Q96AA8 (JKIP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Janus kinase and microtubule-interacting protein 2

Alternative name(s):
CTCL tumor antigen HD-CL-04
Neuroendocrine long coiled-coil protein 1

Gene names

Name:	JAKMIP2
Synonyms:	JAMIP2, KIAA0555, NECC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	810 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Golgi apparatus Ref.2.
Tissue specificity	Highly expressed in brain, moderately expressed in thymus, spleen and lung, and weakly expressed in kidney, liver and peripheral blood lymphocytes. Aslo expressed in adrenal and pituitary glands, as well as testis. Ref.2 Ref.7
Sequence similarities	Belongs to the JAKMIP family.
Sequence caution	The sequence BAA25481.2 differs from that shown. Reason: Frameshift at position 805.

Ontologies

Keywords
Cellular component	Golgi apparatus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96AA8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96AA8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     539-559: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q96AA8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     805-810: SNRKHG → FLFLFLFFSLAFILWP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 810	810	Janus kinase and microtubule-interacting protein 2		PRO_0000050762
Regions
	Coiled coil	13 – 102	90	Potential
	Coiled coil	148 – 178	31	Potential
	Coiled coil	207 – 244	38	Potential
	Coiled coil	280 – 419	140	Potential
	Coiled coil	468 – 597	130	Potential
	Coiled coil	664 – 808	145	Potential
Natural variations
	Alternative sequence	539 – 559	21	Missing in isoform 2.		VSP_002430
	Alternative sequence	805 – 810	6	SNRKHG → FLFLFLFFSLAFILWP in isoform 3.		VSP_028230
	Natural variant	106	1	V → I. Corresponds to variant rs3749736 [ dbSNP | Ensembl ].		VAR_022059
	Natural variant	315	1	R → C in a colorectal cancer sample; somatic mutation. Ref.8		VAR_035930

