Q96A70 (ADC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine decarboxylase
Short name=ADC
Short name=ARGDC
EC=4.1.1.19

Alternative name(s):
ODC-paralogue
Short name=ODC-p
Ornithine decarboxylase-like protein

Gene names

Name:	ADC
Synonyms:	KIAA1945, ODCP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	460 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Decarboxylates L-arginine to agmatine. Truncated splice isoforms probably lack activity. Ref.2
Catalytic activity	L-arginine = agmatine + CO2.
Cofactor	Pyridoxal phosphate By similarity.
Tissue specificity	Highly expressed in brain. Also expressed in testis. Ref.1 Ref.2
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	agmatine biosynthetic process Traceable author statement. Source: Reactome ornithine metabolic process Inferred from electronic annotation. Source: Compara polyamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW polyamine metabolic process Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome spermatogenesis Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cytosol Traceable author statement. Source: Reactome mitochondrion Inferred from electronic annotation. Source: Compara
Molecular_function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC ornithine decarboxylase activator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q96A70-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96A70-2)

The sequence of this isoform differs from the canonical sequence as follows:
     305-305: E → EAPLPPPHIATCAASEPSPPA

Isoform 3 (identifier: Q96A70-3)

The sequence of this isoform differs from the canonical sequence as follows:
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Isoform 4 (identifier: Q96A70-4)

The sequence of this isoform differs from the canonical sequence as follows:
     151-151: K → KFVQQRGTACLIR
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Isoform 6 (identifier: Q96A70-5)

The sequence of this isoform differs from the canonical sequence as follows:
     94-251: Missing.
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 460	460	Arginine decarboxylase		PRO_0000149944
Amino acid modifications
	Modified residue	70	1	N6-(pyridoxal phosphate)lysine By similarity
Natural variations
	Alternative sequence	94 – 251	158	Missing in isoform 6.		VSP_003754
	Alternative sequence	151	1	K → KFVQQRGTACLIR in isoform 4.		VSP_003755
	Alternative sequence	305	1	E → EAPLPPPHIATCAASEPSPP A in isoform 2.		VSP_003756
	Alternative sequence	344 – 362	19	KPSTE…GPAVD → SKNHSPCYMSLESIHFIAV in isoform 3, isoform 4 and isoform 6.		VSP_003757
	Alternative sequence	363 – 460	98	Missing in isoform 3, isoform 4 and isoform 6.		VSP_003758
	Natural variant	288	1	A → S. Corresponds to variant rs16835244 [ dbSNP | Ensembl ].		VAR_050611
Experimental info
	Sequence conflict	1 – 35	35	MAGYL…SQATT → QQGSSVASTEPGSGTWKDHG WHAQGASWMGSHIHPLLVIQ in BAB85531. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 0E00667CA4BB0B56	FASTA	460	49,980
	10 20 30 40 50 60 MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL 70 80 90 100 110 120 PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ HIGIPASKII CANPCKQIAQ 130 140 150 160 170 180 IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA KMVLCIATDD SHSLSCLSLK FGVSLKSCRH 190 200 210 220 230 240 LLENAKKHHV EVVGVSFHIG SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP 250 260 270 280 290 300 GTEGAKVRFE EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD 310 320 330 340 350 360 QPGREEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI LQKKPSTEQP LYSSSLWGPA 370 380 390 400 410 420 VDGCDCVAEG LWLPQLHVGD WLVFDNMGAY TVGMGSPFWG TQACHITYAM SRVAWEALRR 430 440 450 460 QLMAAEQEDD VEGVCKPLSC GWEITDTLCV GPVFTPASIM
	Isoform 2 [UniParc]. Checksum: DA50F0600F2EC947	FASTA	480	51,886
	10 20 30 40 50 60 MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL 70 80 90 100 110 120 PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ HIGIPASKII CANPCKQIAQ 130 140 150 160 170 180 IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA KMVLCIATDD SHSLSCLSLK FGVSLKSCRH 190 200 210 220 230 240 LLENAKKHHV EVVGVSFHIG SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP 250 260 270 280 290 300 GTEGAKVRFE EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD 310 320 330 340 350 360 QPGREAPLPP PHIATCAASE PSPPAEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI 370 380 390 400 410 420 LQKKPSTEQP LYSSSLWGPA VDGCDCVAEG LWLPQLHVGD WLVFDNMGAY TVGMGSPFWG 430 440 450 460 470 480 TQACHITYAM SRVAWEALRR QLMAAEQEDD VEGVCKPLSC GWEITDTLCV GPVFTPASIM
	Isoform 3 [UniParc]. Checksum: 39D276D8C9746B1C	FASTA	362	39,357
	10 20 30 40 50 60 MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL 70 80 90 100 110 120 PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ HIGIPASKII CANPCKQIAQ 130 140 150 160 170 180 IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA KMVLCIATDD SHSLSCLSLK FGVSLKSCRH 190 200 210 220 230 240 LLENAKKHHV EVVGVSFHIG SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP 250 260 270 280 290 300 GTEGAKVRFE EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD 310 320 330 340 350 360 QPGREEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI LQKSKNHSPC YMSLESIHFI AV
	Isoform 4 [UniParc]. Checksum: 85EDB219B7463152	FASTA	374	40,730
	10 20 30 40 50 60 MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL 70 80 90 100 110 120 PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ HIGIPASKII CANPCKQIAQ 130 140 150 160 170 180 IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA KFVQQRGTAC LIRMVLCIAT DDSHSLSCLS 190 200 210 220 230 240 LKFGVSLKSC RHLLENAKKH HVEVVGVSFH IGSGCPDPQA YAQSIADARL VFEMGTELGH 250 260 270 280 290 300 KMHVLDLGGG FPGTEGAKVR FEEIASVINS ALDLYFPEGC GVDIFAELGR YYVTSAFTVA 310 320 330 340 350 360 VSIIAKKEVL LDQPGREEEN GSTSKTIVYH LDEGVYGIFN SVLFDNICPT PILQKSKNHS 370 PCYMSLESIH FIAV
	Isoform 6 [UniParc]. Checksum: 2FB9097EBD4C9F69	FASTA	204	22,300
	10 20 30 40 50 60 MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL 70 80 90 100 110 120 PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKIASVINS ALDLYFPEGC GVDIFAELGR 130 140 150 160 170 180 YYVTSAFTVA VSIIAKKEVL LDQPGREEEN GSTSKTIVYH LDEGVYGIFN SVLFDNICPT 190 200 PILQKSKNHS PCYMSLESIH FIAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes." Pitkaenen L.T., Heiskala M., Andersson L.C. Biochem. Biophys. Res. Commun. 287:1051-1057(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 6), TISSUE SPECIFICITY.
[2]	"Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine." Zhu M.-Y., Iyo A., Piletz J.E., Regunathan S. Biochim. Biophys. Acta 1670:156-164(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[3]	"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Substantia nigra and Testis.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY050634 mRNA. Translation: AAL08049.1. AY050635 mRNA. Translation: AAL08050.1. AY050636 mRNA. Translation: AAL08051.1. AY050637 mRNA. Translation: AAL08052.1. AY050638 mRNA. Translation: AAL08053.1. AY325129 mRNA. Translation: AAQ62560.1. AB075825 mRNA. Translation: BAB85531.1. AK057051 mRNA. Translation: BAB71356.1. AK095127 mRNA. Translation: BAC04489.1. AK315677 mRNA. Translation: BAG38042.1. AL020995 Genomic DNA. Translation: CAI19353.1. AL020995 Genomic DNA. Translation: CAI19354.1. AL020995 Genomic DNA. Translation: CAI19355.1. CH471059 Genomic DNA. Translation: EAX07472.1. CH471059 Genomic DNA. Translation: EAX07481.1. BC010449 mRNA. Translation: AAH10449.1. BC028128 mRNA. Translation: AAH28128.1.
IPI	IPI00165042. IPI00218757. IPI00218758. IPI00218760. IPI00411394.
RefSeq	NP_443724.1. NM_052998.2.
UniGene	Hs.101807.
3D structure databases
ProteinModelPortal	Q96A70.
ModBase	Search...
PTM databases
PhosphoSite	Q96A70.
Polymorphism databases
DMDM	24636807.
Proteomic databases
PaxDb	Q96A70.
PRIDE	Q96A70.
Protocols and materials databases
DNASU	113451.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000294517; ENSP00000294517; ENSG00000142920. ENST00000358680; ENSP00000351508; ENSG00000142920. ENST00000373440; ENSP00000362539; ENSG00000142920. ENST00000373441; ENSP00000362540; ENSG00000142920. ENST00000373443; ENSP00000362542; ENSG00000142920. ENST00000398167; ENSP00000381233; ENSG00000142920.
GeneID	113451.
KEGG	hsa:113451.
UCSC	uc001bwr.3. human. uc001bwy.1. human. uc009vuf.1. human. uc009vug.3. human.
Organism-specific databases
CTD	113451.
GeneCards	GC01P033546.
HGNC	HGNC:29957. ADC.
HPA	HPA028045. HPA028527.
MIM	608353. gene.
neXtProt	NX_Q96A70.
PharmGKB	PA142672642.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0019.
HOVERGEN	HBG005456.
KO	K01583.
OMA	LFDNICP.
OrthoDB	EOG4X97H0.
PhylomeDB	Q96A70.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q96A70.
Bgee	Q96A70.
Genevestigator	Q96A70.
GermOnline	ENSG00000142920. Homo sapiens.
Family and domain databases
Gene3D	2.40.37.10. 1 hit.
InterPro	IPR009006. Ala_racemase/Decarboxylase_C. IPR022643. De-COase2_C. IPR022657. De-COase2_CS. IPR022644. De-COase2_N. IPR022653. De-COase2_pyr-phos_BS. IPR000183. Orn/DAP/Arg_de-COase. IPR002433. Orn_de-COase. [Graphical view]
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00125. L-Arginine. DB00114. Pyridoxal Phosphate.
GenomeRNAi	113451.
NextBio	78840.
SOURCE	Search...

Entry information

Entry name

ADC_HUMAN

Accession

Primary (citable) accession number: Q96A70
Secondary accession number(s): B2RDU5 , D3DPQ9, Q5TIF4, Q5TIF5, Q5TIF6, Q8TF56, Q96L54, Q96L55, Q96L56, Q96L57, Q96MD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.