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Q96A72

- MGN2_HUMAN

UniProt

Q96A72 - MGN2_HUMAN

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Protein

Protein mago nashi homolog 2

Gene
MAGOHB, MAGOH2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway By similarity.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. mRNA transport Source: UniProtKB-KW
  3. RNA splicing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing, mRNA transport, Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein mago nashi homolog 2
Gene namesi
Name:MAGOHB
Synonyms:MAGOH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:25504. MAGOHB.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394899.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 148147Protein mago nashi homolog 2PRO_0000174146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine4 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96A72.
PaxDbiQ96A72.
PRIDEiQ96A72.

PTM databases

PhosphoSiteiQ96A72.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ96A72.
BgeeiQ96A72.
CleanExiHS_MAGOHB.
GenevestigatoriQ96A72.

Interactioni

Subunit structurei

Interacts with RBM8A and is part of the exon junction complex (EJC) By similarity.

Protein-protein interaction databases

BioGridi120420. 11 interactions.
IntActiQ96A72. 7 interactions.
MINTiMINT-1479383.
STRINGi9606.ENSP00000319240.

Structurei

3D structure databases

ProteinModelPortaliQ96A72.
SMRiQ96A72. Positions 6-148.

Family & Domainsi

Sequence similaritiesi

Belongs to the mago nashi family.

Phylogenomic databases

eggNOGiNOG276860.
HOGENOMiHOG000207428.
HOVERGENiHBG004353.
InParanoidiQ96A72.
KOiK12877.
OMAiGHEFLEY.
PhylomeDBiQ96A72.
TreeFamiTF300128.

Family and domain databases

Gene3Di3.30.1560.10. 1 hit.
InterProiIPR004023. Mago_nashi.
[Graphical view]
PANTHERiPTHR12638. PTHR12638. 1 hit.
PfamiPF02792. Mago_nashi. 1 hit.
[Graphical view]
SUPFAMiSSF89817. SSF89817. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96A72-1 [UniParc]FASTAAdd to Basket

« Hide

MAVASDFYLR YYVGHKGKFG HEFLEFEFRP DGKLRYANNS NYKNDVMIRK    50
EAYVHKSVME ELKRIIDDSE ITKEDDALWP PPDRVGRQEL EIVIGDEHIS 100
FTTSKIGSLI DVNQSKDPEG LRVFYYLVQD LKCLVFSLIG LHFKIKPI 148
Length:148
Mass (Da):17,276
Last modified:December 1, 2001 - v1
Checksum:i0C7D8F79ACC09E39
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti119 – 1191E → K in a breast cancer sample; somatic mutation. 1 Publication
VAR_036431

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF165518 mRNA. Translation: AAF86648.1.
AK001154 mRNA. Translation: BAA91522.1.
AK022720 mRNA. Translation: BAB14202.1.
BC010905 mRNA. Translation: AAH10905.1.
CCDSiCCDS8628.1.
RefSeqiNP_060518.1. NM_018048.3.
UniGeneiHs.104650.

Genome annotation databases

EnsembliENST00000320756; ENSP00000319240; ENSG00000111196.
GeneIDi55110.
KEGGihsa:55110.
UCSCiuc001qyq.2. human.

Polymorphism databases

DMDMi74731095.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF165518 mRNA. Translation: AAF86648.1 .
AK001154 mRNA. Translation: BAA91522.1 .
AK022720 mRNA. Translation: BAB14202.1 .
BC010905 mRNA. Translation: AAH10905.1 .
CCDSi CCDS8628.1.
RefSeqi NP_060518.1. NM_018048.3.
UniGenei Hs.104650.

3D structure databases

ProteinModelPortali Q96A72.
SMRi Q96A72. Positions 6-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120420. 11 interactions.
IntActi Q96A72. 7 interactions.
MINTi MINT-1479383.
STRINGi 9606.ENSP00000319240.

PTM databases

PhosphoSitei Q96A72.

Polymorphism databases

DMDMi 74731095.

Proteomic databases

MaxQBi Q96A72.
PaxDbi Q96A72.
PRIDEi Q96A72.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320756 ; ENSP00000319240 ; ENSG00000111196 .
GeneIDi 55110.
KEGGi hsa:55110.
UCSCi uc001qyq.2. human.

Organism-specific databases

CTDi 55110.
GeneCardsi GC12M010756.
HGNCi HGNC:25504. MAGOHB.
neXtProti NX_Q96A72.
PharmGKBi PA162394899.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276860.
HOGENOMi HOG000207428.
HOVERGENi HBG004353.
InParanoidi Q96A72.
KOi K12877.
OMAi GHEFLEY.
PhylomeDBi Q96A72.
TreeFami TF300128.

Miscellaneous databases

ChiTaRSi MAGOHB. human.
GenomeRNAii 55110.
NextBioi 58729.
PROi Q96A72.

Gene expression databases

ArrayExpressi Q96A72.
Bgeei Q96A72.
CleanExi HS_MAGOHB.
Genevestigatori Q96A72.

Family and domain databases

Gene3Di 3.30.1560.10. 1 hit.
InterProi IPR004023. Mago_nashi.
[Graphical view ]
PANTHERi PTHR12638. PTHR12638. 1 hit.
Pfami PF02792. Mago_nashi. 1 hit.
[Graphical view ]
SUPFAMi SSF89817. SSF89817. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
    Gu J., Huang Q., Yu Y., Xu S., Wang Y., Han Z., Chen Z., Zhou J., Tu Y., Gu W., Fu G., Huang C.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hematopoietic stem cell.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-10; 65-73 AND 106-116, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Ovarian carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-119.

Entry informationi

Entry nameiMGN2_HUMAN
AccessioniPrimary (citable) accession number: Q96A72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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