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Protein

Leucine-rich repeat-containing protein 59

Gene

LRRC59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 59
Alternative name(s):
Ribosome-binding protein p34
Short name:
p34
Gene namesi
Name:LRRC59
ORF Names:PRO1855
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28817. LRRC59.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 244CytoplasmicSequence analysisAdd BLAST244
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 307LumenalSequence analysisAdd BLAST42

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • endoplasmic reticulum Source: HPA
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • mitochondrial nucleoid Source: BHF-UCL
  • nuclear envelope Source: UniProtKB-SubCell
  • organelle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55379.
OpenTargetsiENSG00000108829.
PharmGKBiPA142671518.

Chemistry databases

ChEMBLiCHEMBL2216743.

Polymorphism and mutation databases

BioMutaiLRRC59.
DMDMi74760704.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002351591 – 307Leucine-rich repeat-containing protein 59Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei73N6-succinyllysineBy similarity1
Modified residuei135N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96AG4.
MaxQBiQ96AG4.
PaxDbiQ96AG4.
PeptideAtlasiQ96AG4.
PRIDEiQ96AG4.
TopDownProteomicsiQ96AG4.

PTM databases

iPTMnetiQ96AG4.
PhosphoSitePlusiQ96AG4.
SwissPalmiQ96AG4.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000108829.
CleanExiHS_LRRC59.
ExpressionAtlasiQ96AG4. baseline and differential.
GenevisibleiQ96AG4. HS.

Organism-specific databases

HPAiHPA030827.
HPA030829.

Interactioni

Subunit structurei

Can form homodimers. Interacts with SGO1. Interacts with FGF1.2 Publications

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi120649. 40 interactors.
IntActiQ96AG4. 30 interactors.
MINTiMINT-5003397.
STRINGi9606.ENSP00000225972.

Structurei

3D structure databases

ProteinModelPortaliQ96AG4.
SMRiQ96AG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 31LRR 1Add BLAST22
Repeati40 – 62LRR 2Add BLAST23
Repeati63 – 84LRR 3Add BLAST22
Repeati86 – 107LRR 4Add BLAST22
Repeati109 – 128LRR 5Add BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili148 – 216Sequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi248 – 256Poly-Leu9

Sequence similaritiesi

Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0473. Eukaryota.
ENOG4111GH4. LUCA.
GeneTreeiENSGT00390000017385.
HOGENOMiHOG000110564.
HOVERGENiHBG081933.
InParanoidiQ96AG4.
OMAiDILQWVL.
OrthoDBiEOG091G0EHN.
PhylomeDBiQ96AG4.
TreeFamiTF316929.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96AG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKAGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATILDLSCNK
60 70 80 90 100
LTTLPSDFCG LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNKLVTL
110 120 130 140 150
PVSFAQLKNL KWLDLKDNPL DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA
160 170 180 190 200
VQADQERERQ RRLEVEREAE KKREAKQRAK EAQERELRKR EKAEEKERRR
210 220 230 240 250
KEYDALKAAK REQEKKPKKE ANQAPKSKSG SRPRKPPPRK HTRSWAVLKL
260 270 280 290 300
LLLLLLFGVA GGLVACRVTE LQQQPLCTSV NTIYDNAVQG LRRHEILQWV

LQTDSQQ
Length:307
Mass (Da):34,930
Last modified:December 1, 2001 - v1
Checksum:iE39C33C72C60448D
GO

Sequence cautioni

The sequence AAF69611 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG38180 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471109 Genomic DNA. Translation: EAW94615.1.
CH471109 Genomic DNA. Translation: EAW94616.1.
BC017168 mRNA. Translation: AAH17168.1.
BC052279 mRNA. Translation: AAH52279.1.
AK316593 mRNA. Translation: BAG38180.1. Different initiation.
AF119857 mRNA. Translation: AAF69611.1. Different initiation.
CCDSiCCDS11566.1.
RefSeqiNP_060979.2. NM_018509.3.
UniGeneiHs.370927.

Genome annotation databases

EnsembliENST00000225972; ENSP00000225972; ENSG00000108829.
GeneIDi55379.
KEGGihsa:55379.
UCSCiuc002iqt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471109 Genomic DNA. Translation: EAW94615.1.
CH471109 Genomic DNA. Translation: EAW94616.1.
BC017168 mRNA. Translation: AAH17168.1.
BC052279 mRNA. Translation: AAH52279.1.
AK316593 mRNA. Translation: BAG38180.1. Different initiation.
AF119857 mRNA. Translation: AAF69611.1. Different initiation.
CCDSiCCDS11566.1.
RefSeqiNP_060979.2. NM_018509.3.
UniGeneiHs.370927.

3D structure databases

ProteinModelPortaliQ96AG4.
SMRiQ96AG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120649. 40 interactors.
IntActiQ96AG4. 30 interactors.
MINTiMINT-5003397.
STRINGi9606.ENSP00000225972.

Chemistry databases

ChEMBLiCHEMBL2216743.

PTM databases

iPTMnetiQ96AG4.
PhosphoSitePlusiQ96AG4.
SwissPalmiQ96AG4.

Polymorphism and mutation databases

BioMutaiLRRC59.
DMDMi74760704.

Proteomic databases

EPDiQ96AG4.
MaxQBiQ96AG4.
PaxDbiQ96AG4.
PeptideAtlasiQ96AG4.
PRIDEiQ96AG4.
TopDownProteomicsiQ96AG4.

Protocols and materials databases

DNASUi55379.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225972; ENSP00000225972; ENSG00000108829.
GeneIDi55379.
KEGGihsa:55379.
UCSCiuc002iqt.4. human.

Organism-specific databases

CTDi55379.
DisGeNETi55379.
GeneCardsiLRRC59.
H-InvDBHIX0013977.
HGNCiHGNC:28817. LRRC59.
HPAiHPA030827.
HPA030829.
MIMi614854. gene.
neXtProtiNX_Q96AG4.
OpenTargetsiENSG00000108829.
PharmGKBiPA142671518.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0473. Eukaryota.
ENOG4111GH4. LUCA.
GeneTreeiENSGT00390000017385.
HOGENOMiHOG000110564.
HOVERGENiHBG081933.
InParanoidiQ96AG4.
OMAiDILQWVL.
OrthoDBiEOG091G0EHN.
PhylomeDBiQ96AG4.
TreeFamiTF316929.

Miscellaneous databases

ChiTaRSiLRRC59. human.
GenomeRNAii55379.
PROiQ96AG4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108829.
CleanExiHS_LRRC59.
ExpressionAtlasiQ96AG4. baseline and differential.
GenevisibleiQ96AG4. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC59_HUMAN
AccessioniPrimary (citable) accession number: Q96AG4
Secondary accession number(s): B2RE83, D3DTX8, Q9P189
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.