Reviewed, UniProtKB/Swiss-Prot Q96AH8 (RAB7B_HUMAN)

Names and origin

Protein names

Recommended name:
    Ras-related protein Rab-7b

Gene names

Name:

RAB7B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Protein transport. Probably involved in vesicular traffic By similarity.
Subcellular location	Lysosome. Note: Associated with lysosomal organelles. Ref.1
Tissue specificity	Expressed inheart, placenta, lung, skeletal muscle and peripheral blood leukocyte. Ref.1
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Lysosome
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Phosphoprotein Prenylation
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Ras-related protein Rab-7b		PRO_0000121125
Regions
	Nucleotide binding	15 – 22	8	GTP By similarity
	Nucleotide binding	63 – 67	5	GTP By similarity
	Nucleotide binding	124 – 127	4	GTP By similarity
	Motif	37 – 45	9	Effector region By similarity
Amino acid modifications
	Modified residue	186	1	Phosphoserine By similarity
	Lipidation	198	1	S-geranylgeranyl cysteine By similarity
	Lipidation	199	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q96AH8-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 161C41ABC0EBA529	FASTA	199	22,511
	10 20 30 40 50 60 MNPRKKVDLK LIIVGAIGVG KTSLLHQYVH KTFYEEYQTT LGASILSKII ILGDTTLKLQ 70 80 90 100 110 120 IWDTGGQERF RSMVSTFYKG SDGCILAFDV TDLESFEALD IWRGDVLAKI VPMEQSYPMV 130 140 150 160 170 180 LLGNKIDLAD RKVPQEVAQG WCREKDIPYF EVSAKNDINV VQAFEMLASR ALSRYQSILE 190 NHLTESIKLS PDQSRSRCC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells." Yang M., Chen T., Han C., Li N., Wan T., Cao X. Biochem. Biophys. Res. Commun. 318:792-799(2004) [PubMed: 15144907] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY094596 mRNA. Translation: AAM22519.1. BC017092 mRNA. Translation: AAH17092.1.
IPI	IPI00059444.
UniGene	Hs.534612
3D structure databases
HSSP	HSSP built from PDB template 1KY3 based on UniProtKB P32939.
ModBase	Search...
Proteomic databases
PRIDE	Q96AH8.
Organism-specific databases
GeneCards	GC01U901021.
H-InvDB	HIX0018463.
HGNC	HGNC:30513. RAB7B.
PharmGKB	PA134940117.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q96AH8.
Gene expression databases
CleanEx	HS_RAB7B.
Family and domain databases
InterPro	IPR003579. GTPase_Rab. IPR013753. Ras. IPR001806. Ras_GTPase. IPR005225. Small_GTP_bd. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RAB7B_HUMAN

Accession

Primary (citable) accession number: Q96AH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	December 1, 2001
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)