Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96AD5

- PLPL2_HUMAN

UniProt

Q96AD5 - PLPL2_HUMAN

Protein

Patatin-like phospholipase domain-containing protein 2

Gene

PNPLA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.3 Publications

    Catalytic activityi

    Triacylglycerol + H2O = diacylglycerol + a carboxylate.

    Enzyme regulationi

    Inhibited by BEL ((E)-6-(bromomethylene)-3-(1-naphthalenyl)-2H-tetrahydropyran-2-one), a suicide substrate inhibitor. No differences in enzymatic activity that uses (1,2-dilinoleoyl)-phosphatidylcholine as substrate was detected in the presence or absence of ATP. Activated by ABHD5 and SERPINF1.2 Publications

    pH dependencei

    Optimum pH is 7.5 with (1,2-dilinoleoyl)-phosphatidylcholine as substrate.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei47 – 471

    GO - Molecular functioni

    1. triglyceride lipase activity Source: UniProtKB

    GO - Biological processi

    1. acylglycerol acyl-chain remodeling Source: Reactome
    2. glycerophospholipid biosynthetic process Source: Reactome
    3. negative regulation of sequestering of triglyceride Source: UniProtKB
    4. phospholipid metabolic process Source: Reactome
    5. positive regulation of triglyceride catabolic process Source: UniProtKB
    6. small molecule metabolic process Source: Reactome
    7. triglyceride catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_121122. Acyl chain remodeling of DAG and TAG.
    UniPathwayiUPA00256.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Patatin-like phospholipase domain-containing protein 2 (EC:3.1.1.3)
    Alternative name(s):
    Adipose triglyceride lipase
    Calcium-independent phospholipase A2
    Desnutrin
    IPLA2-zeta
    Pigment epithelium-derived factor
    TTS2.2
    Transport-secretion protein 2
    Short name:
    TTS2
    Gene namesi
    Name:PNPLA2
    Synonyms:ATGL
    ORF Names:FP17548
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:30802. PNPLA2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. endoplasmic reticulum membrane Source: Reactome
    3. integral component of membrane Source: UniProtKB-KW
    4. intracellular membrane-bounded organelle Source: HPA
    5. lipid particle Source: UniProtKB
    6. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Lipid droplet, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Genetic variations in PNPLA2 may be associated with risk of diabetes mellitus type 2.
    Neutral lipid storage disease with myopathy (NLSDM) [MIM:610717]: Neutral lipid storage disorder (NLSD) with myopathy but without ichthyosis. NLSDs are characterized by the presence of triglyceride-containing cytoplasmic droplets in leukocytes and in other tissues, including bone marrow, skin, and muscle. Individuals with NLSDM did not show obesity, in spite of a defect in triglyceride degradation in fibroblasts and in marked triglyceride storage in liver, muscles, and other visceral cells.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti195 – 1951P → L in NLSDM. 1 Publication
    VAR_032995

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi47 – 471S → A: Reduces rate of lipid hydrolysis; does not affect the localization around the rim of the adiposomes. 2 Publications

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi610717. phenotype.
    Orphaneti98908. Neutral lipid storage myopathy.
    PharmGKBiPA134903083.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Patatin-like phospholipase domain-containing protein 2PRO_0000292527Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Modified residuei372 – 3721Phosphoserine; in vitroBy similarity
    Modified residuei404 – 4041Phosphoserine; by PKA1 Publication
    Modified residuei428 – 4281Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation at Ser-404 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity By similarity. Phosphorylation at Ser-404 is increased upon beta-adrenergic stimulation.By similarity2 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ96AD5.
    PaxDbiQ96AD5.
    PRIDEiQ96AD5.

    PTM databases

    PhosphoSiteiQ96AD5.

    Expressioni

    Tissue specificityi

    Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level).4 Publications

    Developmental stagei

    Induced during differentiation of primary preadipocytes to adipocytes. Expression increased from fetal to adult in retinal pigment epithelium.3 Publications

    Gene expression databases

    BgeeiQ96AD5.
    CleanExiHS_PNPLA2.
    GenevestigatoriQ96AD5.

    Organism-specific databases

    HPAiHPA055173.

    Interactioni

    Subunit structurei

    Interacts with ABHD5; this association stimulates PNPLA2 triglyceride hydrolase activity By similarity. Interacts with SERPINF1; interacts at one site of interaction. Despite a colocalization in lipid droplets, it probably does not interact with PLIN By similarity. Interacts with PLIN5; prevents interaction with ABHD5 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi121370. 12 interactions.
    IntActiQ96AD5. 7 interactions.
    MINTiMINT-1184430.
    STRINGi9606.ENSP00000337701.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96AD5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicSequence Analysis
    Topological domaini30 – 504475LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 179170PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi45 – 495GXSXG

    Sequence similaritiesi

    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG261571.
    HOVERGENiHBG007046.
    InParanoidiQ96AD5.
    KOiK16816.
    OMAiLVLREMC.
    OrthoDBiEOG7J9VQR.
    PhylomeDBiQ96AD5.
    TreeFamiTF314272.

