Reviewed, UniProtKB/Swiss-Prot Q96AJ9 (VTI1A_HUMAN)

Names and origin

Protein names

Recommended name:
    Vesicle transport through interaction with t-SNAREs homolog 1A
Alternative name(s):
    Vesicle transport v-SNARE protein Vti1-like 2
    Vti1-rp2

Gene names

Name:

VTI1A

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence By similarity. UniProtKB O89116
Sequence similarities	Belongs to the VTI1 family. UniProtKB O89116

Ontologies

Keywords
Biological process	Protein transport Transport
Domain	Coiled coil
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	intracellular protein transport Inferred from electronic annotation. Source: InterPro retrograde transport, endosome to Golgi Inferred from direct assay. Source: HGNC
Cellular component	SNARE complex Traceable author statement. Source: HGNC
Molecular function	SNAP receptor activity Inferred from direct assay. Source: HGNC protein transporter activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Vesicle transport through interaction with t-SNAREs homolog 1A		PRO_0000218225
Regions
	Coiled coil	31 – 92	62	Potential
	Coiled coil	112 – 178	67	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q96AJ9-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 751DB052B552BC09	FASTA	203	23,435
	10 20 30 40 50 60 MSSDFEGYEQ DFAVLTAEIT SKIARVPRLP PDEKKQMVAN VEKQLEEAKE LLEQMDLEVR 70 80 90 100 110 120 EIPPQSRGMY SNRMRSYKQE MGKLETDFKR SRIAYSDEVR NELLGDDGNS SENQRAHLLD 130 140 150 160 170 180 NTERLERSSR RLEAGYQIAV ETEQIGQEML ENLSHDREKI QRARERLRET DANLGKSSRI 190 200 LTGMLRRGCS VKKQCNLSLA PKA

References

[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL139120, AC022018 Genomic DNA. Translation: CAM15142.1. CH471066 Genomic DNA. Translation: EAW49525.1. BC017052 mRNA. Translation: AAH17052.1.
IPI	IPI00059472.
RefSeq	NP_660207.2.
UniGene	Hs.194554
3D structure databases
SMR	Q96AJ9. Positions 8-94, 113-187.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96AJ9.
PTM databases
PhosphoSite	Q96AJ9.
Proteomic databases
PeptideAtlas	Q96AJ9.
PRIDE	Q96AJ9.
Genome annotation databases
Ensembl	ENST00000432306; ENSP00000395017; ENSG00000151532; Homo sapiens. [Genome view]
GeneID	143187.
KEGG	hsa:143187.
UCSC	uc001kzy.2. human.
Organism-specific databases
CTD	143187.
GeneCards	GC10P114197.
HGNC	HGNC:17792. VTI1A.
PharmGKB	PA134928049.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q96AJ9.
Gene expression databases
ArrayExpress	Q96AJ9.
Bgee	Q96AJ9.
CleanEx	HS_VTI1A.
Genevestigator	Q96AJ9.
GermOnline	ENSG00000151532. Homo sapiens.
Family and domain databases
InterPro	IPR000727. T_SNARE. IPR007705. V-SNARE. [Graphical view]
Pfam	PF05008. V-SNARE. 1 hit. [Graphical view]
SMART	SM00397. t_SNARE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	84666.

Entry information

Entry name

VTI1A_HUMAN

Accession

Primary (citable) accession number: Q96AJ9
Secondary accession number(s): A2A307

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	December 1, 2001
Last modified:	November 24, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.