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Protein

Pentraxin-4

Gene

PTX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi322Calcium 1PROSITE-ProRule annotation1
Metal bindingi323Calcium 1PROSITE-ProRule annotation1
Metal bindingi406Calcium 1PROSITE-ProRule annotation1
Metal bindingi406Calcium 2By similarity1
Metal bindingi407Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi408Calcium 1PROSITE-ProRule annotation1
Metal bindingi408Calcium 2By similarity1

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pentraxin-4
Gene namesi
Name:PTX4
Synonyms:C16orf38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14171. PTX4.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000251692.
PharmGKBiPA25553.

Polymorphism and mutation databases

BioMutaiPTX4.
DMDMi189042530.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000032064526 – 478Pentraxin-4Add BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi67N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi300 ↔ 364PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96A99.
PeptideAtlasiQ96A99.
PRIDEiQ96A99.

Expressioni

Tissue specificityi

Widely expressed at low levels with highest levels in small intestine, testis and brain. Very low expression in endothelial cells, monocytes, neutrophils and lymphocytes. Isoform 1 is not expressed in small intestine.1 Publication

Inductioni

Not induced by bacterial lipopolysaccharideS (LPS) or IL1/interleukin-1 in endothelium, monocytes or neutrophils. Not induced by PHA in lymphocytes.1 Publication

Gene expression databases

CleanExiHS_C16orf38.
ExpressionAtlasiQ96A99. baseline and differential.

Organism-specific databases

HPAiHPA064718.

Structurei

3D structure databases

ProteinModelPortaliQ96A99.
SMRiQ96A99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini269 – 473Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST205

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH7B. Eukaryota.
ENOG410ZS0T. LUCA.
GeneTreeiENSGT00760000119128.
HOVERGENiHBG108201.
InParanoidiQ96A99.
OMAiALSFCSW.
OrthoDBiEOG091G0AHP.
PhylomeDBiQ96A99.
TreeFamiTF330208.

Family and domain databases

CDDicd00152. PTX. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR001759. Pentraxin-related.
PfamiView protein in Pfam
PF00354. Pentaxin. 1 hit.
PRINTSiPR00895. PENTAXIN.
SMARTiView protein in SMART
SM00159. PTX. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS51828. PTX_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q96A99-1) [UniParc]FASTAAdd to basket
Also known as: PTX4(2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCSWRKTLS FFLVFVPIYL HGASSQEAAP VGPRKPFFER LRRLEEQFRR
60 70 80 90 100
FQEVTWTHLQ NIASNYNVSY NVDVRFRSLA EESQAVAQAV NRSQASVQGE
110 120 130 140 150
LAQLKAWVRK LQRRGRKVDT RLRALDLTLG ERSQQRARER KAHKAQRDAL
160 170 180 190 200
QDSLARLEGL VHSQGARLAA LEGRLPVAHP GTAALGPALV PTPTQPEELG
210 220 230 240 250
PTSLKLQRDR QELRAASEHR GPPQDSSAPL QGRREPPASG SHRVLSGTAP
260 270 280 290 300
KDPRQQAWSP QVPGEICGVG PTLVFPNAST RNVVFLSPGF VTALRALSFC
310 320 330 340 350
SWVRTASGRL GTLLSYATED NDNKLVLHGR DSLLPGSIHF VIGDPAFREL
360 370 380 390 400
PLQLLLDGQW HHICVIWTST QGRYWLHVDR RLVATGSRFR EGYEIPPGGS
410 420 430 440 450
LVLGQEQDSV GGGFDSSEAF VGSMSGLAIW DRALVPGEVA NLAIGKEFPT
460 470
GAILTLANAA LAGGFVQGAN CTCLERCP
Length:478
Mass (Da):52,339
Last modified:February 26, 2008 - v2
Checksum:i2404908AB8A01F60
GO
Isoform 1 (identifier: Q96A99-2) [UniParc]FASTAAdd to basket
Also known as: PTX4(1), Long

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: MGCSWRKTLS...FERLRRLEEQ → MGSGNWEVTG...SAVGLSGLRW

Note: Not expressed in small intestine.1 Publication
Show »
Length:473
Mass (Da):51,306
Checksum:iC6EBA44415A855B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0600842G → E. Corresponds to variant dbSNP:rs2745103Ensembl.1
Natural variantiVAR_03924992R → W. Corresponds to variant dbSNP:rs2745101Ensembl.1
Natural variantiVAR_039250220R → G. Corresponds to variant dbSNP:rs2667673Ensembl.1
Natural variantiVAR_039251234R → Q. Corresponds to variant dbSNP:rs12445920Ensembl.1
Natural variantiVAR_039252281R → K. Corresponds to variant dbSNP:rs2745098Ensembl.1
Natural variantiVAR_039253317A → S. Corresponds to variant dbSNP:rs13332460Ensembl.1
Natural variantiVAR_062130444I → V. Corresponds to variant dbSNP:rs59554810Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0402031 – 47MGCSW…RLEEQ → MGSGNWEVTGPPCGSRCERP PGLPRGVHGQFRSAVGLSGL RW in isoform 1. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031705 Genomic DNA. No translation available.
AE006467 Genomic DNA. Translation: AAK61283.1.
CH471112 Genomic DNA. Translation: EAW85652.1.
BC156066 mRNA. Translation: AAI56067.1.
BC156944 mRNA. Translation: AAI56945.1.
CCDSiCCDS32362.1. [Q96A99-2]
RefSeqiNP_001013680.1. NM_001013658.1. [Q96A99-2]
NP_001315537.1. NM_001328608.1. [Q96A99-1]
UniGeneiHs.553770.

Genome annotation databases

EnsembliENST00000293922; ENSP00000293922; ENSG00000251692. [Q96A99-2]
ENST00000447419; ENSP00000445277; ENSG00000251692. [Q96A99-1]
GeneIDi390667.
KEGGihsa:390667.
UCSCiuc010uvf.2. human. [Q96A99-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPTX4_HUMAN
AccessioniPrimary (citable) accession number: Q96A99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 5, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot