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Protein

Protein mago nashi homolog 2

Gene

MAGOHB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. mRNA transport Source: UniProtKB-KW
  3. RNA splicing Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing, mRNA transport, Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein mago nashi homolog 2
Gene namesi
Name:MAGOHB
Synonyms:MAGOH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:25504. MAGOHB.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. catalytic step 2 spliceosome Source: GO_Central
  2. exon-exon junction complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394899.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed4 Publications
Chaini2 – 148147Protein mago nashi homolog 2PRO_0000174146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine4 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96A72.
PaxDbiQ96A72.
PRIDEiQ96A72.

PTM databases

PhosphoSiteiQ96A72.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ96A72.
CleanExiHS_MAGOHB.
ExpressionAtlasiQ96A72. baseline and differential.
GenevestigatoriQ96A72.

Interactioni

Subunit structurei

Interacts with RBM8A and is part of the exon junction complex (EJC).By similarity

Protein-protein interaction databases

BioGridi120420. 25 interactions.
IntActiQ96A72. 7 interactions.
MINTiMINT-1479383.
STRINGi9606.ENSP00000319240.

Structurei

3D structure databases

ProteinModelPortaliQ96A72.
SMRiQ96A72. Positions 6-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mago nashi family.Curated

Phylogenomic databases

eggNOGiNOG276860.
GeneTreeiENSGT00390000003156.
HOGENOMiHOG000207428.
HOVERGENiHBG004353.
InParanoidiQ96A72.
KOiK12877.
OMAiQDSEIMK.
PhylomeDBiQ96A72.
TreeFamiTF300128.

Family and domain databases

Gene3Di3.30.1560.10. 1 hit.
InterProiIPR004023. Mago_nashi.
[Graphical view]
PANTHERiPTHR12638. PTHR12638. 1 hit.
PfamiPF02792. Mago_nashi. 1 hit.
[Graphical view]
SUPFAMiSSF89817. SSF89817. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96A72-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVASDFYLR YYVGHKGKFG HEFLEFEFRP DGKLRYANNS NYKNDVMIRK
60 70 80 90 100
EAYVHKSVME ELKRIIDDSE ITKEDDALWP PPDRVGRQEL EIVIGDEHIS
110 120 130 140
FTTSKIGSLI DVNQSKDPEG LRVFYYLVQD LKCLVFSLIG LHFKIKPI
Length:148
Mass (Da):17,276
Last modified:December 1, 2001 - v1
Checksum:i0C7D8F79ACC09E39
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti119 – 1191E → K in a breast cancer sample; somatic mutation. 1 Publication
VAR_036431

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF165518 mRNA. Translation: AAF86648.1.
AK001154 mRNA. Translation: BAA91522.1.
AK022720 mRNA. Translation: BAB14202.1.
BC010905 mRNA. Translation: AAH10905.1.
CCDSiCCDS8628.1.
RefSeqiNP_060518.1. NM_018048.3.
UniGeneiHs.104650.

Genome annotation databases

EnsembliENST00000320756; ENSP00000319240; ENSG00000111196.
GeneIDi55110.
KEGGihsa:55110.
UCSCiuc001qyq.2. human.

Polymorphism databases

DMDMi74731095.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF165518 mRNA. Translation: AAF86648.1.
AK001154 mRNA. Translation: BAA91522.1.
AK022720 mRNA. Translation: BAB14202.1.
BC010905 mRNA. Translation: AAH10905.1.
CCDSiCCDS8628.1.
RefSeqiNP_060518.1. NM_018048.3.
UniGeneiHs.104650.

3D structure databases

ProteinModelPortaliQ96A72.
SMRiQ96A72. Positions 6-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120420. 25 interactions.
IntActiQ96A72. 7 interactions.
MINTiMINT-1479383.
STRINGi9606.ENSP00000319240.

PTM databases

PhosphoSiteiQ96A72.

Polymorphism databases

DMDMi74731095.

Proteomic databases

MaxQBiQ96A72.
PaxDbiQ96A72.
PRIDEiQ96A72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320756; ENSP00000319240; ENSG00000111196.
GeneIDi55110.
KEGGihsa:55110.
UCSCiuc001qyq.2. human.

Organism-specific databases

CTDi55110.
GeneCardsiGC12M010756.
HGNCiHGNC:25504. MAGOHB.
neXtProtiNX_Q96A72.
PharmGKBiPA162394899.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG276860.
GeneTreeiENSGT00390000003156.
HOGENOMiHOG000207428.
HOVERGENiHBG004353.
InParanoidiQ96A72.
KOiK12877.
OMAiQDSEIMK.
PhylomeDBiQ96A72.
TreeFamiTF300128.

Miscellaneous databases

ChiTaRSiMAGOHB. human.
GenomeRNAii55110.
NextBioi58729.
PROiQ96A72.

Gene expression databases

BgeeiQ96A72.
CleanExiHS_MAGOHB.
ExpressionAtlasiQ96A72. baseline and differential.
GenevestigatoriQ96A72.

Family and domain databases

Gene3Di3.30.1560.10. 1 hit.
InterProiIPR004023. Mago_nashi.
[Graphical view]
PANTHERiPTHR12638. PTHR12638. 1 hit.
PfamiPF02792. Mago_nashi. 1 hit.
[Graphical view]
SUPFAMiSSF89817. SSF89817. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
    Gu J., Huang Q., Yu Y., Xu S., Wang Y., Han Z., Chen Z., Zhou J., Tu Y., Gu W., Fu G., Huang C.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hematopoietic stem cell.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-10; 65-73 AND 106-116, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Ovarian carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-119.

Entry informationi

Entry nameiMGN2_HUMAN
AccessioniPrimary (citable) accession number: Q96A72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.