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Protein

Mas-related G-protein coupled receptor member F

Gene

MRGPRF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172935-MONOMER.

Protein family/group databases

TCDBi9.A.14.13.7. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member F
Short name:
Mas-related gene F protein
Alternative name(s):
G-protein coupled receptor 140
G-protein coupled receptor 168
Gene namesi
Name:MRGPRF
Synonyms:GPR140, GPR168, MRGF
ORF Names:PSEC0142
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24828. MRGPRF.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 66Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini67 – 82CytoplasmicSequence analysisAdd BLAST16
Transmembranei83 – 104Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini105 – 123ExtracellularSequence analysisAdd BLAST19
Transmembranei124 – 144Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini145 – 160CytoplasmicSequence analysisAdd BLAST16
Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini182 – 198ExtracellularSequence analysisAdd BLAST17
Transmembranei199 – 220Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini221 – 241CytoplasmicSequence analysisAdd BLAST21
Transmembranei242 – 263Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini264 – 273ExtracellularSequence analysis10
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 343CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116535.
OpenTargetsiENSG00000172935.
PharmGKBiPA134896544.

Polymorphism and mutation databases

BioMutaiMRGPRF.
DMDMi24638055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697641 – 343Mas-related G-protein coupled receptor member FAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96AM1.
PeptideAtlasiQ96AM1.
PRIDEiQ96AM1.

PTM databases

iPTMnetiQ96AM1.
PhosphoSitePlusiQ96AM1.

Expressioni

Gene expression databases

BgeeiENSG00000172935.
CleanExiHS_MRGPRF.
ExpressionAtlasiQ96AM1. baseline and differential.
GenevisibleiQ96AM1. HS.

Organism-specific databases

HPAiHPA028811.

Interactioni

Protein-protein interaction databases

IntActiQ96AM1. 4 interactors.
STRINGi9606.ENSP00000309782.

Structurei

3D structure databases

ProteinModelPortaliQ96AM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJRZ. Eukaryota.
ENOG4111BJC. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102190.
InParanoidiQ96AM1.
KOiK08394.
OMAiGAACRHM.
OrthoDBiEOG091G0EB8.
PhylomeDBiQ96AM1.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026228. MRGPCRF.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF3. PTHR11334:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02112. MRGPCRF.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96AM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNCSWEAH PGNRNKMCPG LSEAPELYSR GFLTIEQIAM LPPPAVMNYI
60 70 80 90 100
FLLLCLCGLV GNGLVLWFFG FSIKRNPFSI YFLHLASADV GYLFSKAVFS
110 120 130 140 150
ILNTGGFLGT FADYIRSVCR VLGLCMFLTG VSLLPAVSAE RCASVIFPAW
160 170 180 190 200
YWRRRPKRLS AVVCALLWVL SLLVTCLHNY FCVFLGRGAP GAACRHMDIF
210 220 230 240 250
LGILLFLLCC PLMVLPCLAL ILHVECRARR RQRSAKLNHV ILAMVSVFLV
260 270 280 290 300
SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ
310 320 330 340
RLWEPLRVVF QRALRDGAEL GEAGGSTPNT VTMEMQCPPG NAS
Length:343
Mass (Da):38,171
Last modified:December 1, 2001 - v1
Checksum:i168A649F5B38F154
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06122016K → R.1 PublicationCorresponds to variant rs11544721dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075450 mRNA. Translation: BAC11628.1.
AK122669 mRNA. Translation: BAG53655.1.
CH471076 Genomic DNA. Translation: EAW74730.1.
BC016964 mRNA. Translation: AAH16964.1.
CCDSiCCDS8188.1.
RefSeqiNP_001091985.1. NM_001098515.1.
NP_659452.3. NM_145015.4.
XP_016872659.1. XM_017017170.1.
UniGeneiHs.118513.
Hs.602397.

Genome annotation databases

EnsembliENST00000309099; ENSP00000309782; ENSG00000172935.
ENST00000441623; ENSP00000403660; ENSG00000172935.
GeneIDi116535.
KEGGihsa:116535.
UCSCiuc001ooo.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075450 mRNA. Translation: BAC11628.1.
AK122669 mRNA. Translation: BAG53655.1.
CH471076 Genomic DNA. Translation: EAW74730.1.
BC016964 mRNA. Translation: AAH16964.1.
CCDSiCCDS8188.1.
RefSeqiNP_001091985.1. NM_001098515.1.
NP_659452.3. NM_145015.4.
XP_016872659.1. XM_017017170.1.
UniGeneiHs.118513.
Hs.602397.

3D structure databases

ProteinModelPortaliQ96AM1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96AM1. 4 interactors.
STRINGi9606.ENSP00000309782.

Protein family/group databases

TCDBi9.A.14.13.7. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiQ96AM1.
PhosphoSitePlusiQ96AM1.

Polymorphism and mutation databases

BioMutaiMRGPRF.
DMDMi24638055.

Proteomic databases

PaxDbiQ96AM1.
PeptideAtlasiQ96AM1.
PRIDEiQ96AM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309099; ENSP00000309782; ENSG00000172935.
ENST00000441623; ENSP00000403660; ENSG00000172935.
GeneIDi116535.
KEGGihsa:116535.
UCSCiuc001ooo.5. human.

Organism-specific databases

CTDi116535.
DisGeNETi116535.
GeneCardsiMRGPRF.
HGNCiHGNC:24828. MRGPRF.
HPAiHPA028811.
MIMi607233. gene.
neXtProtiNX_Q96AM1.
OpenTargetsiENSG00000172935.
PharmGKBiPA134896544.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJRZ. Eukaryota.
ENOG4111BJC. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102190.
InParanoidiQ96AM1.
KOiK08394.
OMAiGAACRHM.
OrthoDBiEOG091G0EB8.
PhylomeDBiQ96AM1.
TreeFamiTF336336.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172935-MONOMER.

Miscellaneous databases

GeneWikiiMRGPRF.
GenomeRNAii116535.
PROiQ96AM1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172935.
CleanExiHS_MRGPRF.
ExpressionAtlasiQ96AM1. baseline and differential.
GenevisibleiQ96AM1. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026228. MRGPCRF.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF3. PTHR11334:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02112. MRGPCRF.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRGRF_HUMAN
AccessioniPrimary (citable) accession number: Q96AM1
Secondary accession number(s): B3KV43, Q8NBK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.