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Q96AG4 (LRC59_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeat-containing protein 59
Alternative name(s):
Ribosome-binding protein p34
Short name=p34
Gene names
Name:LRRC59
ORF Names:PRO1855
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. Ref.10

Subunit structure

Can form homodimers. Interacts with SGOL1. Interacts with FGF1. Ref.3 Ref.6

Subcellular location

Microsome membrane; Single-pass type II membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note: Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1. Ref.3 Ref.10

Tissue specificity

Widely expressed. Ref.3

Sequence similarities

Contains 5 LRR (leucine-rich) repeats.

Sequence caution

The sequence AAF69611.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAG38180.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Leucine-rich repeat-containing protein 59
PRO_0000235159

Regions

Topological domain1 – 244244Cytoplasmic Potential
Transmembrane245 – 26521Helical; Potential
Topological domain266 – 30742Lumenal Potential
Repeat10 – 3122LRR 1
Repeat40 – 6223LRR 2
Repeat63 – 8422LRR 3
Repeat86 – 10722LRR 4
Repeat109 – 12820LRR 5
Coiled coil148 – 21669 Potential
Compositional bias248 – 2569Poly-Leu

Amino acid modifications

Modified residue11N-acetylmethionine Ref.9
Modified residue231Phosphoserine Ref.7
Modified residue251Phosphoserine Ref.7
Modified residue731N6-succinyllysine By similarity
Modified residue1351N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q96AG4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: E39C33C72C60448D

FASTA30734,930
        10         20         30         40         50         60 
MTKAGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATILDLSCNK LTTLPSDFCG 

        70         80         90        100        110        120 
LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNKLVTL PVSFAQLKNL KWLDLKDNPL 

       130        140        150        160        170        180 
DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA VQADQERERQ RRLEVEREAE KKREAKQRAK 

       190        200        210        220        230        240 
EAQERELRKR EKAEEKERRR KEYDALKAAK REQEKKPKKE ANQAPKSKSG SRPRKPPPRK 

       250        260        270        280        290        300 
HTRSWAVLKL LLLLLLFGVA GGLVACRVTE LQQQPLCTSV NTIYDNAVQG LRRHEILQWV 


LQTDSQQ 

« Hide

References

« Hide 'large scale' references
[1]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Uterus.
[3]"Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor."
Skjerpen C.S., Wesche J., Olsnes S.
J. Biol. Chem. 277:23864-23871(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 72-83, HOMODIMERIZATION, INTERACTION WITH FGF1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-307.
Tissue: Mammary tumor.
[5]"Functional prediction of the coding sequences of 79 new genes deduced by analysis of cDNA clones from human fetal liver."
Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-307.
Tissue: Fetal liver.
[6]"Shugoshin collaborates with protein phosphatase 2A to protect cohesin."
Kitajima T.S., Sakuno T., Ishiguro K., Iemura S., Natsume T., Kawashima S.A., Watanabe Y.
Nature 441:46-52(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SGOL1.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1."
Zhen Y., Sorensen V., Skjerpen C.S., Haugsten E.M., Jin Y., Walchli S., Olsnes S., Wiedlocha A.
Traffic 13:650-664(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH471109 Genomic DNA. Translation: EAW94615.1.
CH471109 Genomic DNA. Translation: EAW94616.1.
BC017168 mRNA. Translation: AAH17168.1.
BC052279 mRNA. Translation: AAH52279.1.
AK316593 mRNA. Translation: BAG38180.1. Different initiation.
AF119857 mRNA. Translation: AAF69611.1. Different initiation.
RefSeqNP_060979.2. NM_018509.3.
UniGeneHs.370927.

3D structure databases

ProteinModelPortalQ96AG4.
SMRQ96AG4. Positions 3-123.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120649. 19 interactions.
IntActQ96AG4. 13 interactions.
MINTMINT-5003397.
STRING9606.ENSP00000225972.

Chemistry

ChEMBLCHEMBL2216743.

PTM databases

PhosphoSiteQ96AG4.

Polymorphism databases

DMDM74760704.

Proteomic databases

PaxDbQ96AG4.
PeptideAtlasQ96AG4.
PRIDEQ96AG4.

Protocols and materials databases

DNASU55379.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000225972; ENSP00000225972; ENSG00000108829.
GeneID55379.
KEGGhsa:55379.
UCSCuc002iqt.3. human.

Organism-specific databases

CTD55379.
GeneCardsGC17M048458.
H-InvDBHIX0013977.
HGNCHGNC:28817. LRRC59.
HPAHPA030827.
HPA030829.
MIM614854. gene.
neXtProtNX_Q96AG4.
PharmGKBPA142671518.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000110564.
HOVERGENHBG081933.
InParanoidQ96AG4.
OMADILQWVL.
PhylomeDBQ96AG4.
TreeFamTF316929.

Gene expression databases

ArrayExpressQ96AG4.
BgeeQ96AG4.
CleanExHS_LRRC59.
GenevestigatorQ96AG4.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
[Graphical view]
PfamPF00560. LRR_1. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLRRC59. human.
GenomeRNAi55379.
NextBio35468347.
PROQ96AG4.
SOURCESearch...

Entry information

Entry nameLRC59_HUMAN
AccessionPrimary (citable) accession number: Q96AG4
Secondary accession number(s): B2RE83, D3DTX8, Q9P189
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: March 19, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM