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Protein

Ras-related protein Rab-7b

Gene

RAB7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi34 – 40GTPBy similarity7
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4
Nucleotide bindingi154 – 155GTPBy similarity2

GO - Molecular functioni

GO - Biological processi

  • late endosome to Golgi transport Source: UniProtKB
  • negative regulation of toll-like receptor 4 signaling pathway Source: UniProtKB
  • negative regulation of toll-like receptor 9 signaling pathway Source: UniProtKB
  • positive regulation of interleukin-6 production Source: UniProtKB
  • positive regulation of megakaryocyte differentiation Source: UniProtKB
  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32715-MONOMER.
ReactomeiR-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-7b
Gene namesi
Name:RAB7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30513. RAB7B.

Subcellular locationi

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • late endosome Source: UniProtKB
  • lysosome Source: UniProtKB
  • phagocytic vesicle Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi338382.
OpenTargetsiENSG00000276600.
PharmGKBiPA134940117.

Polymorphism and mutation databases

DMDMi50401122.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211251 – 199Ras-related protein Rab-7bAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineBy similarity1
Lipidationi198S-geranylgeranyl cysteineBy similarity1
Lipidationi199S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ96AH8.
PeptideAtlasiQ96AH8.
PRIDEiQ96AH8.
TopDownProteomicsiQ96AH8.

PTM databases

PhosphoSitePlusiQ96AH8.

Expressioni

Tissue specificityi

Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.1 Publication

Gene expression databases

CleanExiHS_RAB7B.
ExpressionAtlasiQ96AH8. baseline and differential.
GenevisibleiQ96AH8. HS.

Interactioni

Protein-protein interaction databases

BioGridi130725. 9 interactors.
IntActiQ96AH8. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ96AH8.
SMRiQ96AH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119125.
HOVERGENiHBG009351.
InParanoidiQ96AH8.
KOiK07898.
OMAiYEEYQTT.
OrthoDBiEOG091G0MVE.
PhylomeDBiQ96AH8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96AH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPRKKVDLK LIIVGAIGVG KTSLLHQYVH KTFYEEYQTT LGASILSKII
60 70 80 90 100
ILGDTTLKLQ IWDTGGQERF RSMVSTFYKG SDGCILAFDV TDLESFEALD
110 120 130 140 150
IWRGDVLAKI VPMEQSYPMV LLGNKIDLAD RKVPQEVAQG WCREKDIPYF
160 170 180 190
EVSAKNDINV VQAFEMLASR ALSRYQSILE NHLTESIKLS PDQSRSRCC
Length:199
Mass (Da):22,511
Last modified:December 1, 2001 - v1
Checksum:i161C41ABC0EBA529
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY094596 mRNA. Translation: AAM22519.1.
BC017092 mRNA. Translation: AAH17092.1.
CCDSiCCDS73011.1.
RefSeqiNP_001157994.1. NM_001164522.2.
NP_796377.3. NM_177403.5.
UniGeneiHs.534612.

Genome annotation databases

EnsembliENST00000617070; ENSP00000482499; ENSG00000276600.
ENST00000617991; ENSP00000479762; ENSG00000276600.
ENST00000623597; ENSP00000485468; ENSG00000276600.
GeneIDi338382.
KEGGihsa:338382.
UCSCiuc031vlc.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY094596 mRNA. Translation: AAM22519.1.
BC017092 mRNA. Translation: AAH17092.1.
CCDSiCCDS73011.1.
RefSeqiNP_001157994.1. NM_001164522.2.
NP_796377.3. NM_177403.5.
UniGeneiHs.534612.

3D structure databases

ProteinModelPortaliQ96AH8.
SMRiQ96AH8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130725. 9 interactors.
IntActiQ96AH8. 2 interactors.

PTM databases

PhosphoSitePlusiQ96AH8.

Polymorphism and mutation databases

DMDMi50401122.

Proteomic databases

EPDiQ96AH8.
PeptideAtlasiQ96AH8.
PRIDEiQ96AH8.
TopDownProteomicsiQ96AH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000617070; ENSP00000482499; ENSG00000276600.
ENST00000617991; ENSP00000479762; ENSG00000276600.
ENST00000623597; ENSP00000485468; ENSG00000276600.
GeneIDi338382.
KEGGihsa:338382.
UCSCiuc031vlc.2. human.

Organism-specific databases

CTDi338382.
DisGeNETi338382.
GeneCardsiRAB7B.
HGNCiHGNC:30513. RAB7B.
neXtProtiNX_Q96AH8.
OpenTargetsiENSG00000276600.
PharmGKBiPA134940117.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119125.
HOVERGENiHBG009351.
InParanoidiQ96AH8.
KOiK07898.
OMAiYEEYQTT.
OrthoDBiEOG091G0MVE.
PhylomeDBiQ96AH8.

Enzyme and pathway databases

BioCyciZFISH:G66-32715-MONOMER.
ReactomeiR-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

GeneWikiiRAB7B.
GenomeRNAii338382.
PROiQ96AH8.

Gene expression databases

CleanExiHS_RAB7B.
ExpressionAtlasiQ96AH8. baseline and differential.
GenevisibleiQ96AH8. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB7B_HUMAN
AccessioniPrimary (citable) accession number: Q96AH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.