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Protein

Tripartite motif-containing protein 52

Gene

TRIM52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 62RING-typeAdd BLAST43
Zinc fingeri222 – 263B box-typeAdd BLAST42

GO - Molecular functioni

GO - Biological processi

  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 52
Alternative name(s):
RING finger protein 102
Gene namesi
Name:TRIM52
Synonyms:RNF102
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000183718.5.
HGNCiHGNC:19024. TRIM52.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183718.
PharmGKBiPA134943216.

Polymorphism and mutation databases

BioMutaiTRIM52.
DMDMi47606198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562801 – 297Tripartite motif-containing protein 52Add BLAST297

Post-translational modificationi

Ubiquitinated.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ96A61.
PeptideAtlasiQ96A61.
PRIDEiQ96A61.

Expressioni

Gene expression databases

BgeeiENSG00000183718.
CleanExiHS_TRIM52.
ExpressionAtlasiQ96A61. baseline and differential.
GenevisibleiQ96A61. HS.

Organism-specific databases

HPAiHPA054565.
HPA056819.

Interactioni

Protein-protein interaction databases

BioGridi124301. 5 interactors.
IntActiQ96A61. 8 interactors.
STRINGi9606.ENSP00000332152.

Structurei

3D structure databases

ProteinModelPortaliQ96A61.
SMRiQ96A61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 164Glu-richAdd BLAST114

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri20 – 62RING-typeAdd BLAST43
Zinc fingeri222 – 263B box-typeAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118838.
HOVERGENiHBG070886.
InParanoidiQ96A61.
KOiK12025.
OMAiSPMQTLQ.
OrthoDBiEOG091G04RX.
PhylomeDBiQ96A61.

Family and domain databases

CDDicd00021. BBOX. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF00643. zf-B_box. 1 hit.
SMARTiView protein in SMART
SM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96A61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGYATTPSP MQTLQEEAVC AICLDYFKDP VSISCGHNFC RGCVTQLWSK
60 70 80 90 100
EDEEDQNEEE DEWEEEEDEE AVGAMDGWDG SIREVLYRGN ADEELFQDQD
110 120 130 140 150
DDELWLGDSG ITNWDNVDYM WDEEEEEEEE DQDYYLGGLR PDLRIDVYRE
160 170 180 190 200
EEILEAYDED EDEELYPDIH PPPSLPLPGQ FTCPQCRKSF TRRSFRPNLQ
210 220 230 240 250
LANMVQIIRQ MCPTPYRGNR SNDQGMCFKH QEALKLFCEV DKEAICVVCR
260 270 280 290
ESRSHKQHSV LPLEEVVQEY QEIKLETTLV GILQIEQESI HSKAYNQ
Length:297
Mass (Da):34,653
Last modified:December 1, 2001 - v1
Checksum:i13381ED57BDCC6AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054802 mRNA. Translation: BAB70809.1.
BC007372 mRNA. Translation: AAH07372.1.
CCDSiCCDS4467.1.
RefSeqiNP_116154.1. NM_032765.3.
UniGeneiHs.458412.
Hs.732588.

Genome annotation databases

EnsembliENST00000611618; ENSP00000483005; ENSG00000183718.
GeneIDi84851.
KEGGihsa:84851.
UCSCiuc003mnp.4. human.

Similar proteinsi

Entry informationi

Entry nameiTRI52_HUMAN
AccessioniPrimary (citable) accession number: Q96A61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families