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Protein

Clusterin-associated protein 1

Gene

CLUAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103351-MONOMER.
ReactomeiR-HSA-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Clusterin-associated protein 1
Alternative name(s):
Qilin
Gene namesi
Name:CLUAP1
Synonyms:KIAA0643
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:19009. CLUAP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23059.
OpenTargetsiENSG00000103351.
PharmGKBiPA128394600.

Polymorphism and mutation databases

BioMutaiCLUAP1.
DMDMi108935970.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002394511 – 413Clusterin-associated protein 1Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei314PhosphoserineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei409PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96AJ1.
MaxQBiQ96AJ1.
PaxDbiQ96AJ1.
PeptideAtlasiQ96AJ1.
PRIDEiQ96AJ1.

PTM databases

iPTMnetiQ96AJ1.
PhosphoSitePlusiQ96AJ1.

Expressioni

Tissue specificityi

Expressed in testis, thyroid and trachea and to a lower extent in spinal cord and adrenal gland. Highly expressed in colon cancer and osteosarcoma cell lines.2 Publications

Gene expression databases

BgeeiENSG00000103351.
CleanExiHS_CLUAP1.
ExpressionAtlasiQ96AJ1. baseline and differential.
GenevisibleiQ96AJ1. HS.

Organism-specific databases

HPAiHPA036976.
HPA044191.

Interactioni

Subunit structurei

Interacts with CLU/clusterin.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA11P433642EBI-739780,EBI-739552
MAGEA11P43364-23EBI-739780,EBI-10178634
MYOGP151735EBI-739780,EBI-3906629

Protein-protein interaction databases

BioGridi116694. 15 interactors.
IntActiQ96AJ1. 17 interactors.
STRINGi9606.ENSP00000460850.

Structurei

3D structure databases

ProteinModelPortaliQ96AJ1.
SMRiQ96AJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili198 – 291Sequence analysisAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi360 – 386Asp-richAdd BLAST27

Sequence similaritiesi

Belongs to the CLUAP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3647. Eukaryota.
ENOG410XRVS. LUCA.
GeneTreeiENSGT00390000008957.
HOGENOMiHOG000257815.
HOVERGENiHBG081253.
InParanoidiQ96AJ1.
KOiK19684.
PhylomeDBiQ96AJ1.
TreeFamiTF314639.

Family and domain databases

InterProiIPR019366. Clusterin-associated_protein-1.
[Graphical view]
PANTHERiPTHR21547. PTHR21547. 1 hit.
PfamiPF10234. Cluap1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96AJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFRDLRNFT EMMRALGYPR HISMENFRTP NFGLVSEVLL WLVKRYEPQT
60 70 80 90 100
DIPPDVDTEQ DRVFFIKAIA QFMATKAHIK LNTKKLYQAD GYAVKELLKI
110 120 130 140 150
TSVLYNAMKT KGMEGSEIVE EDVNKFKFDL GSKIADLKAA RQLASEITSK
160 170 180 190 200
GASLYDLLGM EVELREMRTE AIARPLEINE TEKVMRIAIK EILTQVQKTK
210 220 230 240 250
DLLNNVASDE ANLEAKIEKR KLELERNRKR LETLQSVRPC FMDEYEKTEE
260 270 280 290 300
ELQKQYDTYL EKFQNLTYLE QQLEDHHRME QERFEEAKNT LCLIQNKLKE
310 320 330 340 350
EEKRLLKSGS NDDSDIDIQE DDESDSELEE RRLPKPQTAM EMLMQGRPGK
360 370 380 390 400
RIVGTMQGGD SDDNEDSEES EIDMEDDDDE DDDLEDESIS LSPTKPNRRV
410
RKSEPLDESD NDF
Length:413
Mass (Da):48,125
Last modified:June 13, 2006 - v4
Checksum:i7A23D4FA2EBE5A9F
GO
Isoform 2 (identifier: Q96AJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-166: Missing.

