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Q96A72

- MGN2_HUMAN

UniProt

Q96A72 - MGN2_HUMAN

Protein

Protein mago nashi homolog 2

Gene

MAGOHB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.By similarity

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. mRNA transport Source: UniProtKB-KW
    3. RNA splicing Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA processing, mRNA splicing, mRNA transport, Transport

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein mago nashi homolog 2
    Gene namesi
    Name:MAGOHB
    Synonyms:MAGOH2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:25504. MAGOHB.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162394899.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed4 Publications
    Chaini2 – 148147Protein mago nashi homolog 2PRO_0000174146Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine4 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ96A72.
    PaxDbiQ96A72.
    PRIDEiQ96A72.

    PTM databases

    PhosphoSiteiQ96A72.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ96A72.
    BgeeiQ96A72.
    CleanExiHS_MAGOHB.
    GenevestigatoriQ96A72.

    Interactioni

    Subunit structurei

    Interacts with RBM8A and is part of the exon junction complex (EJC).By similarity

    Protein-protein interaction databases

    BioGridi120420. 11 interactions.
    IntActiQ96A72. 7 interactions.
    MINTiMINT-1479383.
    STRINGi9606.ENSP00000319240.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96A72.
    SMRiQ96A72. Positions 6-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mago nashi family.Curated

    Phylogenomic databases

    eggNOGiNOG276860.
    HOGENOMiHOG000207428.
    HOVERGENiHBG004353.
    InParanoidiQ96A72.
    KOiK12877.
    OMAiGHEFLEY.
    PhylomeDBiQ96A72.
    TreeFamiTF300128.

    Family and domain databases

    Gene3Di3.30.1560.10. 1 hit.
    InterProiIPR004023. Mago_nashi.
    [Graphical view]
    PANTHERiPTHR12638. PTHR12638. 1 hit.
    PfamiPF02792. Mago_nashi. 1 hit.
    [Graphical view]
    SUPFAMiSSF89817. SSF89817. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96A72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVASDFYLR YYVGHKGKFG HEFLEFEFRP DGKLRYANNS NYKNDVMIRK    50
    EAYVHKSVME ELKRIIDDSE ITKEDDALWP PPDRVGRQEL EIVIGDEHIS 100
    FTTSKIGSLI DVNQSKDPEG LRVFYYLVQD LKCLVFSLIG LHFKIKPI 148
    Length:148
    Mass (Da):17,276
    Last modified:December 1, 2001 - v1
    Checksum:i0C7D8F79ACC09E39
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti119 – 1191E → K in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036431

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF165518 mRNA. Translation: AAF86648.1.
    AK001154 mRNA. Translation: BAA91522.1.
    AK022720 mRNA. Translation: BAB14202.1.
    BC010905 mRNA. Translation: AAH10905.1.
    CCDSiCCDS8628.1.
    RefSeqiNP_060518.1. NM_018048.3.
    UniGeneiHs.104650.

    Genome annotation databases

    EnsembliENST00000320756; ENSP00000319240; ENSG00000111196.
    GeneIDi55110.
    KEGGihsa:55110.
    UCSCiuc001qyq.2. human.

    Polymorphism databases

    DMDMi74731095.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF165518 mRNA. Translation: AAF86648.1 .
    AK001154 mRNA. Translation: BAA91522.1 .
    AK022720 mRNA. Translation: BAB14202.1 .
    BC010905 mRNA. Translation: AAH10905.1 .
    CCDSi CCDS8628.1.
    RefSeqi NP_060518.1. NM_018048.3.
    UniGenei Hs.104650.

    3D structure databases

    ProteinModelPortali Q96A72.
    SMRi Q96A72. Positions 6-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120420. 11 interactions.
    IntActi Q96A72. 7 interactions.
    MINTi MINT-1479383.
    STRINGi 9606.ENSP00000319240.

    PTM databases

    PhosphoSitei Q96A72.

    Polymorphism databases

    DMDMi 74731095.

    Proteomic databases

    MaxQBi Q96A72.
    PaxDbi Q96A72.
    PRIDEi Q96A72.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320756 ; ENSP00000319240 ; ENSG00000111196 .
    GeneIDi 55110.
    KEGGi hsa:55110.
    UCSCi uc001qyq.2. human.

    Organism-specific databases

    CTDi 55110.
    GeneCardsi GC12M010756.
    HGNCi HGNC:25504. MAGOHB.
    neXtProti NX_Q96A72.
    PharmGKBi PA162394899.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG276860.
    HOGENOMi HOG000207428.
    HOVERGENi HBG004353.
    InParanoidi Q96A72.
    KOi K12877.
    OMAi GHEFLEY.
    PhylomeDBi Q96A72.
    TreeFami TF300128.

    Miscellaneous databases

    ChiTaRSi MAGOHB. human.
    GenomeRNAii 55110.
    NextBioi 58729.
    PROi Q96A72.

    Gene expression databases

    ArrayExpressi Q96A72.
    Bgeei Q96A72.
    CleanExi HS_MAGOHB.
    Genevestigatori Q96A72.

    Family and domain databases

    Gene3Di 3.30.1560.10. 1 hit.
    InterProi IPR004023. Mago_nashi.
    [Graphical view ]
    PANTHERi PTHR12638. PTHR12638. 1 hit.
    Pfami PF02792. Mago_nashi. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89817. SSF89817. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
      Gu J., Huang Q., Yu Y., Xu S., Wang Y., Han Z., Chen Z., Zhou J., Tu Y., Gu W., Fu G., Huang C.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hematopoietic stem cell.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-10; 65-73 AND 106-116, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Ovarian carcinoma.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-119.

    Entry informationi

    Entry nameiMGN2_HUMAN
    AccessioniPrimary (citable) accession number: Q96A72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3