Reviewed, UniProtKB/Swiss-Prot Q96AB3 (ISOC2_HUMAN)

Names and origin

Protein names

Recommended name:
    Isochorismatase domain-containing protein 2, mitochondrial

Gene names

Name:

ISOC2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the isochorismatase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing
Domain	Transit peptide
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein destabilization Inferred from mutant phenotype. Source: UniProtKB
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: UniProtKB
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSM8	O95777	1	EBI-372799,EBI-347779

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96AB3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96AB3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     116-116: L → LDPRSYPGLALTSLYPQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 58	58	Mitochondrion Potential
	Chain	59 – 205	147	Isochorismatase domain-containing protein 2, mitochondrial		PRO_0000268671
Amino acid modifications
	Modified residue	7	1	Phosphoserine Ref.4
Natural variations
	Alternative sequence	116	1	L → LDPRSYPGLALTSLYPQ in isoform 2.		VSP_022000

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2F3B0EFB2C7B705F	FASTA	205	22,337
	10 20 30 40 50 60 MAAARPSLGR VLPGSSVLFL CDMQEKFRHN IAYFPQIVSV AARMLKVARL LEVPVMLTEQ 70 80 90 100 110 120 YPQGLGPTVP ELGTEGLRPL AKTCFSMVPA LQQELDSRPQ LRSVLLCGIE AQACILNTTL 130 140 150 160 170 180 DLLDRGLQVH VVVDACSSRS QVDRLVALAR MRQSGAFLST SEGLILQLVG DAVHPQFKEI 190 200 QKLIKEPAPD SGLLGLFQGQ NSLLH
	Isoform 2. Checksum: B2CD325D71A2D767	FASTA	221	24,097
	10 20 30 40 50 60 MAAARPSLGR VLPGSSVLFL CDMQEKFRHN IAYFPQIVSV AARMLKVARL LEVPVMLTEQ 70 80 90 100 110 120 YPQGLGPTVP ELGTEGLRPL AKTCFSMVPA LQQELDSRPQ LRSVLLCGIE AQACILDPRS 130 140 150 160 170 180 YPGLALTSLY PQNTTLDLLD RGLQVHVVVD ACSSRSQVDR LVALARMRQS GAFLSTSEGL 190 200 210 220 ILQLVGDAVH PQFKEIQKLI KEPAPDSGLL GLFQGQNSLL H

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Small intestine.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, MASS SPECTROMETRY.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK027122 mRNA. Translation: BAB15666.1. CR457377 mRNA. Translation: CAG33658.1. BC017344 mRNA. Translation: AAH17344.1.
IPI	IPI00003031. IPI00551022.
RefSeq	NP_001129673.1. NP_078986.1.
UniGene	Hs.467306
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96AB3. 2 interactions.
Proteomic databases
PeptideAtlas	Q96AB3.
PRIDE	Q96AB3.
Genome annotation databases
Ensembl	ENSG00000063241. Homo sapiens. [Contig view]
GeneID	79763.
KEGG	hsa:79763.
UCSC	uc002qla.1. human. uc002qlb.1. human.
Organism-specific databases
GeneCards	GC19M060657.
HGNC	HGNC:26278. ISOC2.
PharmGKB	PA134981722.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q96AB3.
OMA	Q96AB3. HNIAYFP.
Gene expression databases
Bgee	Q96AB3.
CleanEx	HS_ISOC2.
GermOnline	ENSG00000063241. Homo sapiens.
Family and domain databases
InterPro	IPR000868. Isochorismatase-like. [Graphical view]
Gene3D	G3DSA:3.40.50.850. Isochorismatase_hydro. 1 hit.
Pfam	PF00857. Isochorismatase. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	69237.

Entry information

Entry name

ISOC2_HUMAN

Accession

Primary (citable) accession number: Q96AB3
Secondary accession number(s): Q9H5G0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 1, 2001
Last modified:	July 7, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)