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Protein

Ras-related and estrogen-regulated growth inhibitor

Gene

RERG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20GTP8
Nucleotide bindingi60 – 64GTP5
Nucleotide bindingi118 – 121GTP4

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB
  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • response to hormone Source: UniProtKB
  • small GTPase mediated signal transduction Source: UniProtKB

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related and estrogen-regulated growth inhibitor
Gene namesi
Name:RERG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000134533.6
HGNCiHGNC:15980 RERG
MIMi612664 gene
neXtProtiNX_Q96A58

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi85004
OpenTargetsiENSG00000134533
PharmGKBiPA34333

Polymorphism and mutation databases

BioMutaiRERG
DMDMi74731090

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827231 – 199Ras-related and estrogen-regulated growth inhibitorAdd BLAST199

Proteomic databases

PaxDbiQ96A58
PeptideAtlasiQ96A58
PRIDEiQ96A58
ProteomicsDBi75918
75919 [Q96A58-2]

PTM databases

iPTMnetiQ96A58
PhosphoSitePlusiQ96A58

Expressioni

Tissue specificityi

Detected in heart, brain, placenta, lung, liver, skin, kidney and pancreas. Detected in estrogen receptor-positive breast-derived cell lines, but not in estrogen receptor-negative cell lines. Expression is decreased or lost in a significant proportion of primary breast tumors with poor clinical prognosis.1 Publication

Inductioni

Up-regulated by estradiol. Down-regulated by tamoxifen.1 Publication

Gene expression databases

BgeeiENSG00000134533
CleanExiHS_RERG
ExpressionAtlasiQ96A58 baseline and differential
GenevisibleiQ96A58 HS

Organism-specific databases

HPAiHPA041387

Interactioni

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124423, 2 interactors
IntActiQ96A58, 1 interactor
STRINGi9606.ENSP00000256953

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 12Combined sources6
Helixi19 – 28Combined sources10
Beta strandi41 – 49Combined sources9
Beta strandi52 – 60Combined sources9
Helixi68 – 76Combined sources9
Beta strandi78 – 85Combined sources8
Helixi89 – 93Combined sources5
Helixi95 – 106Combined sources12
Beta strandi113 – 118Combined sources6
Helixi120 – 125Combined sources6
Helixi130 – 140Combined sources11
Beta strandi142 – 146Combined sources5
Turni149 – 151Combined sources3
Helixi156 – 171Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ATVX-ray1.90A1-174[»]
ProteinModelPortaliQ96A58
SMRiQ96A58
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96A58

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi168 – 171Poly-Arg4

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ96A58
KOiK07855
OMAiGEYDHQA
OrthoDBiEOG091G0M6D
PhylomeDBiQ96A58
TreeFamiTF318030

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKSAEVKLA IFGRAGVGKS ALVVRFLTKR FIWEYDPTLE STYRHQATID
60 70 80 90 100
DEVVSMEILD TAGQEDTIQR EGHMRWGEGF VLVYDITDRG SFEEVLPLKN
110 120 130 140 150
ILDEIKKPKN VTLILVGNKA DLDHSRQVST EEGEKLATEL ACAFYECSAC
160 170 180 190
TGEGNITEIF YELCREVRRR RMVQGKTRRR SSTTHVKQAI NKMLTKISS
Length:199
Mass (Da):22,608
Last modified:December 1, 2001 - v1
Checksum:i18A0F8BDD40CEAF0
GO
Isoform 2 (identifier: Q96A58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-39: Missing.

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):20,258
Checksum:i7ED342E305E84D22
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04339321 – 39Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF339750 mRNA Translation: AAK98530.1
AK295343 mRNA Translation: BAG58314.1
AK313881 mRNA Translation: BAG36607.1
AC007543 Genomic DNA No translation available.
AC022334 Genomic DNA No translation available.
AC092183 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96345.1
BC007997 mRNA Translation: AAH07997.1
CCDSiCCDS53753.1 [Q96A58-2]
CCDS8673.1 [Q96A58-1]
RefSeqiNP_001177655.1, NM_001190726.1 [Q96A58-2]
NP_116307.1, NM_032918.2 [Q96A58-1]
UniGeneiHs.199487

Genome annotation databases

EnsembliENST00000256953; ENSP00000256953; ENSG00000134533 [Q96A58-1]
ENST00000536465; ENSP00000438280; ENSG00000134533 [Q96A58-1]
ENST00000538313; ENSP00000441505; ENSG00000134533 [Q96A58-1]
ENST00000546331; ENSP00000444485; ENSG00000134533 [Q96A58-2]
GeneIDi85004
KEGGihsa:85004
UCSCiuc001rcs.4 human [Q96A58-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRERG_HUMAN
AccessioniPrimary (citable) accession number: Q96A58
Secondary accession number(s): B2R9R0, B4DI02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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