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Q96A56

- T53I1_HUMAN

UniProt

Q96A56 - T53I1_HUMAN

Protein

Tumor protein p53-inducible nuclear protein 1

Gene

TP53INP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.3 Publications

    GO - Molecular functioni

    1. antioxidant activity Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. autophagic cell death Source: UniProtKB
    3. autophagy Source: UniProtKB-KW
    4. cell cycle arrest Source: UniProtKB
    5. cellular response to ethanol Source: Ensembl
    6. cellular response to hydroperoxide Source: Ensembl
    7. cellular response to methyl methanesulfonate Source: Ensembl
    8. cellular response to UV Source: Ensembl
    9. negative regulation of cell migration Source: UniProtKB
    10. negative regulation of cell proliferation Source: UniProtKB
    11. positive regulation of apoptotic process Source: Ensembl
    12. positive regulation of apoptotic signaling pathway Source: Ensembl
    13. positive regulation of autophagy Source: UniProtKB
    14. positive regulation of transcription, DNA-templated Source: UniProtKB
    15. response to heat Source: Ensembl
    16. response to stress Source: UniProtKB
    17. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Antioxidant

    Keywords - Biological processi

    Apoptosis, Autophagy, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor protein p53-inducible nuclear protein 1
    Alternative name(s):
    Stress-induced protein
    p53-dependent damage-inducible nuclear protein 1
    Short name:
    p53DINP1
    Gene namesi
    Name:TP53INP1
    Synonyms:P53DINP1, SIP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:18022. TP53INP1.

    Subcellular locationi

    Cytoplasmcytosol. Nucleus. NucleusPML body. Cytoplasmic vesicleautophagosome
    Note: Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

    GO - Cellular componenti

    1. autophagic vacuole Source: UniProtKB
    2. cytoplasmic vesicle Source: UniProtKB-KW
    3. cytosol Source: UniProtKB
    4. nucleus Source: UniProtKB
    5. PML body Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA38278.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Tumor protein p53-inducible nuclear protein 1PRO_0000072406Add
    BLAST

    Proteomic databases

    PRIDEiQ96A56.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.2 Publications

    Inductioni

    By adriamycin, gamma irradiation and H2O2, in a p53/TP53-dependent way. At lower levels by UV irradiation. By TP73.2 Publications

    Gene expression databases

    ArrayExpressiQ96A56.
    BgeeiQ96A56.
    CleanExiHS_TP53INP1.
    GenevestigatoriQ96A56.

    Organism-specific databases

    HPAiHPA005856.

    Interactioni

    Subunit structurei

    Interacts with p53/TP53 and HIPK2. Interacts with PRKCG, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B AND MAP1LC3C.4 Publications

    Protein-protein interaction databases

    BioGridi125152. 3 interactions.
    STRINGi9606.ENSP00000344215.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96A56.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi25 – 3713LIRAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi14 – 174Poly-Ser
    Compositional biasi20 – 6142Glu-richAdd
    BLAST

    Domaini

    The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.

    Phylogenomic databases

    eggNOGiNOG39796.
    HOGENOMiHOG000010288.
    HOVERGENiHBG055647.
    InParanoidiQ96A56.
    KOiK15310.
    OMAiWAVHQPC.
    OrthoDBiEOG7MSMPN.
    PhylomeDBiQ96A56.
    TreeFamiTF333017.

    Family and domain databases

    InterProiIPR029431. TP53INP.
    IPR029556. TP53INP1.
    [Graphical view]
    PANTHERiPTHR31671. PTHR31671. 1 hit.
    PTHR31671:SF0. PTHR31671:SF0. 1 hit.
    PfamiPF14839. DOR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96A56-1) [UniParc]FASTAAdd to Basket

    Also known as: p53DINP1a, alpha, SIP27, TEAP

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFQRLNKMFV GEVSSSSNQE PEFNEKEDDE WILVDFIDTC TGFSAEEEEE    50
    EEDISEESPT EHPSVFSCLP ASLECLADTS DSCFLQFESC PMEESWFITP 100
    PPCFTAGGLT TIKVETSPME NLLIEHPSMS VYAVHNSCPG LSEATRGTDE 150
    LHSPSSPRVE AQNEMGQHIH CYVAALAAHT TFLEQPKSFR PSQWIKEHSE 200
    RQPLNRNSLR RQNLTRDCHP RQVKHNGWVV HQPCPRQYNY 240
    Length:240
    Mass (Da):27,366
    Last modified:December 1, 2001 - v1
    Checksum:i1950D66EDDB4A186
    GO
    Isoform 2 (identifier: Q96A56-2) [UniParc]FASTAAdd to Basket

    Also known as: p53DINP1b, beta, SIP18

    The sequence of this isoform differs from the canonical sequence as follows:
         159-240: VEAQNEMGQH...HQPCPRQYNY → ARKSCL

    Show »
    Length:164
    Mass (Da):18,244
    Checksum:i8C5B27F2CFB47B8E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti75 – 751C → R.
    Corresponds to variant rs11991800 [ dbSNP | Ensembl ].
    VAR_051404

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei159 – 24082VEAQN…RQYNY → ARKSCL in isoform 2. 2 PublicationsVSP_013176Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017926 mRNA. Translation: BAB62149.1.
    AB017927 mRNA. Translation: BAB62150.1.
    AB062056 Genomic DNA. Translation: BAB62151.1.
    AB062056 Genomic DNA. Translation: BAB62152.1.
    AF409114 mRNA. Translation: AAL04513.1.
    AF409115 mRNA. Translation: AAL04514.1.
    AK315071 mRNA. Translation: BAG37542.1.
    CH471060 Genomic DNA. Translation: EAW91740.1.
    BC074813 mRNA. Translation: AAH74813.1.
    BC074868 mRNA. Translation: AAH74868.1.
    CCDSiCCDS47899.1. [Q96A56-2]
    CCDS6265.1. [Q96A56-1]
    RefSeqiNP_001129205.1. NM_001135733.1. [Q96A56-2]
    NP_150601.1. NM_033285.3. [Q96A56-1]
    UniGeneiHs.492261.

