Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96AQ2

- TM125_HUMAN

UniProt

Q96AQ2 - TM125_HUMAN

Protein

Transmembrane protein 125

Gene

TMEM125

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 125
    Gene namesi
    Name:TMEM125
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28275. TMEM125.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485644.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219Transmembrane protein 125PRO_0000251716Add
    BLAST

    Proteomic databases

    PRIDEiQ96AQ2.

    Expressioni

    Gene expression databases

    BgeeiQ96AQ2.
    CleanExiHS_TMEM125.
    GenevestigatoriQ96AQ2.

    Organism-specific databases

    HPAiHPA015796.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96AQ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000154606.
    HOVERGENiHBG080613.
    InParanoidiQ96AQ2.
    OMAiMNCIRSR.
    PhylomeDBiQ96AQ2.
    TreeFamiTF332758.

    Family and domain databases

    InterProiIPR028165. TMEM125.
    [Graphical view]
    PfamiPF15109. TMEM125. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96AQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEQEAQAPG GRGLPPDMLA EQVELWWSQQ PRRSALCFVV AVGLVAGCGA    50
    GGVALLSTTS SRSGEWRLAT GTVLCLLALL VLVKQLMSSA VQDMNCIRQA 100
    HHVALLRSGG GADALVVLLS GLVLLVTGLT LAGLAAAPAP ARPLAAMLSV 150
    GIALAALGSL LLLGLLLYQV GVSGHCPSIC MATPSTHSGH GGHGSIFSIS 200
    GQLSAGRRHE TTSSIASLI 219
    Length:219
    Mass (Da):22,172
    Last modified:December 1, 2001 - v1
    Checksum:i868D23D63AD804A0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti107 – 1071R → L in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035669
    Natural varianti112 – 1121A → D.
    Corresponds to variant rs35880191 [ dbSNP | Ensembl ].
    VAR_051428

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471059 Genomic DNA. Translation: EAX07110.1.
    CH471059 Genomic DNA. Translation: EAX07111.1.
    BC016858 mRNA. Translation: AAH16858.1.
    CCDSiCCDS480.1.
    RefSeqiNP_653227.1. NM_144626.2.
    XP_005270523.1. XM_005270466.1.
    XP_005270524.1. XM_005270467.2.
    UniGeneiHs.104476.

    Genome annotation databases

    EnsembliENST00000432792; ENSP00000429275; ENSG00000179178.
    ENST00000439858; ENSP00000429775; ENSG00000179178.
    GeneIDi128218.
    KEGGihsa:128218.
    UCSCiuc001cir.3. human.

    Polymorphism databases

    DMDMi74731141.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471059 Genomic DNA. Translation: EAX07110.1 .
    CH471059 Genomic DNA. Translation: EAX07111.1 .
    BC016858 mRNA. Translation: AAH16858.1 .
    CCDSi CCDS480.1.
    RefSeqi NP_653227.1. NM_144626.2.
    XP_005270523.1. XM_005270466.1.
    XP_005270524.1. XM_005270467.2.
    UniGenei Hs.104476.

    3D structure databases

    ProteinModelPortali Q96AQ2.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 74731141.

    Proteomic databases

    PRIDEi Q96AQ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000432792 ; ENSP00000429275 ; ENSG00000179178 .
    ENST00000439858 ; ENSP00000429775 ; ENSG00000179178 .
    GeneIDi 128218.
    KEGGi hsa:128218.
    UCSCi uc001cir.3. human.

    Organism-specific databases

    CTDi 128218.
    GeneCardsi GC01P043735.
    HGNCi HGNC:28275. TMEM125.
    HPAi HPA015796.
    neXtProti NX_Q96AQ2.
    PharmGKBi PA143485644.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000154606.
    HOVERGENi HBG080613.
    InParanoidi Q96AQ2.
    OMAi MNCIRSR.
    PhylomeDBi Q96AQ2.
    TreeFami TF332758.

    Miscellaneous databases

    GenomeRNAii 128218.
    NextBioi 82246.
    PROi Q96AQ2.

    Gene expression databases

    Bgeei Q96AQ2.
    CleanExi HS_TMEM125.
    Genevestigatori Q96AQ2.

    Family and domain databases

    InterProi IPR028165. TMEM125.
    [Graphical view ]
    Pfami PF15109. TMEM125. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    3. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-107.

    Entry informationi

    Entry nameiTM125_HUMAN
    AccessioniPrimary (citable) accession number: Q96AQ2
    Secondary accession number(s): D3DPX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3