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Protein

Leucine-rich repeat-containing protein 59

Gene

LRRC59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 59
Alternative name(s):
Ribosome-binding protein p34
Short name:
p34
Gene namesi
Name:LRRC59
ORF Names:PRO1855
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28817. LRRC59.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 244244CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence AnalysisAdd
BLAST
Topological domaini266 – 30742LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: HPA
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • mitochondrial nucleoid Source: BHF-UCL
  • nuclear envelope Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671518.

Polymorphism and mutation databases

BioMutaiLRRC59.
DMDMi74760704.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Leucine-rich repeat-containing protein 59PRO_0000235159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei23 – 231Phosphoserine2 Publications
Modified residuei25 – 251Phosphoserine1 Publication
Modified residuei73 – 731N6-succinyllysineBy similarity
Modified residuei135 – 1351N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96AG4.
PaxDbiQ96AG4.
PeptideAtlasiQ96AG4.
PRIDEiQ96AG4.

PTM databases

PhosphoSiteiQ96AG4.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ96AG4.
CleanExiHS_LRRC59.
ExpressionAtlasiQ96AG4. baseline and differential.
GenevisibleiQ96AG4. HS.

Organism-specific databases

HPAiHPA030827.
HPA030829.

Interactioni

Subunit structurei

Can form homodimers. Interacts with SGOL1. Interacts with FGF1.2 Publications

Protein-protein interaction databases

BioGridi120649. 26 interactions.
IntActiQ96AG4. 16 interactions.
MINTiMINT-5003397.
STRINGi9606.ENSP00000225972.

Structurei

3D structure databases

ProteinModelPortaliQ96AG4.
SMRiQ96AG4. Positions 3-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati10 – 3122LRR 1Add
BLAST
Repeati40 – 6223LRR 2Add
BLAST
Repeati63 – 8422LRR 3Add
BLAST
Repeati86 – 10722LRR 4Add
BLAST
Repeati109 – 12820LRR 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili148 – 21669Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi248 – 2569Poly-Leu

Sequence similaritiesi

Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00390000017385.
HOGENOMiHOG000110564.
HOVERGENiHBG081933.
InParanoidiQ96AG4.
OMAiDILQWVL.
PhylomeDBiQ96AG4.
TreeFamiTF316929.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96AG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKAGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATILDLSCNK
60 70 80 90 100
LTTLPSDFCG LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNKLVTL
110 120 130 140 150
PVSFAQLKNL KWLDLKDNPL DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA
160 170 180 190 200
VQADQERERQ RRLEVEREAE KKREAKQRAK EAQERELRKR EKAEEKERRR
210 220 230 240 250
KEYDALKAAK REQEKKPKKE ANQAPKSKSG SRPRKPPPRK HTRSWAVLKL
260 270 280 290 300
LLLLLLFGVA GGLVACRVTE LQQQPLCTSV NTIYDNAVQG LRRHEILQWV

LQTDSQQ
Length:307
Mass (Da):34,930
Last modified:December 1, 2001 - v1
Checksum:iE39C33C72C60448D
GO

Sequence cautioni

The sequence AAF69611.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG38180.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471109 Genomic DNA. Translation: EAW94615.1.
CH471109 Genomic DNA. Translation: EAW94616.1.
BC017168 mRNA. Translation: AAH17168.1.
BC052279 mRNA. Translation: AAH52279.1.
AK316593 mRNA. Translation: BAG38180.1. Different initiation.
AF119857 mRNA. Translation: AAF69611.1. Different initiation.
CCDSiCCDS11566.1.
RefSeqiNP_060979.2. NM_018509.3.
UniGeneiHs.370927.

Genome annotation databases

EnsembliENST00000225972; ENSP00000225972; ENSG00000108829.
GeneIDi55379.
KEGGihsa:55379.
UCSCiuc002iqt.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471109 Genomic DNA. Translation: EAW94615.1.
CH471109 Genomic DNA. Translation: EAW94616.1.
BC017168 mRNA. Translation: AAH17168.1.
BC052279 mRNA. Translation: AAH52279.1.
AK316593 mRNA. Translation: BAG38180.1. Different initiation.
AF119857 mRNA. Translation: AAF69611.1. Different initiation.
CCDSiCCDS11566.1.
RefSeqiNP_060979.2. NM_018509.3.
UniGeneiHs.370927.

3D structure databases

ProteinModelPortaliQ96AG4.
SMRiQ96AG4. Positions 3-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120649. 26 interactions.
IntActiQ96AG4. 16 interactions.
MINTiMINT-5003397.
STRINGi9606.ENSP00000225972.

Chemistry

ChEMBLiCHEMBL2216743.

PTM databases

PhosphoSiteiQ96AG4.

Polymorphism and mutation databases

BioMutaiLRRC59.
DMDMi74760704.

Proteomic databases

MaxQBiQ96AG4.
PaxDbiQ96AG4.
PeptideAtlasiQ96AG4.
PRIDEiQ96AG4.

Protocols and materials databases

DNASUi55379.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225972; ENSP00000225972; ENSG00000108829.
GeneIDi55379.
KEGGihsa:55379.
UCSCiuc002iqt.3. human.

Organism-specific databases

CTDi55379.
GeneCardsiGC17M048458.
H-InvDBHIX0013977.
HGNCiHGNC:28817. LRRC59.
HPAiHPA030827.
HPA030829.
MIMi614854. gene.
neXtProtiNX_Q96AG4.
PharmGKBiPA142671518.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00390000017385.
HOGENOMiHOG000110564.
HOVERGENiHBG081933.
InParanoidiQ96AG4.
OMAiDILQWVL.
PhylomeDBiQ96AG4.
TreeFamiTF316929.

Miscellaneous databases

ChiTaRSiLRRC59. human.
GenomeRNAii55379.
NextBioi35468347.
PROiQ96AG4.
SOURCEiSearch...

Gene expression databases

BgeeiQ96AG4.
CleanExiHS_LRRC59.
ExpressionAtlasiQ96AG4. baseline and differential.
GenevisibleiQ96AG4. HS.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Uterus.
  3. "Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor."
    Skjerpen C.S., Wesche J., Olsnes S.
    J. Biol. Chem. 277:23864-23871(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 72-83, HOMODIMERIZATION, INTERACTION WITH FGF1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-307.
    Tissue: Mammary tumor.
  5. "Functional prediction of the coding sequences of 79 new genes deduced by analysis of cDNA clones from human fetal liver."
    Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-307.
    Tissue: Fetal liver.
  6. "Shugoshin collaborates with protein phosphatase 2A to protect cohesin."
    Kitajima T.S., Sakuno T., Ishiguro K., Iemura S., Natsume T., Kawashima S.A., Watanabe Y.
    Nature 441:46-52(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SGOL1.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1."
    Zhen Y., Sorensen V., Skjerpen C.S., Haugsten E.M., Jin Y., Walchli S., Olsnes S., Wiedlocha A.
    Traffic 13:650-664(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiLRC59_HUMAN
AccessioniPrimary (citable) accession number: Q96AG4
Secondary accession number(s): B2RE83, D3DTX8, Q9P189
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.