Reviewed, UniProtKB/Swiss-Prot Q96AM1 (MRGRF_HUMAN)

Names and origin

Protein names

Recommended name:
    Mas-related G-protein coupled receptor member F
      Short name=Mas-related gene F protein
Alternative name(s):
    G-protein coupled receptor 140
    G-protein coupled receptor 168

Gene names

Name:	MRGPRF
Synonyms:	GPR140, GPR168, MRGF
ORF Names:	PSEC0142

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Mas-related G-protein coupled receptor member F		PRO_0000069764
Regions
	Topological domain	1 – 44	44	Extracellular Potential
	Transmembrane	45 – 66	22	1 Potential
	Topological domain	67 – 82	16	Cytoplasmic Potential
	Transmembrane	83 – 104	22	2 Potential
	Topological domain	105 – 123	19	Extracellular Potential
	Transmembrane	124 – 144	21	3 Potential
	Topological domain	145 – 160	16	Cytoplasmic Potential
	Transmembrane	161 – 181	21	4 Potential
	Topological domain	182 – 198	17	Extracellular Potential
	Transmembrane	199 – 220	22	5 Potential
	Topological domain	221 – 241	21	Cytoplasmic Potential
	Transmembrane	242 – 263	22	6 Potential
	Topological domain	264 – 273	10	Extracellular Potential
	Transmembrane	274 – 294	21	7 Potential
	Topological domain	295 – 343	49	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	16	1	K → R: dbSNP rs11544721. Ref.2		VAR_061220

Sequences

	Sequence		Length	Mass (Da)
	Q96AM1-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 168A649F5B38F154	FASTA	343	38,171
	10 20 30 40 50 60 MAGNCSWEAH PGNRNKMCPG LSEAPELYSR GFLTIEQIAM LPPPAVMNYI FLLLCLCGLV 70 80 90 100 110 120 GNGLVLWFFG FSIKRNPFSI YFLHLASADV GYLFSKAVFS ILNTGGFLGT FADYIRSVCR 130 140 150 160 170 180 VLGLCMFLTG VSLLPAVSAE RCASVIFPAW YWRRRPKRLS AVVCALLWVL SLLVTCLHNY 190 200 210 220 230 240 FCVFLGRGAP GAACRHMDIF LGILLFLLCC PLMVLPCLAL ILHVECRARR RQRSAKLNHV 250 260 270 280 290 300 ILAMVSVFLV SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ 310 320 330 340 RLWEPLRVVF QRALRDGAEL GEAGGSTPNT VTMEMQCPPG NAS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[2]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-16. Tissue: Placenta.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK075450 mRNA. Translation: BAC11628.1. AK122669 mRNA. Translation: BAG53655.1. CH471076 Genomic DNA. Translation: EAW74730.1. BC016964 mRNA. Translation: AAH16964.1.
IPI	IPI00059513.
RefSeq	NP_001091985.1. NP_659452.3.
UniGene	Hs.118513 Hs.602397
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q96AM1.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q96AM1.
Genome annotation databases
Ensembl	ENST00000309099; ENSP00000309782; ENSG00000172935; Homo sapiens. [Genome view] ENST00000441623; ENSP00000403660; ENSG00000172935; Homo sapiens. [Genome view]
GeneID	116535.
KEGG	hsa:116535.
UCSC	uc001ooo.2. human.
Organism-specific databases
CTD	116535.
GeneCards	GC11M068528.
HGNC	HGNC:24828. MRGPRF.
MIM	607233. gene.
PharmGKB	PA134896544.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG126829.
HOVERGEN	Q96AM1.
InParanoid	Q96AM1.
OMA	CPLMVLP.
OrthoDB	EOG92C0TX.
PhylomeDB	Q96AM1.
Gene expression databases
ArrayExpress	Q96AM1.
Bgee	Q96AM1.
CleanEx	HS_MRGPRF.
Genevestigator	Q96AM1.
GermOnline	ENSG00000172935. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	90852.
SOURCE	Search...

Entry information

Entry name

MRGRF_HUMAN

Accession

Primary (citable) accession number: Q96AM1
Secondary accession number(s): B3KV43, Q8NBK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	December 1, 2001
Last modified:	January 19, 2010
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.