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Q96AJ1

- CLUA1_HUMAN

UniProt

Q96AJ1 - CLUA1_HUMAN

Protein

Clusterin-associated protein 1

Gene

CLUAP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 4 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell projection organization Source: UniProtKB-KW

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Clusterin-associated protein 1
    Alternative name(s):
    Qilin
    Gene namesi
    Name:CLUAP1
    Synonyms:KIAA0643
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:19009. CLUAP1.

    Subcellular locationi

    GO - Cellular componenti

    1. cilium Source: UniProtKB-SubCell
    2. intracellular membrane-bounded organelle Source: HPA
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Cell projection, Cilium, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394600.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413Clusterin-associated protein 1PRO_0000239451Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei409 – 4091Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96AJ1.
    PaxDbiQ96AJ1.
    PRIDEiQ96AJ1.

    PTM databases

    PhosphoSiteiQ96AJ1.

    Expressioni

    Tissue specificityi

    Expressed in testis, thyroid and trachea and to a lower extent in spinal cord and adrenal gland. Highly expressed in colon cancer and osteosarcoma cell lines.2 Publications

    Gene expression databases

    ArrayExpressiQ96AJ1.
    BgeeiQ96AJ1.
    CleanExiHS_CLUAP1.
    GenevestigatoriQ96AJ1.

    Organism-specific databases

    HPAiHPA036976.
    HPA044191.

    Interactioni

    Subunit structurei

    Interacts with CLU/clusterin.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAGEA11P433642EBI-739780,EBI-739552

    Protein-protein interaction databases

    BioGridi116694. 6 interactions.
    IntActiQ96AJ1. 2 interactions.
    STRINGi9606.ENSP00000344392.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96AJ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili198 – 29194Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi360 – 38627Asp-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CLUAP1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG330295.
    HOGENOMiHOG000257815.
    HOVERGENiHBG081253.
    InParanoidiQ96AJ1.
    OrthoDBiEOG7XDBG7.
    PhylomeDBiQ96AJ1.
    TreeFamiTF314639.

    Family and domain databases

    InterProiIPR019366. Clusterin-associated_protein-1.
    [Graphical view]
    PANTHERiPTHR21547. PTHR21547. 1 hit.
    PfamiPF10234. Cluap1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96AJ1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFRDLRNFT EMMRALGYPR HISMENFRTP NFGLVSEVLL WLVKRYEPQT    50
    DIPPDVDTEQ DRVFFIKAIA QFMATKAHIK LNTKKLYQAD GYAVKELLKI 100
    TSVLYNAMKT KGMEGSEIVE EDVNKFKFDL GSKIADLKAA RQLASEITSK 150
    GASLYDLLGM EVELREMRTE AIARPLEINE TEKVMRIAIK EILTQVQKTK 200
    DLLNNVASDE ANLEAKIEKR KLELERNRKR LETLQSVRPC FMDEYEKTEE 250
    ELQKQYDTYL EKFQNLTYLE QQLEDHHRME QERFEEAKNT LCLIQNKLKE 300
    EEKRLLKSGS NDDSDIDIQE DDESDSELEE RRLPKPQTAM EMLMQGRPGK 350
    RIVGTMQGGD SDDNEDSEES EIDMEDDDDE DDDLEDESIS LSPTKPNRRV 400
    RKSEPLDESD NDF 413
    Length:413
    Mass (Da):48,125
    Last modified:June 13, 2006 - v4
    Checksum:i7A23D4FA2EBE5A9F
    GO
    Isoform 2 (identifier: Q96AJ1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-166: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:247
    Mass (Da):29,093
    Checksum:i04DEC4E12F4D36F3
    GO

    Sequence cautioni

    The sequence BAA31618.1 differs from that shown. Reason: Intron retention.
    The sequence BAB14523.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681A → S.
    Corresponds to variant rs34115694 [ dbSNP | Ensembl ].
    VAR_050869
    Natural varianti401 – 4011R → W.1 Publication
    Corresponds to variant rs9790 [ dbSNP | Ensembl ].
    VAR_050870

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 166166Missing in isoform 2. 1 PublicationVSP_019229Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB089691 mRNA. Translation: BAD44779.1.
    AB014543 mRNA. Translation: BAA31618.1. Sequence problems.
    AK023319 mRNA. Translation: BAB14523.1. Different initiation.
    AK023359 mRNA. Translation: BAB14542.1.
    BC017070 mRNA. Translation: AAH17070.3.
    CCDSiCCDS32381.1. [Q96AJ1-1]
    CCDS45398.1. [Q96AJ1-2]
    RefSeqiNP_055856.1. NM_015041.2. [Q96AJ1-1]
    NP_079069.1. NM_024793.2. [Q96AJ1-2]
    UniGeneiHs.155995.

