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Q96A65

- EXOC4_HUMAN

UniProt

Q96A65 - EXOC4_HUMAN

Protein

Exocyst complex component 4

Gene

EXOC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein N-terminus binding Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. membrane organization Source: Reactome
    3. protein transport Source: UniProtKB-KW
    4. vesicle docking involved in exocytosis Source: InterPro

    Keywords - Biological processi

    Exocytosis, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_15550. Insulin processing.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exocyst complex component 4
    Alternative name(s):
    Exocyst complex component Sec8
    Gene namesi
    Name:EXOC4
    Synonyms:KIAA1699, SEC8, SEC8L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:30389. EXOC4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: LIFEdb
    2. exocyst Source: InterPro
    3. growth cone membrane Source: Ensembl
    4. membrane Source: UniProtKB
    5. myelin sheath abaxonal region Source: Ensembl
    6. plasma membrane Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134944654.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 974973Exocyst complex component 4PRO_0000118934Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei9 – 91N6-acetyllysine1 Publication
    Modified residuei237 – 2371Phosphothreonine4 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ96A65.
    PaxDbiQ96A65.
    PRIDEiQ96A65.

    PTM databases

    PhosphoSiteiQ96A65.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96A65.
    BgeeiQ96A65.
    CleanExiHS_EXOC4.
    GenevestigatoriQ96A65.

    Organism-specific databases

    HPAiHPA031443.

    Interactioni

    Subunit structurei

    The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 By similarity. Interacts with BIRC6/bruce. Interacts with MYRIP By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BIRC6Q9NR093EBI-355383,EBI-1765160

    Protein-protein interaction databases

    BioGridi121906. 24 interactions.
    DIPiDIP-32976N.
    IntActiQ96A65. 18 interactions.
    MINTiMINT-3050699.
    STRINGi9606.ENSP00000253861.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96A65.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili32 – 11483Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SEC8 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG270077.
    HOGENOMiHOG000044203.
    HOVERGENiHBG036151.
    InParanoidiQ96A65.
    KOiK06111.
    OMAiMQLNILV.
    OrthoDBiEOG72NRRP.
    PhylomeDBiQ96A65.
    TreeFamiTF313954.

    Family and domain databases

    InterProiIPR007191. Sec8_exocyst.
    [Graphical view]
    PfamiPF04048. Sec8_exocyst. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96A65-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA    50
    YEKCDRDLDE LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC 100
    KMLLHCKRDE LRKLWIEGIE HKHVLNLLDE IENIKQVPQK LEQCMASKHY 150
    LSATDMLVSA VESLEGPLLQ VEGLSDLRLE LHSKKMNLHL VLIDELHRHL 200
    YIKSTSRVVQ RNKEKGKISS LVKDASVPLI DVTNLPTPRK FLDTSHYSTA 250
    GSSSVREINL QDIKEDLELD PEENSTLFMG ILIKGLAKLK KIPETVKAII 300
    ERLEQELKQI VKRSTTQVAD SGYQRGENVT VENQPRLLLE LLELLFDKFN 350
    AVAAAHSVVL GYLQDTVVTP LTQQEDIKLY DMADVWVKIQ DVLQMLLTEY 400
    LDMKNTRTAS EPSAQLSYAS TGREFAAFFA KKKPQRPKNS LFKFESSSHA 450
    ISMSAYLREQ RRELYSRSGE LQGGPDDNLI EGGGTKFVCK PGARNITVIF 500
    HPLLRFIQEI EHALGLGPAK QCPLREFLTV YIKNIFLNQV LAEINKEIEG 550
    VTKTSDPLKI LANADTMKVL GVQRPLLQST IIVEKTVQDL LNLMHDLSAY 600
    SDQFLNMVCV KLQEYKDTCT AAYRGIVQSE EKLVISASWA KDDDISRLLK 650
    SLPNWMNMAQ PKQLRPKREE EEDFIRAAFG KESEVLIGNL GDKLIPPQDI 700
    LRDVSDLKAL ANMHESLEWL ASRTKSAFSN LSTSQMLSPA QDSHTNTDLP 750
    PVSEQIMQTL SELAKSFQDM ADRCLLVLHL EVRVHCFHYL IPLAKEGNYA 800
    IVANVESMDY DPLVVKLNKD ISAIEEAMSA SLQQHKFQYI FEGLGHLISC 850
    ILINGAQYFR RISESGIKKM CRNIFVLQQN LTNITMSREA DLDFARQYYE 900
    MLYNTADELL NLVVDQGVKY TELEYIHALT LLHRSQTGVG ELTTQNTRLQ 950
    RLKEIICEQA AIKQATKDKK ITTV 974
    Length:974
    Mass (Da):110,498
    Last modified:December 1, 2001 - v1
    Checksum:i122CD929C2635786
    GO
    Isoform 2 (identifier: Q96A65-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         474-974: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:473
    Mass (Da):53,857
    Checksum:i22D54FC6F3334D88
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti293 – 2931P → S in CAD39134. (PubMed:17974005)Curated
    Sequence conflicti338 – 3381L → T in AAF66445. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti220 – 2201S → F in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036292
    Natural varianti599 – 5991A → T in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036293

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei474 – 974501Missing in isoform 2. CuratedVSP_047159Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF380839 mRNA. Translation: AAK57456.1.
    AK022751 mRNA. Translation: BAB14225.1.
    AK027688 mRNA. Translation: BAB55298.1.
    AL831989 mRNA. Translation: CAD89977.1.
    AL834475 mRNA. Translation: CAD39134.1.
    AC007790 Genomic DNA. No translation available.
    AC009178 Genomic DNA. No translation available.
    AC009180 Genomic DNA. No translation available.
    AC009358 Genomic DNA. No translation available.
    AC024086 Genomic DNA. No translation available.
    AC083872 Genomic DNA. No translation available.
    AC083875 Genomic DNA. No translation available.
    AC093147 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24073.1.
    CH471070 Genomic DNA. Translation: EAW83804.1.
    AB051486 mRNA. Translation: BAB21790.1.
    AF132734 mRNA. Translation: AAF66445.1.
    CCDSiCCDS43648.1. [Q96A65-2]
    CCDS5829.1. [Q96A65-1]
    RefSeqiNP_068579.3. NM_021807.3. [Q96A65-1]
    UniGeneiHs.321273.

    Genome annotation databases

    EnsembliENST00000253861; ENSP00000253861; ENSG00000131558. [Q96A65-1]
    ENST00000393161; ENSP00000376868; ENSG00000131558. [Q96A65-2]
    GeneIDi60412.
    KEGGihsa:60412.
    UCSCiuc003vrk.3. human. [Q96A65-1]

    Polymorphism databases

    DMDMi24418674.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF380839 mRNA. Translation: AAK57456.1 .
    AK022751 mRNA. Translation: BAB14225.1 .
    AK027688 mRNA. Translation: BAB55298.1 .
    AL831989 mRNA. Translation: CAD89977.1 .
    AL834475 mRNA. Translation: CAD39134.1 .
    AC007790 Genomic DNA. No translation available.
    AC009178 Genomic DNA. No translation available.
    AC009180 Genomic DNA. No translation available.
    AC009358 Genomic DNA. No translation available.
    AC024086 Genomic DNA. No translation available.
    AC083872 Genomic DNA. No translation available.
    AC083875 Genomic DNA. No translation available.
    AC093147 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24073.1 .
    CH471070 Genomic DNA. Translation: EAW83804.1 .
    AB051486 mRNA. Translation: BAB21790.1 .
    AF132734 mRNA. Translation: AAF66445.1 .
    CCDSi CCDS43648.1. [Q96A65-2 ]
    CCDS5829.1. [Q96A65-1 ]
    RefSeqi NP_068579.3. NM_021807.3. [Q96A65-1 ]
    UniGenei Hs.321273.

    3D structure databases

    ProteinModelPortali Q96A65.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121906. 24 interactions.
    DIPi DIP-32976N.
    IntActi Q96A65. 18 interactions.
    MINTi MINT-3050699.
    STRINGi 9606.ENSP00000253861.

    PTM databases

    PhosphoSitei Q96A65.

    Polymorphism databases

    DMDMi 24418674.

    Proteomic databases

    MaxQBi Q96A65.
    PaxDbi Q96A65.
    PRIDEi Q96A65.

    Protocols and materials databases

    DNASUi 60412.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253861 ; ENSP00000253861 ; ENSG00000131558 . [Q96A65-1 ]
    ENST00000393161 ; ENSP00000376868 ; ENSG00000131558 . [Q96A65-2 ]
    GeneIDi 60412.
    KEGGi hsa:60412.
    UCSCi uc003vrk.3. human. [Q96A65-1 ]

    Organism-specific databases

    CTDi 60412.
    GeneCardsi GC07P132937.
    HGNCi HGNC:30389. EXOC4.
    HPAi HPA031443.
    MIMi 608185. gene.
    neXtProti NX_Q96A65.
    PharmGKBi PA134944654.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG270077.
    HOGENOMi HOG000044203.
    HOVERGENi HBG036151.
    InParanoidi Q96A65.
    KOi K06111.
    OMAi MQLNILV.
    OrthoDBi EOG72NRRP.
    PhylomeDBi Q96A65.
    TreeFami TF313954.

    Enzyme and pathway databases

    Reactomei REACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_15550. Insulin processing.

    Miscellaneous databases

    ChiTaRSi EXOC4. human.
    GeneWikii EXOC4.
    GenomeRNAii 60412.
    NextBioi 65320.
    PROi Q96A65.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96A65.
    Bgeei Q96A65.
    CleanExi HS_EXOC4.
    Genevestigatori Q96A65.

    Family and domain databases

    InterProi IPR007191. Sec8_exocyst.
    [Graphical view ]
    Pfami PF04048. Sec8_exocyst. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human secretory protein Sec8 related to testis development."
      Sha J.H.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Melanoma and Skeletal muscle.
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Bienvenut W.V., Campbell A., Ozanne B.W.
      Submitted (JUN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-11; 224-239; 314-325 AND 889-896, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Foreskin fibroblast.
    8. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-974 (ISOFORM 1).
      Tissue: Brain.
    9. Luo W.Q., Chen J.H., Huang X.W., Zhou Y., Zhou H.J., Hu S.N., Yuan J.G.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 338-974 (ISOFORM 1).
    10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-237, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
      Pohl C., Jentsch S.
      Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BIRC6/BRUCE.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-237, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-237, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-237, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-220 AND THR-599.

    Entry informationi

    Entry nameiEXOC4_HUMAN
    AccessioniPrimary (citable) accession number: Q96A65
    Secondary accession number(s): E9PED2
    , Q541U8, Q9C0G4, Q9H9K0, Q9P102
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3