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: D81480AD76DA6A10	FASTA	810	94,934
	10 20 30 40 50 60 MSKKGRNKGE KPEALIVALQ AANEDLRTKL TDIQIELHQE KSKVSKLERE KTQEAKRIRE 70 80 90 100 110 120 LEQRKHTVLV TELKAKLHEE KMKELQAVRE NLIKQHEQEM SRTVKVRDGE IQRLKSALCA 130 140 150 160 170 180 LRDGSSDKVR TALTIEAREE ARKLFDTERL KLLQEIADLK TAKKQVDEAL SNMIQADKIK 190 200 210 220 230 240 AGDLRSEHQS HQEAISKIKW ESERDIRRLM DEIKAKDRII FSLEKELETQ TGYVQKLQLQ 250 260 270 280 290 300 KEALDEQLFL VKEAECNMSS PKREIPGRAG DGSEHCSSPD LRRNQKRIAE LNATIRKLED 310 320 330 340 350 360 RNTLLGDERN ELLKRVRETE KQCKPLLERN KCLAKRNDEL MVSLQRMEEK LKAVTKENSE 370 380 390 400 410 420 MREKITSHPP LKKLKSLNDL DQANEEQETE FLKLQVIEQQ NIIDELTRDR EKLIRRRKHR 430 440 450 460 470 480 RSSKPIKRPV LDPFIGYDED SMDSETSSMA SFRTDRTPAT PDDDLDESLA AEESELRFRQ 490 500 510 520 530 540 LTKEYQALQR AYALLQEQTG GIIDAEREAK AQEQLQAEVL RYKAKIEDLE ATLAQKGQDS 550 560 570 580 590 600 HWVEDKQLFI KRNQELLEKI EKQEAENHRL QQELQDARDQ NELLEFRNLE LEERERRSPP 610 620 630 640 650 660 FNLQIHPFSD GVSALQIYCM KEGVKDVNIP DLIKQLDILG DNGNLRNEEQ VAIIQASTVL 670 680 690 700 710 720 SLAEKWIQQI EGAEAALHQK MMELESDMEQ FCKIKGYLEE ELDYRKQALD QAYMRIQELE 730 740 750 760 770 780 ATLYNALQQE TVIKFGELLS EKQQEELRTA VEKLRRQMLR KSREYDCQIL QERMELLQQA 790 800 810 HQRIRDLEDK TDIQKRQIKD LEEKSNRKHG
	Isoform 2 [UniParc]. Checksum: F29E58996FBA5A3A	FASTA	789	92,296
	10 20 30 40 50 60 MSKKGRNKGE KPEALIVALQ AANEDLRTKL TDIQIELHQE KSKVSKLERE KTQEAKRIRE 70 80 90 100 110 120 LEQRKHTVLV TELKAKLHEE KMKELQAVRE NLIKQHEQEM SRTVKVRDGE IQRLKSALCA 130 140 150 160 170 180 LRDGSSDKVR TALTIEAREE ARKLFDTERL KLLQEIADLK TAKKQVDEAL SNMIQADKIK 190 200 210 220 230 240 AGDLRSEHQS HQEAISKIKW ESERDIRRLM DEIKAKDRII FSLEKELETQ TGYVQKLQLQ 250 260 270 280 290 300 KEALDEQLFL VKEAECNMSS PKREIPGRAG DGSEHCSSPD LRRNQKRIAE LNATIRKLED 310 320 330 340 350 360 RNTLLGDERN ELLKRVRETE KQCKPLLERN KCLAKRNDEL MVSLQRMEEK LKAVTKENSE 370 380 390 400 410 420 MREKITSHPP LKKLKSLNDL DQANEEQETE FLKLQVIEQQ NIIDELTRDR EKLIRRRKHR 430 440 450 460 470 480 RSSKPIKRPV LDPFIGYDED SMDSETSSMA SFRTDRTPAT PDDDLDESLA AEESELRFRQ 490 500 510 520 530 540 LTKEYQALQR AYALLQEQTG GIIDAEREAK AQEQLQAEVL RYKAKIEDLE ATLAQKGQIE 550 560 570 580 590 600 KQEAENHRLQ QELQDARDQN ELLEFRNLEL EERERRSPPF NLQIHPFSDG VSALQIYCMK 610 620 630 640 650 660 EGVKDVNIPD LIKQLDILGD NGNLRNEEQV AIIQASTVLS LAEKWIQQIE GAEAALHQKM 670 680 690 700 710 720 MELESDMEQF CKIKGYLEEE LDYRKQALDQ AYMRIQELEA TLYNALQQET VIKFGELLSE 730 740 750 760 770 780 KQQEELRTAV EKLRRQMLRK SREYDCQILQ ERMELLQQAH QRIRDLEDKT DIQKRQIKDL EEKSNRKHG
	Isoform 3 [UniParc]. Checksum: 7C1D5257F1E325AE	FASTA	820	96,258
	10 20 30 40 50 60 MSKKGRNKGE KPEALIVALQ AANEDLRTKL TDIQIELHQE KSKVSKLERE KTQEAKRIRE 70 80 90 100 110 120 LEQRKHTVLV TELKAKLHEE KMKELQAVRE NLIKQHEQEM SRTVKVRDGE IQRLKSALCA 130 140 150 160 170 180 LRDGSSDKVR TALTIEAREE ARKLFDTERL KLLQEIADLK TAKKQVDEAL SNMIQADKIK 190 200 210 220 230 240 AGDLRSEHQS HQEAISKIKW ESERDIRRLM DEIKAKDRII FSLEKELETQ TGYVQKLQLQ 250 260 270 280 290 300 KEALDEQLFL VKEAECNMSS PKREIPGRAG DGSEHCSSPD LRRNQKRIAE LNATIRKLED 310 320 330 340 350 360 RNTLLGDERN ELLKRVRETE KQCKPLLERN KCLAKRNDEL MVSLQRMEEK LKAVTKENSE 370 380 390 400 410 420 MREKITSHPP LKKLKSLNDL DQANEEQETE FLKLQVIEQQ NIIDELTRDR EKLIRRRKHR 430 440 450 460 470 480 RSSKPIKRPV LDPFIGYDED SMDSETSSMA SFRTDRTPAT PDDDLDESLA AEESELRFRQ 490 500 510 520 530 540 LTKEYQALQR AYALLQEQTG GIIDAEREAK AQEQLQAEVL RYKAKIEDLE ATLAQKGQDS 550 560 570 580 590 600 HWVEDKQLFI KRNQELLEKI EKQEAENHRL QQELQDARDQ NELLEFRNLE LEERERRSPP 610 620 630 640 650 660 FNLQIHPFSD GVSALQIYCM KEGVKDVNIP DLIKQLDILG DNGNLRNEEQ VAIIQASTVL 670 680 690 700 710 720 SLAEKWIQQI EGAEAALHQK MMELESDMEQ FCKIKGYLEE ELDYRKQALD QAYMRIQELE 730 740 750 760 770 780 ATLYNALQQE TVIKFGELLS EKQQEELRTA VEKLRRQMLR KSREYDCQIL QERMELLQQA 790 800 810 820 HQRIRDLEDK TDIQKRQIKD LEEKFLFLFL FFSLAFILWP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins." Cruz-Garcia D., Vazquez-Martinez R., Peinado J.R., Anouar Y., Tonon M.C., Vaudry H., Castano J.P., Malagon M.M. FEBS Lett. 581:3149-3156(2007) [PubMed: 17572408] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Cervix carcinoma.
[3]	"SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma." Hartmann T.B., Thiel D., Dummer R., Schadendorf D., Eichmueller S. Br. J. Dermatol. 150:252-258(2004) [PubMed: 14996095] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: T-cell lymphoma.
[4]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed: 9628581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle.
[7]	"Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules." Steindler C., Li Z., Algarte M., Alcover A., Libri V., Ragimbeau J., Pellegrini S. J. Biol. Chem. 279:43168-43177(2004) [PubMed: 15277531] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-315.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK291280 mRNA. Translation: BAF83969.1. EF512550 mRNA. Translation: ABP62932.1. AF273057 mRNA. Translation: AAM44460.1. AB011127 mRNA. Translation: BAA25481.2. Frameshift. CH471062 Genomic DNA. Translation: EAW61820.1. BC017354 mRNA. Translation: AAH17354.1.
IPI	IPI00059369. IPI00479428. IPI00867585.
PIR	T00331.
RefSeq	NP_055605.2. NM_014790.3.
UniGene	Hs.184323.
3D structure databases
ProteinModelPortal	Q96AA8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96AA8. 1 interaction.
MINT	MINT-1445731.
STRING	Q96AA8.
PTM databases
PhosphoSite	Q96AA8.
Polymorphism databases
DMDM	20140696.
Proteomic databases
PRIDE	Q96AA8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265272; ENSP00000265272; ENSG00000176049.
GeneID	9832.
KEGG	hsa:9832.
UCSC	uc003loq.1. human. uc003lor.1. human.
Organism-specific databases
CTD	9832.
GeneCards	GC05M146949.
H-InvDB	HIX0017968.
HGNC	HGNC:29067. JAKMIP2.
MIM	611197. gene.
neXtProt	NX_Q96AA8.
PharmGKB	PA143485509.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18572.
GeneTree	ENSGT00390000002812.
HOVERGEN	HBG054249.
OMA	DIQIELH.
OrthoDB	EOG4BP1B5.
PhylomeDB	Q96AA8.
Gene expression databases
ArrayExpress	Q96AA8.
Bgee	Q96AA8.
CleanEx	HS_JAKMIP2.
Genevestigator	Q96AA8.
GermOnline	ENSG00000176049. Homo sapiens.
Family and domain databases
InterPro	IPR024836. JAKMIP. [Graphical view]
PANTHER	PTHR18935. PTHR18935. 1 hit.
ProtoNet	Search...
Other
NextBio	37050.
SOURCE	Search...

Entry information

Entry name

JKIP2_HUMAN

Accession

Primary (citable) accession number: Q96AA8
Secondary accession number(s): A4ZZA7 , A8K5G5, O60302, Q548S1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.