Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96AG4

- LRC59_HUMAN

UniProt

Q96AG4 - LRC59_HUMAN

Protein

Leucine-rich repeat-containing protein 59

Gene

LRRC59

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.1 Publication

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeat-containing protein 59
    Alternative name(s):
    Ribosome-binding protein p34
    Short name:
    p34
    Gene namesi
    Name:LRRC59
    ORF Names:PRO1855
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:28817. LRRC59.

    Subcellular locationi

    Microsome membrane By similarity; Single-pass type II membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope
    Note: Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: HPA
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: UniProtKB
    5. mitochondrial nucleoid Source: BHF-UCL
    6. nuclear envelope Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671518.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Leucine-rich repeat-containing protein 59PRO_0000235159Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei23 – 231Phosphoserine1 Publication
    Modified residuei25 – 251Phosphoserine1 Publication
    Modified residuei73 – 731N6-succinyllysineBy similarity
    Modified residuei135 – 1351N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ96AG4.
    PaxDbiQ96AG4.
    PeptideAtlasiQ96AG4.
    PRIDEiQ96AG4.

    PTM databases

    PhosphoSiteiQ96AG4.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ96AG4.
    BgeeiQ96AG4.
    CleanExiHS_LRRC59.
    GenevestigatoriQ96AG4.

    Organism-specific databases

    HPAiHPA030827.
    HPA030829.

    Interactioni

    Subunit structurei

    Can form homodimers. Interacts with SGOL1. Interacts with FGF1.2 Publications

    Protein-protein interaction databases

    BioGridi120649. 17 interactions.
    IntActiQ96AG4. 13 interactions.
    MINTiMINT-5003397.
    STRINGi9606.ENSP00000225972.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96AG4.
    SMRiQ96AG4. Positions 3-123.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 244244CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini266 – 30742LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei245 – 26521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati10 – 3122LRR 1Add
    BLAST
    Repeati40 – 6223LRR 2Add
    BLAST
    Repeati63 – 8422LRR 3Add
    BLAST
    Repeati86 – 10722LRR 4Add
    BLAST
    Repeati109 – 12820LRR 5Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili148 – 21669Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi248 – 2569Poly-Leu

    Sequence similaritiesi

    Contains 5 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Coiled coil, Leucine-rich repeat, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000110564.
    HOVERGENiHBG081933.
    InParanoidiQ96AG4.
    OMAiDILQWVL.
    PhylomeDBiQ96AG4.
    TreeFamiTF316929.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    [Graphical view]
    PfamiPF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96AG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKAGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATILDLSCNK    50
    LTTLPSDFCG LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNKLVTL 100
    PVSFAQLKNL KWLDLKDNPL DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA 150
    VQADQERERQ RRLEVEREAE KKREAKQRAK EAQERELRKR EKAEEKERRR 200
    KEYDALKAAK REQEKKPKKE ANQAPKSKSG SRPRKPPPRK HTRSWAVLKL 250
    LLLLLLFGVA GGLVACRVTE LQQQPLCTSV NTIYDNAVQG LRRHEILQWV 300
    LQTDSQQ 307
    Length:307
    Mass (Da):34,930
    Last modified:December 1, 2001 - v1
    Checksum:iE39C33C72C60448D
    GO

    Sequence cautioni

    The sequence AAF69611.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG38180.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471109 Genomic DNA. Translation: EAW94615.1.
    CH471109 Genomic DNA. Translation: EAW94616.1.
    BC017168 mRNA. Translation: AAH17168.1.
    BC052279 mRNA. Translation: AAH52279.1.
    AK316593 mRNA. Translation: BAG38180.1. Different initiation.
    AF119857 mRNA. Translation: AAF69611.1. Different initiation.
    CCDSiCCDS11566.1.
    RefSeqiNP_060979.2. NM_018509.3.
    UniGeneiHs.370927.

    Genome annotation databases

    EnsembliENST00000225972; ENSP00000225972; ENSG00000108829.
    GeneIDi55379.
    KEGGihsa:55379.
    UCSCiuc002iqt.3. human.

    Polymorphism databases

    DMDMi74760704.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471109 Genomic DNA. Translation: EAW94615.1 .
    CH471109 Genomic DNA. Translation: EAW94616.1 .
    BC017168 mRNA. Translation: AAH17168.1 .
    BC052279 mRNA. Translation: AAH52279.1 .
    AK316593 mRNA. Translation: BAG38180.1 . Different initiation.
    AF119857 mRNA. Translation: AAF69611.1 . Different initiation.
    CCDSi CCDS11566.1.
    RefSeqi NP_060979.2. NM_018509.3.
    UniGenei Hs.370927.

    3D structure databases

    ProteinModelPortali Q96AG4.
    SMRi Q96AG4. Positions 3-123.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120649. 17 interactions.
    IntActi Q96AG4. 13 interactions.
    MINTi MINT-5003397.
    STRINGi 9606.ENSP00000225972.

    Chemistry

    ChEMBLi CHEMBL2216743.

    PTM databases

    PhosphoSitei Q96AG4.

    Polymorphism databases

    DMDMi 74760704.

    Proteomic databases

    MaxQBi Q96AG4.
    PaxDbi Q96AG4.
    PeptideAtlasi Q96AG4.
    PRIDEi Q96AG4.

    Protocols and materials databases

    DNASUi 55379.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225972 ; ENSP00000225972 ; ENSG00000108829 .
    GeneIDi 55379.
    KEGGi hsa:55379.
    UCSCi uc002iqt.3. human.

    Organism-specific databases

    CTDi 55379.
    GeneCardsi GC17M048458.
    H-InvDB HIX0013977.
    HGNCi HGNC:28817. LRRC59.
    HPAi HPA030827.
    HPA030829.
    MIMi 614854. gene.
    neXtProti NX_Q96AG4.
    PharmGKBi PA142671518.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000110564.
    HOVERGENi HBG081933.
    InParanoidi Q96AG4.
    OMAi DILQWVL.
    PhylomeDBi Q96AG4.
    TreeFami TF316929.

    Miscellaneous databases

    ChiTaRSi LRRC59. human.
    GenomeRNAii 55379.
    NextBioi 35468347.
    PROi Q96AG4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96AG4.
    Bgeei Q96AG4.
    CleanExi HS_LRRC59.
    Genevestigatori Q96AG4.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    [Graphical view ]
    Pfami PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Uterus.
    3. "Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor."
      Skjerpen C.S., Wesche J., Olsnes S.
      J. Biol. Chem. 277:23864-23871(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 72-83, HOMODIMERIZATION, INTERACTION WITH FGF1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-307.
      Tissue: Mammary tumor.
    5. "Functional prediction of the coding sequences of 79 new genes deduced by analysis of cDNA clones from human fetal liver."
      Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-307.
      Tissue: Fetal liver.
    6. "Shugoshin collaborates with protein phosphatase 2A to protect cohesin."
      Kitajima T.S., Sakuno T., Ishiguro K., Iemura S., Natsume T., Kawashima S.A., Watanabe Y.
      Nature 441:46-52(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SGOL1.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1."
      Zhen Y., Sorensen V., Skjerpen C.S., Haugsten E.M., Jin Y., Walchli S., Olsnes S., Wiedlocha A.
      Traffic 13:650-664(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.

    Entry informationi

    Entry nameiLRC59_HUMAN
    AccessioniPrimary (citable) accession number: Q96AG4
    Secondary accession number(s): B2RE83, D3DTX8, Q9P189
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3