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Q96A54

- ADR1_HUMAN

UniProt

Q96A54 - ADR1_HUMAN

Protein

Adiponectin receptor protein 1

Gene

ADIPOR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.1 Publication

    GO - Molecular functioni

    1. hormone binding Source: UniProtKB
    2. protein kinase binding Source: BHF-UCL
    3. receptor activity Source: RefGenome

    GO - Biological processi

    1. adiponectin-activated signaling pathway Source: RefGenome
    2. fatty acid oxidation Source: UniProtKB
    3. hormone-mediated signaling pathway Source: UniProtKB
    4. leptin-mediated signaling pathway Source: Ensembl
    5. negative regulation of cell growth Source: Ensembl
    6. positive regulation of insulin receptor signaling pathway Source: Ensembl
    7. positive regulation of JAK-STAT cascade Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adiponectin receptor protein 1
    Alternative name(s):
    Progestin and adipoQ receptor family member I
    Gene namesi
    Name:ADIPOR1
    Synonyms:PAQR1, TESBP1A
    ORF Names:CGI-45
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:24040. ADIPOR1.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Localized to the cell membrane and intracellular organelles.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. membrane Source: UniProtKB
    3. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134861801.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Adiponectin receptor protein 1PRO_0000218827Add
    BLAST

    Proteomic databases

    MaxQBiQ96A54.
    PaxDbiQ96A54.
    PRIDEiQ96A54.

    PTM databases

    PhosphoSiteiQ96A54.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.2 Publications

    Gene expression databases

    ArrayExpressiQ96A54.
    BgeeiQ96A54.
    CleanExiHS_ADIPOR1.
    GenevestigatoriQ96A54.

    Organism-specific databases

    HPAiHPA048306.

    Interactioni

    Subunit structurei

    May form homomultimer and heteromultimers.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-1632076,EBI-1632076
    APPL1Q9UKG16EBI-1632076,EBI-741243

    Protein-protein interaction databases

    BioGridi119283. 8 interactions.
    DIPiDIP-48622N.
    IntActiQ96A54. 6 interactions.
    STRINGi9606.ENSP00000341785.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96A54.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 136136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 17013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini192 – 20918CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini231 – 2355ExtracellularSequence Analysis
    Topological domaini257 – 26711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini289 – 2968ExtracellularSequence Analysis
    Topological domaini318 – 33114CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini353 – 37523ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei137 – 15721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei210 – 23021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.

    Sequence similaritiesi

    Belongs to the ADIPOR family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1272.
    HOGENOMiHOG000197115.
    HOVERGENiHBG013916.
    InParanoidiQ96A54.
    KOiK07297.
    OMAiAAFIHFY.
    OrthoDBiEOG7BS49P.
    PhylomeDBiQ96A54.
    TreeFamiTF313640.

    Family and domain databases

    InterProiIPR004254. HlyIII-related.
    [Graphical view]
    PANTHERiPTHR20855. PTHR20855. 1 hit.
    PfamiPF03006. HlyIII. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96A54-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSHKGSVVA QGNGAPASNR EADTVELAEL GPLLEEKGKR VIANPPKAEE    50
    EQTCPVPQEE EEEVRVLTLP LQAHHAMEKM EEFVYKVWEG RWRVIPYDVL 100
    PDWLKDNDYL LHGHRPPMPS FRACFKSIFR IHTETGNIWT HLLGFVLFLF 150
    LGILTMLRPN MYFMAPLQEK VVFGMFFLGA VLCLSFSWLF HTVYCHSEKV 200
    SRTFSKLDYS GIALLIMGSF VPWLYYSFYC SPQPRLIYLS IVCVLGISAI 250
    IVAQWDRFAT PKHRQTRAGV FLGLGLSGVV PTMHFTIAEG FVKATTVGQM 300
    GWFFLMAVMY ITGAGLYAAR IPERFFPGKF DIWFQSHQIF HVLVVAAAFV 350
    HFYGVSNLQE FRYGLEGGCT DDTLL 375
    Length:375
    Mass (Da):42,616
    Last modified:December 1, 2001 - v1
    Checksum:i1CC0300A7D178EB0
    GO

