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Protein

Ras-related and estrogen-regulated growth inhibitor

Gene

RERG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208GTP
Nucleotide bindingi60 – 645GTP
Nucleotide bindingi118 – 1214GTP

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB
  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • protein transport Source: InterPro
  • response to hormone Source: UniProtKB
  • small GTPase mediated signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related and estrogen-regulated growth inhibitor
Gene namesi
Name:RERG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:15980. RERG.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • membrane Source: InterPro
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34333.

Polymorphism and mutation databases

BioMutaiRERG.
DMDMi74731090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Ras-related and estrogen-regulated growth inhibitorPRO_0000082723Add
BLAST

Proteomic databases

PaxDbiQ96A58.
PRIDEiQ96A58.

PTM databases

iPTMnetiQ96A58.
PhosphoSiteiQ96A58.

Expressioni

Tissue specificityi

Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.1 Publication

Inductioni

Up-regulated by estradiol. Down-regulated by tamoxifen.1 Publication

Gene expression databases

BgeeiQ96A58.
CleanExiHS_RERG.
ExpressionAtlasiQ96A58. baseline and differential.
GenevisibleiQ96A58. HS.

Organism-specific databases

HPAiHPA041387.

Interactioni

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124423. 1 interaction.
IntActiQ96A58. 1 interaction.
STRINGi9606.ENSP00000256953.

Structurei

Secondary structure

1
199
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 126Combined sources
Helixi19 – 2810Combined sources
Beta strandi41 – 499Combined sources
Beta strandi52 – 609Combined sources
Helixi68 – 769Combined sources
Beta strandi78 – 858Combined sources
Helixi89 – 935Combined sources
Helixi95 – 10612Combined sources
Beta strandi113 – 1186Combined sources
Helixi120 – 1256Combined sources
Helixi130 – 14011Combined sources
Beta strandi142 – 1465Combined sources
Turni149 – 1513Combined sources
Helixi156 – 17116Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ATVX-ray1.90A1-174[»]
ProteinModelPortaliQ96A58.
SMRiQ96A58. Positions 5-172.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96A58.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi168 – 1714Poly-Arg

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ96A58.
KOiK07855.
OMAiTAGQHED.
OrthoDBiEOG7NSB3N.
PhylomeDBiQ96A58.
TreeFamiTF318030.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKSAEVKLA IFGRAGVGKS ALVVRFLTKR FIWEYDPTLE STYRHQATID
60 70 80 90 100
DEVVSMEILD TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN
110 120 130 140 150
ILDEIKKPKN VTLILVGNKA DLDHSRQVST EEGEKLATEL ACAFYECSAC
160 170 180 190
TGEGNITEIF YELCREVRRR RMVQGKTRRR SSTTHVKQAI NKMLTKISS
Length:199
Mass (Da):22,608
Last modified:December 1, 2001 - v1
Checksum:i18A0F8BDD40CEAF0
GO
Isoform 2 (identifier: Q96A58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-39: Missing.

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):20,258
Checksum:i7ED342E305E84D22
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei21 – 3919Missing in isoform 2. 1 PublicationVSP_043393Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF339750 mRNA. Translation: AAK98530.1.
AK295343 mRNA. Translation: BAG58314.1.
AK313881 mRNA. Translation: BAG36607.1.
AC007543 Genomic DNA. No translation available.
AC022334 Genomic DNA. No translation available.
AC092183 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96345.1.
BC007997 mRNA. Translation: AAH07997.1.
CCDSiCCDS53753.1. [Q96A58-2]
CCDS8673.1. [Q96A58-1]
RefSeqiNP_001177655.1. NM_001190726.1. [Q96A58-2]
NP_116307.1. NM_032918.2. [Q96A58-1]
UniGeneiHs.199487.

Genome annotation databases

EnsembliENST00000256953; ENSP00000256953; ENSG00000134533. [Q96A58-1]
ENST00000536465; ENSP00000438280; ENSG00000134533. [Q96A58-1]
ENST00000538313; ENSP00000441505; ENSG00000134533. [Q96A58-1]
ENST00000546331; ENSP00000444485; ENSG00000134533. [Q96A58-2]
GeneIDi85004.
KEGGihsa:85004.
UCSCiuc001rcs.4. human. [Q96A58-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF339750 mRNA. Translation: AAK98530.1.
AK295343 mRNA. Translation: BAG58314.1.
AK313881 mRNA. Translation: BAG36607.1.
AC007543 Genomic DNA. No translation available.
AC022334 Genomic DNA. No translation available.
AC092183 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96345.1.
BC007997 mRNA. Translation: AAH07997.1.
CCDSiCCDS53753.1. [Q96A58-2]
CCDS8673.1. [Q96A58-1]
RefSeqiNP_001177655.1. NM_001190726.1. [Q96A58-2]
NP_116307.1. NM_032918.2. [Q96A58-1]
UniGeneiHs.199487.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ATVX-ray1.90A1-174[»]
ProteinModelPortaliQ96A58.
SMRiQ96A58. Positions 5-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124423. 1 interaction.
IntActiQ96A58. 1 interaction.
STRINGi9606.ENSP00000256953.

PTM databases

iPTMnetiQ96A58.
PhosphoSiteiQ96A58.

Polymorphism and mutation databases

BioMutaiRERG.
DMDMi74731090.

Proteomic databases

PaxDbiQ96A58.
PRIDEiQ96A58.

Protocols and materials databases

DNASUi85004.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256953; ENSP00000256953; ENSG00000134533. [Q96A58-1]
ENST00000536465; ENSP00000438280; ENSG00000134533. [Q96A58-1]
ENST00000538313; ENSP00000441505; ENSG00000134533. [Q96A58-1]
ENST00000546331; ENSP00000444485; ENSG00000134533. [Q96A58-2]
GeneIDi85004.
KEGGihsa:85004.
UCSCiuc001rcs.4. human. [Q96A58-1]

Organism-specific databases

CTDi85004.
GeneCardsiRERG.
HGNCiHGNC:15980. RERG.
HPAiHPA041387.
MIMi612664. gene.
neXtProtiNX_Q96A58.
PharmGKBiPA34333.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ96A58.
KOiK07855.
OMAiTAGQHED.
OrthoDBiEOG7NSB3N.
PhylomeDBiQ96A58.
TreeFamiTF318030.

Miscellaneous databases

ChiTaRSiRERG. human.
EvolutionaryTraceiQ96A58.
GenomeRNAii85004.
PROiQ96A58.
SOURCEiSearch...

Gene expression databases

BgeeiQ96A58.
CleanExiHS_RERG.
ExpressionAtlasiQ96A58. baseline and differential.
GenevisibleiQ96A58. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer."
    Finlin B.S., Gau C.-L., Murphy G.A., Shao H., Kimel T., Seitz R.S., Chiu Y.-F., Botstein D., Brown P.O., Der C.J., Tamanoi F., Andres D.A., Perou C.M.
    J. Biol. Chem. 276:42259-42267(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Caudate nucleus and Trachea.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  6. "The crystal structure of human RERG in the GDP bound state."
    Structural genomics consortium (SGC)
    Submitted (OCT-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1-174 IN COMPLEX WITH GDP.

Entry informationi

Entry nameiRERG_HUMAN
AccessioniPrimary (citable) accession number: Q96A58
Secondary accession number(s): B2R9R0, B4DI02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.