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Protein

Tuberoinfundibular peptide of 39 residues

Gene

PTH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.4 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiREACT_18372. Class B/2 (Secretin family receptors).
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Tuberoinfundibular peptide of 39 residues
Short name:
TIP39
Alternative name(s):
Parathyroid hormone 2
Gene namesi
Name:PTH2
Synonyms:TIP39, TIPF39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30828. PTH2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400324.

Polymorphism and mutation databases

BioMutaiPTH2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Propeptidei31 – 5929PRO_0000045942Add
BLAST
Peptidei62 – 10039Tuberoinfundibular peptide of 39 residuesPRO_0000045943Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ96A98.
PRIDEiQ96A98.

Expressioni

Tissue specificityi

Highly expressed in fetal and adult brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart.1 Publication

Gene expression databases

BgeeiQ96A98.
CleanExiHS_PTH2.
GenevestigatoriQ96A98.

Interactioni

Subunit structurei

Ligand of high affinity for the PTH2 receptor (PTH2R).

Protein-protein interaction databases

STRINGi9606.ENSP00000270631.

Structurei

3D structure databases

ProteinModelPortaliQ96A98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46945.
GeneTreeiENSGT00410000026259.
HOGENOMiHOG000154591.
HOVERGENiHBG094047.
InParanoidiQ96A98.
OMAiYMHKLLV.
OrthoDBiEOG7MSMRW.
PhylomeDBiQ96A98.
TreeFamiTF353520.

Family and domain databases

InterProiIPR029396. TIP39.
[Graphical view]
PfamiPF14980. TIP39. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96A98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METRQVSRSP RVRLLLLLLL LLVVPWGVRT ASGVALPPVG VLSLRPPGRA
60 70 80 90 100
WADPATPRPR RSLALADDAA FRERARLLAA LERRHWLNSY MHKLLVLDAP
Length:100
Mass (Da):11,202
Last modified:December 1, 2001 - v1
Checksum:i7F0F1A273829E8F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037555 mRNA. Translation: AAK68689.1.
BC093995 mRNA. Translation: AAH93995.1.
BC093997 mRNA. Translation: AAH93997.1.
AY048588 mRNA. Translation: AAL06597.1.
CCDSiCCDS12763.1.
RefSeqiNP_848544.1. NM_178449.3.
UniGeneiHs.339845.

Genome annotation databases

EnsembliENST00000270631; ENSP00000270631; ENSG00000142538.
GeneIDi113091.
KEGGihsa:113091.
UCSCiuc002pnn.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037555 mRNA. Translation: AAK68689.1.
BC093995 mRNA. Translation: AAH93995.1.
BC093997 mRNA. Translation: AAH93997.1.
AY048588 mRNA. Translation: AAL06597.1.
CCDSiCCDS12763.1.
RefSeqiNP_848544.1. NM_178449.3.
UniGeneiHs.339845.

3D structure databases

ProteinModelPortaliQ96A98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000270631.

Polymorphism and mutation databases

BioMutaiPTH2.

Proteomic databases

PaxDbiQ96A98.
PRIDEiQ96A98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270631; ENSP00000270631; ENSG00000142538.
GeneIDi113091.
KEGGihsa:113091.
UCSCiuc002pnn.1. human.

Organism-specific databases

CTDi113091.
GeneCardsiGC19M049925.
HGNCiHGNC:30828. PTH2.
MIMi608386. gene.
neXtProtiNX_Q96A98.
PharmGKBiPA162400324.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46945.
GeneTreeiENSGT00410000026259.
HOGENOMiHOG000154591.
HOVERGENiHBG094047.
InParanoidiQ96A98.
OMAiYMHKLLV.
OrthoDBiEOG7MSMRW.
PhylomeDBiQ96A98.
TreeFamiTF353520.

Enzyme and pathway databases

ReactomeiREACT_18372. Class B/2 (Secretin family receptors).
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiTIP39.
GenomeRNAii113091.
NextBioi78739.
PROiQ96A98.
SOURCEiSearch...

Gene expression databases

BgeeiQ96A98.
CleanExiHS_PTH2.
GenevestigatoriQ96A98.

Family and domain databases

InterProiIPR029396. TIP39.
[Graphical view]
PfamiPF14980. TIP39. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family."
    Hansen I.A., Jakob O., Wortmann S., Arzberger T., Allolio B., Blind E.
    J. Endocrinol. 174:95-102(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH PTH2R.
    Tissue: Brain.
  2. "Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception."
    Dobolyi A., Ueda H., Uchida H., Palkovits M., Usdin T.B.
    Proc. Natl. Acad. Sci. U.S.A. 99:1651-1656(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor."
    Della Penna K., Kinose F., Sun H., Koblan K.S., Wang H.
    Neuropharmacology 44:141-153(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues."
    John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H.
    Endocrinology 143:1047-1057(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-85, FUNCTION, INTERACTION WITH PTH2R.
    Tissue: Brain.
  6. "PTH2 receptor-mediated inhibitory effect of parathyroid hormone and TIP39 on cell proliferation."
    Misiano P., Scott B.B., Scheideler M.A., Garnier M.
    Eur. J. Pharmacol. 468:159-166(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization."
    Bisello A., Manen D., Pierroz D.D., Usdin T.B., Rizzoli R., Ferrari S.L.
    Mol. Endocrinol. 18:1486-1498(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTIP39_HUMAN
AccessioniPrimary (citable) accession number: Q96A98
Secondary accession number(s): Q96DJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 1, 2001
Last modified: April 29, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.