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Q96AC6 (KIFC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIFC2
Gene names
Name:KIFC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length838 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites By similarity.

Subcellular location

Cytoplasmcytoskeleton Probable.

Sequence similarities

Belongs to the kinesin-like protein family.

Contains 1 kinesin-motor domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   LigandATP-binding
Nucleotide-binding
   Molecular functionMotor protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmicrotubule-based movement

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

kinesin complex

Inferred from electronic annotation. Source: InterPro

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule motor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 838838Kinesin-like protein KIFC2
PRO_0000125429

Regions

Domain406 – 661256Kinesin-motor
Nucleotide binding484 – 4918ATP By similarity
Coiled coil186 – 351166 Potential
Compositional bias181 – 332152Gln-rich
Compositional bias720 – 831112Pro-rich

Natural variations

Natural variant671G → E.
Corresponds to variant rs35817880 [ dbSNP | Ensembl ].
VAR_049684
Natural variant1661S → F.
Corresponds to variant rs12675537 [ dbSNP | Ensembl ].
VAR_049685

Sequences

Sequence LengthMass (Da)Tools
Q96AC6 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5C692E0B67A0BE77

FASTA83890,147
        10         20         30         40         50         60 
MYAFYSLLIY IFYSLFRRDG GAAAAAEPGD PAQRARKPRG RRRPDLPAPE LWTELTGLAA 

        70         80         90        100        110        120 
SSEPEDGSEG AAEGRAAAVS LEEALLRLAE FLSVQLGAEE SCGGPADLGQ SGEVPSLLTV 

       130        140        150        160        170        180 
TSQLLALLAW LRSPRGRQAL LQGTQPAPRV RPPSPDGSTS QEESPSHFTA VPGEPLGDET 

       190        200        210        220        230        240 
QGQQPLQLEE DQRAWQRLEQ LILGQLEELK QQLEQQEEEL GRLRLGVGAT DSEKRVQHLT 

       250        260        270        280        290        300 
LENEALKQSL SLMRDLLLHW GPGPPIRAPQ EEAEALLELQ GRLQEAQDTT EALRAQLGVQ 

       310        320        330        340        350        360 
EVQLQGLQGA LQQLQQETEQ NCRRELQQMH GQLAGLRARM ASLRQGCGDL RGLVSTFTQS 

       370        380        390        400        410        420 
CQGSLSEARG QVSWALGALS SGGPGTQLPE GQQGPPAGCP GRLPELKGNI RVLCRLRPGT 

       430        440        450        460        470        480 
SSSLVSVEPG PGGTVTTCYR GRHRRFRLDW VFPPDASQEE VFRELEPAVL SCLRGYSVCI 

       490        500        510        520        530        540 
FTYGQTGTGK TYSMEGPPED PGIVPRALQS LFREMGAGRQ HRVTLSMVEI YNEAVRDLLA 

       550        560        570        580        590        600 
PGPPERLAVR QGPEGQGGIQ VAGLTHWDVP NLETLHQMLK LGRSNRATAA TAMNQRSSRS 

       610        620        630        640        650        660 
HALVTLTLRA ASPPRAPGTA GTLHLVDLAG SERARKAGAA GPPRGDPDGA RRLREAQTIN 

       670        680        690        700        710        720 
RSLLALGGVM AALRAHRPHV PFRDSQLTRL LQPALGPGTT AVLLLQVGAG AGQVCACRSP 

       730        740        750        760        770        780 
PTRARPPAPL ARRSPRGRRI SGRQSAPSSS PTEWVKWSWG QPGAAGSRAP PGRLLPSAPT 

       790        800        810        820        830 
LRSPGPPAPL RRPLAVLHAP VPTTARARLS RPQRACPSSP GSRPCPWGLR PGLCWQRR 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC017311 mRNA. Translation: AAH17311.1.
RefSeqNP_665697.1. NM_145754.2.
UniGeneHs.528713.

3D structure databases

ProteinModelPortalQ96AC6.
SMRQ96AC6. Positions 409-743.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124785. 4 interactions.
IntActQ96AC6. 7 interactions.
MINTMINT-7241349.
STRING9606.ENSP00000301332.

PTM databases

PhosphoSiteQ96AC6.

Polymorphism databases

DMDM34098674.

Proteomic databases

PaxDbQ96AC6.
PRIDEQ96AC6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301332; ENSP00000301332; ENSG00000167702.
GeneID90990.
KEGGhsa:90990.
UCSCuc003zcz.3. human.

Organism-specific databases

CTD90990.
GeneCardsGC08P145691.
HGNCHGNC:29530. KIFC2.
HPAHPA029264.
neXtProtNX_Q96AC6.
PharmGKBPA134874212.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5059.
HOGENOMHOG000113226.
HOVERGENHBG052258.
InParanoidQ96AC6.
KOK10406.
OMARELQQMH.
OrthoDBEOG7ZKS9J.
PhylomeDBQ96AC6.
TreeFamTF105238.

Gene expression databases

ArrayExpressQ96AC6.
BgeeQ96AC6.
CleanExHS_KIFC2.
GenevestigatorQ96AC6.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKIFC2. human.
GenomeRNAi90990.
NextBio77060.
PROQ96AC6.

Entry information

Entry nameKIFC2_HUMAN
AccessionPrimary (citable) accession number: Q96AC6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM