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Protein

Putative monooxygenase p33MONOX

Gene

KIAA1191

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Putative monooxygenase p33MONOX (EC:1.-.-.-)
Alternative name(s):
Brain-derived rescue factor p60MONOX
Flavin monooxygenase motif-containing protein of 33 kDa
Gene namesi
Name:KIAA1191
Synonyms:P33MONOX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29209. KIAA1191.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485516.

Polymorphism and mutation databases

DMDMi74731096.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Putative monooxygenase p33MONOXPRO_0000307730Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441PhosphothreonineBy similarity
Modified residuei175 – 1751PhosphothreonineBy similarity
Modified residuei182 – 1821PhosphoserineCombined sources
Modified residuei183 – 1831PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96A73.
MaxQBiQ96A73.
PaxDbiQ96A73.
PeptideAtlasiQ96A73.
PRIDEiQ96A73.

PTM databases

iPTMnetiQ96A73.
PhosphoSiteiQ96A73.

Expressioni

Tissue specificityi

Down-regulated in the occipital lobe of an early stage Alzheimer disease patients.1 Publication

Gene expression databases

BgeeiENSG00000122203.
CleanExiHS_KIAA1191.
ExpressionAtlasiQ96A73. baseline and differential.
GenevisibleiQ96A73. HS.

Organism-specific databases

HPAiHPA044701.
HPA048145.

Interactioni

Subunit structurei

Interacts with COBRA1, NOL12 and PRNP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
POT1Q9NUX52EBI-725897,EBI-752420

Protein-protein interaction databases

BioGridi121428. 21 interactions.
IntActiQ96A73. 14 interactions.
MINTiMINT-4715724.
STRINGi9606.ENSP00000298569.

Structurei

3D structure databases

ProteinModelPortaliQ96A73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi67 – 7711Flavin-containing monooxygenase motifAdd
BLAST

Sequence similaritiesi

Belongs to the P33MONOX family.Curated

Phylogenomic databases

eggNOGiENOG410IH5Y. Eukaryota.
ENOG410YBU1. LUCA.
GeneTreeiENSGT00390000000537.
HOVERGENiHBG055539.
InParanoidiQ96A73.
OMAiAQKPSPM.
OrthoDBiEOG091G0FR1.
PhylomeDBiQ96A73.
TreeFamiTF332226.

Family and domain databases

InterProiIPR026759. P33MONOX.
[Graphical view]
PfamiPF15302. P33MONOX. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASRQPEVPA LEASAPLGKM SLPIGIYRRA VSYDDTLEDP APMTPPPSDM
60 70 80 90 100
GSVPWKPVIP ERKYQHLAKV EEGEASLPSP AMTLSSAIDS VDKVPVVKAK
110 120 130 140 150
ATHVIMNSLI TKQTQESIQH FERQAGLRDA GYTPHKGLTT EETKYLRVAE
160 170 180 190 200
ALHKLKLQSG EVTKEERQPA SAQSTPSTTP HSSPKQRPRG WFTSGSSTAL
210 220 230 240 250
PGPNPSTMDS GSGDKDRNLS DKWSLFGPRS LQKYDSGSFA TQAYRGAQKP
260 270 280 290 300
SPLELIRAQA NRMAEDPAAL KPPKMDIPVM EGKKQPPRAH NLKPRDLNVL

TPTGF
Length:305
Mass (Da):33,247
Last modified:December 1, 2001 - v1
Checksum:i0BC0519F401593CF
GO
Isoform 2 (identifier: Q96A73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:286
Mass (Da):31,312
Checksum:i1BFED70C31D87693
GO
Isoform 3 (identifier: Q96A73-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-207: Missing.

Show »
Length:98
Mass (Da):10,836
Checksum:iA17B8FC1941E885A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561K → R in BAB14957 (PubMed:14702039).Curated
Sequence conflicti97 – 971V → A in CAB99231 (PubMed:17974005).Curated
Sequence conflicti225 – 2251L → P in CAG33612 (Ref. 3) Curated
Sequence conflicti250 – 2501P → S in CAB99231 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 207207Missing in isoform 3. 1 PublicationVSP_028800Add
BLAST
Alternative sequencei1 – 1919Missing in isoform 2. 1 PublicationVSP_028801Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ073392 mRNA. Translation: AAY82896.1.
AK024675 mRNA. Translation: BAB14957.1.
AK315428 mRNA. Translation: BAG37816.1.
CR457331 mRNA. Translation: CAG33612.1.
AL390217 mRNA. Translation: CAB99231.1.
BX648859 mRNA. Translation: CAH56134.1.
AC138956 Genomic DNA. No translation available.
CH471195 Genomic DNA. Translation: EAW85087.1.
BC006316 mRNA. Translation: AAH06316.1.
BC010448 mRNA. Translation: AAH10448.1.
BC012848 mRNA. Translation: AAH12848.1.
BC017097 mRNA. Translation: AAH17097.1.
AB033017 mRNA. Translation: BAA86505.1.
CCDSiCCDS43402.1. [Q96A73-2]
CCDS4399.1. [Q96A73-1]
RefSeqiNP_001073152.1. NM_001079684.2. [Q96A73-2]
NP_001073153.1. NM_001079685.2. [Q96A73-1]
NP_001274264.1. NM_001287335.1.
NP_001274265.1. NM_001287336.1. [Q96A73-2]
NP_065177.2. NM_020444.4. [Q96A73-1]
XP_005265998.1. XM_005265941.1. [Q96A73-2]
XP_005266003.1. XM_005265946.4. [Q96A73-2]
UniGeneiHs.743257.

