Q96A54 (ADR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adiponectin receptor protein 1

Alternative name(s):
Progestin and adipoQ receptor family member I

Gene names

Name:	ADIPOR1
Synonyms:	PAQR1, TESBP1A
ORF Names:	CGI-45

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. Ref.8
Subunit structure	May form homo and heteromultimers. Ref.8
Subcellular location	Membrane; Multi-pass membrane protein. Note: Localized to the cell membrane and intracellular organelles. Ref.8
Tissue specificity	Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. Ref.8 Ref.1
Domain	The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
Sequence similarities	Belongs to the ADIPOR family.
Sequence caution	The sequence AAD34040.1 differs from that shown. Reason: Frameshift at position 369.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid oxidation Ref.8 Inferred from direct assay. Source: UniProtKB hormone-mediated signaling pathway Ref.8 Inferred from direct assay. Source: UniProtKB
Cellular component	integral to membrane Ref.8 Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from direct assay. Source: BHF-UCL
Molecular function	hormone binding Ref.8 Inferred from direct assay. Source: UniProtKB protein kinase binding Inferred from physical interaction. Source: BHF-UCL receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		3	EBI-1632076,EBI-1632076
APPL1	Q9UKG1	6	EBI-1632076,EBI-741243

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Adiponectin receptor protein 1		PRO_0000218827
Regions
	Topological domain	1 – 136	136	Cytoplasmic Potential
	Transmembrane	137 – 157	21	Helical; Name=1; Potential
	Topological domain	158 – 170	13	Extracellular Potential
	Transmembrane	171 – 191	21	Helical; Name=2; Potential
	Topological domain	192 – 209	18	Cytoplasmic Potential
	Transmembrane	210 – 230	21	Helical; Name=3; Potential
	Topological domain	231 – 235	5	Extracellular Potential
	Transmembrane	236 – 256	21	Helical; Name=4; Potential
	Topological domain	257 – 267	11	Cytoplasmic Potential
	Transmembrane	268 – 288	21	Helical; Name=5; Potential
	Topological domain	289 – 296	8	Extracellular Potential
	Transmembrane	297 – 317	21	Helical; Name=6; Potential
	Topological domain	318 – 331	14	Cytoplasmic Potential
	Transmembrane	332 – 352	21	Helical; Name=7; Potential
	Topological domain	353 – 375	23	Extracellular Potential
Experimental info
	Sequence conflict	183	1	C → W in BAG50922. Ref.4
	Sequence conflict	340	1	F → Y in BAD96223. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q96A54-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 1CC0300A7D178EB0	FASTA	375	42,616
	10 20 30 40 50 60 MSSHKGSVVA QGNGAPASNR EADTVELAEL GPLLEEKGKR VIANPPKAEE EQTCPVPQEE 70 80 90 100 110 120 EEEVRVLTLP LQAHHAMEKM EEFVYKVWEG RWRVIPYDVL PDWLKDNDYL LHGHRPPMPS 130 140 150 160 170 180 FRACFKSIFR IHTETGNIWT HLLGFVLFLF LGILTMLRPN MYFMAPLQEK VVFGMFFLGA 190 200 210 220 230 240 VLCLSFSWLF HTVYCHSEKV SRTFSKLDYS GIALLIMGSF VPWLYYSFYC SPQPRLIYLS 250 260 270 280 290 300 IVCVLGISAI IVAQWDRFAT PKHRQTRAGV FLGLGLSGVV PTMHFTIAEG FVKATTVGQM 310 320 330 340 350 360 GWFFLMAVMY ITGAGLYAAR IPERFFPGKF DIWFQSHQIF HVLVVAAAFV HFYGVSNLQE 370 FRYGLEGGCT DDTLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif." Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D. J. Mol. Evol. 61:372-380(2005) [PubMed: 16044242] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Cloning and characterization of TESBP1A." Sugihara T. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed: 10810093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adipose tissue.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Skin.
[8]	"Cloning of adiponectin receptors that mediate antidiabetic metabolic effects." Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., Sugiyama T., Miyagishi M., Hara K., Tsunoda M., Murakami K., Ohteki T., Uchida S., Takekawa S., Waki H., Tsuno N.H., Shibata Y., Terauchi Y. , Froguel P., Tobe K., Koyasu S., Taira K., Kitamura T., Shimizu T., Nagai R., Kadowaki T. Nature 423:762-769(2003) [PubMed: 12802337] [Abstract] Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, TOPOLOGY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY424279 mRNA. Translation: AAR08367.1. AF125179 mRNA. Translation: AAQ13552.1. AF151803 mRNA. Translation: AAD34040.1. Frameshift. AK001484 mRNA. Translation: BAG50922.1. AK222503 mRNA. Translation: BAD96223.1. CH471067 Genomic DNA. Translation: EAW91450.1. BC001594 mRNA. Translation: AAH01594.1. BC010743 mRNA. Translation: AAH10743.1.
IPI	IPI00059263.
RefSeq	NP_001121159.1. NP_057083.2.
UniGene	Hs.5298.
3D structure databases
ProteinModelPortal	Q96A54.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96A54. 9 interactions.
STRING	Q96A54.
Proteomic databases
PRIDE	Q96A54.
Genome annotation databases
Ensembl	ENST00000340990; ENSP00000341785; ENSG00000159346; Homo sapiens. [Genome view] ENST00000436244; ENSP00000395469; ENSG00000159346; Homo sapiens. [Genome view]
GeneID	51094.
KEGG	hsa:51094.
UCSC	uc001gyq.2. human.
Organism-specific databases
CTD	51094.
GeneCards	GC01M202909.
H-InvDB	HIX0001482.
HGNC	HGNC:24040. ADIPOR1.
HPA	CAB015935.
MIM	607945. gene.
PharmGKB	PA134861801.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG749828.
HOVERGEN	HBG013916.
InParanoid	Q96A54.
OMA	EQACPVP.
OrthoDB	EOG93JFQD.
PhylomeDB	Q96A54.
Gene expression databases
ArrayExpress	Q96A54.
Bgee	Q96A54.
CleanEx	HS_ADIPOR1.
Genevestigator	Q96A54.
GermOnline	ENSG00000159346. Homo sapiens.
Family and domain databases
InterPro	IPR004254. HlyIII_related. [Graphical view]
PANTHER	PTHR20855. HlyIII_related. 1 hit.
Pfam	PF03006. HlyIII. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	53785.
SOURCE	Search...

Entry information

Entry name

ADR1_HUMAN

Accession

Primary (citable) accession number: Q96A54
Secondary accession number(s): B3KMB0 , Q53HS7, Q53YY6, Q9Y360

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	December 1, 2001
Last modified:	August 10, 2010
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.