Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q96AJ9

- VTI1A_HUMAN

UniProt

Q96AJ9 - VTI1A_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Vesicle transport through interaction with t-SNAREs homolog 1A

Gene

VTI1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.2 Publications

GO - Molecular functioni

  1. SNAP receptor activity Source: HGNC

GO - Biological processi

  1. intracellular protein transport Source: InterPro
  2. retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport through interaction with t-SNAREs homolog 1A
Alternative name(s):
Vesicle transport v-SNARE protein Vti1-like 2
Vti1-rp2
Gene namesi
Name:VTI1A
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:17792. VTI1A.

Subcellular locationi

Cytoplasmic vesicle 1 Publication. Golgi apparatus membrane By similarity; Single-pass type IV membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 192192CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence AnalysisAdd
BLAST
Topological domaini214 – 2174ExtracellularSequence Analysis

GO - Cellular componenti

  1. clathrin-coated vesicle Source: ParkinsonsUK-UCL
  2. endosome Source: ParkinsonsUK-UCL
  3. Golgi apparatus Source: UniProtKB
  4. integral component of membrane Source: UniProtKB-KW
  5. neuronal cell body Source: ParkinsonsUK-UCL
  6. neuron projection terminus Source: ParkinsonsUK-UCL
  7. perinuclear region of cytoplasm Source: ParkinsonsUK-UCL
  8. SNARE complex Source: ParkinsonsUK-UCL
  9. synaptic vesicle Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134928049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Vesicle transport through interaction with t-SNAREs homolog 1APRO_0000218225Add
BLAST

Proteomic databases

MaxQBiQ96AJ9.
PaxDbiQ96AJ9.
PeptideAtlasiQ96AJ9.
PRIDEiQ96AJ9.

PTM databases

PhosphoSiteiQ96AJ9.

Expressioni

Gene expression databases

BgeeiQ96AJ9.
CleanExiHS_VTI1A.
GenevestigatoriQ96AJ9.

Organism-specific databases

HPAiHPA054108.

Interactioni

Subunit structurei

Interacts with distinct SNARE complexes that contain either STX5 or STX6. Interacts with NAPA and, to a lesser extent, with NAPG. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.By similarity

Protein-protein interaction databases

BioGridi126789. 11 interactions.
DIPiDIP-44223N.
IntActiQ96AJ9. 3 interactions.
MINTiMINT-3050814.
STRINGi9606.ENSP00000376792.

Structurei

3D structure databases

ProteinModelPortaliQ96AJ9.
SMRiQ96AJ9. Positions 8-94, 113-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili31 – 9262Sequence AnalysisAdd
BLAST
Coiled coili112 – 17867Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the VTI1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239679.
GeneTreeiENSGT00530000063466.
HOGENOMiHOG000116573.
HOVERGENiHBG104027.
InParanoidiQ96AJ9.
KOiK08493.
OMAiADFKRSR.
OrthoDBiEOG7MKW77.
PhylomeDBiQ96AJ9.
TreeFamiTF312874.

Family and domain databases

InterProiIPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
IPR007705. Vesicle_trsprt_v-SNARE_N.
[Graphical view]
PfamiPF05008. V-SNARE. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: Q96AJ9-2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSDFEGYEQ DFAVLTAEIT SKIARVPRLP PDEKKQMVAN VEKQLEEAKE
60 70 80 90 100
LLEQMDLEVR EIPPQSRGMY SNRMRSYKQE MGKLETDFKR SRIAYSDEVR
110 120 130 140 150
NELLGDDGNS SENQRAHLLD NTERLERSSR RLEAGYQIAV ETEQIGQEML
160 170 180 190 200
ENLSHDREKI QRARERLRET DANLGKSSRI LTGMLRRIIQ NRILLVILGI
210
IVVITILMAI TFSVRRH
Length:217
Mass (Da):25,218
Last modified:January 25, 2012 - v2
Checksum:i3FE5FE787B5958F0
GO
Isoform 1 (identifier: Q96AJ9-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-217: IIQNRILLVILGIIVVITILMAITFSVRRH → GCSVKKQCNLSLAPKA

Note: No experimental confirmation available.

