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Q96A70

- AZIN2_HUMAN

UniProt

Q96A70 - AZIN2_HUMAN

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Protein

Antizyme inhibitor 2

Gene

AZIN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizymes OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC1 degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).3 Publications

GO - Molecular functioni

  1. catalytic activity Source: InterPro
  2. ornithine decarboxylase activator activity Source: UniProtKB
  3. putrescine transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. agmatine biosynthetic process Source: Reactome
  2. cellular nitrogen compound metabolic process Source: Reactome
  3. negative regulation of protein catabolic process Source: UniProtKB
  4. ornithine metabolic process Source: Ensembl
  5. polyamine biosynthetic process Source: UniProtKB-KW
  6. polyamine metabolic process Source: Reactome
  7. positive regulation of catalytic activity Source: UniProtKB
  8. positive regulation of polyamine transmembrane transport Source: UniProtKB
  9. putrescine transport Source: UniProtKB
  10. small molecule metabolic process Source: Reactome
  11. spermatogenesis Source: UniProtKB
  12. trans-Golgi network membrane organization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Polyamine biosynthesis, Transport

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS06971-MONOMER.
ReactomeiREACT_14800. Agmatine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Antizyme inhibitor 2
Short name:
AzI2
Alternative name(s):
Arginine decarboxylase
Short name:
ADC
Short name:
ARGDC
Ornithine decarboxylase-like protein
Short name:
ODC-like protein
ornithine decarboxylase paralog
Short name:
ODC-p
Gene namesi
Name:AZIN2
Synonyms:ADC, KIAA1945, ODCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29957. AZIN2.

Subcellular locationi

Nucleus. Cytoplasm By similarity. Cytoplasmperinuclear region. Membrane By similarity. Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment By similarity. Golgi apparatuscis-Golgi network By similarity. Golgi apparatustrans-Golgi network. Cytoplasmic granule. Cell projectionaxon. Cell projectiondendrite. Perikaryon
Note: Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in a antizyme-dependent manner. Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules (By similarity). Detected as vesicle-like pattern in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN). Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules.By similarity

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. cis-Golgi network Source: UniProtKB
  3. cytoplasmic vesicle Source: UniProtKB
  4. cytosol Source: Reactome
  5. dendrite Source: UniProtKB
  6. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB
  7. granular vesicle Source: UniProtKB
  8. mitochondrion Source: Ensembl
  9. nucleus Source: UniProtKB
  10. perikaryon Source: UniProtKB
  11. perinuclear region of cytoplasm Source: UniProtKB
  12. trans-Golgi network Source: UniProtKB
  13. transport vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672642.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Antizyme inhibitor 2PRO_0000149944Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701N6-(pyridoxal phosphate)lysineBy similarity

Post-translational modificationi

Ubiquitinated, leading to its proteosomal degradation; a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteosomal-independent manner.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ96A70.
PaxDbiQ96A70.
PRIDEiQ96A70.

PTM databases

PhosphoSiteiQ96A70.

Expressioni

Tissue specificityi

Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis.5 Publications

Gene expression databases

BgeeiQ96A70.
ExpressionAtlasiQ96A70. baseline and differential.
GenevestigatoriQ96A70.

Organism-specific databases

HPAiHPA028045.
HPA028527.

Interactioni

Subunit structurei

Interacts with OAZ1, OAZ2 and OAZ3; the interactions stabilize the complex by inhibiting AZIN2 ubiquitination and degradation. Does not form an heterodimer with ODC1 (By similarity). Monomer. Interaction with OAZ1, OAZ2 and OAZ3; the interactions lead to increased ornithine decarboxylase (ODC) activity and decreased rate of ODC1 degradation.By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ96A70.
SMRiQ96A70. Positions 7-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 14024Necessary for polyamine uptake stimulationBy similarityAdd
BLAST

Domaini

The N-terminus domain is necessary for its localization to the ER-Golgi intermediate compartment (ERGIC).By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0019.
GeneTreeiENSGT00390000011560.
HOVERGENiHBG005456.
InParanoidiQ96A70.
KOiK01583.
OMAiSHMEVVG.
OrthoDBiEOG73Z2T6.
PhylomeDBiQ96A70.
TreeFamiTF300760.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q96A70-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV
60 70 80 90 100
RKHFCFLKCL PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ
110 120 130 140 150
HIGIPASKII CANPCKQIAQ IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA
160 170 180 190 200
KMVLCIATDD SHSLSCLSLK FGVSLKSCRH LLENAKKHHV EVVGVSFHIG
210 220 230 240 250
SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP GTEGAKVRFE
260 270 280 290 300
EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD
310 320 330 340 350
QPGREEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI LQKKPSTEQP
360 370 380 390 400
LYSSSLWGPA VDGCDCVAEG LWLPQLHVGD WLVFDNMGAY TVGMGSPFWG
410 420 430 440 450
TQACHITYAM SRVAWEALRR QLMAAEQEDD VEGVCKPLSC GWEITDTLCV
460
GPVFTPASIM
Length:460
Mass (Da):49,980
Last modified:December 1, 2001 - v1
Checksum:i0E00667CA4BB0B56
GO
Isoform 2 (identifier: Q96A70-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-305: E → EAPLPPPHIATCAASEPSPPA

