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Protein

Exocyst complex component 4

Gene

EXOC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB
  • Ral GTPase binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_15550. Insulin processing.
REACT_268299. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 4
Alternative name(s):
Exocyst complex component Sec8
Gene namesi
Name:EXOC4
Synonyms:KIAA1699, SEC8, SEC8L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:30389. EXOC4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944654.

Polymorphism and mutation databases

BioMutaiEXOC4.
DMDMi24418674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 974973Exocyst complex component 4PRO_0000118934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications
Modified residuei9 – 91N6-acetyllysine1 Publication
Modified residuei226 – 2261Phosphoserine1 Publication
Modified residuei237 – 2371Phosphothreonine4 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96A65.
PaxDbiQ96A65.
PRIDEiQ96A65.

PTM databases

PhosphoSiteiQ96A65.

Expressioni

Gene expression databases

BgeeiQ96A65.
CleanExiHS_EXOC4.
GenevisibleiQ96A65. HS.

Organism-specific databases

HPAiHPA031443.
HPA031444.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BIRC6Q9NR093EBI-355383,EBI-1765160
SPAG9O602713EBI-355383,EBI-1023301

Protein-protein interaction databases

BioGridi121906. 27 interactions.
DIPiDIP-32976N.
IntActiQ96A65. 20 interactions.
MINTiMINT-3050699.
STRINGi9606.ENSP00000253861.

Structurei

3D structure databases

ProteinModelPortaliQ96A65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili32 – 11483Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SEC8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG270077.
GeneTreeiENSGT00390000001439.
HOGENOMiHOG000044203.
HOVERGENiHBG036151.
InParanoidiQ96A65.
OMAiFALHIDI.
OrthoDBiEOG72NRRP.
PhylomeDBiQ96A65.
TreeFamiTF313954.

Family and domain databases

InterProiIPR007191. Sec8_exocyst.
[Graphical view]
PfamiPF04048. Sec8_exocyst. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA
60 70 80 90 100
YEKCDRDLDE LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC
110 120 130 140 150
KMLLHCKRDE LRKLWIEGIE HKHVLNLLDE IENIKQVPQK LEQCMASKHY
160 170 180 190 200
LSATDMLVSA VESLEGPLLQ VEGLSDLRLE LHSKKMNLHL VLIDELHRHL
210 220 230 240 250
YIKSTSRVVQ RNKEKGKISS LVKDASVPLI DVTNLPTPRK FLDTSHYSTA
260 270 280 290 300
GSSSVREINL QDIKEDLELD PEENSTLFMG ILIKGLAKLK KIPETVKAII
310 320 330 340 350
ERLEQELKQI VKRSTTQVAD SGYQRGENVT VENQPRLLLE LLELLFDKFN
360 370 380 390 400
AVAAAHSVVL GYLQDTVVTP LTQQEDIKLY DMADVWVKIQ DVLQMLLTEY
410 420 430 440 450
LDMKNTRTAS EPSAQLSYAS TGREFAAFFA KKKPQRPKNS LFKFESSSHA
460 470 480 490 500
ISMSAYLREQ RRELYSRSGE LQGGPDDNLI EGGGTKFVCK PGARNITVIF
510 520 530 540 550
HPLLRFIQEI EHALGLGPAK QCPLREFLTV YIKNIFLNQV LAEINKEIEG
560 570 580 590 600
VTKTSDPLKI LANADTMKVL GVQRPLLQST IIVEKTVQDL LNLMHDLSAY
610 620 630 640 650
SDQFLNMVCV KLQEYKDTCT AAYRGIVQSE EKLVISASWA KDDDISRLLK
660 670 680 690 700
SLPNWMNMAQ PKQLRPKREE EEDFIRAAFG KESEVLIGNL GDKLIPPQDI
710 720 730 740 750
LRDVSDLKAL ANMHESLEWL ASRTKSAFSN LSTSQMLSPA QDSHTNTDLP
760 770 780 790 800
PVSEQIMQTL SELAKSFQDM ADRCLLVLHL EVRVHCFHYL IPLAKEGNYA
810 820 830 840 850
IVANVESMDY DPLVVKLNKD ISAIEEAMSA SLQQHKFQYI FEGLGHLISC
860 870 880 890 900
ILINGAQYFR RISESGIKKM CRNIFVLQQN LTNITMSREA DLDFARQYYE
910 920 930 940 950
MLYNTADELL NLVVDQGVKY TELEYIHALT LLHRSQTGVG ELTTQNTRLQ
960 970
RLKEIICEQA AIKQATKDKK ITTV
Length:974
Mass (Da):110,498
Last modified:December 1, 2001 - v1
Checksum:i122CD929C2635786
GO
Isoform 2 (identifier: Q96A65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     474-974: Missing.

Note: Gene prediction based on EST data.
Show »
Length:473
Mass (Da):53,857
Checksum:i22D54FC6F3334D88
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti293 – 2931P → S in CAD39134 (PubMed:17974005).Curated
Sequence conflicti338 – 3381L → T in AAF66445 (Ref. 9) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti220 – 2201S → F in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036292
Natural varianti599 – 5991A → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036293

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei474 – 974501Missing in isoform 2. CuratedVSP_047159Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380839 mRNA. Translation: AAK57456.1.
AK022751 mRNA. Translation: BAB14225.1.
AK027688 mRNA. Translation: BAB55298.1.
AL831989 mRNA. Translation: CAD89977.1.
AL834475 mRNA. Translation: CAD39134.1.
AC007790 Genomic DNA. No translation available.
AC009178 Genomic DNA. No translation available.
AC009180 Genomic DNA. No translation available.
AC009358 Genomic DNA. No translation available.
AC024086 Genomic DNA. No translation available.
AC083872 Genomic DNA. No translation available.
AC083875 Genomic DNA. No translation available.
AC093147 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24073.1.
CH471070 Genomic DNA. Translation: EAW83804.1.
AB051486 mRNA. Translation: BAB21790.1.
AF132734 mRNA. Translation: AAF66445.1.
CCDSiCCDS43648.1. [Q96A65-2]
CCDS5829.1. [Q96A65-1]
RefSeqiNP_068579.3. NM_021807.3. [Q96A65-1]
UniGeneiHs.321273.

Genome annotation databases

EnsembliENST00000253861; ENSP00000253861; ENSG00000131558.
ENST00000393161; ENSP00000376868; ENSG00000131558. [Q96A65-2]
GeneIDi60412.
UCSCiuc003vrk.3. human. [Q96A65-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF380839 mRNA. Translation: AAK57456.1.
AK022751 mRNA. Translation: BAB14225.1.
AK027688 mRNA. Translation: BAB55298.1.
AL831989 mRNA. Translation: CAD89977.1.
AL834475 mRNA. Translation: CAD39134.1.
AC007790 Genomic DNA. No translation available.
AC009178 Genomic DNA. No translation available.
AC009180 Genomic DNA. No translation available.
AC009358 Genomic DNA. No translation available.
AC024086 Genomic DNA. No translation available.
AC083872 Genomic DNA. No translation available.
AC083875 Genomic DNA. No translation available.
AC093147 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24073.1.
CH471070 Genomic DNA. Translation: EAW83804.1.
AB051486 mRNA. Translation: BAB21790.1.
AF132734 mRNA. Translation: AAF66445.1.
CCDSiCCDS43648.1. [Q96A65-2]
CCDS5829.1. [Q96A65-1]
RefSeqiNP_068579.3. NM_021807.3. [Q96A65-1]
UniGeneiHs.321273.

3D structure databases

ProteinModelPortaliQ96A65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121906. 27 interactions.
DIPiDIP-32976N.
IntActiQ96A65. 20 interactions.
MINTiMINT-3050699.
STRINGi9606.ENSP00000253861.

PTM databases

PhosphoSiteiQ96A65.

Polymorphism and mutation databases

BioMutaiEXOC4.
DMDMi24418674.

Proteomic databases

MaxQBiQ96A65.
PaxDbiQ96A65.
PRIDEiQ96A65.

Protocols and materials databases

DNASUi60412.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253861; ENSP00000253861; ENSG00000131558.
ENST00000393161; ENSP00000376868; ENSG00000131558. [Q96A65-2]
GeneIDi60412.
UCSCiuc003vrk.3. human. [Q96A65-1]

Organism-specific databases

CTDi60412.
GeneCardsiGC07P132937.
HGNCiHGNC:30389. EXOC4.
HPAiHPA031443.
HPA031444.
MIMi608185. gene.
neXtProtiNX_Q96A65.
PharmGKBiPA134944654.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG270077.
GeneTreeiENSGT00390000001439.
HOGENOMiHOG000044203.
HOVERGENiHBG036151.
InParanoidiQ96A65.
OMAiFALHIDI.
OrthoDBiEOG72NRRP.
PhylomeDBiQ96A65.
TreeFamiTF313954.

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_15550. Insulin processing.
REACT_268299. VxPx cargo-targeting to cilium.

Miscellaneous databases

ChiTaRSiEXOC4. human.
GeneWikiiEXOC4.
GenomeRNAii60412.
NextBioi65320.
PROiQ96A65.
SOURCEiSearch...

Gene expression databases

BgeeiQ96A65.
CleanExiHS_EXOC4.
GenevisibleiQ96A65. HS.

Family and domain databases

InterProiIPR007191. Sec8_exocyst.
[Graphical view]
PfamiPF04048. Sec8_exocyst. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human secretory protein Sec8 related to testis development."
    Sha J.H.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Melanoma and Skeletal muscle.
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Bienvenut W.V., Campbell A., Ozanne B.W.
    Submitted (JUN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-11; 224-239; 314-325 AND 889-896, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Foreskin fibroblast.
  8. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-974 (ISOFORM 1).
    Tissue: Brain.
  9. Luo W.Q., Chen J.H., Huang X.W., Zhou Y., Zhou H.J., Hu S.N., Yuan J.G.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 338-974 (ISOFORM 1).
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-237, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
    Pohl C., Jentsch S.
    Cell 132:832-845(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BIRC6/BRUCE.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-237, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-237, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-237, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  19. Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-220 AND THR-599.

Entry informationi

Entry nameiEXOC4_HUMAN
AccessioniPrimary (citable) accession number: Q96A65
Secondary accession number(s): E9PED2
, Q541U8, Q9C0G4, Q9H9K0, Q9P102
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.