Show »
Length:203
Mass (Da):23,435
Checksum:i751DB052B552BC09
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831K → E in BAG64649. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei188 – 21730IIQNR…SVRRH → GCSVKKQCNLSLAPKA in isoform 1. 1 PublicationVSP_039848Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303646 mRNA. Translation: BAG64649.1.
AL139120, AC022018, AL158212 Genomic DNA. Translation: CAH71781.2.
AL139120, AC022018 Genomic DNA. Translation: CAM15142.1.
AL158212, AC022018, AL139120 Genomic DNA. Translation: CAM22437.1.
CH471066 Genomic DNA. Translation: EAW49524.1.
CH471066 Genomic DNA. Translation: EAW49525.1.
BC017052 mRNA. Translation: AAH17052.1.
CCDSiCCDS7575.2. [Q96AJ9-2]
RefSeqiNP_660207.2. NM_145206.2. [Q96AJ9-2]
XP_005269601.1. XM_005269544.2. [Q96AJ9-1]
UniGeneiHs.194554.

Genome annotation databases

GeneIDi143187.
KEGGihsa:143187.
UCSCiuc001kzy.3. human. [Q96AJ9-1]
uc001kzz.3. human. [Q96AJ9-2]

Polymorphism databases

DMDMi374095459.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303646 mRNA. Translation: BAG64649.1 .
AL139120 , AC022018 , AL158212 Genomic DNA. Translation: CAH71781.2 .
AL139120 , AC022018 Genomic DNA. Translation: CAM15142.1 .
AL158212 , AC022018 , AL139120 Genomic DNA. Translation: CAM22437.1 .
CH471066 Genomic DNA. Translation: EAW49524.1 .
CH471066 Genomic DNA. Translation: EAW49525.1 .
BC017052 mRNA. Translation: AAH17052.1 .
CCDSi CCDS7575.2. [Q96AJ9-2 ]
RefSeqi NP_660207.2. NM_145206.2. [Q96AJ9-2 ]
XP_005269601.1. XM_005269544.2. [Q96AJ9-1 ]
UniGenei Hs.194554.

3D structure databases

ProteinModelPortali Q96AJ9.
SMRi Q96AJ9. Positions 8-94, 113-190.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126789. 11 interactions.
DIPi DIP-44223N.
IntActi Q96AJ9. 3 interactions.
MINTi MINT-3050814.
STRINGi 9606.ENSP00000376792.

PTM databases

PhosphoSitei Q96AJ9.

Polymorphism databases

DMDMi 374095459.

Proteomic databases

MaxQBi Q96AJ9.
PaxDbi Q96AJ9.
PeptideAtlasi Q96AJ9.
PRIDEi Q96AJ9.

Protocols and materials databases

DNASUi 143187.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 143187.
KEGGi hsa:143187.
UCSCi uc001kzy.3. human. [Q96AJ9-1 ]
uc001kzz.3. human. [Q96AJ9-2 ]

Organism-specific databases

CTDi 143187.
GeneCardsi GC10P114197.
H-InvDB HIX0023094.
HGNCi HGNC:17792. VTI1A.
HPAi HPA054108.
MIMi 614316. gene.
neXtProti NX_Q96AJ9.
PharmGKBi PA134928049.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG239679.
GeneTreei ENSGT00530000063466.
HOGENOMi HOG000116573.
HOVERGENi HBG104027.
InParanoidi Q96AJ9.
KOi K08493.
OMAi ADFKRSR.
OrthoDBi EOG7MKW77.
PhylomeDBi Q96AJ9.
TreeFami TF312874.

Miscellaneous databases

ChiTaRSi VTI1A. human.
GeneWikii VTI1A.
GenomeRNAii 143187.
NextBioi 84666.
PROi Q96AJ9.
SOURCEi Search...

Gene expression databases

Bgeei Q96AJ9.
CleanExi HS_VTI1A.
Genevestigatori Q96AJ9.

Family and domain databases

InterProi IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
IPR007705. Vesicle_trsprt_v-SNARE_N.
[Graphical view ]
Pfami PF05008. V-SNARE. 1 hit.
[Graphical view ]
SMARTi SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thymus.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  5. "A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells."
    Ganley I.G., Espinosa E., Pfeffer S.R.
    J. Cell Biol. 180:159-172(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels."
    Flowerdew S.E., Burgoyne R.D.
    Biochem. J. 418:529-540(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVTI1A_HUMAN
AccessioniPrimary (citable) accession number: Q96AJ9
Secondary accession number(s): A2A307, B4E137, Q5W0D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: January 25, 2012
Last modified: November 26, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3