    Sequence cautioni

    The sequence AAD34040.1 differs from that shown. Reason: Frameshift at position 369.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti183 – 1831C → W in BAG50922. (PubMed:14702039)Curated
    Sequence conflicti340 – 3401F → Y in BAD96223. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424279 mRNA. Translation: AAR08367.1.
    AF125179 mRNA. Translation: AAQ13552.1.
    AF151803 mRNA. Translation: AAD34040.1. Frameshift.
    AK001484 mRNA. Translation: BAG50922.1.
    AK222503 mRNA. Translation: BAD96223.1.
    CH471067 Genomic DNA. Translation: EAW91450.1.
    BC001594 mRNA. Translation: AAH01594.1.
    BC010743 mRNA. Translation: AAH10743.1.
    CCDSiCCDS1430.1.
    RefSeqiNP_001277482.1. NM_001290553.1.
    NP_001277486.1. NM_001290557.1.
    NP_001277558.1. NM_001290629.1.
    NP_057083.2. NM_015999.5.
    UniGeneiHs.5298.
    Hs.713729.

    Genome annotation databases

    EnsembliENST00000340990; ENSP00000341785; ENSG00000159346.
    GeneIDi51094.
    KEGGihsa:51094.
    UCSCiuc001gyq.5. human.

    Polymorphism databases

    DMDMi38372248.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424279 mRNA. Translation: AAR08367.1 .
    AF125179 mRNA. Translation: AAQ13552.1 .
    AF151803 mRNA. Translation: AAD34040.1 . Frameshift.
    AK001484 mRNA. Translation: BAG50922.1 .
    AK222503 mRNA. Translation: BAD96223.1 .
    CH471067 Genomic DNA. Translation: EAW91450.1 .
    BC001594 mRNA. Translation: AAH01594.1 .
    BC010743 mRNA. Translation: AAH10743.1 .
    CCDSi CCDS1430.1.
    RefSeqi NP_001277482.1. NM_001290553.1.
    NP_001277486.1. NM_001290557.1.
    NP_001277558.1. NM_001290629.1.
    NP_057083.2. NM_015999.5.
    UniGenei Hs.5298.
    Hs.713729.

    3D structure databases

    ProteinModelPortali Q96A54.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119283. 8 interactions.
    DIPi DIP-48622N.
    IntActi Q96A54. 6 interactions.
    STRINGi 9606.ENSP00000341785.

    Chemistry

    GuidetoPHARMACOLOGYi 649.

    PTM databases

    PhosphoSitei Q96A54.

    Polymorphism databases

    DMDMi 38372248.

    Proteomic databases

    MaxQBi Q96A54.
    PaxDbi Q96A54.
    PRIDEi Q96A54.

    Protocols and materials databases

    DNASUi 51094.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340990 ; ENSP00000341785 ; ENSG00000159346 .
    GeneIDi 51094.
    KEGGi hsa:51094.
    UCSCi uc001gyq.5. human.

    Organism-specific databases

    CTDi 51094.
    GeneCardsi GC01M202909.
    HGNCi HGNC:24040. ADIPOR1.
    HPAi HPA048306.
    MIMi 607945. gene.
    neXtProti NX_Q96A54.
    PharmGKBi PA134861801.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1272.
    HOGENOMi HOG000197115.
    HOVERGENi HBG013916.
    InParanoidi Q96A54.
    KOi K07297.
    OMAi AAFIHFY.
    OrthoDBi EOG7BS49P.
    PhylomeDBi Q96A54.
    TreeFami TF313640.

    Miscellaneous databases

    ChiTaRSi ADIPOR1. human.
    GeneWikii ADIPOR1.
    GenomeRNAii 51094.
    NextBioi 53785.
    PROi Q96A54.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96A54.
    Bgeei Q96A54.
    CleanExi HS_ADIPOR1.
    Genevestigatori Q96A54.

    Family and domain databases

    InterProi IPR004254. HlyIII-related.
    [Graphical view ]
    PANTHERi PTHR20855. PTHR20855. 1 hit.
    Pfami PF03006. HlyIII. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
      Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
      J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Cloning and characterization of TESBP1A."
      Sugihara T.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adipose tissue.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Skin.
    8. Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, TOPOLOGY.

    Entry informationi

    Entry nameiADR1_HUMAN
    AccessioniPrimary (citable) accession number: Q96A54
    Secondary accession number(s): B3KMB0
    , Q53HS7, Q53YY6, Q9Y360
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3