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UniProtKB - Q96AC6 (KIFC2_HUMAN)

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Protein

Kinesin-like protein KIFC2

Gene

KIFC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi484 – 491ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIFC2
Gene namesi
Name:KIFC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:29530. KIFC2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167702.
PharmGKBiPA134874212.

Polymorphism and mutation databases

BioMutaiKIFC2.
DMDMi34098674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254291 – 838Kinesin-like protein KIFC2Add BLAST838

Proteomic databases

PaxDbiQ96AC6.
PeptideAtlasiQ96AC6.
PRIDEiQ96AC6.

PTM databases

iPTMnetiQ96AC6.
PhosphoSitePlusiQ96AC6.

Expressioni

Gene expression databases

BgeeiENSG00000167702.
CleanExiHS_KIFC2.
GenevisibleiQ96AC6. HS.

Organism-specific databases

HPAiHPA029264.

Interactioni

GO - Molecular functioni

Complete GO annotation...

Protein-protein interaction databases

BioGridi124785. 3 interactors.
IntActiQ96AC6. 7 interactors.
MINTiMINT-7241349.
STRINGi9606.ENSP00000301332.

Structurei

3D structure databases

ProteinModelPortaliQ96AC6.
SMRiQ96AC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini409 – 740Kinesin motorPROSITE-ProRule annotationAdd BLAST332

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili186 – 351Sequence analysisAdd BLAST166

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 332Gln-richAdd BLAST152
Compositional biasi720 – 831Pro-richAdd BLAST112

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0239. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00550000074610.
HOGENOMiHOG000113226.
HOVERGENiHBG052258.
InParanoidiQ96AC6.
KOiK10406.
OMAiEDQRAWQ.
OrthoDBiEOG091G03NM.
PhylomeDBiQ96AC6.
TreeFamiTF105238.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00129. KISc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96AC6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYAFYSLLIY IFYSLFRRDG GAAAAAEPGD PAQRARKPRG RRRPDLPAPE 
        60         70         80         90        100
LWTELTGLAA SSEPEDGSEG AAEGRAAAVS LEEALLRLAE FLSVQLGAEE 
       110        120        130        140        150
SCGGPADLGQ SGEVPSLLTV TSQLLALLAW LRSPRGRQAL LQGTQPAPRV 
       160        170        180        190        200
RPPSPDGSTS QEESPSHFTA VPGEPLGDET QGQQPLQLEE DQRAWQRLEQ 
       210        220        230        240        250
LILGQLEELK QQLEQQEEEL GRLRLGVGAT DSEKRVQHLT LENEALKQSL 
       260        270        280        290        300
SLMRDLLLHW GPGPPIRAPQ EEAEALLELQ GRLQEAQDTT EALRAQLGVQ 
       310        320        330        340        350
EVQLQGLQGA LQQLQQETEQ NCRRELQQMH GQLAGLRARM ASLRQGCGDL 
       360        370        380        390        400
RGLVSTFTQS CQGSLSEARG QVSWALGALS SGGPGTQLPE GQQGPPAGCP 
       410        420        430        440        450
GRLPELKGNI RVLCRLRPGT SSSLVSVEPG PGGTVTTCYR GRHRRFRLDW 
       460        470        480        490        500
VFPPDASQEE VFRELEPAVL SCLRGYSVCI FTYGQTGTGK TYSMEGPPED 
       510        520        530        540        550
PGIVPRALQS LFREMGAGRQ HRVTLSMVEI YNEAVRDLLA PGPPERLAVR 
       560        570        580        590        600
QGPEGQGGIQ VAGLTHWDVP NLETLHQMLK LGRSNRATAA TAMNQRSSRS 
       610        620        630        640        650
HALVTLTLRA ASPPRAPGTA GTLHLVDLAG SERARKAGAA GPPRGDPDGA 
       660        670        680        690        700
RRLREAQTIN RSLLALGGVM AALRAHRPHV PFRDSQLTRL LQPALGPGTT 
       710        720        730        740        750
AVLLLQVGAG AGQVCACRSP PTRARPPAPL ARRSPRGRRI SGRQSAPSSS 
       760        770        780        790        800
PTEWVKWSWG QPGAAGSRAP PGRLLPSAPT LRSPGPPAPL RRPLAVLHAP 
       810        820        830 
VPTTARARLS RPQRACPSSP GSRPCPWGLR PGLCWQRR
Length:838
Mass (Da):90,147
Last modified:December 1, 2001 - v1
Checksum:i5C692E0B67A0BE77
GO
Isoform 2 (identifier: Q96AC6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-252: Missing.
     523-551: VTLSMVEIYNEAVRDLLAPGPPERLAVRQ → RYHGRCLSPAESPEHPRPGLPPCRARSPL
     552-838: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):32,600
Checksum:i4893497BE5D7E08C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04968467G → E. Corresponds to variant dbSNP:rs35817880Ensembl.1
Natural variantiVAR_049685166S → F. Corresponds to variant dbSNP:rs12675537Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561021 – 252Missing in isoform 2. 1 PublicationAdd BLAST252
Alternative sequenceiVSP_056103523 – 551VTLSM…LAVRQ → RYHGRCLSPAESPEHPRPGL PPCRARSPL in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_056104552 – 838Missing in isoform 2. 1 PublicationAdd BLAST287

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055045 mRNA. Translation: BAB70844.1.
AC084125 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82085.1.
BC017311 mRNA. Translation: AAH17311.1.
CCDSiCCDS6427.1. [Q96AC6-1]
RefSeqiNP_665697.1. NM_145754.3. [Q96AC6-1]
UniGeneiHs.528713.

Genome annotation databases

EnsembliENST00000301332; ENSP00000301332; ENSG00000167702. [Q96AC6-1]
GeneIDi90990.
KEGGihsa:90990.
UCSCiuc003zcz.4. human. [Q96AC6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKIFC2_HUMAN
AccessioniPrimary (citable) accession number: Q96AC6
Secondary accession number(s): E9PHB2, Q96NN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families