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Q96A70

- AZIN2_HUMAN

UniProt

Q96A70 - AZIN2_HUMAN

Protein

Antizyme inhibitor 2

Gene

AZIN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizymes OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC1 degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).3 Publications

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-EC
    2. ornithine decarboxylase activator activity Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. putrescine transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. agmatine biosynthetic process Source: Reactome
    2. cellular nitrogen compound metabolic process Source: Reactome
    3. negative regulation of protein catabolic process Source: UniProtKB
    4. ornithine metabolic process Source: Ensembl
    5. polyamine biosynthetic process Source: UniProtKB-KW
    6. polyamine metabolic process Source: Reactome
    7. positive regulation of catalytic activity Source: UniProtKB
    8. positive regulation of polyamine transmembrane transport Source: UniProtKB
    9. putrescine transport Source: UniProtKB
    10. small molecule metabolic process Source: Reactome
    11. spermatogenesis Source: UniProtKB
    12. trans-Golgi network membrane organization Source: UniProtKB

    Keywords - Biological processi

    Polyamine biosynthesis, Transport

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMetaCyc:HS06971-MONOMER.
    ReactomeiREACT_14800. Agmatine biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Antizyme inhibitor 2
    Short name:
    AzI2
    Alternative name(s):
    Arginine decarboxylase
    Short name:
    ADC
    Short name:
    ARGDC
    Ornithine decarboxylase-like protein
    Short name:
    ODC-like protein
    ornithine decarboxylase paralog
    Short name:
    ODC-p
    Gene namesi
    Name:AZIN2
    Synonyms:ADC, KIAA1945, ODCP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29957. AZIN2.

    Subcellular locationi

    Nucleus. Cytoplasm By similarity. Cytoplasmperinuclear region. Membrane By similarity. Cytoplasmic vesicle. Endoplasmic reticulum-Golgi intermediate compartment By similarity. Golgi apparatuscis-Golgi network By similarity. Golgi apparatustrans-Golgi network. Cytoplasmic granule. Cell projectionaxon. Cell projectiondendrite. Perikaryon
    Note: Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in a antizyme-dependent manner. Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules By similarity. Detected as vesicle-like pattern in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN). Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules.By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. cis-Golgi network Source: UniProtKB
    3. cytoplasmic vesicle Source: UniProtKB
    4. cytosol Source: Reactome
    5. dendrite Source: UniProtKB
    6. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB
    7. granular vesicle Source: UniProtKB
    8. mitochondrion Source: Ensembl
    9. nucleus Source: UniProtKB
    10. perikaryon Source: UniProtKB
    11. perinuclear region of cytoplasm Source: UniProtKB
    12. trans-Golgi network Source: UniProtKB
    13. transport vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672642.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 460460Antizyme inhibitor 2PRO_0000149944Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei70 – 701N6-(pyridoxal phosphate)lysineBy similarity

    Post-translational modificationi

    Ubiquitinated, leading to its proteosomal degradation; a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteosomal-independent manner.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ96A70.
    PRIDEiQ96A70.

    PTM databases

    PhosphoSiteiQ96A70.

    Expressioni

    Tissue specificityi

    Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis.5 Publications

    Gene expression databases

    ArrayExpressiQ96A70.
    BgeeiQ96A70.
    GenevestigatoriQ96A70.

    Organism-specific databases

    HPAiHPA028045.
    HPA028527.

    Interactioni

    Subunit structurei

    Interacts with OAZ1, OAZ2 and OAZ3; the interactions stabilize the complex by inhibiting AZIN2 ubiquitination and degradation. Does not form an heterodimer with ODC1 By similarity. Monomer. Interaction with OAZ1, OAZ2 and OAZ3; the interactions lead to increased ornithine decarboxylase (ODC) activity and decreased rate of ODC1 degradation.By similarity1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ96A70.
    SMRiQ96A70. Positions 7-420.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni117 – 14024Necessary for polyamine uptake stimulationBy similarityAdd
    BLAST

    Domaini

    The N-terminus domain is necessary for its localization to the ER-Golgi intermediate compartment (ERGIC).By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0019.
    HOVERGENiHBG005456.
    KOiK01583.
    OMAiSHMEVVG.
    OrthoDBiEOG73Z2T6.
    PhylomeDBiQ96A70.
    TreeFamiTF300760.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR002433. Orn_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PRINTSiPR01179. ODADCRBXLASE.
    PR01182. ORNDCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q96A70-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV    50
    RKHFCFLKCL PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ 100
    HIGIPASKII CANPCKQIAQ IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA 150
    KMVLCIATDD SHSLSCLSLK FGVSLKSCRH LLENAKKHHV EVVGVSFHIG 200
    SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP GTEGAKVRFE 250
    EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD 300
    QPGREEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI LQKKPSTEQP 350
    LYSSSLWGPA VDGCDCVAEG LWLPQLHVGD WLVFDNMGAY TVGMGSPFWG 400
    TQACHITYAM SRVAWEALRR QLMAAEQEDD VEGVCKPLSC GWEITDTLCV 450
    GPVFTPASIM 460
    Length:460
    Mass (Da):49,980
    Last modified:December 1, 2001 - v1
    Checksum:i0E00667CA4BB0B56
    GO
    Isoform 2 (identifier: Q96A70-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         305-305: E → EAPLPPPHIATCAASEPSPPA

    Show »
    Length:480
    Mass (Da):51,886
    Checksum:iDA50F0600F2EC947
    GO
    Isoform 3 (identifier: Q96A70-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
         363-460: Missing.

    Show »
    Length:362
    Mass (Da):39,357
    Checksum:i39D276D8C9746B1C
    GO
    Isoform 4 (identifier: Q96A70-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         151-151: K → KFVQQRGTACLIR
         344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
         363-460: Missing.

    Show »
    Length:374
    Mass (Da):40,730
    Checksum:i85EDB219B7463152
    GO
    Isoform 6 (identifier: Q96A70-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         94-251: Missing.
         344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
         363-460: Missing.

    Show »
    Length:204
    Mass (Da):22,300
    Checksum:i2FB9097EBD4C9F69
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 3535MAGYL…SQATT → QQGSSVASTEPGSGTWKDHG WHAQGASWMGSHIHPLLVIQ in BAB85531. (PubMed:11853319)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti288 – 2881A → S.
    Corresponds to variant rs16835244 [ dbSNP | Ensembl ].
    VAR_050611

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei94 – 251158Missing in isoform 6. 1 PublicationVSP_003754Add
    BLAST
    Alternative sequencei151 – 1511K → KFVQQRGTACLIR in isoform 4. 1 PublicationVSP_003755
    Alternative sequencei305 – 3051E → EAPLPPPHIATCAASEPSPP A in isoform 2. 1 PublicationVSP_003756
    Alternative sequencei344 – 36219KPSTE…GPAVD → SKNHSPCYMSLESIHFIAV in isoform 3, isoform 4 and isoform 6. 1 PublicationVSP_003757Add
    BLAST
    Alternative sequencei363 – 46098Missing in isoform 3, isoform 4 and isoform 6. 1 PublicationVSP_003758Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY050634 mRNA. Translation: AAL08049.1.
    AY050635 mRNA. Translation: AAL08050.1.
    AY050636 mRNA. Translation: AAL08051.1.
    AY050637 mRNA. Translation: AAL08052.1.
    AY050638 mRNA. Translation: AAL08053.1.
    AY325129 mRNA. Translation: AAQ62560.1.
    AB075825 mRNA. Translation: BAB85531.1.
    AK057051 mRNA. Translation: BAB71356.1.
    AK095127 mRNA. Translation: BAC04489.1.
    AK315677 mRNA. Translation: BAG38042.1.
    AL020995 Genomic DNA. Translation: CAI19353.1.
    AL020995 Genomic DNA. Translation: CAI19354.1.
    AL020995 Genomic DNA. Translation: CAI19355.1.
    CH471059 Genomic DNA. Translation: EAX07472.1.
    CH471059 Genomic DNA. Translation: EAX07481.1.
    BC010449 mRNA. Translation: AAH10449.1.
    BC028128 mRNA. Translation: AAH28128.1.
    CCDSiCCDS375.1. [Q96A70-1]
    RefSeqiNP_443724.1. NM_052998.3. [Q96A70-1]
    XP_005270461.1. XM_005270404.1. [Q96A70-1]
    XP_005270464.1. XM_005270407.1.
    XP_006710373.1. XM_006710310.1. [Q96A70-1]
    UniGeneiHs.101807.

    Genome annotation databases

    EnsembliENST00000294517; ENSP00000294517; ENSG00000142920. [Q96A70-1]
    ENST00000373440; ENSP00000362539; ENSG00000142920. [Q96A70-5]
    ENST00000373441; ENSP00000362540; ENSG00000142920. [Q96A70-2]
    ENST00000373443; ENSP00000362542; ENSG00000142920. [Q96A70-1]
    GeneIDi113451.
    KEGGihsa:113451.
    UCSCiuc001bwr.3. human. [Q96A70-1]
    uc001bwy.1. human. [Q96A70-3]
    uc009vuf.1. human. [Q96A70-5]
    uc009vug.3. human. [Q96A70-2]

    Polymorphism databases

    DMDMi24636807.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY050634 mRNA. Translation: AAL08049.1 .
    AY050635 mRNA. Translation: AAL08050.1 .
    AY050636 mRNA. Translation: AAL08051.1 .
    AY050637 mRNA. Translation: AAL08052.1 .
    AY050638 mRNA. Translation: AAL08053.1 .
    AY325129 mRNA. Translation: AAQ62560.1 .
    AB075825 mRNA. Translation: BAB85531.1 .
    AK057051 mRNA. Translation: BAB71356.1 .
    AK095127 mRNA. Translation: BAC04489.1 .
    AK315677 mRNA. Translation: BAG38042.1 .
    AL020995 Genomic DNA. Translation: CAI19353.1 .
    AL020995 Genomic DNA. Translation: CAI19354.1 .
    AL020995 Genomic DNA. Translation: CAI19355.1 .
    CH471059 Genomic DNA. Translation: EAX07472.1 .
    CH471059 Genomic DNA. Translation: EAX07481.1 .
    BC010449 mRNA. Translation: AAH10449.1 .
    BC028128 mRNA. Translation: AAH28128.1 .
    CCDSi CCDS375.1. [Q96A70-1 ]
    RefSeqi NP_443724.1. NM_052998.3. [Q96A70-1 ]
    XP_005270461.1. XM_005270404.1. [Q96A70-1 ]
    XP_005270464.1. XM_005270407.1.
    XP_006710373.1. XM_006710310.1. [Q96A70-1 ]
    UniGenei Hs.101807.

