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Protein

Transmembrane protein 125

Gene

TMEM125

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 125
Gene namesi
Name:TMEM125
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28275. TMEM125.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179178.
PharmGKBiPA143485644.

Polymorphism and mutation databases

BioMutaiTMEM125.
DMDMi74731141.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002517161 – 219Transmembrane protein 125Add BLAST219

Proteomic databases

EPDiQ96AQ2.
PaxDbiQ96AQ2.
PeptideAtlasiQ96AQ2.
PRIDEiQ96AQ2.

PTM databases

iPTMnetiQ96AQ2.
PhosphoSitePlusiQ96AQ2.

Expressioni

Gene expression databases

BgeeiENSG00000179178.
CleanExiHS_TMEM125.
ExpressionAtlasiQ96AQ2. baseline and differential.
GenevisibleiQ96AQ2. HS.

Organism-specific databases

HPAiHPA015796.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000429275.

Structurei

3D structure databases

ProteinModelPortaliQ96AQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZE5. Eukaryota.
ENOG4111SNN. LUCA.
GeneTreeiENSGT00390000003015.
HOGENOMiHOG000154606.
HOVERGENiHBG080613.
InParanoidiQ96AQ2.
OMAiNDMYISG.
OrthoDBiEOG091G0SBI.
PhylomeDBiQ96AQ2.
TreeFamiTF332758.

Family and domain databases

InterProiView protein in InterPro
IPR028165. TMEM125.
PfamiView protein in Pfam
PF15109. TMEM125. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96AQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQEAQAPG GRGLPPDMLA EQVELWWSQQ PRRSALCFVV AVGLVAGCGA
60 70 80 90 100
GGVALLSTTS SRSGEWRLAT GTVLCLLALL VLVKQLMSSA VQDMNCIRQA
110 120 130 140 150
HHVALLRSGG GADALVVLLS GLVLLVTGLT LAGLAAAPAP ARPLAAMLSV
160 170 180 190 200
GIALAALGSL LLLGLLLYQV GVSGHCPSIC MATPSTHSGH GGHGSIFSIS
210
GQLSAGRRHE TTSSIASLI
Length:219
Mass (Da):22,172
Last modified:December 1, 2001 - v1
Checksum:i868D23D63AD804A0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035669107R → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_051428112A → D. Corresponds to variant dbSNP:rs35880191Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471059 Genomic DNA. Translation: EAX07110.1.
CH471059 Genomic DNA. Translation: EAX07111.1.
BC016858 mRNA. Translation: AAH16858.1.
CCDSiCCDS480.1.
RefSeqiNP_001307173.1. NM_001320244.1.
NP_653227.1. NM_144626.2.
XP_005270524.1. XM_005270467.3.
XP_011539007.1. XM_011540705.2.
UniGeneiHs.104476.

Genome annotation databases

EnsembliENST00000432792; ENSP00000429275; ENSG00000179178.
ENST00000439858; ENSP00000429775; ENSG00000179178.
GeneIDi128218.
KEGGihsa:128218.
UCSCiuc001cir.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTM125_HUMAN
AccessioniPrimary (citable) accession number: Q96AQ2
Secondary accession number(s): D3DPX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations