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Q96A56

- T53I1_HUMAN

UniProt

Q96A56 - T53I1_HUMAN

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Protein

Tumor protein p53-inducible nuclear protein 1

Gene

TP53INP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.3 Publications

GO - Molecular functioni

  1. antioxidant activity Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. autophagic cell death Source: UniProtKB
  3. autophagy Source: UniProtKB-KW
  4. cell cycle arrest Source: UniProtKB
  5. cellular response to ethanol Source: Ensembl
  6. cellular response to hydroperoxide Source: Ensembl
  7. cellular response to methyl methanesulfonate Source: Ensembl
  8. cellular response to UV Source: Ensembl
  9. negative regulation of cell migration Source: UniProtKB
  10. negative regulation of cell proliferation Source: UniProtKB
  11. positive regulation of apoptotic process Source: Ensembl
  12. positive regulation of apoptotic signaling pathway Source: Ensembl
  13. positive regulation of autophagy Source: UniProtKB
  14. positive regulation of transcription, DNA-templated Source: UniProtKB
  15. response to heat Source: Ensembl
  16. response to stress Source: UniProtKB
  17. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Antioxidant

Keywords - Biological processi

Apoptosis, Autophagy, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein p53-inducible nuclear protein 1
Alternative name(s):
Stress-induced protein
p53-dependent damage-inducible nuclear protein 1
Short name:
p53DINP1
Gene namesi
Name:TP53INP1
Synonyms:P53DINP1, SIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:18022. TP53INP1.

Subcellular locationi

Cytoplasmcytosol. Nucleus. NucleusPML body. Cytoplasmic vesicleautophagosome
Note: Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

GO - Cellular componenti

  1. autophagic vacuole Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. cytosol Source: UniProtKB
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA38278.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Tumor protein p53-inducible nuclear protein 1PRO_0000072406Add
BLAST

Proteomic databases

PRIDEiQ96A56.

Expressioni

Tissue specificityi

Ubiquitously expressed.2 Publications

Inductioni

By adriamycin, gamma irradiation and H2O2, in a p53/TP53-dependent way. At lower levels by UV irradiation. By TP73.2 Publications

Gene expression databases

BgeeiQ96A56.
CleanExiHS_TP53INP1.
GenevestigatoriQ96A56.

Organism-specific databases

HPAiHPA005856.

Interactioni

Subunit structurei

Interacts with p53/TP53 and HIPK2. Interacts with PRKCG, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B AND MAP1LC3C.4 Publications

Protein-protein interaction databases

BioGridi125152. 3 interactions.
STRINGi9606.ENSP00000344215.

Structurei

3D structure databases

ProteinModelPortaliQ96A56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi25 – 3713LIRAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 174Poly-Ser
Compositional biasi20 – 6142Glu-richAdd
BLAST

Domaini

The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.

Phylogenomic databases

eggNOGiNOG39796.
GeneTreeiENSGT00530000063829.
HOGENOMiHOG000010288.
HOVERGENiHBG055647.
InParanoidiQ96A56.
KOiK15310.
OMAiWAVHQPC.
OrthoDBiEOG7MSMPN.
PhylomeDBiQ96A56.
TreeFamiTF333017.

Family and domain databases

InterProiIPR029431. TP53INP.
IPR029556. TP53INP1.
[Graphical view]
PANTHERiPTHR31671. PTHR31671. 1 hit.
PTHR31671:SF0. PTHR31671:SF0. 1 hit.
PfamiPF14839. DOR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96A56-1) [UniParc]FASTAAdd to Basket

Also known as: p53DINP1a, alpha, SIP27, TEAP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQRLNKMFV GEVSSSSNQE PEFNEKEDDE WILVDFIDTC TGFSAEEEEE
60 70 80 90 100
EEDISEESPT EHPSVFSCLP ASLECLADTS DSCFLQFESC PMEESWFITP
110 120 130 140 150
PPCFTAGGLT TIKVETSPME NLLIEHPSMS VYAVHNSCPG LSEATRGTDE
160 170 180 190 200
LHSPSSPRVE AQNEMGQHIH CYVAALAAHT TFLEQPKSFR PSQWIKEHSE
210 220 230 240
RQPLNRNSLR RQNLTRDCHP RQVKHNGWVV HQPCPRQYNY
Length:240
Mass (Da):27,366
Last modified:December 1, 2001 - v1
Checksum:i1950D66EDDB4A186
GO
Isoform 2 (identifier: Q96A56-2) [UniParc]FASTAAdd to Basket

Also known as: p53DINP1b, beta, SIP18

The sequence of this isoform differs from the canonical sequence as follows:
     159-240: VEAQNEMGQH...HQPCPRQYNY → ARKSCL

Show »
Length:164
Mass (Da):18,244
Checksum:i8C5B27F2CFB47B8E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751C → R.
Corresponds to variant rs11991800 [ dbSNP | Ensembl ].
VAR_051404

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei159 – 24082VEAQN…RQYNY → ARKSCL in isoform 2. 2 PublicationsVSP_013176Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017926 mRNA. Translation: BAB62149.1.
AB017927 mRNA. Translation: BAB62150.1.
AB062056 Genomic DNA. Translation: BAB62151.1.
AB062056 Genomic DNA. Translation: BAB62152.1.
AF409114 mRNA. Translation: AAL04513.1.
AF409115 mRNA. Translation: AAL04514.1.
AK315071 mRNA. Translation: BAG37542.1.
CH471060 Genomic DNA. Translation: EAW91740.1.
BC074813 mRNA. Translation: AAH74813.1.
BC074868 mRNA. Translation: AAH74868.1.
CCDSiCCDS47899.1. [Q96A56-2]
CCDS6265.1. [Q96A56-1]
RefSeqiNP_001129205.1. NM_001135733.1. [Q96A56-2]
NP_150601.1. NM_033285.3. [Q96A56-1]
UniGeneiHs.492261.

Genome annotation databases

EnsembliENST00000342697; ENSP00000344215; ENSG00000164938. [Q96A56-1]
ENST00000448464; ENSP00000390063; ENSG00000164938. [Q96A56-2]
GeneIDi94241.
KEGGihsa:94241.
UCSCiuc003yhg.3. human. [Q96A56-1]
uc003yhh.3. human. [Q96A56-2]

Polymorphism databases

DMDMi61216823.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017926 mRNA. Translation: BAB62149.1 .
AB017927 mRNA. Translation: BAB62150.1 .
AB062056 Genomic DNA. Translation: BAB62151.1 .
AB062056 Genomic DNA. Translation: BAB62152.1 .
AF409114 mRNA. Translation: AAL04513.1 .
AF409115 mRNA. Translation: AAL04514.1 .
AK315071 mRNA. Translation: BAG37542.1 .
CH471060 Genomic DNA. Translation: EAW91740.1 .
BC074813 mRNA. Translation: AAH74813.1 .
BC074868 mRNA. Translation: AAH74868.1 .
CCDSi CCDS47899.1. [Q96A56-2 ]
CCDS6265.1. [Q96A56-1 ]
RefSeqi NP_001129205.1. NM_001135733.1. [Q96A56-2 ]
NP_150601.1. NM_033285.3. [Q96A56-1 ]
UniGenei Hs.492261.

3D structure databases

ProteinModelPortali Q96A56.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125152. 3 interactions.
STRINGi 9606.ENSP00000344215.

Polymorphism databases

DMDMi 61216823.

Proteomic databases

PRIDEi Q96A56.

Protocols and materials databases

DNASUi 94241.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342697 ; ENSP00000344215 ; ENSG00000164938 . [Q96A56-1 ]
ENST00000448464 ; ENSP00000390063 ; ENSG00000164938 . [Q96A56-2 ]
GeneIDi 94241.
KEGGi hsa:94241.
UCSCi uc003yhg.3. human. [Q96A56-1 ]
uc003yhh.3. human. [Q96A56-2 ]

Organism-specific databases

CTDi 94241.
GeneCardsi GC08M095938.
HGNCi HGNC:18022. TP53INP1.
HPAi HPA005856.
MIMi 606185. gene.
neXtProti NX_Q96A56.
PharmGKBi PA38278.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39796.
GeneTreei ENSGT00530000063829.
HOGENOMi HOG000010288.
HOVERGENi HBG055647.
InParanoidi Q96A56.
KOi K15310.
OMAi WAVHQPC.
OrthoDBi EOG7MSMPN.
PhylomeDBi Q96A56.
TreeFami TF333017.

Miscellaneous databases

ChiTaRSi TP53INP1. human.
GeneWikii TP53INP1.
GenomeRNAii 94241.
NextBioi 78499.
PROi Q96A56.
SOURCEi Search...

Gene expression databases

Bgeei Q96A56.
CleanExi HS_TP53INP1.
Genevestigatori Q96A56.

Family and domain databases

InterProi IPR029431. TP53INP.
IPR029556. TP53INP1.
[Graphical view ]
PANTHERi PTHR31671. PTHR31671. 1 hit.
PTHR31671:SF0. PTHR31671:SF0. 1 hit.
Pfami PF14839. DOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "p53DINP1, a p53-inducible gene, regulate p53-dependent apoptosis."
    Okamura S., Arakawa H., Tanaka T., Nakanishi H., Ng C.C., Taya Y., Monden M., Nakamura Y.
    Mol. Cell 8:85-94(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, FUNCTION.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), INDUCTION, TISSUE SPECIFICITY.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Trachea.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  6. "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity."
    Tomasini R., Samir A.A., Carrier A., Isnardon D., Cecchinelli B., Soddu S., Malissen B., Dagorn J.-C., Iovanna J.L., Dusetti N.J.
    J. Biol. Chem. 278:37722-37729(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TP53 AND HIPK2, SUBCELLULAR LOCATION.
  7. "Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage."
    Yoshida K., Liu H., Miki Y.
    J. Biol. Chem. 281:5734-5740(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PRKCG.
  8. "TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death."
    Seillier M., Peuget S., Gayet O., Gauthier C., N'guessan P., Monte M., Carrier A., Iovanna J.L., Dusetti N.J.
    Cell Death Differ. 19:1525-1535(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GABARAP; GABARAPL2 AND MAP1LC3A.
  9. "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
    Sancho A., Duran J., Garcia-Espana A., Mauvezin C., Alemu E.A., Lamark T., Macias M.J., Desalle R., Royo M., Sala D., Chicote J.U., Palacin M., Johansen T., Zorzano A.
    PLoS ONE 7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH GABARAP; GABARAPL1; GABARAPL2; MAP1LC3A; MAP1LC3B AND MAP1LC3C.

Entry informationi

Entry nameiT53I1_HUMAN
AccessioniPrimary (citable) accession number: Q96A56
Secondary accession number(s): B2RCE5, Q969R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3