Genome annotation databases

EnsembliENST00000298569; ENSP00000298569; ENSG00000122203. [Q96A73-1]
ENST00000393725; ENSP00000377326; ENSG00000122203. [Q96A73-2]
ENST00000510164; ENSP00000421061; ENSG00000122203. [Q96A73-1]
ENST00000614420; ENSP00000479627; ENSG00000122203. [Q96A73-2]
GeneIDi57179.
KEGGihsa:57179.
UCSCiuc003mdw.5. human. [Q96A73-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ073392 mRNA. Translation: AAY82896.1.
AK024675 mRNA. Translation: BAB14957.1.
AK315428 mRNA. Translation: BAG37816.1.
CR457331 mRNA. Translation: CAG33612.1.
AL390217 mRNA. Translation: CAB99231.1.
BX648859 mRNA. Translation: CAH56134.1.
AC138956 Genomic DNA. No translation available.
CH471195 Genomic DNA. Translation: EAW85087.1.
BC006316 mRNA. Translation: AAH06316.1.
BC010448 mRNA. Translation: AAH10448.1.
BC012848 mRNA. Translation: AAH12848.1.
BC017097 mRNA. Translation: AAH17097.1.
AB033017 mRNA. Translation: BAA86505.1.
CCDSiCCDS43402.1. [Q96A73-2]
CCDS4399.1. [Q96A73-1]
RefSeqiNP_001073152.1. NM_001079684.2. [Q96A73-2]
NP_001073153.1. NM_001079685.2. [Q96A73-1]
NP_001274264.1. NM_001287335.1.
NP_001274265.1. NM_001287336.1. [Q96A73-2]
NP_065177.2. NM_020444.4. [Q96A73-1]
XP_005265998.1. XM_005265941.1. [Q96A73-2]
XP_005266003.1. XM_005265946.4. [Q96A73-2]
UniGeneiHs.743257.

3D structure databases

ProteinModelPortaliQ96A73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121428. 21 interactions.
IntActiQ96A73. 14 interactions.
MINTiMINT-4715724.
STRINGi9606.ENSP00000298569.

PTM databases

iPTMnetiQ96A73.
PhosphoSiteiQ96A73.

Polymorphism and mutation databases

DMDMi74731096.

Proteomic databases

EPDiQ96A73.
MaxQBiQ96A73.
PaxDbiQ96A73.
PeptideAtlasiQ96A73.
PRIDEiQ96A73.

Protocols and materials databases

DNASUi57179.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298569; ENSP00000298569; ENSG00000122203. [Q96A73-1]
ENST00000393725; ENSP00000377326; ENSG00000122203. [Q96A73-2]
ENST00000510164; ENSP00000421061; ENSG00000122203. [Q96A73-1]
ENST00000614420; ENSP00000479627; ENSG00000122203. [Q96A73-2]
GeneIDi57179.
KEGGihsa:57179.
UCSCiuc003mdw.5. human. [Q96A73-1]

Organism-specific databases

CTDi57179.
GeneCardsiKIAA1191.
HGNCiHGNC:29209. KIAA1191.
HPAiHPA044701.
HPA048145.
neXtProtiNX_Q96A73.
PharmGKBiPA143485516.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH5Y. Eukaryota.
ENOG410YBU1. LUCA.
GeneTreeiENSGT00390000000537.
HOVERGENiHBG055539.
InParanoidiQ96A73.
OMAiAQKPSPM.
OrthoDBiEOG091G0FR1.
PhylomeDBiQ96A73.
TreeFamiTF332226.

Miscellaneous databases

ChiTaRSiKIAA1191. human.
GenomeRNAii57179.
PROiQ96A73.

Gene expression databases

BgeeiENSG00000122203.
CleanExiHS_KIAA1191.
ExpressionAtlasiQ96A73. baseline and differential.
GenevisibleiQ96A73. HS.

Family and domain databases

InterProiIPR026759. P33MONOX.
[Graphical view]
PfamiPF15302. P33MONOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP33MX_HUMAN
AccessioniPrimary (citable) accession number: Q96A73
Secondary accession number(s): B2RD69
, B8K1S6, Q6IA24, Q8NDU3, Q9BRE5, Q9H7D5, Q9ULM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.