125_HUMAN

UniProt

Q96AQ2 - TM125_HUMAN

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Protein

Transmembrane protein 125

Gene

TMEM125

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 125
Gene namesi
Name:TMEM125
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:28275. TMEM125.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485644.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Transmembrane protein 125PRO_0000251716Add
BLAST

Proteomic databases

PRIDEiQ96AQ2.

Expressioni

Gene expression databases

BgeeiQ96AQ2.
CleanExiHS_TMEM125.
GenevestigatoriQ96AQ2.

Organism-specific databases

HPAiHPA015796.

Structurei

3D structure databases

ProteinModelPortaliQ96AQ2.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621HelicalSequence AnalysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000003015.
HOGENOMiHOG000154606.
HOVERGENiHBG080613.
InParanoidiQ96AQ2.
OMAiMNCIRSR.
PhylomeDBiQ96AQ2.
TreeFamiTF332758.

Family and domain databases

InterProiIPR028165. TMEM125.
[Graphical view]
PfamiPF15109. TMEM125. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96AQ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEQEAQAPG GRGLPPDMLA EQVELWWSQQ PRRSALCFVV AVGLVAGCGA
60 70 80 90 100
GGVALLSTTS SRSGEWRLAT GTVLCLLALL VLVKQLMSSA VQDMNCIRQA
110 120 130 140 150
HHVALLRSGG GADALVVLLS GLVLLVTGLT LAGLAAAPAP ARPLAAMLSV
160 170 180 190 200
GIALAALGSL LLLGLLLYQV GVSGHCPSIC MATPSTHSGH GGHGSIFSIS
210
GQLSAGRRHE TTSSIASLI
Length:219
Mass (Da):22,172
Last modified:December 1, 2001 - v1
Checksum:i868D23D63AD804A0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 1071R → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_035669
Natural varianti112 – 1121A → D.
Corresponds to variant rs35880191 [ dbSNP | Ensembl ].
VAR_051428

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471059 Genomic DNA. Translation: EAX07110.1.
CH471059 Genomic DNA. Translation: EAX07111.1.
BC016858 mRNA. Translation: AAH16858.1.
CCDSiCCDS480.1.
RefSeqiNP_653227.1. NM_144626.2.
XP_005270523.1. XM_005270466.1.
XP_005270524.1. XM_005270467.2.
UniGeneiHs.104476.

Genome annotation databases

EnsembliENST00000432792; ENSP00000429275; ENSG00000179178.
ENST00000439858; ENSP00000429775; ENSG00000179178.
GeneIDi128218.
KEGGihsa:128218.
UCSCiuc001cir.3. human.

Polymorphism databases

DMDMi74731141.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471059 Genomic DNA. Translation: EAX07110.1 .
CH471059 Genomic DNA. Translation: EAX07111.1 .
BC016858 mRNA. Translation: AAH16858.1 .
CCDSi CCDS480.1.
RefSeqi NP_653227.1. NM_144626.2.
XP_005270523.1. XM_005270466.1.
XP_005270524.1. XM_005270467.2.
UniGenei Hs.104476.

3D structure databases

ProteinModelPortali Q96AQ2.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 74731141.

Proteomic databases

PRIDEi Q96AQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000432792 ; ENSP00000429275 ; ENSG00000179178 .
ENST00000439858 ; ENSP00000429775 ; ENSG00000179178 .
GeneIDi 128218.
KEGGi hsa:128218.
UCSCi uc001cir.3. human.

Organism-specific databases

CTDi 128218.
GeneCardsi GC01P043735.
HGNCi HGNC:28275. TMEM125.
HPAi HPA015796.
neXtProti NX_Q96AQ2.
PharmGKBi PA143485644.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00390000003015.
HOGENOMi HOG000154606.
HOVERGENi HBG080613.
InParanoidi Q96AQ2.
OMAi MNCIRSR.
PhylomeDBi Q96AQ2.
TreeFami TF332758.

Miscellaneous databases

GenomeRNAii 128218.
NextBioi 82246.
PROi Q96AQ2.

Gene expression databases

Bgeei Q96AQ2.
CleanExi HS_TMEM125.
Genevestigatori Q96AQ2.

Family and domain databases

InterProi IPR028165. TMEM125.
[Graphical view ]
Pfami PF15109. TMEM125. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  3. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-107.

Entry informationi

Entry nameiTM125_HUMAN
AccessioniPrimary (citable) accession number: Q96AQ2
Secondary accession number(s): D3DPX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3