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Q96AJ9

- VTI1A_HUMAN

UniProt

Q96AJ9 - VTI1A_HUMAN

Protein

Vesicle transport through interaction with t-SNAREs homolog 1A

Gene

VTI1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence.2 Publications

    GO - Molecular functioni

    1. SNAP receptor activity Source: HGNC

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. retrograde transport, endosome to Golgi Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vesicle transport through interaction with t-SNAREs homolog 1A
    Alternative name(s):
    Vesicle transport v-SNARE protein Vti1-like 2
    Vti1-rp2
    Gene namesi
    Name:VTI1A
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:17792. VTI1A.

    Subcellular locationi

    Cytoplasmic vesicle 1 Publication. Golgi apparatus membrane By similarity; Single-pass type IV membrane protein By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. Golgi apparatus Source: UniProtKB
    3. Golgi membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. SNARE complex Source: HGNC

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134928049.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217Vesicle transport through interaction with t-SNAREs homolog 1APRO_0000218225Add
    BLAST

    Proteomic databases

    MaxQBiQ96AJ9.
    PaxDbiQ96AJ9.
    PeptideAtlasiQ96AJ9.
    PRIDEiQ96AJ9.

    PTM databases

    PhosphoSiteiQ96AJ9.

    Expressioni

    Gene expression databases

    BgeeiQ96AJ9.
    CleanExiHS_VTI1A.
    GenevestigatoriQ96AJ9.

    Organism-specific databases

    HPAiHPA054108.

    Interactioni

    Subunit structurei

    Interacts with distinct SNARE complexes that contain either STX5 or STX6. Interacts with NAPA and, to a lesser extent, with NAPG. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A.By similarity

    Protein-protein interaction databases

    BioGridi126789. 8 interactions.
    DIPiDIP-44223N.
    IntActiQ96AJ9. 3 interactions.
    MINTiMINT-3050814.
    STRINGi9606.ENSP00000376792.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96AJ9.
    SMRiQ96AJ9. Positions 8-94, 113-190.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 192192CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini214 – 2174ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili31 – 9262Sequence AnalysisAdd
    BLAST
    Coiled coili112 – 17867Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the VTI1 family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG239679.
    HOGENOMiHOG000116573.
    HOVERGENiHBG104027.
    KOiK08493.
    OMAiADFKRSR.
    OrthoDBiEOG7MKW77.
    PhylomeDBiQ96AJ9.
    TreeFamiTF312874.

    Family and domain databases

    InterProiIPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    IPR007705. Vesicle_trsprt_v-SNARE_N.
    [Graphical view]
    PfamiPF05008. V-SNARE. 1 hit.
    [Graphical view]
    SMARTiSM00397. t_SNARE. 1 hit.
    [Graphical view]
    SUPFAMiSSF47661. SSF47661. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: Q96AJ9-2) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSDFEGYEQ DFAVLTAEIT SKIARVPRLP PDEKKQMVAN VEKQLEEAKE    50
    LLEQMDLEVR EIPPQSRGMY SNRMRSYKQE MGKLETDFKR SRIAYSDEVR 100
    NELLGDDGNS SENQRAHLLD NTERLERSSR RLEAGYQIAV ETEQIGQEML 150
    ENLSHDREKI QRARERLRET DANLGKSSRI LTGMLRRIIQ NRILLVILGI 200
    IVVITILMAI TFSVRRH 217
    Length:217
    Mass (Da):25,218
    Last modified:January 25, 2012 - v2
    Checksum:i3FE5FE787B5958F0
    GO
    Isoform 1 (identifier: Q96AJ9-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         188-217: IIQNRILLVILGIIVVITILMAITFSVRRH → GCSVKKQCNLSLAPKA

    Note: No experimental confirmation available.

    Show »
    Length:203
    Mass (Da):23,435
    Checksum:i751DB052B552BC09
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 831K → E in BAG64649. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei188 – 21730IIQNR…SVRRH → GCSVKKQCNLSLAPKA in isoform 1. 1 PublicationVSP_039848Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK303646 mRNA. Translation: BAG64649.1.
    AL139120, AC022018, AL158212 Genomic DNA. Translation: CAH71781.2.
    AL139120, AC022018 Genomic DNA. Translation: CAM15142.1.
    AL158212, AC022018, AL139120 Genomic DNA. Translation: CAM22437.1.
    CH471066 Genomic DNA. Translation: EAW49524.1.
    CH471066 Genomic DNA. Translation: EAW49525.1.
    BC017052 mRNA. Translation: AAH17052.1.
    CCDSiCCDS7575.2. [Q96AJ9-2]
    RefSeqiNP_660207.2. NM_145206.2. [Q96AJ9-2]
    XP_005269601.1. XM_005269544.2. [Q96AJ9-1]
    UniGeneiHs.194554.

    Genome annotation databases

    EnsembliENST00000393077; ENSP00000376792; ENSG00000151532. [Q96AJ9-2]
    ENST00000432306; ENSP00000395017; ENSG00000151532. [Q96AJ9-1]
    GeneIDi143187.
    KEGGihsa:143187.
    UCSCiuc001kzy.3. human. [Q96AJ9-1]
    uc001kzz.3. human. [Q96AJ9-2]

    Polymorphism databases

    DMDMi374095459.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK303646 mRNA. Translation: BAG64649.1 .
    AL139120 , AC022018 , AL158212 Genomic DNA. Translation: CAH71781.2 .
    AL139120 , AC022018 Genomic DNA. Translation: CAM15142.1 .
    AL158212 , AC022018 , AL139120 Genomic DNA. Translation: CAM22437.1 .
    CH471066 Genomic DNA. Translation: EAW49524.1 .
    CH471066 Genomic DNA. Translation: EAW49525.1 .
    BC017052 mRNA. Translation: AAH17052.1 .
    CCDSi CCDS7575.2. [Q96AJ9-2 ]
    RefSeqi NP_660207.2. NM_145206.2. [Q96AJ9-2 ]
    XP_005269601.1. XM_005269544.2. [Q96AJ9-1 ]
    UniGenei Hs.194554.

    3D structure databases

    ProteinModelPortali Q96AJ9.
    SMRi Q96AJ9. Positions 8-94, 113-190.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126789. 8 interactions.
    DIPi DIP-44223N.
    IntActi Q96AJ9. 3 interactions.
    MINTi MINT-3050814.
    STRINGi 9606.ENSP00000376792.

    PTM databases

    PhosphoSitei Q96AJ9.

    Polymorphism databases

    DMDMi 374095459.

    Proteomic databases

    MaxQBi Q96AJ9.
    PaxDbi Q96AJ9.
    PeptideAtlasi Q96AJ9.
    PRIDEi Q96AJ9.

    Protocols and materials databases

    DNASUi 143187.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000393077 ; ENSP00000376792 ; ENSG00000151532 . [Q96AJ9-2 ]
    ENST00000432306 ; ENSP00000395017 ; ENSG00000151532 . [Q96AJ9-1 ]
    GeneIDi 143187.
    KEGGi hsa:143187.
    UCSCi uc001kzy.3. human. [Q96AJ9-1 ]
    uc001kzz.3. human. [Q96AJ9-2 ]

    Organism-specific databases

    CTDi 143187.
    GeneCardsi GC10P114197.
    H-InvDB HIX0023094.
    HGNCi HGNC:17792. VTI1A.
    HPAi HPA054108.
    MIMi 614316. gene.
    neXtProti NX_Q96AJ9.
    PharmGKBi PA134928049.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG239679.
    HOGENOMi HOG000116573.
    HOVERGENi HBG104027.
    KOi K08493.
    OMAi ADFKRSR.
    OrthoDBi EOG7MKW77.
    PhylomeDBi Q96AJ9.
    TreeFami TF312874.

    Miscellaneous databases

    GeneWikii VTI1A.
    GenomeRNAii 143187.
    NextBioi 84666.
    PROi Q96AJ9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96AJ9.
    CleanExi HS_VTI1A.
    Genevestigatori Q96AJ9.

    Family and domain databases

    InterProi IPR010989. t-SNARE.
    IPR000727. T_SNARE_dom.
    IPR007705. Vesicle_trsprt_v-SNARE_N.
    [Graphical view ]
    Pfami PF05008. V-SNARE. 1 hit.
    [Graphical view ]
    SMARTi SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47661. SSF47661. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Thymus.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    5. "A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells."
      Ganley I.G., Espinosa E., Pfeffer S.R.
      J. Cell Biol. 180:159-172(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels."
      Flowerdew S.E., Burgoyne R.D.
      Biochem. J. 418:529-540(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVTI1A_HUMAN
    AccessioniPrimary (citable) accession number: Q96AJ9
    Secondary accession number(s): A2A307, B4E137, Q5W0D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3