Q96AB3 (ISOC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Isochorismatase domain-containing protein 2, mitochondrial

Gene names

Name:

ISOC2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with CDKN2A. Ref.5
Subcellular location	Mitochondrion By similarity. Cytoplasm. Nucleus. Note: Localizes to the nucleus in the presence of CDKN2A. Ref.5
Sequence similarities	Belongs to the isochorismatase family.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion Nucleus
Coding sequence diversity	Alternative splicing
Domain	Transit peptide
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein destabilization Inferred from mutant phenotype Ref.5. Source: BHF-UCL
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay Ref.5. Source: BHF-UCL
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction Ref.5. Source: BHF-UCL
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NAA38	O95777	1	EBI-372799,EBI-347779

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96AB3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96AB3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     116-116: L → LDPRSYPGLALTSLYPQ

Isoform 3 (identifier: Q96AB3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     47-116: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 58	58	Mitochondrion Potential
	Chain	59 – 205	147	Isochorismatase domain-containing protein 2, mitochondrial		PRO_0000268671
Amino acid modifications
	Modified residue	7	1	Phosphoserine Ref.6
	Modified residue	182	1	N6-acetyllysine Ref.7
Natural variations
	Alternative sequence	47 – 116	70	Missing in isoform 3.		VSP_038741
	Alternative sequence	116	1	L → LDPRSYPGLALTSLYPQ in isoform 2.		VSP_022000

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2F3B0EFB2C7B705F	FASTA	205	22,337
	10 20 30 40 50 60 MAAARPSLGR VLPGSSVLFL CDMQEKFRHN IAYFPQIVSV AARMLKVARL LEVPVMLTEQ 70 80 90 100 110 120 YPQGLGPTVP ELGTEGLRPL AKTCFSMVPA LQQELDSRPQ LRSVLLCGIE AQACILNTTL 130 140 150 160 170 180 DLLDRGLQVH VVVDACSSRS QVDRLVALAR MRQSGAFLST SEGLILQLVG DAVHPQFKEI 190 200 QKLIKEPAPD SGLLGLFQGQ NSLLH
	Isoform 2 [UniParc]. Checksum: B2CD325D71A2D767	FASTA	221	24,097
	10 20 30 40 50 60 MAAARPSLGR VLPGSSVLFL CDMQEKFRHN IAYFPQIVSV AARMLKVARL LEVPVMLTEQ 70 80 90 100 110 120 YPQGLGPTVP ELGTEGLRPL AKTCFSMVPA LQQELDSRPQ LRSVLLCGIE AQACILDPRS 130 140 150 160 170 180 YPGLALTSLY PQNTTLDLLD RGLQVHVVVD ACSSRSQVDR LVALARMRQS GAFLSTSEGL 190 200 210 220 ILQLVGDAVH PQFKEIQKLI KEPAPDSGLL GLFQGQNSLL H
	Isoform 3 [UniParc]. Checksum: 5EADDB9D9BAE2085	FASTA	135	14,765
	10 20 30 40 50 60 MAAARPSLGR VLPGSSVLFL CDMQEKFRHN IAYFPQIVSV AARMLKNTTL DLLDRGLQVH 70 80 90 100 110 120 VVVDACSSRS QVDRLVALAR MRQSGAFLST SEGLILQLVG DAVHPQFKEI QKLIKEPAPD 130 SGLLGLFQGQ NSLLH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Small intestine and Stomach.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a." Huang X., Shi Z., Wang W., Bai J., Chen Z., Xu J., Zhang D., Fu S. Biochem. Biophys. Res. Commun. 361:287-293(2007) [PubMed: 17658461] [Abstract] Cited for: INTERACTION WITH CDKN2A, SUBCELLULAR LOCATION.
[6]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-182, MASS SPECTROMETRY.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK027122 mRNA. Translation: BAB15666.1. AK131324 mRNA. Translation: BAD18484.2. CR457377 mRNA. Translation: CAG33658.1. CH471135 Genomic DNA. Translation: EAW72379.1. BC017344 mRNA. Translation: AAH17344.1.
IPI	IPI00003031. IPI00442223. IPI00551022.
RefSeq	NP_001129673.1. NM_001136201.1. NP_001129674.1. NM_001136202.1. NP_078986.1. NM_024710.2.
UniGene	Hs.467306.
3D structure databases
HSSP	HSSP built from PDB template 2B34 based on UniProtKB Q20062.
ProteinModelPortal	Q96AB3.
SMR	Q96AB3. Positions 9-195.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96AB3. 2 interactions.
MINT	MINT-1379196.
STRING	Q96AB3.
PTM databases
PhosphoSite	Q96AB3.
Polymorphism databases
DMDM	74731104.
Proteomic databases
PeptideAtlas	Q96AB3.
PRIDE	Q96AB3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000425675; ENSP00000401726; ENSG00000063241.
GeneID	79763.
KEGG	hsa:79763.
UCSC	uc002qla.1. human. uc002qlb.1. human.
Organism-specific databases
CTD	79763.
GeneCards	GC19M055964.
H-InvDB	HIX0202739.
HGNC	HGNC:26278. ISOC2.
HPA	HPA043142.
MIM	612928. gene.
neXtProt	NX_Q96AB3.
PharmGKB	PA134981722.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06410.
GeneTree	ENSGT00390000006753.
HOVERGEN	HBG056777.
InParanoid	Q96AB3.
OMA	HNIAYFP.
Gene expression databases
ArrayExpress	Q96AB3.
Bgee	Q96AB3.
CleanEx	HS_ISOC2.
Genevestigator	Q96AB3.
GermOnline	ENSG00000063241. Homo sapiens.
Family and domain databases
InterPro	IPR000868. Isochorismatase-like. [Graphical view]
Gene3D	G3DSA:3.40.50.850. Isochorismatase_hydro. 1 hit.
Pfam	PF00857. Isochorismatase. 1 hit. [Graphical view]
SUPFAM	SSF52499. Iscrsm_hydrolase. 1 hit.
ProtoNet	Search...
Other
NextBio	ISOC2.
SOURCE	Search...

Entry information

Entry name

ISOC2_HUMAN

Accession

Primary (citable) accession number: Q96AB3
Secondary accession number(s): Q6ZN91, Q9H5G0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.