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Protein

Zinc finger with UFM1-specific peptidase domain protein

Gene

ZUFSP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri2 – 2423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri154 – 17724C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri193 – 21523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger with UFM1-specific peptidase domain protein
Gene namesi
Name:ZUFSP
Synonyms:C6orf113
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21224. ZUFSP.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162411072.

Polymorphism and mutation databases

BioMutaiZUFSP.
DMDMi74762646.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578Zinc finger with UFM1-specific peptidase domain proteinPRO_0000244336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei262 – 2621N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96AP4.
PaxDbiQ96AP4.
PRIDEiQ96AP4.

PTM databases

iPTMnetiQ96AP4.
PhosphoSiteiQ96AP4.

Expressioni

Gene expression databases

BgeeiQ96AP4.
CleanExiHS_ZUFSP.
ExpressionAtlasiQ96AP4. baseline and differential.
GenevisibleiQ96AP4. HS.

Organism-specific databases

HPAiHPA044426.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RPS21Q8WVC23EBI-744706,EBI-10276945

Protein-protein interaction databases

BioGridi128708. 6 interactions.
IntActiQ96AP4. 3 interactions.
MINTiMINT-1450238.
STRINGi9606.ENSP00000357565.

Structurei

3D structure databases

ProteinModelPortaliQ96AP4.
SMRiQ96AP4. Positions 2-32, 147-176, 188-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili234 – 26734Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri2 – 2423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri154 – 17724C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri193 – 21523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4696. Eukaryota.
ENOG410XRQT. LUCA.
GeneTreeiENSGT00390000008232.
HOGENOMiHOG000155812.
HOVERGENiHBG055781.
InParanoidiQ96AP4.
OMAiDPGCPSR.
OrthoDBiEOG79KPFM.
PhylomeDBiQ96AP4.
TreeFamiTF323699.

Family and domain databases

InterProiIPR012462. Peptidase_C78_UfSP1/2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF07910. Peptidase_C78. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96AP4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSCNICGET VTSEPDMKAH LIVHMESEII CPFCKLSGVN YDEMCFHIET
60 70 80 90 100
AHFEQNTLER NFERINTVQY GTSDNKKDNT LQCGMEVNSS ILSGCASNHP
110 120 130 140 150
KNSAQNLTKD STLKHEGFYS ENLTESRKFL KSREKQSSLT EIKGSVYETT
160 170 180 190 200
YSPPECPFCG KIEEHSEDME THVKTKHANL LDIPLEDCDQ PLYDCPMCGL
210 220 230 240 250
ICTNYHILQE HVDLHLEENS FQQGMDRVQC SGDLQLAHQL QQEEDRKRRS
260 270 280 290 300
EESRQEIEEF QKLQRQYGLD NSGGYKQQQL RNMEIEVNRG RMPPSEFHRR
310 320 330 340 350
KADMMESLAL GFDDGKTKTS GIIEALHRYY QNAATDVRRV WLSSVVDHFH
360 370 380 390 400
SSLGDKGWGC GYRNFQMLLS SLLQNDAYND CLKGMLIPCI PKIQSMIEDA
410 420 430 440 450
WKEGFDPQGA SQLNNRLQGT KAWIGACEVY ILLTSLRVKC HIVDFHKSTG
460 470 480 490 500
PLGTHPRLFE WILNYYSSEG EGSPKVVCTS KPPIYLQHQG HSRTVIGIEE
510 520 530 540 550
KKNRTLCLLI LDPGCPSREM QKLLKQDIEA SSLKQLRKSM GNLKHKQYQI
560 570
LAVEGALSLE EKLARRQASQ VFTAEKIP
Length:578
Mass (Da):65,959
Last modified:December 1, 2001 - v1
Checksum:i8590426B41F2C9A0
GO
Isoform 2 (identifier: Q96AP4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-519: Missing.

Note: No experimental confirmation available.
Show »
Length:59
Mass (Da):6,724
Checksum:iE71C39FE59D781BC
GO

Sequence cautioni

The sequence CAI20499.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti379 – 3791N → D.1 Publication
Corresponds to variant rs4946188 [ dbSNP | Ensembl ].
VAR_026889

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 519519Missing in isoform 2. 1 PublicationVSP_019533Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054582 mRNA. Translation: BAB70765.1.
BX537872 mRNA. Translation: CAD97873.1.
AL132795 Genomic DNA. Translation: CAI20498.1.
AL132795 Genomic DNA. Translation: CAI20499.1. Sequence problems.
BC015420 mRNA. Translation: AAH15420.1.
BC016879 mRNA. Translation: AAH16879.1.
CCDSiCCDS5110.1. [Q96AP4-1]
RefSeqiNP_659499.2. NM_145062.2. [Q96AP4-1]
XP_011533867.1. XM_011535565.1. [Q96AP4-1]
UniGeneiHs.29857.

Genome annotation databases

EnsembliENST00000368576; ENSP00000357565; ENSG00000153975. [Q96AP4-1]
GeneIDi221302.
KEGGihsa:221302.
UCSCiuc003pxf.3. human. [Q96AP4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054582 mRNA. Translation: BAB70765.1.
BX537872 mRNA. Translation: CAD97873.1.
AL132795 Genomic DNA. Translation: CAI20498.1.
AL132795 Genomic DNA. Translation: CAI20499.1. Sequence problems.
BC015420 mRNA. Translation: AAH15420.1.
BC016879 mRNA. Translation: AAH16879.1.
CCDSiCCDS5110.1. [Q96AP4-1]
RefSeqiNP_659499.2. NM_145062.2. [Q96AP4-1]
XP_011533867.1. XM_011535565.1. [Q96AP4-1]
UniGeneiHs.29857.

3D structure databases

ProteinModelPortaliQ96AP4.
SMRiQ96AP4. Positions 2-32, 147-176, 188-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128708. 6 interactions.
IntActiQ96AP4. 3 interactions.
MINTiMINT-1450238.
STRINGi9606.ENSP00000357565.

PTM databases

iPTMnetiQ96AP4.
PhosphoSiteiQ96AP4.

Polymorphism and mutation databases

BioMutaiZUFSP.
DMDMi74762646.

Proteomic databases

MaxQBiQ96AP4.
PaxDbiQ96AP4.
PRIDEiQ96AP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368576; ENSP00000357565; ENSG00000153975. [Q96AP4-1]
GeneIDi221302.
KEGGihsa:221302.
UCSCiuc003pxf.3. human. [Q96AP4-1]

Organism-specific databases

CTDi221302.
GeneCardsiZUFSP.
H-InvDBHIX0006169.
HGNCiHGNC:21224. ZUFSP.
HPAiHPA044426.
neXtProtiNX_Q96AP4.
PharmGKBiPA162411072.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4696. Eukaryota.
ENOG410XRQT. LUCA.
GeneTreeiENSGT00390000008232.
HOGENOMiHOG000155812.
HOVERGENiHBG055781.
InParanoidiQ96AP4.
OMAiDPGCPSR.
OrthoDBiEOG79KPFM.
PhylomeDBiQ96AP4.
TreeFamiTF323699.

Miscellaneous databases

GenomeRNAii221302.
PROiQ96AP4.

Gene expression databases

BgeeiQ96AP4.
CleanExiHS_ZUFSP.
ExpressionAtlasiQ96AP4. baseline and differential.
GenevisibleiQ96AP4. HS.

Family and domain databases

InterProiIPR012462. Peptidase_C78_UfSP1/2.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF07910. Peptidase_C78. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-379.
    Tissue: Neuroblastoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Heart.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Duodenum and Uterus.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-262, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZUFSP_HUMAN
AccessioniPrimary (citable) accession number: Q96AP4
Secondary accession number(s): Q5TD92, Q6PJH7, Q96NV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although related to the Ufm1-specific proteases, it lacks the conserved His active site, suggesting that it is probably inactive.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.