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Protein

Kinesin-like protein KIFC2

Gene

KIFC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi484 – 491ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167702-MONOMER.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIFC2
Gene namesi
Name:KIFC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:29530. KIFC2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167702.
PharmGKBiPA134874212.

Polymorphism and mutation databases

BioMutaiKIFC2.
DMDMi34098674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254291 – 838Kinesin-like protein KIFC2Add BLAST838

Proteomic databases

PaxDbiQ96AC6.
PeptideAtlasiQ96AC6.
PRIDEiQ96AC6.

PTM databases

iPTMnetiQ96AC6.
PhosphoSitePlusiQ96AC6.

Expressioni

Gene expression databases

BgeeiENSG00000167702.
CleanExiHS_KIFC2.
GenevisibleiQ96AC6. HS.

Organism-specific databases

HPAiHPA029264.

Interactioni

Protein-protein interaction databases

BioGridi124785. 4 interactors.
IntActiQ96AC6. 7 interactors.
MINTiMINT-7241349.
STRINGi9606.ENSP00000301332.

Structurei

3D structure databases

ProteinModelPortaliQ96AC6.
SMRiQ96AC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini409 – 740Kinesin motorPROSITE-ProRule annotationAdd BLAST332

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili186 – 351Sequence analysisAdd BLAST166

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 332Gln-richAdd BLAST152
Compositional biasi720 – 831Pro-richAdd BLAST112

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0239. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00550000074610.
HOGENOMiHOG000113226.
HOVERGENiHBG052258.
InParanoidiQ96AC6.
KOiK10406.
OMAiRELQQMH.
OrthoDBiEOG091G03NM.
PhylomeDBiQ96AC6.
TreeFamiTF105238.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96AC6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYAFYSLLIY IFYSLFRRDG GAAAAAEPGD PAQRARKPRG RRRPDLPAPE
60 70 80 90 100
LWTELTGLAA SSEPEDGSEG AAEGRAAAVS LEEALLRLAE FLSVQLGAEE
110 120 130 140 150
SCGGPADLGQ SGEVPSLLTV TSQLLALLAW LRSPRGRQAL LQGTQPAPRV
160 170 180 190 200
RPPSPDGSTS QEESPSHFTA VPGEPLGDET QGQQPLQLEE DQRAWQRLEQ
210 220 230 240 250
LILGQLEELK QQLEQQEEEL GRLRLGVGAT DSEKRVQHLT LENEALKQSL
260 270 280 290 300
SLMRDLLLHW GPGPPIRAPQ EEAEALLELQ GRLQEAQDTT EALRAQLGVQ
310 320 330 340 350
EVQLQGLQGA LQQLQQETEQ NCRRELQQMH GQLAGLRARM ASLRQGCGDL
360 370 380 390 400
RGLVSTFTQS CQGSLSEARG QVSWALGALS SGGPGTQLPE GQQGPPAGCP
410 420 430 440 450
GRLPELKGNI RVLCRLRPGT SSSLVSVEPG PGGTVTTCYR GRHRRFRLDW
460 470 480 490 500
VFPPDASQEE VFRELEPAVL SCLRGYSVCI FTYGQTGTGK TYSMEGPPED
510 520 530 540 550
PGIVPRALQS LFREMGAGRQ HRVTLSMVEI YNEAVRDLLA PGPPERLAVR
560 570 580 590 600
QGPEGQGGIQ VAGLTHWDVP NLETLHQMLK LGRSNRATAA TAMNQRSSRS
610 620 630 640 650
HALVTLTLRA ASPPRAPGTA GTLHLVDLAG SERARKAGAA GPPRGDPDGA
660 670 680 690 700
RRLREAQTIN RSLLALGGVM AALRAHRPHV PFRDSQLTRL LQPALGPGTT
710 720 730 740 750
AVLLLQVGAG AGQVCACRSP PTRARPPAPL ARRSPRGRRI SGRQSAPSSS
760 770 780 790 800
PTEWVKWSWG QPGAAGSRAP PGRLLPSAPT LRSPGPPAPL RRPLAVLHAP
810 820 830
VPTTARARLS RPQRACPSSP GSRPCPWGLR PGLCWQRR
Length:838
Mass (Da):90,147
Last modified:December 1, 2001 - v1
Checksum:i5C692E0B67A0BE77
GO
Isoform 2 (identifier: Q96AC6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.
     523-551: VTLSMVEIYNEAVRDLLAPGPPERLAVRQ → RYHGRCLSPAESPEHPRPGLPPCRARSPL
     552-838: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):32,600
Checksum:i4893497BE5D7E08C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04968467G → E.Corresponds to variant rs35817880dbSNPEnsembl.1
Natural variantiVAR_049685166S → F.Corresponds to variant rs12675537dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561021 – 252Missing in isoform 2. 1 PublicationAdd BLAST252
Alternative sequenceiVSP_056103523 – 551VTLSM…LAVRQ → RYHGRCLSPAESPEHPRPGL PPCRARSPL in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_056104552 – 838Missing in isoform 2. 1 PublicationAdd BLAST287

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055045 mRNA. Translation: BAB70844.1.
AC084125 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82085.1.
BC017311 mRNA. Translation: AAH17311.1.
CCDSiCCDS6427.1. [Q96AC6-1]
RefSeqiNP_665697.1. NM_145754.3. [Q96AC6-1]
UniGeneiHs.528713.

Genome annotation databases

EnsembliENST00000301332; ENSP00000301332; ENSG00000167702. [Q96AC6-1]
GeneIDi90990.
KEGGihsa:90990.
UCSCiuc003zcz.4. human. [Q96AC6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055045 mRNA. Translation: BAB70844.1.
AC084125 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82085.1.
BC017311 mRNA. Translation: AAH17311.1.
CCDSiCCDS6427.1. [Q96AC6-1]
RefSeqiNP_665697.1. NM_145754.3. [Q96AC6-1]
UniGeneiHs.528713.

3D structure databases

ProteinModelPortaliQ96AC6.
SMRiQ96AC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124785. 4 interactors.
IntActiQ96AC6. 7 interactors.
MINTiMINT-7241349.
STRINGi9606.ENSP00000301332.

PTM databases

iPTMnetiQ96AC6.
PhosphoSitePlusiQ96AC6.

Polymorphism and mutation databases

BioMutaiKIFC2.
DMDMi34098674.

Proteomic databases

PaxDbiQ96AC6.
PeptideAtlasiQ96AC6.
PRIDEiQ96AC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301332; ENSP00000301332; ENSG00000167702. [Q96AC6-1]
GeneIDi90990.
KEGGihsa:90990.
UCSCiuc003zcz.4. human. [Q96AC6-1]

Organism-specific databases

CTDi90990.
GeneCardsiKIFC2.
HGNCiHGNC:29530. KIFC2.
HPAiHPA029264.
MIMi615216. gene.
neXtProtiNX_Q96AC6.
OpenTargetsiENSG00000167702.
PharmGKBiPA134874212.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0239. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00550000074610.
HOGENOMiHOG000113226.
HOVERGENiHBG052258.
InParanoidiQ96AC6.
KOiK10406.
OMAiRELQQMH.
OrthoDBiEOG091G03NM.
PhylomeDBiQ96AC6.
TreeFamiTF105238.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167702-MONOMER.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Miscellaneous databases

ChiTaRSiKIFC2. human.
GenomeRNAii90990.
PROiQ96AC6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167702.
CleanExiHS_KIFC2.
GenevisibleiQ96AC6. HS.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIFC2_HUMAN
AccessioniPrimary (citable) accession number: Q96AC6
Secondary accession number(s): E9PHB2, Q96NN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.