Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-7b

Gene

RAB7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTPBy similarity
Nucleotide bindingi34 – 407GTPBy similarity
Nucleotide bindingi63 – 675GTPBy similarity
Nucleotide bindingi124 – 1274GTPBy similarity
Nucleotide bindingi154 – 1552GTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • late endosome to Golgi transport Source: UniProtKB
  • negative regulation of toll-like receptor 4 signaling pathway Source: UniProtKB
  • negative regulation of toll-like receptor 9 signaling pathway Source: UniProtKB
  • positive regulation of interleukin-6 production Source: UniProtKB
  • positive regulation of megakaryocyte differentiation Source: UniProtKB
  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-7b
Gene namesi
Name:RAB7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30513. RAB7B.

Subcellular locationi

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • late endosome Source: UniProtKB
  • lysosome Source: UniProtKB
  • phagocytic vesicle Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134940117.

Polymorphism and mutation databases

DMDMi50401122.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Ras-related protein Rab-7bPRO_0000121125Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei186 – 1861PhosphoserineBy similarity
Lipidationi198 – 1981S-geranylgeranyl cysteineBy similarity
Lipidationi199 – 1991S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ96AH8.
PRIDEiQ96AH8.
TopDownProteomicsiQ96AH8.

PTM databases

PhosphoSiteiQ96AH8.

Expressioni

Tissue specificityi

Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.1 Publication

Gene expression databases

CleanExiHS_RAB7B.
ExpressionAtlasiQ96AH8. baseline and differential.
GenevisibleiQ96AH8. HS.

Interactioni

Protein-protein interaction databases

BioGridi130725. 9 interactions.
IntActiQ96AH8. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96AH8.
SMRiQ96AH8. Positions 6-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119125.
HOVERGENiHBG009351.
InParanoidiQ96AH8.
KOiK07898.
OMAiYEEYQTT.
PhylomeDBiQ96AH8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96AH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPRKKVDLK LIIVGAIGVG KTSLLHQYVH KTFYEEYQTT LGASILSKII
60 70 80 90 100
ILGDTTLKLQ IWDTGGQERF RSMVSTFYKG SDGCILAFDV TDLESFEALD
110 120 130 140 150
IWRGDVLAKI VPMEQSYPMV LLGNKIDLAD RKVPQEVAQG WCREKDIPYF
160 170 180 190
EVSAKNDINV VQAFEMLASR ALSRYQSILE NHLTESIKLS PDQSRSRCC
Length:199
Mass (Da):22,511
Last modified:December 1, 2001 - v1
Checksum:i161C41ABC0EBA529
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY094596 mRNA. Translation: AAM22519.1.
BC017092 mRNA. Translation: AAH17092.1.
CCDSiCCDS73011.1.
RefSeqiNP_001157994.1. NM_001164522.2.
NP_796377.3. NM_177403.5.
UniGeneiHs.534612.

Genome annotation databases

EnsembliENST00000617070; ENSP00000482499; ENSG00000276600.
ENST00000617991; ENSP00000479762; ENSG00000276600.
ENST00000623597; ENSP00000485468; ENSG00000276600.
GeneIDi338382.
KEGGihsa:338382.
UCSCiuc031vlc.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY094596 mRNA. Translation: AAM22519.1.
BC017092 mRNA. Translation: AAH17092.1.
CCDSiCCDS73011.1.
RefSeqiNP_001157994.1. NM_001164522.2.
NP_796377.3. NM_177403.5.
UniGeneiHs.534612.

3D structure databases

ProteinModelPortaliQ96AH8.
SMRiQ96AH8. Positions 6-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130725. 9 interactions.
IntActiQ96AH8. 1 interaction.

PTM databases

PhosphoSiteiQ96AH8.

Polymorphism and mutation databases

DMDMi50401122.

Proteomic databases

EPDiQ96AH8.
PRIDEiQ96AH8.
TopDownProteomicsiQ96AH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000617070; ENSP00000482499; ENSG00000276600.
ENST00000617991; ENSP00000479762; ENSG00000276600.
ENST00000623597; ENSP00000485468; ENSG00000276600.
GeneIDi338382.
KEGGihsa:338382.
UCSCiuc031vlc.2. human.

Organism-specific databases

CTDi338382.
GeneCardsiRAB7B.
HGNCiHGNC:30513. RAB7B.
neXtProtiNX_Q96AH8.
PharmGKBiPA134940117.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119125.
HOVERGENiHBG009351.
InParanoidiQ96AH8.
KOiK07898.
OMAiYEEYQTT.
PhylomeDBiQ96AH8.

Miscellaneous databases

GeneWikiiRAB7B.
GenomeRNAii338382.
NextBioi96961.
PROiQ96AH8.

Gene expression databases

CleanExiHS_RAB7B.
ExpressionAtlasiQ96AH8. baseline and differential.
GenevisibleiQ96AH8. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells."
    Yang M., Chen T., Han C., Li N., Wan T., Cao X.
    Biochem. Biophys. Res. Commun. 318:792-799(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  3. Cited for: REVIEW ON FUNCTION.
  4. "Rab7b controls trafficking from endosomes to the TGN."
    Progida C., Cogli L., Piro F., De Luca A., Bakke O., Bucci C.
    J. Cell Sci. 123:1480-1491(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  5. "Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association."
    He D., Chen T., Yang M., Zhu X., Wang C., Cao X., Cai Z.
    J. Mol. Med. 89:137-150(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes."
    Seto S., Tsujimura K., Koide Y.
    Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRAB7B_HUMAN
AccessioniPrimary (citable) accession number: Q96AH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.