    Family and domain databases

    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR002641. Patatin/PLipase_A2-rel.
    [Graphical view]
    PfamiPF01734. Patatin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96AD5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFPREKTWNI SFAGCGFLGV YYVGVASCLR EHAPFLVANA THIYGASAGA    50
    LTATALVTGV CLGEAGAKFI EVSKEARKRF LGPLHPSFNL VKIIRSFLLK 100
    VLPADSHEHA SGRLGISLTR VSDGENVIIS HFNSKDELIQ ANVCSGFIPV 150
    YCGLIPPSLQ GVRYVDGGIS DNLPLYELKN TITVSPFSGE SDICPQDSST 200
    NIHELRVTNT SIQFNLRNLY RLSKALFPPE PLVLREMCKQ GYRDGLRFLQ 250
    RNGLLNRPNP LLALPPARPH GPEDKDQAVE SAQAEDYSQL PGEDHILEHL 300
    PARLNEALLE ACVEPTDLLT TLSNMLPVRL ATAMMVPYTL PLESALSFTI 350
    RLLEWLPDVP EDIRWMKEQT GSICQYLVMR AKRKLGRHLP SRLPEQVELR 400
    RVQSLPSVPL SCAAYREALP GWMRNNLSLG DALAKWEECQ RQLLLGLFCT 450
    NVAFPPEALR MRAPADPAPA PADPASPQHQ LAGPAPLLST PAPEARPVIG 500
    ALGL 504
    Length:504
    Mass (Da):55,316
    Last modified:December 1, 2001 - v1
    Checksum:iD9C16F942AB0B3C7
    GO
    Isoform 2 (identifier: Q96AD5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-324: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:180
    Mass (Da):19,875
    Checksum:i00655EB8A70EF89A
    GO

    Sequence cautioni

    The sequence AAP34448.1 differs from that shown. Reason: Frameshift at position 501.
    The sequence CAC01131.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAC01132.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631R → G in AAC09354. 1 PublicationCurated
    Sequence conflicti296 – 2961I → V in AAW81962. (PubMed:15550674)Curated
    Sequence conflicti333 – 3331A → G in AAP34448. (PubMed:15498874)Curated
    Sequence conflicti351 – 3511R → C in AAW81962. (PubMed:15550674)Curated
    Sequence conflicti402 – 4021V → L in CAC01131. 1 PublicationCurated
    Sequence conflicti402 – 4021V → L in CAC01132. 1 PublicationCurated
    Sequence conflicti419 – 4191L → P in AAW81962. (PubMed:15550674)Curated

    Polymorphismi

    Genetic variations in PNPLA2 may be associated with plasma free fatty acids, triglycerides levels, and fasting glucose concentrations.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti195 – 1951P → L in NLSDM. 1 Publication
    VAR_032995
    Natural varianti219 – 2191L → F.1 Publication
    VAR_032996
    Natural varianti252 – 2521N → K.1 Publication
    Corresponds to variant rs140201358 [ dbSNP | Ensembl ].
    VAR_032997
    Natural varianti481 – 4811L → P.3 Publications
    Corresponds to variant rs1138693 [ dbSNP | Ensembl ].
    VAR_032998

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 324324Missing in isoform 2. 1 PublicationVSP_026421Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY894804 mRNA. Translation: AAW81962.1.
    AJ278475 mRNA. Translation: CAC01131.1. Different initiation.
    AJ278476 mRNA. Translation: CAC01132.1. Different initiation.
    AY203925 mRNA. Translation: AAP34448.1. Frameshift.
    BC011958 mRNA. Translation: AAH11958.1.
    BC017280 mRNA. Translation: AAH17280.1.
    AF055000 mRNA. Translation: AAC09354.1.
    CCDSiCCDS7718.1. [Q96AD5-1]
    RefSeqiNP_065109.1. NM_020376.3. [Q96AD5-1]
    UniGeneiHs.654697.

    Genome annotation databases

    EnsembliENST00000336615; ENSP00000337701; ENSG00000177666. [Q96AD5-1]
    GeneIDi57104.
    KEGGihsa:57104.
    UCSCiuc001lrt.3. human. [Q96AD5-1]

    Polymorphism databases

    DMDMi74731110.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY894804 mRNA. Translation: AAW81962.1 .
    AJ278475 mRNA. Translation: CAC01131.1 . Different initiation.
    AJ278476 mRNA. Translation: CAC01132.1 . Different initiation.
    AY203925 mRNA. Translation: AAP34448.1 . Frameshift.
    BC011958 mRNA. Translation: AAH11958.1 .
    BC017280 mRNA. Translation: AAH17280.1 .
    AF055000 mRNA. Translation: AAC09354.1 .
    CCDSi CCDS7718.1. [Q96AD5-1 ]
    RefSeqi NP_065109.1. NM_020376.3. [Q96AD5-1 ]
    UniGenei Hs.654697.