    Genome annotation databases

    EnsembliENST00000342697; ENSP00000344215; ENSG00000164938. [Q96A56-1]
    ENST00000448464; ENSP00000390063; ENSG00000164938. [Q96A56-2]
    GeneIDi94241.
    KEGGihsa:94241.
    UCSCiuc003yhg.3. human. [Q96A56-1]
    uc003yhh.3. human. [Q96A56-2]

    Polymorphism databases

    DMDMi61216823.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017926 mRNA. Translation: BAB62149.1 .
    AB017927 mRNA. Translation: BAB62150.1 .
    AB062056 Genomic DNA. Translation: BAB62151.1 .
    AB062056 Genomic DNA. Translation: BAB62152.1 .
    AF409114 mRNA. Translation: AAL04513.1 .
    AF409115 mRNA. Translation: AAL04514.1 .
    AK315071 mRNA. Translation: BAG37542.1 .
    CH471060 Genomic DNA. Translation: EAW91740.1 .
    BC074813 mRNA. Translation: AAH74813.1 .
    BC074868 mRNA. Translation: AAH74868.1 .
    CCDSi CCDS47899.1. [Q96A56-2 ]
    CCDS6265.1. [Q96A56-1 ]
    RefSeqi NP_001129205.1. NM_001135733.1. [Q96A56-2 ]
    NP_150601.1. NM_033285.3. [Q96A56-1 ]
    UniGenei Hs.492261.

    3D structure databases

    ProteinModelPortali Q96A56.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125152. 3 interactions.
    STRINGi 9606.ENSP00000344215.

    Polymorphism databases

    DMDMi 61216823.

    Proteomic databases

    PRIDEi Q96A56.

    Protocols and materials databases

    DNASUi 94241.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342697 ; ENSP00000344215 ; ENSG00000164938 . [Q96A56-1 ]
    ENST00000448464 ; ENSP00000390063 ; ENSG00000164938 . [Q96A56-2 ]
    GeneIDi 94241.
    KEGGi hsa:94241.
    UCSCi uc003yhg.3. human. [Q96A56-1 ]
    uc003yhh.3. human. [Q96A56-2 ]

    Organism-specific databases

    CTDi 94241.
    GeneCardsi GC08M095938.
    HGNCi HGNC:18022. TP53INP1.
    HPAi HPA005856.
    MIMi 606185. gene.
    neXtProti NX_Q96A56.
    PharmGKBi PA38278.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39796.
    HOGENOMi HOG000010288.
    HOVERGENi HBG055647.
    InParanoidi Q96A56.
    KOi K15310.
    OMAi WAVHQPC.
    OrthoDBi EOG7MSMPN.
    PhylomeDBi Q96A56.
    TreeFami TF333017.

    Miscellaneous databases

    ChiTaRSi TP53INP1. human.
    GeneWikii TP53INP1.
    GenomeRNAii 94241.
    NextBioi 78499.
    PROi Q96A56.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96A56.
    Bgeei Q96A56.
    CleanExi HS_TP53INP1.
    Genevestigatori Q96A56.

    Family and domain databases

    InterProi IPR029431. TP53INP.
    IPR029556. TP53INP1.
    [Graphical view ]
    PANTHERi PTHR31671. PTHR31671. 1 hit.
    PTHR31671:SF0. PTHR31671:SF0. 1 hit.
    Pfami PF14839. DOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "p53DINP1, a p53-inducible gene, regulate p53-dependent apoptosis."
      Okamura S., Arakawa H., Tanaka T., Nakanishi H., Ng C.C., Taya Y., Monden M., Nakamura Y.
      Mol. Cell 8:85-94(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, FUNCTION.
      Tissue: Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), INDUCTION, TISSUE SPECIFICITY.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Trachea.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    6. "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity."
      Tomasini R., Samir A.A., Carrier A., Isnardon D., Cecchinelli B., Soddu S., Malissen B., Dagorn J.-C., Iovanna J.L., Dusetti N.J.
      J. Biol. Chem. 278:37722-37729(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TP53 AND HIPK2, SUBCELLULAR LOCATION.
    7. "Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage."
      Yoshida K., Liu H., Miki Y.
      J. Biol. Chem. 281:5734-5740(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PRKCG.
    8. "TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death."
      Seillier M., Peuget S., Gayet O., Gauthier C., N'guessan P., Monte M., Carrier A., Iovanna J.L., Dusetti N.J.
      Cell Death Differ. 19:1525-1535(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GABARAP; GABARAPL2 AND MAP1LC3A.
    9. "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
      Sancho A., Duran J., Garcia-Espana A., Mauvezin C., Alemu E.A., Lamark T., Macias M.J., Desalle R., Royo M., Sala D., Chicote J.U., Palacin M., Johansen T., Zorzano A.
      PLoS ONE 7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH GABARAP; GABARAPL1; GABARAPL2; MAP1LC3A; MAP1LC3B AND MAP1LC3C.

    Entry informationi

    Entry nameiT53I1_HUMAN
    AccessioniPrimary (citable) accession number: Q96A56
    Secondary accession number(s): B2RCE5, Q969R9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3