Q96A83 (COQA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Collagen alpha-1(XXVI) chain

Alternative name(s):
Alpha-1 type XXVI collagen
EMI domain-containing protein 2
Emilin and multimerin domain-containing protein 2
Short name=Emu2

Gene names

Name:	COL26A1
Synonyms:	EMID2, EMU2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Homotrimer or heterotrimer By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Post-translational modification	Hydroxylated on proline residues By similarity.
Sequence similarities	Contains 2 collagen-like domains. Contains 1 EMI domain.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Collagen Repeat Signal
PTM	Disulfide bond Glycoprotein Hydroxylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	collagen catabolic process Traceable author statement. Source: Reactome extracellular matrix disassembly Traceable author statement. Source: Reactome
Cellular_component	collagen Inferred from electronic annotation. Source: UniProtKB-KW endoplasmic reticulum lumen Traceable author statement. Source: Reactome extracellular region Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96A83-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96A83-2)

The sequence of this isoform differs from the canonical sequence as follows:
     94-95: Missing.

Note: May be due to a competing acceptor splice site.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 441	421	Collagen alpha-1(XXVI) chain		PRO_0000007825
Regions
	Domain	52 – 128	77	EMI
	Domain	199 – 267	69	Collagen-like 1
	Domain	302 – 355	54	Collagen-like 2
Amino acid modifications
	Glycosylation	70	1	N-linked (GlcNAc...) Potential
	Glycosylation	132	1	N-linked (GlcNAc...) Potential
	Disulfide bond	56 ↔ 118		By similarity
	Disulfide bond	83 ↔ 89		By similarity
	Disulfide bond	117 ↔ 126		By similarity
Natural variations
	Alternative sequence	94 – 95	2	Missing in isoform 2.		VSP_008447
	Natural variant	427	1	P → L. Corresponds to variant rs17471501 [ dbSNP | Ensembl ].		VAR_057530

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 896CA2AC52B20E92	FASTA	441	45,381
	10 20 30 40 50 60 MKLALLLPWA CCCLCGSALA TGFLYPFSAA ALQQHGYPEP GAGSPGSGYA SRRHWCHHTV 70 80 90 100 110 120 TRTVSCQVQN GSETVVQRVY QSCRWPGPCA NLVSYRTLIR PTYRVSYRTV TVLEWRCCPG 130 140 150 160 170 180 FTGSNCDEEC MNCTRLSDMS ERLTTLEAKV LLLEAAERPS SPDNDLPAPE STPPTWNEDF 190 200 210 220 230 240 LPDAIPLAHP VPRQRRPTGP AGPPGQTGPP GPAGPPGSKG DRGQTGEKGP AGPPGLLGPP 250 260 270 280 290 300 GPRGLPGEMG RPGPPGPPGP AGNPGPSPNS PQGALYSLQP PTDKDNGDSR LASAIVDTVL 310 320 330 340 350 360 AGVPGPRGPP GPPGPPGPRG PPGPPGTPGS QGLAGERGTV GPSGEPGVKG EEGEKAATAE 370 380 390 400 410 420 GEGVQQLREA LKILAERVLI LEHMIGIHDP LASPEGGSGQ DAALRANLKM KRGGAQPDGV 430 440 LAALLGPDPG QKSVDQASSR K
	Isoform 2 [UniParc]. Checksum: 9F13E4A77BA723D9	FASTA	439	45,131
	10 20 30 40 50 60 MKLALLLPWA CCCLCGSALA TGFLYPFSAA ALQQHGYPEP GAGSPGSGYA SRRHWCHHTV 70 80 90 100 110 120 TRTVSCQVQN GSETVVQRVY QSCRWPGPCA NLVRTLIRPT YRVSYRTVTV LEWRCCPGFT 130 140 150 160 170 180 GSNCDEECMN CTRLSDMSER LTTLEAKVLL LEAAERPSSP DNDLPAPEST PPTWNEDFLP 190 200 210 220 230 240 DAIPLAHPVP RQRRPTGPAG PPGQTGPPGP AGPPGSKGDR GQTGEKGPAG PPGLLGPPGP 250 260 270 280 290 300 RGLPGEMGRP GPPGPPGPAG NPGPSPNSPQ GALYSLQPPT DKDNGDSRLA SAIVDTVLAG 310 320 330 340 350 360 VPGPRGPPGP PGPPGPRGPP GPPGTPGSQG LAGERGTVGP SGEPGVKGEE GEKAATAEGE 370 380 390 400 410 420 GVQQLREALK ILAERVLILE HMIGIHDPLA SPEGGSGQDA ALRANLKMKR GGAQPDGVLA 430 ALLGPDPGQK SVDQASSRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Developmental expression and biochemical characterization of Emu family members." Leimeister C., Steidl C., Schumacher N., Erhard S., Gessler M. Dev. Biol. 249:204-218(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ416091 mRNA. Translation: CAC94778.1. AC004953 Genomic DNA. No translation available. AC004965 Genomic DNA. No translation available. AC006329 Genomic DNA. No translation available. BC109254 mRNA. Translation: AAI09255.1. BC110393 mRNA. Translation: AAI10394.1.
IPI	IPI00059297. IPI00374096.
RefSeq	NP_597714.2. NM_133457.2.
UniGene	Hs.654854.
3D structure databases
ProteinModelPortal	Q96A83.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96A83. 1 interaction.
MINT	MINT-2878718.
STRING	9606.ENSP00000381022.
PTM databases
PhosphoSite	Q96A83.
Polymorphism databases
DMDM	37537825.
Proteomic databases
PaxDb	Q96A83.
PRIDE	Q96A83.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000397927; ENSP00000381022; ENSG00000160963.
GeneID	136227.
KEGG	hsa:136227.
UCSC	uc003uyo.1. human. uc010lhy.1. human.
Organism-specific databases
CTD	136227.
GeneCards	GC07P101006.
H-InvDB	HIX0033568.
HGNC	HGNC:18038. COL26A1.
MIM	608927. gene.
neXtProt	NX_Q96A83.
PharmGKB	PA134887081.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG74199.
HOGENOM	HOG000038011.
HOVERGEN	HBG096014.
InParanoid	Q96A83.
OrthoDB	EOG47WNPG.
Enzyme and pathway databases
Reactome	REACT_118779. Extracellular matrix organization.
Gene expression databases
ArrayExpress	Q96A83.
Bgee	Q96A83.
CleanEx	HS_EMID2.
Genevestigator	Q96A83.
GermOnline	ENSG00000160963. Homo sapiens.
Family and domain databases
InterPro	IPR008160. Collagen. IPR011489. EMI_domain. [Graphical view]
Pfam	PF01391. Collagen. 2 hits. PF07546. EMI. 1 hit. [Graphical view]
PROSITE	PS51041. EMI. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	136227.
NextBio	83553.
SOURCE	Search...

Entry information

Entry name

COQA1_HUMAN

Accession

Primary (citable) accession number: Q96A83
Secondary accession number(s): Q32M90

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	December 1, 2001
Last modified:	May 29, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.