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Protein

Transmembrane protein 143

Gene

TMEM143

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 143
Gene namesi
Name:TMEM143
ORF Names:UNQ5922/PRO19813
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000161558.10.
HGNCiHGNC:25603. TMEM143.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161558.
PharmGKBiPA144596251.

Polymorphism and mutation databases

BioMutaiTMEM143.
DMDMi74731136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002859581 – 459Transmembrane protein 143Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei332PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96AN5.
MaxQBiQ96AN5.
PaxDbiQ96AN5.
PeptideAtlasiQ96AN5.
PRIDEiQ96AN5.

PTM databases

iPTMnetiQ96AN5.
PhosphoSitePlusiQ96AN5.

Expressioni

Gene expression databases

BgeeiENSG00000161558.
CleanExiHS_TMEM143.
ExpressionAtlasiQ96AN5. baseline and differential.
GenevisibleiQ96AN5. HS.

Organism-specific databases

HPAiHPA014476.

Interactioni

Protein-protein interaction databases

BioGridi120551. 6 interactors.
IntActiQ96AN5. 1 interactor.
STRINGi9606.ENSP00000293261.

Structurei

3D structure databases

ProteinModelPortaliQ96AN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJB5. Eukaryota.
ENOG41105JD. LUCA.
GeneTreeiENSGT00390000004312.
HOGENOMiHOG000013108.
HOVERGENiHBG103031.
InParanoidiQ96AN5.
OMAiRASKMFG.
OrthoDBiEOG091G0HXS.
PhylomeDBiQ96AN5.
TreeFamiTF329116.

Family and domain databases

InterProiView protein in InterPro
IPR022227. DUF3754.
PfamiView protein in Pfam
PF12576. DUF3754. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96AN5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVELWLRLR GKGLAMLHVT RGVWGSRVRV WPLLPALLGP PRALSSLAAK
60 70 80 90 100
MGEYRKMWNP REPRDWAQQY RERFIPFSKE QLLRLLIQEF HSSPAEKAAL
110 120 130 140 150
EAFSAHVDFC TLFHYHQILA RLQALYDPIN PDRETLDQPS LTDPQRLSNE
160 170 180 190 200
QEVLRALEPL LAQANFSPLS EDTLAYALVV HHPQDEVQVT VNLDQYVYIH
210 220 230 240 250
FWALGQRVGQ MPLKSSVGSR RGFFTKLPPA ERRYFKRVVL AARTKRGHLV
260 270 280 290 300
LKSFKDTPLE GLEQLLPELK VRTPTLQRAL LNLMLVVSGV AIFVNVGMVV
310 320 330 340 350
LTDLKVATSL LLLLFAIFMG LRASKMFGQR RSAQALELAH MLYYRSTSNN
360 370 380 390 400
SELLSALALR AQDEHTKEAL LAHSFLARRP GGTQGSPEET SRWLRSEVEN
410 420 430 440 450
WLLAKSGCEV TFNGTRALAH LQALTPSMGL YPPPGFPKLD PVAPITSEPP

QATPSSNIS
Length:459
Mass (Da):51,715
Last modified:December 1, 2001 - v1
Checksum:iE2BF3166AF38BF80
GO
Isoform 2 (identifier: Q96AN5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-187: Missing.

Show »
Length:359
Mass (Da):40,412
Checksum:iBE77855DDC34FAC6
GO
Isoform 3 (identifier: Q96AN5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-128: EFHSSPAEKA...LARLQALYDP → VTGIPLESGR...PNPGPAAGLI
     129-459: Missing.

Show »
Length:128
Mass (Da):14,304
Checksum:i0C0B0AEF4D7FA72D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032058143D → N. Corresponds to variant dbSNP:rs34488893Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02493088 – 187Missing in isoform 2. 2 PublicationsAdd BLAST100
Alternative sequenceiVSP_02493189 – 128EFHSS…ALYDP → VTGIPLESGREGGFGGVLSP RGLLHPVPLPPNPGPAAGLI in isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_024932129 – 459Missing in isoform 3. 1 PublicationAdd BLAST331

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358161 mRNA. Translation: AAQ88528.1.
AK001784 mRNA. No translation available.
AK291521 mRNA. Translation: BAF84210.1.
CH471177 Genomic DNA. Translation: EAW52337.1.
BC016919 mRNA. Translation: AAH16919.1.
CCDSiCCDS12716.1. [Q96AN5-1]
CCDS77325.1. [Q96AN5-2]
RefSeqiNP_001290469.1. NM_001303540.1. [Q96AN5-2]
NP_060743.2. NM_018273.3. [Q96AN5-1]
UniGeneiHs.351335.

Genome annotation databases

EnsembliENST00000293261; ENSP00000293261; ENSG00000161558. [Q96AN5-1]
ENST00000377431; ENSP00000366649; ENSG00000161558. [Q96AN5-2]
GeneIDi55260.
KEGGihsa:55260.
UCSCiuc002pix.2. human. [Q96AN5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM143_HUMAN
AccessioniPrimary (citable) accession number: Q96AN5
Secondary accession number(s): A8K656, Q6UXY4, Q9NV49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations