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Protein

Antizyme inhibitor 2

Gene

AZIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizymes OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC1 degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728).3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Polyamine biosynthesis, Transport

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS06971-MONOMER.
ZFISH:HS06971-MONOMER.
BRENDAi4.1.1.17. 2681.
4.1.1.19. 2681.
ReactomeiR-HSA-351143. Agmatine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Antizyme inhibitor 2
Short name:
AzI2
Alternative name(s):
Arginine decarboxylase
Short name:
ADC
Short name:
ARGDC
Ornithine decarboxylase-like protein
Short name:
ODC-like protein
ornithine decarboxylase paralog
Short name:
ODC-p
Gene namesi
Name:AZIN2
Synonyms:ADC, KIAA1945, ODCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29957. AZIN2.

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB
  • cis-Golgi network Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB
  • cytosol Source: Reactome
  • dendrite Source: UniProtKB
  • endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB
  • granular vesicle Source: UniProtKB
  • mitochondrion Source: Ensembl
  • nucleus Source: UniProtKB
  • perikaryon Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • trans-Golgi network Source: UniProtKB
  • transport vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi113451.
OpenTargetsiENSG00000142920.
PharmGKBiPA142672642.

Chemistry databases

DrugBankiDB00125. L-Arginine.

Polymorphism and mutation databases

BioMutaiADC.
DMDMi24636807.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499441 – 460Antizyme inhibitor 2Add BLAST460

Post-translational modificationi

Ubiquitinated, leading to its proteosomal degradation; a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteosomal-independent manner.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei70Not modifiedBy similarity1

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ96A70.
PaxDbiQ96A70.
PeptideAtlasiQ96A70.
PRIDEiQ96A70.

PTM databases

iPTMnetiQ96A70.
PhosphoSitePlusiQ96A70.

Expressioni

Tissue specificityi

Expressed in the neocortex, thalamus, hippocampus, cerebellum, medulla oblongata, gray and white matter. Expressed in neurons, oligodendrocytes, basket, Purkinje and pyramidal cells. Expressed in spermatocytes and Leydig cells of the testis. Expressed in luteal theca cells lining corpus luteum cysts and in hilus cells of the ovary. Expressed in primary and neoplastic mast cells (MC) (at protein level). Highly expressed in brain. Also expressed in testis.5 Publications

Gene expression databases

BgeeiENSG00000142920.
GenevisibleiQ96A70. HS.

Organism-specific databases

HPAiHPA028045.
HPA028527.

Interactioni

Subunit structurei

Interacts with OAZ1, OAZ2 and OAZ3; the interactions stabilize the complex by inhibiting AZIN2 ubiquitination and degradation. Does not form a heterodimer with ODC1 (By similarity). Monomer. Interaction with OAZ1, OAZ2 and OAZ3; the interactions lead to increased ornithine decarboxylase (ODC) activity and decreased rate of ODC1 degradation.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
OAZ3Q9UMX25EBI-10281609,EBI-10281601
OAZ3Q9UMX2-24EBI-10281609,EBI-12049527

Protein-protein interaction databases

BioGridi125246. 10 interactors.
IntActiQ96A70. 1 interactor.
STRINGi9606.ENSP00000294517.

Structurei

3D structure databases

ProteinModelPortaliQ96A70.
SMRiQ96A70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni117 – 140Necessary for polyamine uptake stimulationBy similarityAdd BLAST24

Domaini

The N-terminus domain is necessary for its localization to the ER-Golgi intermediate compartment (ERGIC).By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOVERGENiHBG005456.
InParanoidiQ96A70.
KOiK01583.
OMAiSHMEVVG.
OrthoDBiEOG091G0AJV.
PhylomeDBiQ96A70.
TreeFamiTF300760.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR031173. Azin2.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF4. PTHR11482:SF4. 1 hit.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q96A70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV
60 70 80 90 100
RKHFCFLKCL PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ
110 120 130 140 150
HIGIPASKII CANPCKQIAQ IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA
160 170 180 190 200
KMVLCIATDD SHSLSCLSLK FGVSLKSCRH LLENAKKHHV EVVGVSFHIG
210 220 230 240 250
SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP GTEGAKVRFE
260 270 280 290 300
EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD
310 320 330 340 350
QPGREEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI LQKKPSTEQP
360 370 380 390 400
LYSSSLWGPA VDGCDCVAEG LWLPQLHVGD WLVFDNMGAY TVGMGSPFWG
410 420 430 440 450
TQACHITYAM SRVAWEALRR QLMAAEQEDD VEGVCKPLSC GWEITDTLCV
460
GPVFTPASIM
Length:460
Mass (Da):49,980
Last modified:December 1, 2001 - v1
Checksum:i0E00667CA4BB0B56
GO
Isoform 2 (identifier: Q96A70-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-305: E → EAPLPPPHIATCAASEPSPPA

Show »
Length:480
Mass (Da):51,886
Checksum:iDA50F0600F2EC947
GO
Isoform 3 (identifier: Q96A70-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Show »
Length:362
Mass (Da):39,357
Checksum:i39D276D8C9746B1C
GO
Isoform 4 (identifier: Q96A70-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-151: K → KFVQQRGTACLIR
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Show »
Length:374
Mass (Da):40,730
Checksum:i85EDB219B7463152
GO
Isoform 6 (identifier: Q96A70-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-251: Missing.
     344-362: KPSTEQPLYSSSLWGPAVD → SKNHSPCYMSLESIHFIAV
     363-460: Missing.

Show »
Length:204
Mass (Da):22,300
Checksum:i2FB9097EBD4C9F69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 35MAGYL…SQATT → QQGSSVASTEPGSGTWKDHG WHAQGASWMGSHIHPLLVIQ in BAB85531 (PubMed:11853319).CuratedAdd BLAST35

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050611288A → S.Corresponds to variant rs16835244dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00375494 – 251Missing in isoform 6. 1 PublicationAdd BLAST158
Alternative sequenceiVSP_003755151K → KFVQQRGTACLIR in isoform 4. 1 Publication1
Alternative sequenceiVSP_003756305E → EAPLPPPHIATCAASEPSPP A in isoform 2. 1 Publication1
Alternative sequenceiVSP_003757344 – 362KPSTE…GPAVD → SKNHSPCYMSLESIHFIAV in isoform 3, isoform 4 and isoform 6. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_003758363 – 460Missing in isoform 3, isoform 4 and isoform 6. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050634 mRNA. Translation: AAL08049.1.
AY050635 mRNA. Translation: AAL08050.1.
AY050636 mRNA. Translation: AAL08051.1.
AY050637 mRNA. Translation: AAL08052.1.
AY050638 mRNA. Translation: AAL08053.1.
AY325129 mRNA. Translation: AAQ62560.1.
AB075825 mRNA. Translation: BAB85531.1.
AK057051 mRNA. Translation: BAB71356.1.
AK095127 mRNA. Translation: BAC04489.1.
AK315677 mRNA. Translation: BAG38042.1.
AL020995 Genomic DNA. Translation: CAI19353.1.
AL020995 Genomic DNA. Translation: CAI19354.1.
AL020995 Genomic DNA. Translation: CAI19355.1.
CH471059 Genomic DNA. Translation: EAX07472.1.
CH471059 Genomic DNA. Translation: EAX07481.1.
BC010449 mRNA. Translation: AAH10449.1.
BC028128 mRNA. Translation: AAH28128.1.
CCDSiCCDS375.1. [Q96A70-1]
CCDS76138.1. [Q96A70-2]
RefSeqiNP_001280491.1. NM_001293562.1. [Q96A70-1]
NP_001288752.1. NM_001301823.1.
NP_001288753.1. NM_001301824.1.
NP_001288754.1. NM_001301825.1. [Q96A70-2]
NP_001288755.1. NM_001301826.1. [Q96A70-3]
NP_443724.1. NM_052998.3. [Q96A70-1]
XP_005270461.1. XM_005270404.2. [Q96A70-1]
XP_005270464.1. XM_005270407.1.
XP_011538865.1. XM_011540563.1. [Q96A70-3]
XP_016855657.1. XM_017000168.1.
XP_016855658.1. XM_017000169.1.
XP_016855659.1. XM_017000170.1.
XP_016855660.1. XM_017000171.1.
XP_016855661.1. XM_017000172.1.
XP_016855662.1. XM_017000173.1.
XP_016855664.1. XM_017000175.1.
UniGeneiHs.101807.

Genome annotation databases

EnsembliENST00000294517; ENSP00000294517; ENSG00000142920. [Q96A70-1]
ENST00000373440; ENSP00000362539; ENSG00000142920. [Q96A70-5]
ENST00000373441; ENSP00000362540; ENSG00000142920. [Q96A70-2]
ENST00000373443; ENSP00000362542; ENSG00000142920. [Q96A70-1]
GeneIDi113451.
KEGGihsa:113451.
UCSCiuc001bwr.3. human. [Q96A70-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050634 mRNA. Translation: AAL08049.1.
AY050635 mRNA. Translation: AAL08050.1.
AY050636 mRNA. Translation: AAL08051.1.
AY050637 mRNA. Translation: AAL08052.1.
AY050638 mRNA. Translation: AAL08053.1.
AY325129 mRNA. Translation: AAQ62560.1.
AB075825 mRNA. Translation: BAB85531.1.
AK057051 mRNA. Translation: BAB71356.1.
AK095127 mRNA. Translation: BAC04489.1.
AK315677 mRNA. Translation: BAG38042.1.
AL020995 Genomic DNA. Translation: CAI19353.1.
AL020995 Genomic DNA. Translation: CAI19354.1.
AL020995 Genomic DNA. Translation: CAI19355.1.
CH471059 Genomic DNA. Translation: EAX07472.1.
CH471059 Genomic DNA. Translation: EAX07481.1.
BC010449 mRNA. Translation: AAH10449.1.
BC028128 mRNA. Translation: AAH28128.1.
CCDSiCCDS375.1. [Q96A70-1]
CCDS76138.1. [Q96A70-2]
RefSeqiNP_001280491.1. NM_001293562.1. [Q96A70-1]
NP_001288752.1. NM_001301823.1.
NP_001288753.1. NM_001301824.1.
NP_001288754.1. NM_001301825.1. [Q96A70-2]
NP_001288755.1. NM_001301826.1. [Q96A70-3]
NP_443724.1. NM_052998.3. [Q96A70-1]
XP_005270461.1. XM_005270404.2. [Q96A70-1]
XP_005270464.1. XM_005270407.1.
XP_011538865.1. XM_011540563.1. [Q96A70-3]
XP_016855657.1. XM_017000168.1.
XP_016855658.1. XM_017000169.1.
XP_016855659.1. XM_017000170.1.
XP_016855660.1. XM_017000171.1.
XP_016855661.1. XM_017000172.1.
XP_016855662.1. XM_017000173.1.
XP_016855664.1. XM_017000175.1.
UniGeneiHs.101807.

3D structure databases

ProteinModelPortaliQ96A70.
SMRiQ96A70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125246. 10 interactors.
IntActiQ96A70. 1 interactor.
STRINGi9606.ENSP00000294517.

Chemistry databases

DrugBankiDB00125. L-Arginine.

PTM databases

iPTMnetiQ96A70.
PhosphoSitePlusiQ96A70.

Polymorphism and mutation databases

BioMutaiADC.
DMDMi24636807.

Proteomic databases

MaxQBiQ96A70.
PaxDbiQ96A70.
PeptideAtlasiQ96A70.
PRIDEiQ96A70.

Protocols and materials databases

DNASUi113451.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294517; ENSP00000294517; ENSG00000142920. [Q96A70-1]
ENST00000373440; ENSP00000362539; ENSG00000142920. [Q96A70-5]
ENST00000373441; ENSP00000362540; ENSG00000142920. [Q96A70-2]
ENST00000373443; ENSP00000362542; ENSG00000142920. [Q96A70-1]
GeneIDi113451.
KEGGihsa:113451.
UCSCiuc001bwr.3. human. [Q96A70-1]

Organism-specific databases

CTDi113451.
DisGeNETi113451.
GeneCardsiAZIN2.
HGNCiHGNC:29957. AZIN2.
HPAiHPA028045.
HPA028527.
MIMi608353. gene.
neXtProtiNX_Q96A70.
OpenTargetsiENSG00000142920.
PharmGKBiPA142672642.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOVERGENiHBG005456.
InParanoidiQ96A70.
KOiK01583.
OMAiSHMEVVG.
OrthoDBiEOG091G0AJV.
PhylomeDBiQ96A70.
TreeFamiTF300760.

Enzyme and pathway databases

BioCyciMetaCyc:HS06971-MONOMER.
ZFISH:HS06971-MONOMER.
BRENDAi4.1.1.17. 2681.
4.1.1.19. 2681.
ReactomeiR-HSA-351143. Agmatine biosynthesis.

Miscellaneous databases

GeneWikiiADC_(gene).
GenomeRNAii113451.
PROiQ96A70.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142920.
GenevisibleiQ96A70. HS.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR031173. Azin2.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF4. PTHR11482:SF4. 1 hit.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAZIN2_HUMAN
AccessioniPrimary (citable) accession number: Q96A70
Secondary accession number(s): B2RDU5
, D3DPQ9, Q5TIF4, Q5TIF5, Q5TIF6, Q8TF56, Q96L54, Q96L55, Q96L56, Q96L57, Q96MD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was initially reported to have ornithine decarboxylase (PubMed:11587527) or arginine decarboxylase (PubMed:14738999) activities, but it was later found that the mouse ortholog does not possess either of them.2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.