    3D structure databases

    ProteinModelPortali Q96A70.
    SMRi Q96A70. Positions 7-420.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    DrugBanki DB00125. L-Arginine.
    DB00114. Pyridoxal Phosphate.

    PTM databases

    PhosphoSitei Q96A70.

    Polymorphism databases

    DMDMi 24636807.

    Proteomic databases

    PaxDbi Q96A70.
    PRIDEi Q96A70.

    Protocols and materials databases

    DNASUi 113451.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294517 ; ENSP00000294517 ; ENSG00000142920 . [Q96A70-1 ]
    ENST00000373440 ; ENSP00000362539 ; ENSG00000142920 . [Q96A70-5 ]
    ENST00000373441 ; ENSP00000362540 ; ENSG00000142920 . [Q96A70-2 ]
    ENST00000373443 ; ENSP00000362542 ; ENSG00000142920 . [Q96A70-1 ]
    GeneIDi 113451.
    KEGGi hsa:113451.
    UCSCi uc001bwr.3. human. [Q96A70-1 ]
    uc001bwy.1. human. [Q96A70-3 ]
    uc009vuf.1. human. [Q96A70-5 ]
    uc009vug.3. human. [Q96A70-2 ]

    Organism-specific databases

    CTDi 113451.
    GeneCardsi GC01P033546.
    HGNCi HGNC:29957. AZIN2.
    HPAi HPA028045.
    HPA028527.
    MIMi 608353. gene.
    neXtProti NX_Q96A70.
    PharmGKBi PA142672642.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0019.
    HOVERGENi HBG005456.
    KOi K01583.
    OMAi SHMEVVG.
    OrthoDBi EOG73Z2T6.
    PhylomeDBi Q96A70.
    TreeFami TF300760.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS06971-MONOMER.
    Reactomei REACT_14800. Agmatine biosynthesis.

    Miscellaneous databases

    GeneWikii ADC_(gene).
    GenomeRNAii 113451.
    NextBioi 78840.
    PROi Q96A70.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96A70.
    Bgeei Q96A70.
    Genevestigatori Q96A70.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR002433. Orn_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PRINTSi PR01179. ODADCRBXLASE.
    PR01182. ORNDCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes."
      Pitkaenen L.T., Heiskala M., Andersson L.C.
      Biochem. Biophys. Res. Commun. 287:1051-1057(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 6), TISSUE SPECIFICITY.
    2. "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine."
      Zhu M.-Y., Iyo A., Piletz J.E., Regunathan S.
      Biochim. Biophys. Acta 1670:156-164(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    3. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Substantia nigra and Testis.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    8. "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase."
      Kanerva K., Makitie L.T., Pelander A., Heiskala M., Andersson L.C.
      Biochem. J. 409:187-192(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH OAZ1; OAZ2 AND OAZ3, UBIQUITINATION.
    9. "High expression of antizyme inhibitor 2, an activator of ornithine decarboxylase in steroidogenic cells of human gonads."
      Makitie L.T., Kanerva K., Sankila A., Andersson L.C.
      Histochem. Cell Biol. 132:633-638(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    10. "Expression of antizyme inhibitor 2 in mast cells and role of polyamines as selective regulators of serotonin secretion."
      Kanerva K., Lappalainen J., Makitie L.T., Virolainen S., Kovanen P.T., Andersson L.C.
      PLoS ONE 4:E6858-E6858(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
    11. "Antizyme inhibitor 2: molecular, cellular and physiological aspects."
      Lopez-Contreras A.J., Ramos-Molina B., Cremades A., Penafiel R.
      Amino Acids 38:603-611(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW, CHARACTERIZATION.
    12. "Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease."
      Makitie L.T., Kanerva K., Polvikoski T., Paetau A., Andersson L.C.
      Brain Pathol. 20:571-580(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    13. "Ornithine decarboxylase antizyme inhibitor 2 regulates intracellular vesicle trafficking."
      Kanerva K., Makitie L.T., Back N., Andersson L.C.
      Exp. Cell Res. 316:1896-1906(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAZIN2_HUMAN
    AccessioniPrimary (citable) accession number: Q96A70
    Secondary accession number(s): B2RDU5
    , D3DPQ9, Q5TIF4, Q5TIF5, Q5TIF6, Q8TF56, Q96L54, Q96L55, Q96L56, Q96L57, Q96MD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was initially reported to have ornithine decarboxylase (PubMed:11587527) or arginine decarboxylase (PubMed:14738999) activities, but it was later found that the mouse ortholog does not possess neither of them.2 Publications

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3