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Protein
Submitted name:

ZNF446 protein

Gene

ZNF446

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
ZNF446 proteinImported
Gene namesi
Name:ZNF446Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ96AF5.
PeptideAtlasiQ96AF5.

Interactioni

Protein-protein interaction databases

IntActiQ96AF5. 22 interactions.
STRINGi9606.ENSP00000472802.

Structurei

3D structure databases

ProteinModelPortaliQ96AF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 10782SCAN boxInterPro annotationAdd
BLAST
Domaini332 – 35928C2H2-typeInterPro annotationAdd
BLAST
Domaini395 – 42228C2H2-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains SCAN box domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOVERGENiHBG098310.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 2 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR027768. Zfp446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PTHR10032:SF73. PTHR10032:SF73. 2 hits.
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96AF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPLGPPCL PVMDPETTLE EPETARLRFR GFCYQEVAGP REALARLREL
60 70 80 90 100
CCQWLQPEAH SKEQMLEMLV LEQFLGTLPP EIQAWVRGQR PGSPEEAAAL
110 120 130 140 150
VEGLQHDPGQ LLGWITAHVL KQEVLPAAQK TEEPLGSPHP SGTVESPGEG
160 170 180 190 200
PQDTRIEGSV QLSCSVKEEP NVDGQEVAPS SPPLAAQSPE GHHGHQEPAS
210 220 230 240 250
TSFHPPRIQE EWGLLDRSQK ELYWDAMLEK YGTVVSLGLP PHQPEAQAQS
260 270 280 290 300
ELGMLLTGTG VCRSLRSGNE SEGPPGCPEA QPPQGPGPAA WEGLSGAATP
310 320 330 340 350
APTVRPGTPP VPTQPTPAET RLEPAATPRK PYTCEQCGRG FDWKSVFVIH
360 370 380 390 400
HRTHTSGPGV QSPGLATGES TEKPPQGEVA FPHHPRHSLT GPRSYPCEEC
410 420
GCSFSWKSQL VIHRKSHRPE VP
Length:422
Mass (Da):45,652
Last modified:December 1, 2001 - v1
Checksum:iB95B032F3C6A1AD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC017206 mRNA. Translation: AAH17206.1.
UniGeneiHs.710284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC017206 mRNA. Translation: AAH17206.1.
UniGeneiHs.710284.

3D structure databases

ProteinModelPortaliQ96AF5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96AF5. 22 interactions.
STRINGi9606.ENSP00000472802.

Proteomic databases

PaxDbiQ96AF5.
PeptideAtlasiQ96AF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOVERGENiHBG098310.

Miscellaneous databases

ChiTaRSiZNF446. human.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 2 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR027768. Zfp446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PTHR10032:SF73. PTHR10032:SF73. 2 hits.
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ96AF5_HUMAN
AccessioniPrimary (citable) accession number: Q96AF5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.