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Protein

Tripartite motif-containing protein 52

Gene

TRIM52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri20 – 6243RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 26342B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 52
Alternative name(s):
RING finger protein 102
Gene namesi
Name:TRIM52
Synonyms:RNF102
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:19024. TRIM52.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134943216.

Polymorphism and mutation databases

BioMutaiTRIM52.
DMDMi47606198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Tripartite motif-containing protein 52PRO_0000056280Add
BLAST

Post-translational modificationi

Ubiquitinated.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ96A61.
PeptideAtlasiQ96A61.
PRIDEiQ96A61.

Expressioni

Gene expression databases

BgeeiENSG00000183718.
CleanExiHS_TRIM52.
ExpressionAtlasiQ96A61. baseline and differential.
GenevisibleiQ96A61. HS.

Organism-specific databases

HPAiHPA054565.
HPA056819.

Interactioni

Protein-protein interaction databases

BioGridi124301. 5 interactions.
IntActiQ96A61. 8 interactions.
STRINGi9606.ENSP00000332152.

Structurei

3D structure databases

ProteinModelPortaliQ96A61.
SMRiQ96A61. Positions 7-85, 220-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi51 – 164114Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri20 – 6243RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 26342B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00840000129824.
HOVERGENiHBG070886.
InParanoidiQ96A61.
KOiK12025.
OMAiPSPMQTL.
OrthoDBiEOG091G04RX.
PhylomeDBiQ96A61.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96A61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGYATTPSP MQTLQEEAVC AICLDYFKDP VSISCGHNFC RGCVTQLWSK
60 70 80 90 100
EDEEDQNEEE DEWEEEEDEE AVGAMDGWDG SIREVLYRGN ADEELFQDQD
110 120 130 140 150
DDELWLGDSG ITNWDNVDYM WDEEEEEEEE DQDYYLGGLR PDLRIDVYRE
160 170 180 190 200
EEILEAYDED EDEELYPDIH PPPSLPLPGQ FTCPQCRKSF TRRSFRPNLQ
210 220 230 240 250
LANMVQIIRQ MCPTPYRGNR SNDQGMCFKH QEALKLFCEV DKEAICVVCR
260 270 280 290
ESRSHKQHSV LPLEEVVQEY QEIKLETTLV GILQIEQESI HSKAYNQ
Length:297
Mass (Da):34,653
Last modified:December 1, 2001 - v1
Checksum:i13381ED57BDCC6AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054802 mRNA. Translation: BAB70809.1.
BC007372 mRNA. Translation: AAH07372.1.
CCDSiCCDS4467.1.
RefSeqiNP_116154.1. NM_032765.2.
UniGeneiHs.458412.

Genome annotation databases

EnsembliENST00000611618; ENSP00000483005; ENSG00000183718.
GeneIDi84851.
KEGGihsa:84851.
UCSCiuc003mnp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054802 mRNA. Translation: BAB70809.1.
BC007372 mRNA. Translation: AAH07372.1.
CCDSiCCDS4467.1.
RefSeqiNP_116154.1. NM_032765.2.
UniGeneiHs.458412.

3D structure databases

ProteinModelPortaliQ96A61.
SMRiQ96A61. Positions 7-85, 220-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124301. 5 interactions.
IntActiQ96A61. 8 interactions.
STRINGi9606.ENSP00000332152.

Polymorphism and mutation databases

BioMutaiTRIM52.
DMDMi47606198.

Proteomic databases

PaxDbiQ96A61.
PeptideAtlasiQ96A61.
PRIDEiQ96A61.

Protocols and materials databases

DNASUi84851.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611618; ENSP00000483005; ENSG00000183718.
GeneIDi84851.
KEGGihsa:84851.
UCSCiuc003mnp.4. human.

Organism-specific databases

CTDi84851.
GeneCardsiTRIM52.
HGNCiHGNC:19024. TRIM52.
HPAiHPA054565.
HPA056819.
neXtProtiNX_Q96A61.
PharmGKBiPA134943216.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00840000129824.
HOVERGENiHBG070886.
InParanoidiQ96A61.
KOiK12025.
OMAiPSPMQTL.
OrthoDBiEOG091G04RX.
PhylomeDBiQ96A61.

Miscellaneous databases

ChiTaRSiTRIM52. human.
GenomeRNAii84851.
PROiQ96A61.

Gene expression databases

BgeeiENSG00000183718.
CleanExiHS_TRIM52.
ExpressionAtlasiQ96A61. baseline and differential.
GenevisibleiQ96A61. HS.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00643. zf-B_box. 1 hit.
[Graphical view]
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI52_HUMAN
AccessioniPrimary (citable) accession number: Q96A61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.