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Protein

Mas-related G-protein coupled receptor member F

Gene

MRGPRF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Protein family/group databases

TCDBi9.A.14.13.7 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member F
Short name:
Mas-related gene F protein
Alternative name(s):
G-protein coupled receptor 140
G-protein coupled receptor 168
Gene namesi
Name:MRGPRF
Synonyms:GPR140, GPR168, MRGF
ORF Names:PSEC0142
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172935.8
HGNCiHGNC:24828 MRGPRF
MIMi607233 gene
neXtProtiNX_Q96AM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 66Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini67 – 82CytoplasmicSequence analysisAdd BLAST16
Transmembranei83 – 104Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini105 – 123ExtracellularSequence analysisAdd BLAST19
Transmembranei124 – 144Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini145 – 160CytoplasmicSequence analysisAdd BLAST16
Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini182 – 198ExtracellularSequence analysisAdd BLAST17
Transmembranei199 – 220Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini221 – 241CytoplasmicSequence analysisAdd BLAST21
Transmembranei242 – 263Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini264 – 273ExtracellularSequence analysis10
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 343CytoplasmicSequence analysisAdd BLAST49

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116535
OpenTargetsiENSG00000172935
PharmGKBiPA134896544

Polymorphism and mutation databases

BioMutaiMRGPRF
DMDMi24638055

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697641 – 343Mas-related G-protein coupled receptor member FAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96AM1
PeptideAtlasiQ96AM1
PRIDEiQ96AM1

PTM databases

iPTMnetiQ96AM1
PhosphoSitePlusiQ96AM1

Expressioni

Gene expression databases

BgeeiENSG00000172935
CleanExiHS_MRGPRF
ExpressionAtlasiQ96AM1 baseline and differential
GenevisibleiQ96AM1 HS

Organism-specific databases

HPAiHPA028811

Interactioni

Protein-protein interaction databases

IntActiQ96AM1, 4 interactors
MINTiQ96AM1
STRINGi9606.ENSP00000309782

Structurei

3D structure databases

ProteinModelPortaliQ96AM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJRZ Eukaryota
ENOG4111BJC LUCA
GeneTreeiENSGT00550000074531
HOGENOMiHOG000015412
HOVERGENiHBG102190
InParanoidiQ96AM1
KOiK08394
OMAiCPLMVLP
OrthoDBiEOG091G0EB8
PhylomeDBiQ96AM1
TreeFamiTF336336

Family and domain databases

CDDicd15109 7tmA_MrgprF, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR026228 MRGPCRF
IPR026234 MRGPCRFAMILY
PANTHERiPTHR11334 PTHR11334, 1 hit
PTHR11334:SF3 PTHR11334:SF3, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR02112 MRGPCRF
PR02108 MRGPCRFAMILY
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96AM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNCSWEAH PGNRNKMCPG LSEAPELYSR GFLTIEQIAM LPPPAVMNYI
60 70 80 90 100
FLLLCLCGLV GNGLVLWFFG FSIKRNPFSI YFLHLASADV GYLFSKAVFS
110 120 130 140 150
ILNTGGFLGT FADYIRSVCR VLGLCMFLTG VSLLPAVSAE RCASVIFPAW
160 170 180 190 200
YWRRRPKRLS AVVCALLWVL SLLVTCLHNY FCVFLGRGAP GAACRHMDIF
210 220 230 240 250
LGILLFLLCC PLMVLPCLAL ILHVECRARR RQRSAKLNHV ILAMVSVFLV
260 270 280 290 300
SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ
310 320 330 340
RLWEPLRVVF QRALRDGAEL GEAGGSTPNT VTMEMQCPPG NAS
Length:343
Mass (Da):38,171
Last modified:December 1, 2001 - v1
Checksum:i168A649F5B38F154
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06122016K → R1 PublicationCorresponds to variant dbSNP:rs11544721Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075450 mRNA Translation: BAC11628.1
AK122669 mRNA Translation: BAG53655.1
CH471076 Genomic DNA Translation: EAW74730.1
BC016964 mRNA Translation: AAH16964.1
CCDSiCCDS8188.1
RefSeqiNP_001091985.1, NM_001098515.1
NP_659452.3, NM_145015.4
XP_016872659.1, XM_017017170.1
UniGeneiHs.118513
Hs.602397

Genome annotation databases

EnsembliENST00000309099; ENSP00000309782; ENSG00000172935
ENST00000441623; ENSP00000403660; ENSG00000172935
GeneIDi116535
KEGGihsa:116535
UCSCiuc001ooo.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMRGRF_HUMAN
AccessioniPrimary (citable) accession number: Q96AM1
Secondary accession number(s): B3KV43, Q8NBK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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