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Q96A98

- TIP39_HUMAN

UniProt

Q96A98 - TIP39_HUMAN

Protein

Tuberoinfundibular peptide of 39 residues

Gene

PTH2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.4 Publications

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Neuropeptide

    Enzyme and pathway databases

    ReactomeiREACT_18372. Class B/2 (Secretin family receptors).
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tuberoinfundibular peptide of 39 residues
    Short name:
    TIP39
    Alternative name(s):
    Parathyroid hormone 2
    Gene namesi
    Name:PTH2
    Synonyms:TIP39, TIPF39
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:30828. PTH2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162400324.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Propeptidei31 – 5929PRO_0000045942Add
    BLAST
    Peptidei62 – 10039Tuberoinfundibular peptide of 39 residuesPRO_0000045943Add
    BLAST

    Keywords - PTMi

    Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiQ96A98.
    PRIDEiQ96A98.

    Expressioni

    Tissue specificityi

    Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart.1 Publication

    Gene expression databases

    BgeeiQ96A98.
    CleanExiHS_PTH2.
    GenevestigatoriQ96A98.

    Interactioni

    Subunit structurei

    Ligand of high affinity for the PTH2 receptor (PTH2R).

    Protein-protein interaction databases

    STRINGi9606.ENSP00000270631.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96A98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the parathyroid hormone family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46945.
    HOGENOMiHOG000154591.
    HOVERGENiHBG094047.
    InParanoidiQ96A98.
    OMAiWGTRTAS.
    OrthoDBiEOG7MSMRW.
    PhylomeDBiQ96A98.
    TreeFamiTF353520.

    Family and domain databases

    InterProiIPR029396. TIP39.
    [Graphical view]
    PfamiPF14980. TIP39. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96A98-1 [UniParc]FASTAAdd to Basket

    « Hide

    METRQVSRSP RVRLLLLLLL LLVVPWGVRT ASGVALPPVG VLSLRPPGRA    50
    WADPATPRPR RSLALADDAA FRERARLLAA LERRHWLNSY MHKLLVLDAP 100
    Length:100
    Mass (Da):11,202
    Last modified:December 1, 2001 - v1
    Checksum:i7F0F1A273829E8F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY037555 mRNA. Translation: AAK68689.1.
    BC093995 mRNA. Translation: AAH93995.1.
    BC093997 mRNA. Translation: AAH93997.1.
    AY048588 mRNA. Translation: AAL06597.1.
    CCDSiCCDS12763.1.
    RefSeqiNP_848544.1. NM_178449.3.
    UniGeneiHs.339845.

    Genome annotation databases

    EnsembliENST00000270631; ENSP00000270631; ENSG00000142538.
    GeneIDi113091.
    KEGGihsa:113091.
    UCSCiuc002pnn.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY037555 mRNA. Translation: AAK68689.1 .
    BC093995 mRNA. Translation: AAH93995.1 .
    BC093997 mRNA. Translation: AAH93997.1 .
    AY048588 mRNA. Translation: AAL06597.1 .
    CCDSi CCDS12763.1.
    RefSeqi NP_848544.1. NM_178449.3.
    UniGenei Hs.339845.

    3D structure databases

    ProteinModelPortali Q96A98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000270631.

    Proteomic databases

    PaxDbi Q96A98.
    PRIDEi Q96A98.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270631 ; ENSP00000270631 ; ENSG00000142538 .
    GeneIDi 113091.
    KEGGi hsa:113091.
    UCSCi uc002pnn.1. human.

    Organism-specific databases

    CTDi 113091.
    GeneCardsi GC19M049925.
    HGNCi HGNC:30828. PTH2.
    MIMi 608386. gene.
    neXtProti NX_Q96A98.
    PharmGKBi PA162400324.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46945.
    HOGENOMi HOG000154591.
    HOVERGENi HBG094047.
    InParanoidi Q96A98.
    OMAi WGTRTAS.
    OrthoDBi EOG7MSMRW.
    PhylomeDBi Q96A98.
    TreeFami TF353520.

    Enzyme and pathway databases

    Reactomei REACT_18372. Class B/2 (Secretin family receptors).
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii TIP39.
    GenomeRNAii 113091.
    NextBioi 78739.
    PROi Q96A98.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96A98.
    CleanExi HS_PTH2.
    Genevestigatori Q96A98.

    Family and domain databases

    InterProi IPR029396. TIP39.
    [Graphical view ]
    Pfami PF14980. TIP39. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family."
      Hansen I.A., Jakob O., Wortmann S., Arzberger T., Allolio B., Blind E.
      J. Endocrinol. 174:95-102(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PTH2R.
      Tissue: Brain.
    2. "Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception."
      Dobolyi A., Ueda H., Uchida H., Palkovits M., Usdin T.B.
      Proc. Natl. Acad. Sci. U.S.A. 99:1651-1656(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor."
      Della Penna K., Kinose F., Sun H., Koblan K.S., Wang H.
      Neuropharmacology 44:141-153(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues."
      John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H.
      Endocrinology 143:1047-1057(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-85, FUNCTION, INTERACTION WITH PTH2R.
      Tissue: Brain.
    6. "PTH2 receptor-mediated inhibitory effect of parathyroid hormone and TIP39 on cell proliferation."
      Misiano P., Scott B.B., Scheideler M.A., Garnier M.
      Eur. J. Pharmacol. 468:159-166(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization."
      Bisello A., Manen D., Pierroz D.D., Usdin T.B., Rizzoli R., Ferrari S.L.
      Mol. Endocrinol. 18:1486-1498(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiTIP39_HUMAN
    AccessioniPrimary (citable) accession number: Q96A98
    Secondary accession number(s): Q96DJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3