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Q96A70 (ADC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine decarboxylase

Short name=ADC
Short name=ARGDC
EC=4.1.1.19
Alternative name(s):
ODC-paralogue
Short name=ODC-p
Ornithine decarboxylase-like protein
Gene names
Name:ADC
Synonyms:KIAA1945, ODCP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length460 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Decarboxylates L-arginine to agmatine. Truncated splice isoforms probably lack activity. Ref.2

Catalytic activity

L-arginine = agmatine + CO2.

Cofactor

Pyridoxal phosphate By similarity.

Tissue specificity

Highly expressed in brain. Also expressed in testis. Ref.1 Ref.2

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q96A70-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96A70-2)

The sequence of this isoform differs from the canonical sequence as follows:
     305-305: E → EAPLPPPHIATCAASEPSPPA
Isoform 3 (identifier: Q96A70-3)

The sequence of this isoform differs from the canonical sequence as follows:
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.
Isoform 4 (identifier: Q96A70-4)

The sequence of this isoform differs from the canonical sequence as follows:
     151-151: K → KFVQQRGTACLIR
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.
Isoform 6 (identifier: Q96A70-5)

The sequence of this isoform differs from the canonical sequence as follows:
     94-251: Missing.
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 460460Arginine decarboxylase
PRO_0000149944

Amino acid modifications

Modified residue701N6-(pyridoxal phosphate)lysine By similarity

Natural variations

Alternative sequence94 – 251158Missing in isoform 6.
VSP_003754
Alternative sequence1511K → KFVQQRGTACLIR in isoform 4.
VSP_003755
Alternative sequence3051E → EAPLPPPHIATCAASEPSPP A in isoform 2.
VSP_003756
Alternative sequence344 – 36219KPSTE…GPAVD → SKNHSPCYMSLESIHFIAV in isoform 3, isoform 4 and isoform 6.
VSP_003757
Alternative sequence363 – 46098Missing in isoform 3, isoform 4 and isoform 6.
VSP_003758
Natural variant2881A → S.
Corresponds to variant rs16835244 [ dbSNP | Ensembl ].
VAR_050611

Experimental info

Sequence conflict1 – 3535MAGYL…SQATT → QQGSSVASTEPGSGTWKDHG WHAQGASWMGSHIHPLLVIQ in BAB85531. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 0E00667CA4BB0B56

FASTA46049,980
        10         20         30         40         50         60 
MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL 

        70         80         90        100        110        120 
PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ HIGIPASKII CANPCKQIAQ 

       130        140        150        160        170        180 
IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA KMVLCIATDD SHSLSCLSLK FGVSLKSCRH 

       190        200        210        220        230        240 
LLENAKKHHV EVVGVSFHIG SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP 

       250        260        270        280        290        300 
GTEGAKVRFE EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD 

       310        320        330        340        350        360 
QPGREEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI LQKKPSTEQP LYSSSLWGPA 

       370        380        390        400        410        420 
VDGCDCVAEG LWLPQLHVGD WLVFDNMGAY TVGMGSPFWG TQACHITYAM SRVAWEALRR 

       430        440        450        460 
QLMAAEQEDD VEGVCKPLSC GWEITDTLCV GPVFTPASIM 

« Hide

Isoform 2 [UniParc].

Checksum: DA50F0600F2EC947
Show »

FASTA48051,886
Isoform 3 [UniParc].

Checksum: 39D276D8C9746B1C
Show »

FASTA36239,357
Isoform 4 [UniParc].

Checksum: 85EDB219B7463152
Show »

FASTA37440,730
Isoform 6 [UniParc].

Checksum: 2FB9097EBD4C9F69
Show »

FASTA20422,300

References

« Hide 'large scale' references
[1]"Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes."
Pitkaenen L.T., Heiskala M., Andersson L.C.
Biochem. Biophys. Res. Commun. 287:1051-1057(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 6), TISSUE SPECIFICITY.
[2]"Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine."
Zhu M.-Y., Iyo A., Piletz J.E., Regunathan S.
Biochim. Biophys. Acta 1670:156-164(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[3]"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
Nagase T., Kikuno R., Ohara O.
DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Substantia nigra and Testis.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY050634 mRNA. Translation: AAL08049.1.
AY050635 mRNA. Translation: AAL08050.1.
AY050636 mRNA. Translation: AAL08051.1.
AY050637 mRNA. Translation: AAL08052.1.
AY050638 mRNA. Translation: AAL08053.1.
AY325129 mRNA. Translation: AAQ62560.1.
AB075825 mRNA. Translation: BAB85531.1.
AK057051 mRNA. Translation: BAB71356.1.
AK095127 mRNA. Translation: BAC04489.1.
AK315677 mRNA. Translation: BAG38042.1.
AL020995 Genomic DNA. Translation: CAI19353.1.
AL020995 Genomic DNA. Translation: CAI19354.1.
AL020995 Genomic DNA. Translation: CAI19355.1.
CH471059 Genomic DNA. Translation: EAX07472.1.
CH471059 Genomic DNA. Translation: EAX07481.1.
BC010449 mRNA. Translation: AAH10449.1.
BC028128 mRNA. Translation: AAH28128.1.
RefSeqNP_443724.1. NM_052998.2.
XP_005270461.1. XM_005270404.1.
XP_005270462.1. XM_005270405.1.
XP_005270464.1. XM_005270407.1.
UniGeneHs.101807.

3D structure databases

ProteinModelPortalQ96A70.
SMRQ96A70. Positions 7-420.
ModBaseSearch...
MobiDBSearch...

Chemistry

DrugBankDB00125. L-Arginine.
DB00114. Pyridoxal Phosphate.

PTM databases

PhosphoSiteQ96A70.

Polymorphism databases

DMDM24636807.

Proteomic databases

PaxDbQ96A70.
PRIDEQ96A70.

Protocols and materials databases

DNASU113451.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000294517; ENSP00000294517; ENSG00000142920. [Q96A70-1]
ENST00000358680; ENSP00000351508; ENSG00000142920. [Q96A70-5]
ENST00000373440; ENSP00000362539; ENSG00000142920. [Q96A70-5]
ENST00000373441; ENSP00000362540; ENSG00000142920. [Q96A70-2]
ENST00000373443; ENSP00000362542; ENSG00000142920. [Q96A70-1]
ENST00000398167; ENSP00000381233; ENSG00000142920. [Q96A70-2]
GeneID113451.
KEGGhsa:113451.
UCSCuc001bwr.3. human. [Q96A70-1]
uc001bwy.1. human. [Q96A70-3]
uc009vuf.1. human. [Q96A70-5]
uc009vug.3. human. [Q96A70-2]

Organism-specific databases

CTD113451.
GeneCardsGC01P033546.
HGNCHGNC:29957. ADC.
HPAHPA028045.
HPA028527.
MIM608353. gene.
neXtProtNX_Q96A70.
PharmGKBPA142672642.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0019.
HOVERGENHBG005456.
KOK01583.
OMASHMEVVG.
OrthoDBEOG73Z2T6.
PhylomeDBQ96A70.
TreeFamTF300760.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressQ96A70.
BgeeQ96A70.
GenevestigatorQ96A70.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiADC_(gene).
GenomeRNAi113451.
NextBio78840.
PROQ96A70.
SOURCESearch...

Entry information

Entry nameADC_HUMAN
AccessionPrimary (citable) accession number: Q96A70
Secondary accession number(s): B2RDU5 expand/collapse secondary AC list , D3DPQ9, Q5TIF4, Q5TIF5, Q5TIF6, Q8TF56, Q96L54, Q96L55, Q96L56, Q96L57, Q96MD9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM