Q96AB6 (NTAN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein N-terminal asparagine amidohydrolase
EC=3.5.1.-

Alternative name(s):
Protein NH2-terminal asparagine amidohydrolase
Short name=PNAA
Protein NH2-terminal asparagine deamidase
Short name=PNAD
Short name=Protein N-terminal Asn amidase
Short name=Protein NTN-amidase

Gene names

Name:

NTAN1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult locomotory behavior Inferred from electronic annotation. Source: Compara memory Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	protein-N-terminal asparagine amidohydrolase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 310	309	Protein N-terminal asparagine amidohydrolase		PRO_0000057971
Natural variations
	Natural variant	283	1	H → N. Corresponds to variant rs1136001 [ dbSNP | Ensembl ].		VAR_051244
	Natural variant	287	1	S → P. Corresponds to variant rs1135999 [ dbSNP | Ensembl ].		VAR_051245

Sequences

	Sequence		Length	Mass (Da)
	Q96AB6 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: C7FE8C550883DFC3	FASTA	310	34,677
	10 20 30 40 50 60 MPLLVEGRRV RLPQSAGDLV RAHPPLEERA RLLRGQSVQQ VGPQGLLYVQ QRELAVTSPK 70 80 90 100 110 120 DGSISILGSD DATTCHIVVL RHTGNGATCL THCDGTDTKA EVPLIMNSIK SFSDHAQCGR 130 140 150 160 170 180 LEVHLVGGFS DDRQLSQKLT HQLLSEFDRQ EDDIHLVTLC VTELNDREEN ENHFPVIYGI 190 200 210 220 230 240 AVNIKTAEIY RASFQDRGPE EQLRAARTLA GGPMISIYDA ETEQLRIGPY SWTPFPHVDF 250 260 270 280 290 300 WLHQDDKQIL ENLSTSPLAE PPHFVEHIRS TLMFLKKHPS PAHTLFSGNK ALLYKKNEDG 310 LWEKISSPGS

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC017336 mRNA. Translation: AAH17336.1.
IPI	IPI00470626.
RefSeq	NP_001257695.1. NM_001270766.1. NP_001257696.1. NM_001270767.1. NP_775745.1. NM_173474.3.
UniGene	Hs.592045.
3D structure databases
ProteinModelPortal	Q96AB6.
ModBase	Search...
PTM databases
PhosphoSite	Q96AB6.
Polymorphism databases
DMDM	37082118.
Proteomic databases
PaxDb	Q96AB6.
PRIDE	Q96AB6.
Protocols and materials databases
DNASU	123803.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000287706; ENSP00000287706; ENSG00000157045.
GeneID	123803.
KEGG	hsa:123803.
UCSC	uc002ddd.3. human.
Organism-specific databases
CTD	123803.
GeneCards	GC16M015131.
HGNC	HGNC:29909. NTAN1.
HPA	CAB029997.
neXtProt	NX_Q96AB6.
PharmGKB	PA134863573.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG76939.
HOGENOM	HOG000047800.
HOVERGEN	HBG052674.
InParanoid	Q96AB6.
KO	K14662.
OMA	CHIVVLR.
OrthoDB	EOG4FJ89K.
PhylomeDB	Q96AB6.
Gene expression databases
ArrayExpress	Q96AB6.
Bgee	Q96AB6.
CleanEx	HS_NTAN1.
Genevestigator	Q96AB6.
GermOnline	ENSG00000157045. Homo sapiens.
Family and domain databases
InterPro	IPR026750. NTAN1. [Graphical view]
PANTHER	PTHR12498. PTHR12498. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	123803.
NextBio	81157.

Entry information

Entry name

NTAN1_HUMAN

Accession

Primary (citable) accession number: Q96AB6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 73 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.