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Protein

Protein mago nashi homolog 2

Gene

MAGOHB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.By similarity

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, mRNA transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72187. mRNA 3'-end processing.
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein mago nashi homolog 2
Gene namesi
Name:MAGOHB
Synonyms:MAGOH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111196.9.
HGNCiHGNC:25504. MAGOHB.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55110.
OpenTargetsiENSG00000111196.
PharmGKBiPA162394899.

Polymorphism and mutation databases

BioMutaiMAGOHB.
DMDMi74731095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001741462 – 148Protein mago nashi homolog 2Add BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96A72.
MaxQBiQ96A72.
PaxDbiQ96A72.
PeptideAtlasiQ96A72.
PRIDEiQ96A72.
TopDownProteomicsiQ96A72.

PTM databases

iPTMnetiQ96A72.
PhosphoSitePlusiQ96A72.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000111196.
CleanExiHS_MAGOHB.
ExpressionAtlasiQ96A72. baseline and differential.
GenevisibleiQ96A72. HS.

Organism-specific databases

HPAiHPA043036.
HPA047754.

Interactioni

Subunit structurei

Interacts with RBM8A and is part of the exon junction complex (EJC).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120420. 34 interactors.
IntActiQ96A72. 59 interactors.
MINTiMINT-1479383.
STRINGi9606.ENSP00000319240.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XJCelectron microscopy3.60v1-148[»]
ProteinModelPortaliQ96A72.
SMRiQ96A72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mago nashi family.Curated

Phylogenomic databases

eggNOGiKOG3392. Eukaryota.
ENOG4111FJ7. LUCA.
GeneTreeiENSGT00390000003156.
HOGENOMiHOG000207428.
HOVERGENiHBG004353.
InParanoidiQ96A72.
KOiK12877.
OMAiDRVGRQX.
OrthoDBiEOG091G0UKA.
PhylomeDBiQ96A72.
TreeFamiTF300128.

Family and domain databases

CDDicd11295. Mago_nashi. 1 hit.
Gene3Di3.30.1560.10. 1 hit.
InterProiView protein in InterPro
IPR004023. Mago_nashi.
IPR036605. Mago_nashi_sf.
PANTHERiPTHR12638. PTHR12638. 1 hit.
PfamiView protein in Pfam
PF02792. Mago_nashi. 1 hit.
SUPFAMiSSF89817. SSF89817. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96A72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVASDFYLR YYVGHKGKFG HEFLEFEFRP DGKLRYANNS NYKNDVMIRK
60 70 80 90 100
EAYVHKSVME ELKRIIDDSE ITKEDDALWP PPDRVGRQEL EIVIGDEHIS
110 120 130 140
FTTSKIGSLI DVNQSKDPEG LRVFYYLVQD LKCLVFSLIG LHFKIKPI
Length:148
Mass (Da):17,276
Last modified:December 1, 2001 - v1
Checksum:i0C7D8F79ACC09E39
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036431119E → K in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF165518 mRNA. Translation: AAF86648.1.
AK001154 mRNA. Translation: BAA91522.1.
AK022720 mRNA. Translation: BAB14202.1.
BC010905 mRNA. Translation: AAH10905.1.
CCDSiCCDS8628.1.
RefSeqiNP_001306914.1. NM_001319985.1.
NP_060518.1. NM_018048.4.
UniGeneiHs.104650.

Genome annotation databases

EnsembliENST00000320756; ENSP00000319240; ENSG00000111196.
GeneIDi55110.
KEGGihsa:55110.
UCSCiuc001qyq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMGN2_HUMAN
AccessioniPrimary (citable) accession number: Q96A72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families