ID   MRGRF_HUMAN             Reviewed;         343 AA.
AC   Q96AM1; B3KV43; Q8NBK8;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-JAN-2012, entry version 91.
DE   RecName: Full=Mas-related G-protein coupled receptor member F;
DE            Short=Mas-related gene F protein;
DE   AltName: Full=G-protein coupled receptor 140;
DE   AltName: Full=G-protein coupled receptor 168;
GN   Name=MRGPRF; Synonyms=GPR140, GPR168, MRGF; ORFNames=PSEC0142;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-16.
RC   TISSUE=Placenta;
RX   PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA   Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA   Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA   Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA   Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA   Isogai T.;
RT   "Signal sequence and keyword trap in silico for selection of full-
RT   length human cDNAs encoding secretion or membrane proteins from oligo-
RT   capped cDNA libraries.";
RL   DNA Res. 12:117-126(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Orphan receptor. May bind to a neuropeptide and may
CC       regulate nociceptor function and/or development, including the
CC       sensation or modulation of pain (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Mas subfamily.
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DR   EMBL; AK075450; BAC11628.1; -; mRNA.
DR   EMBL; AK122669; BAG53655.1; -; mRNA.
DR   EMBL; CH471076; EAW74730.1; -; Genomic_DNA.
DR   EMBL; BC016964; AAH16964.1; -; mRNA.
DR   IPI; IPI00059513; -.
DR   RefSeq; NP_001091985.1; NM_001098515.1.
DR   RefSeq; NP_659452.3; NM_145015.4.
DR   UniGene; Hs.118513; -.
DR   UniGene; Hs.602397; -.
DR   ProteinModelPortal; Q96AM1; -.
DR   SMR; Q96AM1; 128-159, 274-307.
DR   STRING; Q96AM1; -.
DR   DMDM; 24638055; -.
DR   PRIDE; Q96AM1; -.
DR   Ensembl; ENST00000309099; ENSP00000309782; ENSG00000172935.
DR   Ensembl; ENST00000441623; ENSP00000403660; ENSG00000172935.
DR   GeneID; 116535; -.
DR   KEGG; hsa:116535; -.
DR   UCSC; uc001ooo.2; human.
DR   CTD; 116535; -.
DR   GeneCards; GC11M068771; -.
DR   HGNC; HGNC:24828; MRGPRF.
DR   HPA; HPA028811; -.
DR   MIM; 607233; gene.
DR   neXtProt; NX_Q96AM1; -.
DR   PharmGKB; PA134896544; -.
DR   GeneTree; ENSGT00550000074531; -.
DR   HOGENOM; HBG126829; -.
DR   HOVERGEN; HBG102190; -.
DR   InParanoid; Q96AM1; -.
DR   OMA; CPLMVLP; -.
DR   OrthoDB; EOG43BMPC; -.
DR   PhylomeDB; Q96AM1; -.
DR   NextBio; 90852; -.
DR   ArrayExpress; Q96AM1; -.
DR   Bgee; Q96AM1; -.
DR   CleanEx; HS_MRGPRF; -.
DR   Genevestigator; Q96AM1; -.
DR   GermOnline; ENSG00000172935; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   KO; K08394; -.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN         1    343       Mas-related G-protein coupled receptor
FT                                member F.
FT                                /FTId=PRO_0000069764.
FT   TOPO_DOM      1     44       Extracellular (Potential).
FT   TRANSMEM     45     66       Helical; Name=1; (Potential).
FT   TOPO_DOM     67     82       Cytoplasmic (Potential).
FT   TRANSMEM     83    104       Helical; Name=2; (Potential).
FT   TOPO_DOM    105    123       Extracellular (Potential).
FT   TRANSMEM    124    144       Helical; Name=3; (Potential).
FT   TOPO_DOM    145    160       Cytoplasmic (Potential).
FT   TRANSMEM    161    181       Helical; Name=4; (Potential).
FT   TOPO_DOM    182    198       Extracellular (Potential).
FT   TRANSMEM    199    220       Helical; Name=5; (Potential).
FT   TOPO_DOM    221    241       Cytoplasmic (Potential).
FT   TRANSMEM    242    263       Helical; Name=6; (Potential).
FT   TOPO_DOM    264    273       Extracellular (Potential).
FT   TRANSMEM    274    294       Helical; Name=7; (Potential).
FT   TOPO_DOM    295    343       Cytoplasmic (Potential).
FT   CARBOHYD      4      4       N-linked (GlcNAc...) (Potential).
FT   VARIANT      16     16       K -> R (in dbSNP:rs11544721).
FT                                /FTId=VAR_061220.
SQ   SEQUENCE   343 AA;  38171 MW;  168A649F5B38F154 CRC64;
     MAGNCSWEAH PGNRNKMCPG LSEAPELYSR GFLTIEQIAM LPPPAVMNYI FLLLCLCGLV
     GNGLVLWFFG FSIKRNPFSI YFLHLASADV GYLFSKAVFS ILNTGGFLGT FADYIRSVCR
     VLGLCMFLTG VSLLPAVSAE RCASVIFPAW YWRRRPKRLS AVVCALLWVL SLLVTCLHNY
     FCVFLGRGAP GAACRHMDIF LGILLFLLCC PLMVLPCLAL ILHVECRARR RQRSAKLNHV
     ILAMVSVFLV SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ
     RLWEPLRVVF QRALRDGAEL GEAGGSTPNT VTMEMQCPPG NAS
//