Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mas-related G-protein coupled receptor member F

Gene

MRGPRF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

TCDBi9.A.14.13.7. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member F
Short name:
Mas-related gene F protein
Alternative name(s):
G-protein coupled receptor 140
G-protein coupled receptor 168
Gene namesi
Name:MRGPRF
Synonyms:GPR140, GPR168, MRGF
ORF Names:PSEC0142
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24828. MRGPRF.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence analysisAdd
BLAST
Transmembranei45 – 6622Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini67 – 8216CytoplasmicSequence analysisAdd
BLAST
Transmembranei83 – 10422Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini105 – 12319ExtracellularSequence analysisAdd
BLAST
Transmembranei124 – 14421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini145 – 16016CytoplasmicSequence analysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini182 – 19817ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 22022Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini221 – 24121CytoplasmicSequence analysisAdd
BLAST
Transmembranei242 – 26322Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini264 – 27310ExtracellularSequence analysis
Transmembranei274 – 29421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini295 – 34349CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134896544.

Polymorphism and mutation databases

BioMutaiMRGPRF.
DMDMi24638055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Mas-related G-protein coupled receptor member FPRO_0000069764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96AM1.
PeptideAtlasiQ96AM1.
PRIDEiQ96AM1.

PTM databases

iPTMnetiQ96AM1.
PhosphoSiteiQ96AM1.

Expressioni

Gene expression databases

BgeeiQ96AM1.
CleanExiHS_MRGPRF.
ExpressionAtlasiQ96AM1. baseline and differential.
GenevisibleiQ96AM1. HS.

Organism-specific databases

HPAiHPA028811.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000309782.

Structurei

3D structure databases

ProteinModelPortaliQ96AM1.
SMRiQ96AM1. Positions 42-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJRZ. Eukaryota.
ENOG4111BJC. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102190.
InParanoidiQ96AM1.
KOiK08394.
OMAiGAACRHM.
OrthoDBiEOG7PZRXW.
PhylomeDBiQ96AM1.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026228. MRGPCRF.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF3. PTHR11334:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02112. MRGPCRF.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96AM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNCSWEAH PGNRNKMCPG LSEAPELYSR GFLTIEQIAM LPPPAVMNYI
60 70 80 90 100
FLLLCLCGLV GNGLVLWFFG FSIKRNPFSI YFLHLASADV GYLFSKAVFS
110 120 130 140 150
ILNTGGFLGT FADYIRSVCR VLGLCMFLTG VSLLPAVSAE RCASVIFPAW
160 170 180 190 200
YWRRRPKRLS AVVCALLWVL SLLVTCLHNY FCVFLGRGAP GAACRHMDIF
210 220 230 240 250
LGILLFLLCC PLMVLPCLAL ILHVECRARR RQRSAKLNHV ILAMVSVFLV
260 270 280 290 300
SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ
310 320 330 340
RLWEPLRVVF QRALRDGAEL GEAGGSTPNT VTMEMQCPPG NAS
Length:343
Mass (Da):38,171
Last modified:December 1, 2001 - v1
Checksum:i168A649F5B38F154
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161K → R.1 Publication
Corresponds to variant rs11544721 [ dbSNP | Ensembl ].
VAR_061220

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075450 mRNA. Translation: BAC11628.1.
AK122669 mRNA. Translation: BAG53655.1.
CH471076 Genomic DNA. Translation: EAW74730.1.
BC016964 mRNA. Translation: AAH16964.1.
CCDSiCCDS8188.1.
RefSeqiNP_001091985.1. NM_001098515.1.
NP_659452.3. NM_145015.4.
UniGeneiHs.118513.
Hs.602397.

Genome annotation databases

EnsembliENST00000309099; ENSP00000309782; ENSG00000172935.
ENST00000441623; ENSP00000403660; ENSG00000172935.
GeneIDi116535.
KEGGihsa:116535.
UCSCiuc001ooo.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075450 mRNA. Translation: BAC11628.1.
AK122669 mRNA. Translation: BAG53655.1.
CH471076 Genomic DNA. Translation: EAW74730.1.
BC016964 mRNA. Translation: AAH16964.1.
CCDSiCCDS8188.1.
RefSeqiNP_001091985.1. NM_001098515.1.
NP_659452.3. NM_145015.4.
UniGeneiHs.118513.
Hs.602397.

3D structure databases

ProteinModelPortaliQ96AM1.
SMRiQ96AM1. Positions 42-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000309782.

Protein family/group databases

TCDBi9.A.14.13.7. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiQ96AM1.
PhosphoSiteiQ96AM1.

Polymorphism and mutation databases

BioMutaiMRGPRF.
DMDMi24638055.

Proteomic databases

PaxDbiQ96AM1.
PeptideAtlasiQ96AM1.
PRIDEiQ96AM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309099; ENSP00000309782; ENSG00000172935.
ENST00000441623; ENSP00000403660; ENSG00000172935.
GeneIDi116535.
KEGGihsa:116535.
UCSCiuc001ooo.5. human.

Organism-specific databases

CTDi116535.
GeneCardsiMRGPRF.
HGNCiHGNC:24828. MRGPRF.
HPAiHPA028811.
MIMi607233. gene.
neXtProtiNX_Q96AM1.
PharmGKBiPA134896544.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJRZ. Eukaryota.
ENOG4111BJC. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102190.
InParanoidiQ96AM1.
KOiK08394.
OMAiGAACRHM.
OrthoDBiEOG7PZRXW.
PhylomeDBiQ96AM1.
TreeFamiTF336336.

Miscellaneous databases

GeneWikiiMRGPRF.
GenomeRNAii116535.
PROiQ96AM1.
SOURCEiSearch...

Gene expression databases

BgeeiQ96AM1.
CleanExiHS_MRGPRF.
ExpressionAtlasiQ96AM1. baseline and differential.
GenevisibleiQ96AM1. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026228. MRGPCRF.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF3. PTHR11334:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02112. MRGPCRF.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-16.
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiMRGRF_HUMAN
AccessioniPrimary (citable) accession number: Q96AM1
Secondary accession number(s): B3KV43, Q8NBK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.