Note: No experimental confirmation available.
Show »
Length:247
Mass (Da):29,093
Checksum:i04DEC4E12F4D36F3
GO

Sequence cautioni

The sequence BAA31618 differs from that shown. Intron retention.Curated
The sequence BAB14523 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05086968A → S.Corresponds to variant rs34115694dbSNPEnsembl.1
Natural variantiVAR_050870401R → W.1 PublicationCorresponds to variant rs9790dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0192291 – 166Missing in isoform 2. 1 PublicationAdd BLAST166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089691 mRNA. Translation: BAD44779.1.
AB014543 mRNA. Translation: BAA31618.1. Sequence problems.
AK023319 mRNA. Translation: BAB14523.1. Different initiation.
AK023359 mRNA. Translation: BAB14542.1.
BC017070 mRNA. Translation: AAH17070.3.
CCDSiCCDS32381.1. [Q96AJ1-1]
CCDS45398.1. [Q96AJ1-2]
RefSeqiNP_055856.1. NM_015041.2. [Q96AJ1-1]
NP_079069.1. NM_024793.2. [Q96AJ1-2]
UniGeneiHs.155995.

Genome annotation databases

EnsembliENST00000572600; ENSP00000460889; ENSG00000103351. [Q96AJ1-2]
ENST00000576634; ENSP00000460850; ENSG00000103351. [Q96AJ1-1]
GeneIDi23059.
KEGGihsa:23059.
UCSCiuc002cvk.3. human. [Q96AJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089691 mRNA. Translation: BAD44779.1.
AB014543 mRNA. Translation: BAA31618.1. Sequence problems.
AK023319 mRNA. Translation: BAB14523.1. Different initiation.
AK023359 mRNA. Translation: BAB14542.1.
BC017070 mRNA. Translation: AAH17070.3.
CCDSiCCDS32381.1. [Q96AJ1-1]
CCDS45398.1. [Q96AJ1-2]
RefSeqiNP_055856.1. NM_015041.2. [Q96AJ1-1]
NP_079069.1. NM_024793.2. [Q96AJ1-2]
UniGeneiHs.155995.

3D structure databases

ProteinModelPortaliQ96AJ1.
SMRiQ96AJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116694. 15 interactors.
IntActiQ96AJ1. 17 interactors.
STRINGi9606.ENSP00000460850.

PTM databases

iPTMnetiQ96AJ1.
PhosphoSitePlusiQ96AJ1.

Polymorphism and mutation databases

BioMutaiCLUAP1.
DMDMi108935970.

Proteomic databases

EPDiQ96AJ1.
MaxQBiQ96AJ1.
PaxDbiQ96AJ1.
PeptideAtlasiQ96AJ1.
PRIDEiQ96AJ1.

Protocols and materials databases

DNASUi23059.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000572600; ENSP00000460889; ENSG00000103351. [Q96AJ1-2]
ENST00000576634; ENSP00000460850; ENSG00000103351. [Q96AJ1-1]
GeneIDi23059.
KEGGihsa:23059.
UCSCiuc002cvk.3. human. [Q96AJ1-1]

Organism-specific databases

CTDi23059.
DisGeNETi23059.
GeneCardsiCLUAP1.
HGNCiHGNC:19009. CLUAP1.
HPAiHPA036976.
HPA044191.
neXtProtiNX_Q96AJ1.
OpenTargetsiENSG00000103351.
PharmGKBiPA128394600.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3647. Eukaryota.
ENOG410XRVS. LUCA.
GeneTreeiENSGT00390000008957.
HOGENOMiHOG000257815.
HOVERGENiHBG081253.
InParanoidiQ96AJ1.
KOiK19684.
PhylomeDBiQ96AJ1.
TreeFamiTF314639.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103351-MONOMER.
ReactomeiR-HSA-5620924. Intraflagellar transport.

Miscellaneous databases

GeneWikiiCLUAP1.
GenomeRNAii23059.
PROiQ96AJ1.

Gene expression databases

BgeeiENSG00000103351.
CleanExiHS_CLUAP1.
ExpressionAtlasiQ96AJ1. baseline and differential.
GenevisibleiQ96AJ1. HS.

Family and domain databases

InterProiIPR019366. Clusterin-associated_protein-1.
[Graphical view]
PANTHERiPTHR21547. PTHR21547. 1 hit.
PfamiPF10234. Cluap1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLUA1_HUMAN
AccessioniPrimary (citable) accession number: Q96AJ1
Secondary accession number(s): O75138
, Q65ZA3, Q9H8R4, Q9H8T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: November 30, 2016
This is version 114 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Associated with a number of cancers such as colon (PubMed:15480429) and bone cancer (PubMed:17203229). Possibly involved in polycystic kidney diseases (PubMed:15530380).3 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.