Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isochorismatase domain-containing protein 2

Gene

ISOC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • metabolic process Source: InterPro
  • protein destabilization Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Isochorismatase domain-containing protein 2
Gene namesi
Name:ISOC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26278. ISOC2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981722.

Polymorphism and mutation databases

BioMutaiISOC2.
DMDMi74731104.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Isochorismatase domain-containing protein 2PRO_0000268671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineCombined sources
Modified residuei202 – 2021PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96AB3.
MaxQBiQ96AB3.
PeptideAtlasiQ96AB3.
PRIDEiQ96AB3.
TopDownProteomicsiQ96AB3-1. [Q96AB3-1]
Q96AB3-2. [Q96AB3-2]

PTM databases

iPTMnetiQ96AB3.
PhosphoSiteiQ96AB3.

Expressioni

Gene expression databases

BgeeiENSG00000063241.
CleanExiHS_ISOC2.
ExpressionAtlasiQ96AB3. baseline and differential.
GenevisibleiQ96AB3. HS.

Organism-specific databases

HPAiHPA043142.

Interactioni

Subunit structurei

Interacts with CDKN2A.1 Publication

Protein-protein interaction databases

BioGridi122871. 25 interactions.
IntActiQ96AB3. 2 interactions.
MINTiMINT-1379196.

Structurei

3D structure databases

ProteinModelPortaliQ96AB3.
SMRiQ96AB3. Positions 9-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isochorismatase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000006753.
HOGENOMiHOG000231573.
HOVERGENiHBG056777.
InParanoidiQ96AB3.
OMAiHNIAYFP.
OrthoDBiEOG091G0LXB.
PhylomeDBiQ96AB3.
TreeFamiTF313459.

Family and domain databases

Gene3Di3.40.50.850. 1 hit.
InterProiIPR000868. Isochorismatase-like.
[Graphical view]
PfamiPF00857. Isochorismatase. 1 hit.
[Graphical view]
SUPFAMiSSF52499. SSF52499. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96AB3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAARPSLGR VLPGSSVLFL CDMQEKFRHN IAYFPQIVSV AARMLKVARL
60 70 80 90 100
LEVPVMLTEQ YPQGLGPTVP ELGTEGLRPL AKTCFSMVPA LQQELDSRPQ
110 120 130 140 150
LRSVLLCGIE AQACILNTTL DLLDRGLQVH VVVDACSSRS QVDRLVALAR
160 170 180 190 200
MRQSGAFLST SEGLILQLVG DAVHPQFKEI QKLIKEPAPD SGLLGLFQGQ

NSLLH
Length:205
Mass (Da):22,337
Last modified:December 1, 2001 - v1
Checksum:i2F3B0EFB2C7B705F
GO
Isoform 2 (identifier: Q96AB3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-116: L → LDPRSYPGLALTSLYPQ

Show »
Length:221
Mass (Da):24,097
Checksum:iB2CD325D71A2D767
GO
Isoform 3 (identifier: Q96AB3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-116: Missing.

Show »
Length:135
Mass (Da):14,765
Checksum:i5EADDB9D9BAE2085
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei47 – 11670Missing in isoform 3. 1 PublicationVSP_038741Add
BLAST
Alternative sequencei116 – 1161L → LDPRSYPGLALTSLYPQ in isoform 2. 2 PublicationsVSP_022000

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027122 mRNA. Translation: BAB15666.1.
AK131324 mRNA. Translation: BAD18484.2.
CR457377 mRNA. Translation: CAG33658.1.
CH471135 Genomic DNA. Translation: EAW72379.1.
BC017344 mRNA. Translation: AAH17344.1.
CCDSiCCDS12925.1. [Q96AB3-2]
CCDS46194.1. [Q96AB3-3]
CCDS46195.1. [Q96AB3-1]
RefSeqiNP_001129673.1. NM_001136201.1. [Q96AB3-1]
NP_001129674.1. NM_001136202.1. [Q96AB3-3]
NP_078986.1. NM_024710.2. [Q96AB3-2]
UniGeneiHs.467306.

Genome annotation databases

EnsembliENST00000085068; ENSP00000085068; ENSG00000063241. [Q96AB3-2]
ENST00000425675; ENSP00000401726; ENSG00000063241. [Q96AB3-1]
ENST00000438389; ENSP00000406364; ENSG00000063241. [Q96AB3-3]
GeneIDi79763.
KEGGihsa:79763.
UCSCiuc002qla.4. human. [Q96AB3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027122 mRNA. Translation: BAB15666.1.
AK131324 mRNA. Translation: BAD18484.2.
CR457377 mRNA. Translation: CAG33658.1.
CH471135 Genomic DNA. Translation: EAW72379.1.
BC017344 mRNA. Translation: AAH17344.1.
CCDSiCCDS12925.1. [Q96AB3-2]
CCDS46194.1. [Q96AB3-3]
CCDS46195.1. [Q96AB3-1]
RefSeqiNP_001129673.1. NM_001136201.1. [Q96AB3-1]
NP_001129674.1. NM_001136202.1. [Q96AB3-3]
NP_078986.1. NM_024710.2. [Q96AB3-2]
UniGeneiHs.467306.

3D structure databases

ProteinModelPortaliQ96AB3.
SMRiQ96AB3. Positions 9-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122871. 25 interactions.
IntActiQ96AB3. 2 interactions.
MINTiMINT-1379196.

PTM databases

iPTMnetiQ96AB3.
PhosphoSiteiQ96AB3.

Polymorphism and mutation databases

BioMutaiISOC2.
DMDMi74731104.

Proteomic databases

EPDiQ96AB3.
MaxQBiQ96AB3.
PeptideAtlasiQ96AB3.
PRIDEiQ96AB3.
TopDownProteomicsiQ96AB3-1. [Q96AB3-1]
Q96AB3-2. [Q96AB3-2]

Protocols and materials databases

DNASUi79763.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000085068; ENSP00000085068; ENSG00000063241. [Q96AB3-2]
ENST00000425675; ENSP00000401726; ENSG00000063241. [Q96AB3-1]
ENST00000438389; ENSP00000406364; ENSG00000063241. [Q96AB3-3]
GeneIDi79763.
KEGGihsa:79763.
UCSCiuc002qla.4. human. [Q96AB3-1]

Organism-specific databases

CTDi79763.
GeneCardsiISOC2.
HGNCiHGNC:26278. ISOC2.
HPAiHPA043142.
MIMi612928. gene.
neXtProtiNX_Q96AB3.
PharmGKBiPA134981722.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000006753.
HOGENOMiHOG000231573.
HOVERGENiHBG056777.
InParanoidiQ96AB3.
OMAiHNIAYFP.
OrthoDBiEOG091G0LXB.
PhylomeDBiQ96AB3.
TreeFamiTF313459.

Miscellaneous databases

GenomeRNAii79763.
PROiQ96AB3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000063241.
CleanExiHS_ISOC2.
ExpressionAtlasiQ96AB3. baseline and differential.
GenevisibleiQ96AB3. HS.

Family and domain databases

Gene3Di3.40.50.850. 1 hit.
InterProiIPR000868. Isochorismatase-like.
[Graphical view]
PfamiPF00857. Isochorismatase. 1 hit.
[Graphical view]
SUPFAMiSSF52499. SSF52499. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiISOC2_HUMAN
AccessioniPrimary (citable) accession number: Q96AB3
Secondary accession number(s): Q6ZN91, Q9H5G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.