Show »
Length:480
Mass (Da):51,886
Checksum:iDA50F0600F2EC947
GO
Isoform 3 (identifier: Q96A70-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Show »
Length:362
Mass (Da):39,357
Checksum:i39D276D8C9746B1C
GO
Isoform 4 (identifier: Q96A70-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-151: K → KFVQQRGTACLIR
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Show »
Length:374
Mass (Da):40,730
Checksum:i85EDB219B7463152
GO
Isoform 6 (identifier: Q96A70-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-251: Missing.
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Show »
Length:204
Mass (Da):22,300
Checksum:i2FB9097EBD4C9F69
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 3535MAGYL…SQATT → QQGSSVASTEPGSGTWKDHG WHAQGASWMGSHIHPLLVIQ in BAB85531. (PubMed:11853319)CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti288 – 2881A → S.
Corresponds to variant rs16835244 [ dbSNP | Ensembl ].
VAR_050611

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei94 – 251158Missing in isoform 6. 1 PublicationVSP_003754Add
BLAST
Alternative sequencei151 – 1511K → KFVQQRGTACLIR in isoform 4. 1 PublicationVSP_003755
Alternative sequencei305 – 3051E → EAPLPPPHIATCAASEPSPP A in isoform 2. 1 PublicationVSP_003756
Alternative sequencei344 – 36219KPSTE…GPAVD → SKNHSPCYMSLESIHFIAV in isoform 3, isoform 4 and isoform 6. 1 PublicationVSP_003757Add
BLAST
Alternative sequencei363 – 46098Missing in isoform 3, isoform 4 and isoform 6. 1 PublicationVSP_003758Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY050634 mRNA. Translation: AAL08049.1.
AY050635 mRNA. Translation: AAL08050.1.
AY050636 mRNA. Translation: AAL08051.1.
AY050637 mRNA. Translation: AAL08052.1.
AY050638 mRNA. Translation: AAL08053.1.
AY325129 mRNA. Translation: AAQ62560.1.
AB075825 mRNA. Translation: BAB85531.1.
AK057051 mRNA. Translation: BAB71356.1.
AK095127 mRNA. Translation: BAC04489.1.
AK315677 mRNA. Translation: BAG38042.1.
AL020995 Genomic DNA. Translation: CAI19353.1.
AL020995 Genomic DNA. Translation: CAI19354.1.
AL020995 Genomic DNA. Translation: CAI19355.1.
CH471059 Genomic DNA. Translation: EAX07472.1.
CH471059 Genomic DNA. Translation: EAX07481.1.
BC010449 mRNA. Translation: AAH10449.1.
BC028128 mRNA. Translation: AAH28128.1.
CCDSiCCDS375.1. [Q96A70-1]
RefSeqiNP_001280491.1. NM_001293562.1. [Q96A70-1]
NP_443724.1. NM_052998.3. [Q96A70-1]
XP_005270461.1. XM_005270404.1. [Q96A70-1]
XP_005270464.1. XM_005270407.1.
XP_006710373.1. XM_006710310.1. [Q96A70-1]
UniGeneiHs.101807.

Genome annotation databases

EnsembliENST00000294517; ENSP00000294517; ENSG00000142920. [Q96A70-1]
ENST00000373440; ENSP00000362539; ENSG00000142920. [Q96A70-5]
ENST00000373441; ENSP00000362540; ENSG00000142920. [Q96A70-2]
ENST00000373443; ENSP00000362542; ENSG00000142920. [Q96A70-1]
GeneIDi113451.
KEGGihsa:113451.
UCSCiuc001bwr.3. human. [Q96A70-1]
uc001bwy.1. human. [Q96A70-3]
uc009vuf.1. human. [Q96A70-5]
uc009vug.3. human. [Q96A70-2]

Polymorphism databases

DMDMi24636807.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY050634 mRNA. Translation: AAL08049.1 .
AY050635 mRNA. Translation: AAL08050.1 .
AY050636 mRNA. Translation: AAL08051.1 .
AY050637 mRNA. Translation: AAL08052.1 .
AY050638 mRNA. Translation: AAL08053.1 .
AY325129 mRNA. Translation: AAQ62560.1 .
AB075825 mRNA. Translation: BAB85531.1 .
AK057051 mRNA. Translation: BAB71356.1 .
AK095127 mRNA. Translation: BAC04489.1 .
AK315677 mRNA. Translation: BAG38042.1 .
AL020995 Genomic DNA. Translation: CAI19353.1 .
AL020995 Genomic DNA. Translation: CAI19354.1 .
AL020995 Genomic DNA. Translation: CAI19355.1 .
CH471059 Genomic DNA. Translation: EAX07472.1 .
CH471059 Genomic DNA. Translation: EAX07481.1 .
BC010449 mRNA. Translation: AAH10449.1 .
BC028128 mRNA. Translation: AAH28128.1 .
CCDSi CCDS375.1. [Q96A70-1 ]
RefSeqi NP_001280491.1. NM_001293562.1. [Q96A70-1 ]
NP_443724.1. NM_052998.3. [Q96A70-1 ]
XP_005270461.1. XM_005270404.1. [Q96A70-1 ]
XP_005270464.1. XM_005270407.1.
XP_006710373.1. XM_006710310.1. [Q96A70-1 ]
UniGenei Hs.101807.

3D structure databases

ProteinModelPortali Q96A70.
SMRi Q96A70. Positions 7-420.
ModBasei Search...
MobiDBi Search...

Chemistry

DrugBanki DB00125. L-Arginine.

PTM databases

PhosphoSitei Q96A70.

Polymorphism databases

DMDMi 24636807.

Proteomic databases

MaxQBi Q96A70.
PaxDbi Q96A70.
PRIDEi Q96A70.

Protocols and materials databases

DNASUi 113451.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294517 ; ENSP00000294517 ; ENSG00000142920 . [Q96A70-1 ]
ENST00000373440 ; ENSP00000362539 ; ENSG00000142920 . [Q96A70-5 ]
ENST00000373441 ; ENSP00000362540 ; ENSG00000142920 . [Q96A70-2 ]
ENST00000373443 ; ENSP00000362542 ; ENSG00000142920 . [Q96A70-1 ]
GeneIDi 113451.
KEGGi hsa:113451.
UCSCi uc001bwr.3. human. [Q96A70-1 ]
uc001bwy.1. human. [Q96A70-3 ]
uc009vuf.1. human. [Q96A70-5 ]
uc009vug.3. human. [Q96A70-2 ]

Organism-specific databases

CTDi 113451.
GeneCardsi GC01P033546.
HGNCi HGNC:29957. AZIN2.
HPAi HPA028045.
HPA028527.
MIMi 608353. gene.
neXtProti NX_Q96A70.
PharmGKBi PA142672642.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0019.
GeneTreei ENSGT00390000011560.
HOVERGENi HBG005456.
InParanoidi Q96A70.
KOi K01583.
OMAi SHMEVVG.
OrthoDBi EOG73Z2T6.
PhylomeDBi Q96A70.
TreeFami TF300760.

Enzyme and pathway databases

BioCyci MetaCyc:HS06971-MONOMER.
Reactomei REACT_14800. Agmatine biosynthesis.

Miscellaneous databases

GeneWikii ADC_(gene).
GenomeRNAii 113451.
NextBioi 78840.
PROi Q96A70.
SOURCEi Search...

Gene expression databases

Bgeei Q96A70.
ExpressionAtlasi Q96A70. baseline and differential.
Genevestigatori Q96A70.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PRINTSi PR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes."
    Pitkaenen L.T., Heiskala M., Andersson L.C.
    Biochem. Biophys. Res. Commun. 287:1051-1057(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 6), TISSUE SPECIFICITY.
  2. "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine."
    Zhu M.-Y., Iyo A., Piletz J.E., Regunathan S.
    Biochim. Biophys. Acta 1670:156-164(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  3. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Substantia nigra and Testis.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  8. "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase."
    Kanerva K., Makitie L.T., Pelander A., Heiskala M., Andersson L.C.
    Biochem. J. 409:187-192(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH OAZ1; OAZ2 AND OAZ3, UBIQUITINATION.
  9. "High expression of antizyme inhibitor 2, an activator of ornithine decarboxylase in steroidogenic cells of human gonads."
    Makitie L.T., Kanerva K., Sankila A., Andersson L.C.
    Histochem. Cell Biol. 132:633-638(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  10. "Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion."
    Kanerva K., Lappalainen J., Makitie L.T., Virolainen S., Kovanen P.T., Andersson L.C.
    PLoS ONE 4:E6858-E6858(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
  11. "Antizyme inhibitor 2: molecular, cellular and physiological aspects."
    Lopez-Contreras A.J., Ramos-Molina B., Cremades A., Penafiel R.
    Amino Acids 38:603-611(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, CHARACTERIZATION.
  12. "Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease."
    Makitie L.T., Kanerva K., Polvikoski T., Paetau A., Andersson L.C.
    Brain Pathol. 20:571-580(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  13. "Ornithine decarboxylase antizyme inhibitor 2 regulates intracellular vesicle trafficking."
    Kanerva K., Makitie L.T., Back N., Andersson L.C.
    Exp. Cell Res. 316:1896-1906(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAZIN2_HUMAN
AccessioniPrimary (citable) accession number: Q96A70
Secondary accession number(s): B2RDU5
, D3DPQ9, Q5TIF4, Q5TIF5, Q5TIF6, Q8TF56, Q96L54, Q96L55, Q96L56, Q96L57, Q96MD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was initially reported to have ornithine decarboxylase (PubMed:11587527) or arginine decarboxylase (PubMed:14738999) activities, but it was later found that the mouse ortholog does not possess neither of them.2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3