Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q96A83 (COQA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-1(XXVI) chain
Alternative name(s):
Alpha-1 type XXVI collagen
EMI domain-containing protein 2
Emilin and multimerin domain-containing protein 2
Short name=Emu2
Gene names
Name:COL26A1
Synonyms:EMID2, EMU2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homotrimer or heterotrimer By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Post-translational modification

Hydroxylated on proline residues By similarity.

Sequence similarities

Contains 2 collagen-like domains.

Contains 1 EMI domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96A83-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96A83-2)

The sequence of this isoform differs from the canonical sequence as follows:
     94-95: Missing.
Note: May be due to a competing acceptor splice site.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 441421Collagen alpha-1(XXVI) chain
PRO_0000007825

Regions

Domain52 – 12877EMI
Domain199 – 26769Collagen-like 1
Domain302 – 35554Collagen-like 2

Amino acid modifications

Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation1321N-linked (GlcNAc...) Potential
Disulfide bond56 ↔ 118 By similarity
Disulfide bond83 ↔ 89 By similarity
Disulfide bond117 ↔ 126 By similarity

Natural variations

Alternative sequence94 – 952Missing in isoform 2.
VSP_008447
Natural variant4271P → L.
Corresponds to variant rs17471501 [ dbSNP | Ensembl ].
VAR_057530

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 896CA2AC52B20E92

FASTA44145,381
        10         20         30         40         50         60 
MKLALLLPWA CCCLCGSALA TGFLYPFSAA ALQQHGYPEP GAGSPGSGYA SRRHWCHHTV 

        70         80         90        100        110        120 
TRTVSCQVQN GSETVVQRVY QSCRWPGPCA NLVSYRTLIR PTYRVSYRTV TVLEWRCCPG 

       130        140        150        160        170        180 
FTGSNCDEEC MNCTRLSDMS ERLTTLEAKV LLLEAAERPS SPDNDLPAPE STPPTWNEDF 

       190        200        210        220        230        240 
LPDAIPLAHP VPRQRRPTGP AGPPGQTGPP GPAGPPGSKG DRGQTGEKGP AGPPGLLGPP 

       250        260        270        280        290        300 
GPRGLPGEMG RPGPPGPPGP AGNPGPSPNS PQGALYSLQP PTDKDNGDSR LASAIVDTVL 

       310        320        330        340        350        360 
AGVPGPRGPP GPPGPPGPRG PPGPPGTPGS QGLAGERGTV GPSGEPGVKG EEGEKAATAE 

       370        380        390        400        410        420 
GEGVQQLREA LKILAERVLI LEHMIGIHDP LASPEGGSGQ DAALRANLKM KRGGAQPDGV 

       430        440 
LAALLGPDPG QKSVDQASSR K 

« Hide

Isoform 2 [UniParc].

Checksum: 9F13E4A77BA723D9
Show »

FASTA43945,131

References

« Hide 'large scale' references
[1]"Developmental expression and biochemical characterization of Emu family members."
Leimeister C., Steidl C., Schumacher N., Erhard S., Gessler M.
Dev. Biol. 249:204-218(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ416091 mRNA. Translation: CAC94778.1.
AC004953 Genomic DNA. No translation available.
AC004965 Genomic DNA. No translation available.
AC006329 Genomic DNA. No translation available.
BC109254 mRNA. Translation: AAI09255.1.
BC110393 mRNA. Translation: AAI10394.1.
CCDSCCDS64739.1. [Q96A83-1]
RefSeqNP_001265492.1. NM_001278563.2. [Q96A83-1]
NP_597714.2. NM_133457.4. [Q96A83-2]
UniGeneHs.654854.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4BJ3X-ray3.04C/D/E308-326[»]
ProteinModelPortalQ96A83.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126448. 1 interaction.
IntActQ96A83. 1 interaction.
MINTMINT-2878718.
STRING9606.ENSP00000381022.

PTM databases

PhosphoSiteQ96A83.

Polymorphism databases

DMDM37537825.

Proteomic databases

PaxDbQ96A83.
PRIDEQ96A83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000397927; ENSP00000381022; ENSG00000160963.
GeneID136227.
KEGGhsa:136227.
UCSCuc003uyo.1. human. [Q96A83-1]

Organism-specific databases

CTD136227.
GeneCardsGC07P101007.
H-InvDBHIX0033568.
HGNCHGNC:18038. COL26A1.
MIM608927. gene.
neXtProtNX_Q96A83.
PharmGKBPA134887081.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG74199.
HOGENOMHOG000038011.
HOVERGENHBG096014.
InParanoidQ96A83.
PhylomeDBQ96A83.

Enzyme and pathway databases

ReactomeREACT_118779. Extracellular matrix organization.

Gene expression databases

ArrayExpressQ96A83.
BgeeQ96A83.
CleanExHS_EMID2.
GenevestigatorQ96A83.

Family and domain databases

InterProIPR008160. Collagen.
IPR011489. EMI_domain.
[Graphical view]
PfamPF01391. Collagen. 2 hits.
PF07546. EMI. 1 hit.
[Graphical view]
PROSITEPS51041. EMI. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiEMID2.
GenomeRNAi136227.
NextBio83553.
PROQ96A83.
SOURCESearch...

Entry information

Entry nameCOQA1_HUMAN
AccessionPrimary (citable) accession number: Q96A83
Secondary accession number(s): Q32M90
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM