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Q96A83

- COQA1_HUMAN

UniProt

Q96A83 - COQA1_HUMAN

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Protein

Collagen alpha-1(XXVI) chain

Gene
COL26A1, EMID2, EMU2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. collagen catabolic process Source: Reactome
  2. extracellular matrix disassembly Source: Reactome
  3. extracellular matrix organization Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_150401. Collagen degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXVI) chain
Alternative name(s):
Alpha-1 type XXVI collagen
EMI domain-containing protein 2
Emilin and multimerin domain-containing protein 2
Short name:
Emu2
Gene namesi
Name:COL26A1
Synonyms:EMID2, EMU2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:18038. COL26A1.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. endoplasmic reticulum lumen Source: Reactome
  3. extracellular region Source: Reactome
  4. plasma membrane Source: Reactome
  5. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887081.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 441421Collagen alpha-1(XXVI) chainPRO_0000007825Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 118 By similarity
Glycosylationi70 – 701N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi83 ↔ 89 By similarity
Disulfide bondi117 ↔ 126 By similarity
Glycosylationi132 – 1321N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Hydroxylated on proline residues By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ96A83.
PRIDEiQ96A83.

PTM databases

PhosphoSiteiQ96A83.

Expressioni

Gene expression databases

ArrayExpressiQ96A83.
BgeeiQ96A83.
CleanExiHS_EMID2.
GenevestigatoriQ96A83.

Interactioni

Subunit structurei

Homotrimer or heterotrimer By similarity.

Protein-protein interaction databases

BioGridi126448. 1 interaction.
IntActiQ96A83. 1 interaction.
MINTiMINT-2878718.
STRINGi9606.ENSP00000381022.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BJ3X-ray3.04C/D/E308-326[»]
ProteinModelPortaliQ96A83.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 12877EMIAdd
BLAST
Domaini199 – 26769Collagen-like 1Add
BLAST
Domaini302 – 35554Collagen-like 2Add
BLAST

Sequence similaritiesi

Contains 1 EMI domain.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG74199.
HOGENOMiHOG000038011.
HOVERGENiHBG096014.
InParanoidiQ96A83.
PhylomeDBiQ96A83.

Family and domain databases

InterProiIPR008160. Collagen.
IPR011489. EMI_domain.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF07546. EMI. 1 hit.
[Graphical view]
PROSITEiPS51041. EMI. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96A83-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKLALLLPWA CCCLCGSALA TGFLYPFSAA ALQQHGYPEP GAGSPGSGYA    50
SRRHWCHHTV TRTVSCQVQN GSETVVQRVY QSCRWPGPCA NLVSYRTLIR 100
PTYRVSYRTV TVLEWRCCPG FTGSNCDEEC MNCTRLSDMS ERLTTLEAKV 150
LLLEAAERPS SPDNDLPAPE STPPTWNEDF LPDAIPLAHP VPRQRRPTGP 200
AGPPGQTGPP GPAGPPGSKG DRGQTGEKGP AGPPGLLGPP GPRGLPGEMG 250
RPGPPGPPGP AGNPGPSPNS PQGALYSLQP PTDKDNGDSR LASAIVDTVL 300
AGVPGPRGPP GPPGPPGPRG PPGPPGTPGS QGLAGERGTV GPSGEPGVKG 350
EEGEKAATAE GEGVQQLREA LKILAERVLI LEHMIGIHDP LASPEGGSGQ 400
DAALRANLKM KRGGAQPDGV LAALLGPDPG QKSVDQASSR K 441
Length:441
Mass (Da):45,381
Last modified:December 1, 2001 - v1
Checksum:i896CA2AC52B20E92
GO
Isoform 2 (identifier: Q96A83-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-95: Missing.

Note: May be due to a competing acceptor splice site.

Show »
Length:439
Mass (Da):45,131
Checksum:i9F13E4A77BA723D9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti427 – 4271P → L.
Corresponds to variant rs17471501 [ dbSNP | Ensembl ].
VAR_057530

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei94 – 952Missing in isoform 2. VSP_008447

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ416091 mRNA. Translation: CAC94778.1.
AC004953 Genomic DNA. No translation available.
AC004965 Genomic DNA. No translation available.
AC006329 Genomic DNA. No translation available.
BC109254 mRNA. Translation: AAI09255.1.
BC110393 mRNA. Translation: AAI10394.1.
CCDSiCCDS64739.1. [Q96A83-1]
RefSeqiNP_001265492.1. NM_001278563.2. [Q96A83-1]
NP_597714.2. NM_133457.4. [Q96A83-2]
UniGeneiHs.654854.

Genome annotation databases

EnsembliENST00000397927; ENSP00000381022; ENSG00000160963.
GeneIDi136227.
KEGGihsa:136227.
UCSCiuc003uyo.1. human. [Q96A83-1]

Polymorphism databases

DMDMi37537825.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ416091 mRNA. Translation: CAC94778.1 .
AC004953 Genomic DNA. No translation available.
AC004965 Genomic DNA. No translation available.
AC006329 Genomic DNA. No translation available.
BC109254 mRNA. Translation: AAI09255.1 .
BC110393 mRNA. Translation: AAI10394.1 .
CCDSi CCDS64739.1. [Q96A83-1 ]
RefSeqi NP_001265492.1. NM_001278563.2. [Q96A83-1 ]
NP_597714.2. NM_133457.4. [Q96A83-2 ]
UniGenei Hs.654854.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BJ3 X-ray 3.04 C/D/E 308-326 [» ]
ProteinModelPortali Q96A83.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126448. 1 interaction.
IntActi Q96A83. 1 interaction.
MINTi MINT-2878718.
STRINGi 9606.ENSP00000381022.

PTM databases

PhosphoSitei Q96A83.

Polymorphism databases

DMDMi 37537825.

Proteomic databases

PaxDbi Q96A83.
PRIDEi Q96A83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397927 ; ENSP00000381022 ; ENSG00000160963 .
GeneIDi 136227.
KEGGi hsa:136227.
UCSCi uc003uyo.1. human. [Q96A83-1 ]

Organism-specific databases

CTDi 136227.
GeneCardsi GC07P101007.
H-InvDB HIX0033568.
HGNCi HGNC:18038. COL26A1.
MIMi 608927. gene.
neXtProti NX_Q96A83.
PharmGKBi PA134887081.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG74199.
HOGENOMi HOG000038011.
HOVERGENi HBG096014.
InParanoidi Q96A83.
PhylomeDBi Q96A83.

Enzyme and pathway databases

Reactomei REACT_121139. Collagen biosynthesis and modifying enzymes.
REACT_150401. Collagen degradation.

Miscellaneous databases

GeneWikii EMID2.
GenomeRNAii 136227.
NextBioi 83553.
PROi Q96A83.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96A83.
Bgeei Q96A83.
CleanExi HS_EMID2.
Genevestigatori Q96A83.

Family and domain databases

InterProi IPR008160. Collagen.
IPR011489. EMI_domain.
[Graphical view ]
Pfami PF01391. Collagen. 2 hits.
PF07546. EMI. 1 hit.
[Graphical view ]
PROSITEi PS51041. EMI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Developmental expression and biochemical characterization of Emu family members."
    Leimeister C., Steidl C., Schumacher N., Erhard S., Gessler M.
    Dev. Biol. 249:204-218(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiCOQA1_HUMAN
AccessioniPrimary (citable) accession number: Q96A83
Secondary accession number(s): Q32M90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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