    Genome annotation databases

    EnsembliENST00000572600; ENSP00000460889; ENSG00000103351. [Q96AJ1-2]
    ENST00000576634; ENSP00000460850; ENSG00000103351. [Q96AJ1-1]
    GeneIDi23059.
    KEGGihsa:23059.
    UCSCiuc002cvk.2. human. [Q96AJ1-1]

    Polymorphism databases

    DMDMi108935970.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB089691 mRNA. Translation: BAD44779.1 .
    AB014543 mRNA. Translation: BAA31618.1 . Sequence problems.
    AK023319 mRNA. Translation: BAB14523.1 . Different initiation.
    AK023359 mRNA. Translation: BAB14542.1 .
    BC017070 mRNA. Translation: AAH17070.3 .
    CCDSi CCDS32381.1. [Q96AJ1-1 ]
    CCDS45398.1. [Q96AJ1-2 ]
    RefSeqi NP_055856.1. NM_015041.2. [Q96AJ1-1 ]
    NP_079069.1. NM_024793.2. [Q96AJ1-2 ]
    UniGenei Hs.155995.

    3D structure databases

    ProteinModelPortali Q96AJ1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116694. 6 interactions.
    IntActi Q96AJ1. 2 interactions.
    STRINGi 9606.ENSP00000344392.

    PTM databases

    PhosphoSitei Q96AJ1.

    Polymorphism databases

    DMDMi 108935970.

    Proteomic databases

    MaxQBi Q96AJ1.
    PaxDbi Q96AJ1.
    PRIDEi Q96AJ1.

    Protocols and materials databases

    DNASUi 23059.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000572600 ; ENSP00000460889 ; ENSG00000103351 . [Q96AJ1-2 ]
    ENST00000576634 ; ENSP00000460850 ; ENSG00000103351 . [Q96AJ1-1 ]
    GeneIDi 23059.
    KEGGi hsa:23059.
    UCSCi uc002cvk.2. human. [Q96AJ1-1 ]

    Organism-specific databases

    CTDi 23059.
    GeneCardsi GC16P003550.
    HGNCi HGNC:19009. CLUAP1.
    HPAi HPA036976.
    HPA044191.
    neXtProti NX_Q96AJ1.
    PharmGKBi PA128394600.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG330295.
    HOGENOMi HOG000257815.
    HOVERGENi HBG081253.
    InParanoidi Q96AJ1.
    OrthoDBi EOG7XDBG7.
    PhylomeDBi Q96AJ1.
    TreeFami TF314639.

    Miscellaneous databases

    GeneWikii CLUAP1.
    GenomeRNAii 23059.
    NextBioi 44121.
    PROi Q96AJ1.

    Gene expression databases

    ArrayExpressi Q96AJ1.
    Bgeei Q96AJ1.
    CleanExi HS_CLUAP1.
    Genevestigatori Q96AJ1.

    Family and domain databases

    InterProi IPR019366. Clusterin-associated_protein-1.
    [Graphical view ]
    PANTHERi PTHR21547. PTHR21547. 1 hit.
    Pfami PF10234. Cluap1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer."
      Takahashi M., Lin Y.-M., Nakamura Y., Furukawa Y.
      Oncogene 23:9289-9294(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CLU, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Colon tumor.
    2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 222-413 (ISOFORMS 1/2).
      Tissue: Ovary.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TRP-401.
      Tissue: Skin.
    5. "Human cilia proteome contains homolog of zebrafish polycystic kidney disease gene qilin."
      Marshall W.F.
      Curr. Biol. 14:R913-R914(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, SUBCELLULAR LOCATION.
    6. "Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system."
      Ishikura H., Ikeda H., Abe H., Ohkuri T., Hiraga H., Isu K., Tsukahara T., Sato N., Kitamura H., Iwasaki N., Takeda N., Minami A., Nishimura T.
      Int. J. Oncol. 30:461-467(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiCLUA1_HUMAN
    AccessioniPrimary (citable) accession number: Q96AJ1
    Secondary accession number(s): O75138
    , Q65ZA3, Q9H8R4, Q9H8T1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 94 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Associated with a number of cancers such as colon (PubMed:15480429) and bone cancer (PubMed:17203229). Possibly involved in polycystic kidney diseases (PubMed:15530380).3 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3