Reviewed, UniProtKB/Swiss-Prot Q96AJ1 (CLUA1_HUMAN)

Names and origin

Protein names

Recommended name:
    Clusterin-associated protein 1

Gene names

Name:	CLUAP1
Synonyms:	KIAA0643

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	413 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in cell proliferation or apoptosis.
Subunit structure	Interacts with CLU/clusterin. Ref.1
Subcellular location	Nucleus. Ref.1
Tissue specificity	Expressed in testis, thyroid and trachea and to a lower extent in spinal cord and adrenal gland. Ref.1
Sequence caution	The sequence BAA31618.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MAGEA11	P43364	1	EBI-739780,EBI-739552

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96AJ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96AJ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 413	413	Clusterin-associated protein 1		PRO_0000239451
Regions
	Coiled coil	198 – 291	94	Potential
	Compositional bias	360 – 386	27	Asp-rich
Natural variations
	Alternative sequence	1 – 166	166	Missing in isoform 2.		VSP_019229
	Natural variant	68	1	A → S: dbSNP rs34115694.		VAR_050869
	Natural variant	401	1	R → W: dbSNP rs9790. Ref.4		VAR_050870

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 13, 2006. Version 4. Checksum: 7A23D4FA2EBE5A9F	FASTA	413	48,125
	10 20 30 40 50 60 MSFRDLRNFT EMMRALGYPR HISMENFRTP NFGLVSEVLL WLVKRYEPQT DIPPDVDTEQ 70 80 90 100 110 120 DRVFFIKAIA QFMATKAHIK LNTKKLYQAD GYAVKELLKI TSVLYNAMKT KGMEGSEIVE 130 140 150 160 170 180 EDVNKFKFDL GSKIADLKAA RQLASEITSK GASLYDLLGM EVELREMRTE AIARPLEINE 190 200 210 220 230 240 TEKVMRIAIK EILTQVQKTK DLLNNVASDE ANLEAKIEKR KLELERNRKR LETLQSVRPC 250 260 270 280 290 300 FMDEYEKTEE ELQKQYDTYL EKFQNLTYLE QQLEDHHRME QERFEEAKNT LCLIQNKLKE 310 320 330 340 350 360 EEKRLLKSGS NDDSDIDIQE DDESDSELEE RRLPKPQTAM EMLMQGRPGK RIVGTMQGGD 370 380 390 400 410 SDDNEDSEES EIDMEDDDDE DDDLEDESIS LSPTKPNRRV RKSEPLDESD NDF
	Isoform 2. Checksum: 04DEC4E12F4D36F3	FASTA	247	29,093
	10 20 30 40 50 60 MRTEAIARPL EINETEKVMR IAIKEILTQV QKTKDLLNNV ASDEANLEAK IEKRKLELER 70 80 90 100 110 120 NRKRLETLQS VRPCFMDEYE KTEEELQKQY DTYLEKFQNL TYLEQQLEDH HRMEQERFEE 130 140 150 160 170 180 AKNTLCLIQN KLKEEEKRLL KSGSNDDSDI DIQEDDESDS ELEERRLPKP QTAMEMLMQG 190 200 210 220 230 240 RPGKRIVGTM QGGDSDDNED SEESEIDMED DDDEDDDLED ESISLSPTKP NRRVRKSEPL DESDNDF

References

[1]	"Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer." Takahashi M., Lin Y.-M., Nakamura Y., Furukawa Y. Oncogene 23:9289-9294(2004) [PubMed: 15480429] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CLU, TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Colon tumor.
[2]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed: 9734811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 222-413 (ISOFORMS 1/2). Tissue: Ovary.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TRP-401. Tissue: Skin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB089691 mRNA. Translation: BAD44779.1. AB014543 mRNA. Translation: BAA31618.1. Sequence problems. AK023319 mRNA. Translation: BAB14523.1. Different initiation. AK023359 mRNA. Translation: BAB14542.1. BC017070 mRNA. Translation: AAH17070.3.
IPI	IPI00152974. IPI00746358.
RefSeq	NP_055856.1. NP_079069.1.
UniGene	Hs.155995
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96AJ1. 2 interactions.
PTM databases
PhosphoSite	Q96AJ1.
Proteomic databases
PRIDE	Q96AJ1.
Genome annotation databases
Ensembl	ENSG00000103351. Homo sapiens. [Contig view]
GeneID	23059.
KEGG	hsa:23059.
Organism-specific databases
GeneCards	GC16P003491.
H-InvDB	HIX0012769.
HGNC	HGNC:19009. CLUAP1.
PharmGKB	PA128394600.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q96AJ1.
HOVERGEN	Q96AJ1.
OMA	Q96AJ1. VAEILIW.
Gene expression databases
ArrayExpress	Q96AJ1.
Bgee	Q96AJ1.
CleanEx	HS_CLUAP1.
GermOnline	ENSG00000103351. Homo sapiens.
Family and domain databases
InterPro	IPR019366. Clusterin-associated_protein-1. [Graphical view]
PANTHER	PTHR21547. Clusterin-associated_protein-1. 1 hit.
Pfam	PF10234. Cluap1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	44121.

Entry information

Entry name

CLUA1_HUMAN

Accession

Primary (citable) accession number: Q96AJ1
Secondary accession number(s): O75138 , Q65ZA3, Q9H8R4, Q9H8T1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	June 13, 2006
Last modified:	June 16, 2009
This is version 50 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)