    3D structure databases

    ProteinModelPortali Q96AD5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121370. 12 interactions.
    IntActi Q96AD5. 7 interactions.
    MINTi MINT-1184430.
    STRINGi 9606.ENSP00000337701.

    PTM databases

    PhosphoSitei Q96AD5.

    Polymorphism databases

    DMDMi 74731110.

    Proteomic databases

    MaxQBi Q96AD5.
    PaxDbi Q96AD5.
    PRIDEi Q96AD5.

    Protocols and materials databases

    DNASUi 57104.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336615 ; ENSP00000337701 ; ENSG00000177666 . [Q96AD5-1 ]
    GeneIDi 57104.
    KEGGi hsa:57104.
    UCSCi uc001lrt.3. human. [Q96AD5-1 ]

    Organism-specific databases

    CTDi 57104.
    GeneCardsi GC11P000819.
    HGNCi HGNC:30802. PNPLA2.
    HPAi HPA055173.
    MIMi 609059. gene.
    610717. phenotype.
    neXtProti NX_Q96AD5.
    Orphaneti 98908. Neutral lipid storage myopathy.
    PharmGKBi PA134903083.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261571.
    HOVERGENi HBG007046.
    InParanoidi Q96AD5.
    KOi K16816.
    OMAi LVLREMC.
    OrthoDBi EOG7J9VQR.
    PhylomeDBi Q96AD5.
    TreeFami TF314272.

    Enzyme and pathway databases

    UniPathwayi UPA00256 .
    Reactomei REACT_121122. Acyl chain remodeling of DAG and TAG.

    Miscellaneous databases

    ChiTaRSi PNPLA2. human.
    GeneWikii PNPLA2.
    GenomeRNAii 57104.
    NextBioi 62941.
    PROi Q96AD5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96AD5.
    CleanExi HS_PNPLA2.
    Genevestigatori Q96AD5.

    Family and domain databases

    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002641. Patatin/PLipase_A2-rel.
    [Graphical view ]
    Pfami PF01734. Patatin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    2. "TTS-2, a novel protein implicated in vesicular transport of the cell surface receptor ICAM-3."
      Strahl T., Shingler W.H., Lammiman M., Gregory C.D., Leach L., Matthias P., Nielsen P.J., Shaw P.E.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-481.
    3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-481.
      Tissue: Brain and Eye.
    5. Yu W., Gibbs R.A.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-504 (ISOFORM 1).
      Tissue: Brain.
    6. "Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities."
      Jenkins C.M., Mancuso D.J., Yan W., Sims H.F., Gibson B., Gross R.W.
      J. Biol. Chem. 279:48968-48975(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ENZYME REGULATION.
    7. Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    8. "Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members."
      Lake A.C., Sun Y., Li J.-L., Kim J.E., Johnson J.W., Li D., Revett T., Shih H.H., Liu W., Paulsen J.E., Gimeno R.E.
      J. Lipid Res. 46:2477-2487(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, MUTAGENESIS OF SER-47.
    9. "The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPARgamma."
      Kim J.Y., Tillison K., Lee J.-H., Rearick D.A., Smas C.M.
      Am. J. Physiol. 291:E115-E127(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    10. "ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells."
      Smirnova E., Goldberg E.B., Makarova K.S., Lin L., Brown W.J., Jackson C.L.
      EMBO Rep. 7:106-113(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-47.
    11. Cited for: ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INTERACTION WITH SERPINF1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-428, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase."
      Pagnon J., Matzaris M., Stark R., Meex R.C., Macaulay S.L., Brown W., O'Brien P.E., Tiganis T., Watt M.J.
      Endocrinology 153:4278-4289(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-404.
    15. "The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes."
      Schoenborn V., Heid I.M., Vollmert C., Lingenhel A., Adams T.D., Hopkins P.N., Illig T., Zimmermann R., Zechner R., Hunt S.C., Kronenberg F.
      Diabetes 55:1270-1275(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PHE-219; LYS-252 AND PRO-481, POLYMORPHISM, ASSOCIATION WITH DIABETES MELLITUS TYPE 2.
    16. "The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy."
      Fischer J., Lefevre C., Morava E., Mussini J.-M., Laforet P., Negre-Salvayre A., Lathrop M., Salvayre R.
      Nat. Genet. 39:28-30(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT NLSDM LEU-195.

    Entry informationi

    Entry nameiPLPL2_HUMAN
    AccessioniPrimary (citable) accession number: Q96AD5
    Secondary accession number(s): O60643
    , Q5EFF5, Q6XYE5, Q96ET6, Q9NQ61, Q9NQ62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3