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Protein

Putative monooxygenase p33MONOX

Gene

KIAA1191

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Putative monooxygenase p33MONOX (EC:1.-.-.-)
Alternative name(s):
Brain-derived rescue factor p60MONOX
Flavin monooxygenase motif-containing protein of 33 kDa
Gene namesi
Name:KIAA1191
Synonyms:P33MONOX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000122203.14
HGNCiHGNC:29209 KIAA1191
neXtProtiNX_Q96A73

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000122203
PharmGKBiPA143485516

Polymorphism and mutation databases

DMDMi74731096

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077301 – 305Putative monooxygenase p33MONOXAdd BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphothreonineBy similarity1
Modified residuei175PhosphothreonineBy similarity1
Modified residuei182PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96A73
MaxQBiQ96A73
PaxDbiQ96A73
PeptideAtlasiQ96A73
PRIDEiQ96A73

PTM databases

iPTMnetiQ96A73
PhosphoSitePlusiQ96A73

Expressioni

Tissue specificityi

Down-regulated in the occipital lobe of an early stage Alzheimer disease patients.1 Publication

Gene expression databases

BgeeiENSG00000122203
CleanExiHS_KIAA1191
ExpressionAtlasiQ96A73 baseline and differential
GenevisibleiQ96A73 HS

Organism-specific databases

HPAiHPA044701
HPA048145

Interactioni

Subunit structurei

Interacts with COBRA1, NOL12 and PRNP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
POT1Q9NUX52EBI-725897,EBI-752420

Protein-protein interaction databases

BioGridi121428, 23 interactors
IntActiQ96A73, 19 interactors
MINTiQ96A73
STRINGi9606.ENSP00000298569

Structurei

3D structure databases

ProteinModelPortaliQ96A73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi67 – 77Flavin-containing monooxygenase motifAdd BLAST11

Sequence similaritiesi

Belongs to the P33MONOX family.Curated

Phylogenomic databases

eggNOGiENOG410IH5Y Eukaryota
ENOG410YBU1 LUCA
GeneTreeiENSGT00390000000537
HOVERGENiHBG055539
InParanoidiQ96A73
OMAiAQKPSPM
OrthoDBiEOG091G0FR1
PhylomeDBiQ96A73
TreeFamiTF332226

Family and domain databases

InterProiView protein in InterPro
IPR026759 P33MONOX
PANTHERiPTHR28342 PTHR28342, 1 hit
PfamiView protein in Pfam
PF15302 P33MONOX, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASRQPEVPA LEASAPLGKM SLPIGIYRRA VSYDDTLEDP APMTPPPSDM
60 70 80 90 100
GSVPWKPVIP ERKYQHLAKV EEGEASLPSP AMTLSSAIDS VDKVPVVKAK
110 120 130 140 150
ATHVIMNSLI TKQTQESIQH FERQAGLRDA GYTPHKGLTT EETKYLRVAE
160 170 180 190 200
ALHKLKLQSG EVTKEERQPA SAQSTPSTTP HSSPKQRPRG WFTSGSSTAL
210 220 230 240 250
PGPNPSTMDS GSGDKDRNLS DKWSLFGPRS LQKYDSGSFA TQAYRGAQKP
260 270 280 290 300
SPLELIRAQA NRMAEDPAAL KPPKMDIPVM EGKKQPPRAH NLKPRDLNVL

TPTGF
Length:305
Mass (Da):33,247
Last modified:December 1, 2001 - v1
Checksum:i0BC0519F401593CF
GO
Isoform 2 (identifier: Q96A73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:286
Mass (Da):31,312
Checksum:i1BFED70C31D87693
GO
Isoform 3 (identifier: Q96A73-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-207: Missing.

Show »
Length:98
Mass (Da):10,836
Checksum:iA17B8FC1941E885A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56K → R in BAB14957 (PubMed:14702039).Curated1
Sequence conflicti97V → A in CAB99231 (PubMed:17974005).Curated1
Sequence conflicti225L → P in CAG33612 (Ref. 3) Curated1
Sequence conflicti250P → S in CAB99231 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0288001 – 207Missing in isoform 3. 1 PublicationAdd BLAST207
Alternative sequenceiVSP_0288011 – 19Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ073392 mRNA Translation: AAY82896.1
AK024675 mRNA Translation: BAB14957.1
AK315428 mRNA Translation: BAG37816.1
CR457331 mRNA Translation: CAG33612.1
AL390217 mRNA Translation: CAB99231.1
BX648859 mRNA Translation: CAH56134.1
AC138956 Genomic DNA No translation available.
CH471195 Genomic DNA Translation: EAW85087.1
BC006316 mRNA Translation: AAH06316.1
BC010448 mRNA Translation: AAH10448.1
BC012848 mRNA Translation: AAH12848.1
BC017097 mRNA Translation: AAH17097.1
AB033017 mRNA Translation: BAA86505.1
CCDSiCCDS43402.1 [Q96A73-2]
CCDS4399.1 [Q96A73-1]
RefSeqiNP_001073152.1, NM_001079684.2 [Q96A73-2]
NP_001073153.1, NM_001079685.2 [Q96A73-1]
NP_001274264.1, NM_001287335.1
NP_001274265.1, NM_001287336.1 [Q96A73-2]
NP_065177.2, NM_020444.4 [Q96A73-1]
XP_005265998.1, XM_005265941.1 [Q96A73-2]
XP_005266003.1, XM_005265946.4 [Q96A73-2]
UniGeneiHs.743257

Genome annotation databases

EnsembliENST00000298569; ENSP00000298569; ENSG00000122203 [Q96A73-1]
ENST00000393725; ENSP00000377326; ENSG00000122203 [Q96A73-2]
ENST00000510164; ENSP00000421061; ENSG00000122203 [Q96A73-1]
ENST00000614420; ENSP00000479627; ENSG00000122203 [Q96A73-2]
GeneIDi57179
KEGGihsa:57179
UCSCiuc003mdw.5 human [Q96A73-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiP33MX_HUMAN
AccessioniPrimary (citable) accession number: Q96A73
Secondary accession number(s): B2RD69
, B8K1S6, Q6IA24, Q8NDU3, Q9BRE5, Q9H7D5, Q9ULM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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