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Protein

Coiled-coil domain-containing protein 74A

Gene

CCDC74A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 74A
Gene namesi
Name:CCDC74A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25197. CCDC74A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485425.

Polymorphism and mutation databases

BioMutaiCCDC74A.
DMDMi74731140.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Coiled-coil domain-containing protein 74APRO_0000274374Add
BLAST

Proteomic databases

PaxDbiQ96AQ1.
PeptideAtlasiQ96AQ1.
PRIDEiQ96AQ1.

PTM databases

iPTMnetiQ96AQ1.
PhosphoSiteiQ96AQ1.

Expressioni

Gene expression databases

BgeeiQ96AQ1.
CleanExiHS_CCDC74A.
ExpressionAtlasiQ96AQ1. baseline and differential.
GenevisibleiQ96AQ1. HS.

Interactioni

Protein-protein interaction databases

BioGridi124734. 2 interactions.
IntActiQ96AQ1. 2 interactions.
MINTiMINT-8417645.
STRINGi9606.ENSP00000295171.

Structurei

3D structure databases

ProteinModelPortaliQ96AQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili47 – 9044Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 266Poly-Arg

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J255. Eukaryota.
ENOG4112DFU. LUCA.
GeneTreeiENSGT00390000007249.
HOGENOMiHOG000111398.
HOVERGENiHBG081034.
InParanoidiQ96AQ1.
OMAiSKTDRTH.
OrthoDBiEOG744TD0.
PhylomeDBiQ96AQ1.
TreeFamiTF329669.

Family and domain databases

InterProiIPR033226. CCDC74.
IPR029422. CCDC74_C.
[Graphical view]
PANTHERiPTHR14882:SF5. PTHR14882:SF5. 1 hit.
PfamiPF14917. CCDC74_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96AQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGAGVAAGT RPPSSPTPGS RRRRQRPSVG VQSLRPQSPQ LRQSDPQKRN
60 70 80 90 100
LDLEKSLQFL QQQHSEMLAK LHEEIEHLKR ENKDLHYKLI MNQTSQKKDG
110 120 130 140 150
PSGNHLSRAS APLGARWVCI NGVWVEPGGP SPARLKEGSS RTHRPGGKRG
160 170 180 190 200
RLAGGSADTV RSPADSLSMS SFQSVKSISN SGKARPQPGS FNKQDSKADV
210 220 230 240 250
SQKADLEEEP LLHNSKLDKV PGVQGQARKE KAEASNAGAA CMGNSQHQGR
260 270 280 290 300
QMGAGAHPPM ILPLPLRKPT TLRQCEVLIR ELWNTNLLQT QELRHLKSLL
310 320 330 340 350
EGSQRPQAAP EEASFPRDQE ATHFPKVSTK SLSKKCLSPP VAERAILPAL
360 370
KQTPKNNFAE RQKRLQAMQK RRLHRSVL
Length:378
Mass (Da):41,605
Last modified:December 1, 2001 - v1
Checksum:i61D9EAAA5EDC34F9
GO
Isoform 2 (identifier: Q96AQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-165: Missing.

Show »
Length:312
Mass (Da):34,910
Checksum:i58D38A8072D6D5F4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti302 – 3021G → R.
Corresponds to variant rs13660 [ dbSNP | Ensembl ].
VAR_030268

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei100 – 16566Missing in isoform 2. 1 PublicationVSP_022729Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093838 Genomic DNA. Translation: AAY14809.1.
BC016861 mRNA. Translation: AAH16861.1.
BC063387 mRNA. Translation: AAH63387.1.
CCDSiCCDS2167.1. [Q96AQ1-1]
CCDS58732.1. [Q96AQ1-2]
RefSeqiNP_001245233.1. NM_001258304.1.
NP_001245234.1. NM_001258305.1.
NP_001245235.1. NM_001258306.1. [Q96AQ1-2]
NP_620125.1. NM_138770.2. [Q96AQ1-1]
UniGeneiHs.351461.

Genome annotation databases

EnsembliENST00000295171; ENSP00000295171; ENSG00000163040. [Q96AQ1-1]
ENST00000409856; ENSP00000387009; ENSG00000163040. [Q96AQ1-2]
GeneIDi90557.
KEGGihsa:90557.
UCSCiuc002tta.5. human. [Q96AQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093838 Genomic DNA. Translation: AAY14809.1.
BC016861 mRNA. Translation: AAH16861.1.
BC063387 mRNA. Translation: AAH63387.1.
CCDSiCCDS2167.1. [Q96AQ1-1]
CCDS58732.1. [Q96AQ1-2]
RefSeqiNP_001245233.1. NM_001258304.1.
NP_001245234.1. NM_001258305.1.
NP_001245235.1. NM_001258306.1. [Q96AQ1-2]
NP_620125.1. NM_138770.2. [Q96AQ1-1]
UniGeneiHs.351461.

3D structure databases

ProteinModelPortaliQ96AQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124734. 2 interactions.
IntActiQ96AQ1. 2 interactions.
MINTiMINT-8417645.
STRINGi9606.ENSP00000295171.

PTM databases

iPTMnetiQ96AQ1.
PhosphoSiteiQ96AQ1.

Polymorphism and mutation databases

BioMutaiCCDC74A.
DMDMi74731140.

Proteomic databases

PaxDbiQ96AQ1.
PeptideAtlasiQ96AQ1.
PRIDEiQ96AQ1.

Protocols and materials databases

DNASUi90557.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295171; ENSP00000295171; ENSG00000163040. [Q96AQ1-1]
ENST00000409856; ENSP00000387009; ENSG00000163040. [Q96AQ1-2]
GeneIDi90557.
KEGGihsa:90557.
UCSCiuc002tta.5. human. [Q96AQ1-1]

Organism-specific databases

CTDi90557.
GeneCardsiCCDC74A.
HGNCiHGNC:25197. CCDC74A.
neXtProtiNX_Q96AQ1.
PharmGKBiPA143485425.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J255. Eukaryota.
ENOG4112DFU. LUCA.
GeneTreeiENSGT00390000007249.
HOGENOMiHOG000111398.
HOVERGENiHBG081034.
InParanoidiQ96AQ1.
OMAiSKTDRTH.
OrthoDBiEOG744TD0.
PhylomeDBiQ96AQ1.
TreeFamiTF329669.

Miscellaneous databases

GenomeRNAii90557.
PROiQ96AQ1.

Gene expression databases

BgeeiQ96AQ1.
CleanExiHS_CCDC74A.
ExpressionAtlasiQ96AQ1. baseline and differential.
GenevisibleiQ96AQ1. HS.

Family and domain databases

InterProiIPR033226. CCDC74.
IPR029422. CCDC74_C.
[Graphical view]
PANTHERiPTHR14882:SF5. PTHR14882:SF5. 1 hit.
PfamiPF14917. CCDC74_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye and Uterus.

Entry informationi

Entry nameiCC74A_HUMAN
AccessioniPrimary (citable) accession number: Q96AQ1
Secondary accession number(s): Q6P4I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.