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Q96A54 (ADR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adiponectin receptor protein 1
Alternative name(s):
Progestin and adipoQ receptor family member I
Gene names
Name:ADIPOR1
Synonyms:PAQR1, TESBP1A
ORF Names:CGI-45
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. Ref.8

Subunit structure

May form homomultimer and heteromultimers. Ref.8

Subcellular location

Membrane; Multi-pass membrane protein. Note: Localized to the cell membrane and intracellular organelles. Ref.8

Tissue specificity

Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. Ref.1 Ref.8

Domain

The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.

Sequence similarities

Belongs to the ADIPOR family.

Sequence caution

The sequence AAD34040.1 differs from that shown. Reason: Frameshift at position 369.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself3EBI-1632076,EBI-1632076
APPL1Q9UKG16EBI-1632076,EBI-741243

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Adiponectin receptor protein 1
PRO_0000218827

Regions

Topological domain1 – 136136Cytoplasmic Potential
Transmembrane137 – 15721Helical; Name=1; Potential
Topological domain158 – 17013Extracellular Potential
Transmembrane171 – 19121Helical; Name=2; Potential
Topological domain192 – 20918Cytoplasmic Potential
Transmembrane210 – 23021Helical; Name=3; Potential
Topological domain231 – 2355Extracellular Potential
Transmembrane236 – 25621Helical; Name=4; Potential
Topological domain257 – 26711Cytoplasmic Potential
Transmembrane268 – 28821Helical; Name=5; Potential
Topological domain289 – 2968Extracellular Potential
Transmembrane297 – 31721Helical; Name=6; Potential
Topological domain318 – 33114Cytoplasmic Potential
Transmembrane332 – 35221Helical; Name=7; Potential
Topological domain353 – 37523Extracellular Potential

Experimental info

Sequence conflict1831C → W in BAG50922. Ref.4
Sequence conflict3401F → Y in BAD96223. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q96A54 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 1CC0300A7D178EB0

FASTA37542,616
        10         20         30         40         50         60 
MSSHKGSVVA QGNGAPASNR EADTVELAEL GPLLEEKGKR VIANPPKAEE EQTCPVPQEE 

        70         80         90        100        110        120 
EEEVRVLTLP LQAHHAMEKM EEFVYKVWEG RWRVIPYDVL PDWLKDNDYL LHGHRPPMPS 

       130        140        150        160        170        180 
FRACFKSIFR IHTETGNIWT HLLGFVLFLF LGILTMLRPN MYFMAPLQEK VVFGMFFLGA 

       190        200        210        220        230        240 
VLCLSFSWLF HTVYCHSEKV SRTFSKLDYS GIALLIMGSF VPWLYYSFYC SPQPRLIYLS 

       250        260        270        280        290        300 
IVCVLGISAI IVAQWDRFAT PKHRQTRAGV FLGLGLSGVV PTMHFTIAEG FVKATTVGQM 

       310        320        330        340        350        360 
GWFFLMAVMY ITGAGLYAAR IPERFFPGKF DIWFQSHQIF HVLVVAAAFV HFYGVSNLQE 

       370 
FRYGLEGGCT DDTLL 

« Hide

References

« Hide 'large scale' references
[1]"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Cloning and characterization of TESBP1A."
Sugihara T.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Adipose tissue.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Skin.
[8]"Cloning of adiponectin receptors that mediate antidiabetic metabolic effects."
Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., Sugiyama T., Miyagishi M., Hara K., Tsunoda M., Murakami K., Ohteki T., Uchida S., Takekawa S., Waki H., Tsuno N.H., Shibata Y., Terauchi Y. expand/collapse author list , Froguel P., Tobe K., Koyasu S., Taira K., Kitamura T., Shimizu T., Nagai R., Kadowaki T.
Nature 423:762-769(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, TOPOLOGY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY424279 mRNA. Translation: AAR08367.1.
AF125179 mRNA. Translation: AAQ13552.1.
AF151803 mRNA. Translation: AAD34040.1. Frameshift.
AK001484 mRNA. Translation: BAG50922.1.
AK222503 mRNA. Translation: BAD96223.1.
CH471067 Genomic DNA. Translation: EAW91450.1.
BC001594 mRNA. Translation: AAH01594.1.
BC010743 mRNA. Translation: AAH10743.1.
RefSeqNP_057083.2. NM_015999.4.
UniGeneHs.713729.

3D structure databases

ProteinModelPortalQ96A54.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119283. 8 interactions.
DIPDIP-48622N.
IntActQ96A54. 6 interactions.
STRING9606.ENSP00000341785.

Chemistry

GuidetoPHARMACOLOGY649.

PTM databases

PhosphoSiteQ96A54.

Polymorphism databases

DMDM38372248.

Proteomic databases

PaxDbQ96A54.
PRIDEQ96A54.

Protocols and materials databases

DNASU51094.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000340990; ENSP00000341785; ENSG00000159346.
ENST00000436244; ENSP00000395469; ENSG00000159346.
GeneID51094.
KEGGhsa:51094.
UCSCuc001gyq.5. human.

Organism-specific databases

CTD51094.
GeneCardsGC01M202909.
HGNCHGNC:24040. ADIPOR1.
HPAHPA048306.
MIM607945. gene.
neXtProtNX_Q96A54.
PharmGKBPA134861801.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1272.
HOGENOMHOG000197115.
HOVERGENHBG013916.
InParanoidQ96A54.
KOK07297.
OMAAAFIHFY.
OrthoDBEOG7BS49P.
PhylomeDBQ96A54.
TreeFamTF313640.

Gene expression databases

ArrayExpressQ96A54.
BgeeQ96A54.
CleanExHS_ADIPOR1.
GenevestigatorQ96A54.

Family and domain databases

InterProIPR004254. HlyIII-related.
[Graphical view]
PANTHERPTHR20855. PTHR20855. 1 hit.
PfamPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSADIPOR1. human.
GeneWikiADIPOR1.
GenomeRNAi51094.
NextBio53785.
PROQ96A54.
SOURCESearch...

Entry information

Entry nameADR1_HUMAN
AccessionPrimary (citable) accession number: Q96A54
Secondary accession number(s): B3KMB0 expand/collapse secondary AC list , Q53HS7, Q53YY6, Q9Y360
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM