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Protein

Adiponectin receptor protein 1

Gene

ADIPOR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi191Zinc1 Publication1
Metal bindingi337Zinc1 Publication1
Metal bindingi341Zinc1 Publication1

GO - Molecular functioni

  • adipokinetic hormone receptor activity Source: UniProtKB
  • adiponectin binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein kinase binding Source: BHF-UCL

GO - Biological processi

  • adiponectin-activated signaling pathway Source: UniProtKB
  • fatty acid oxidation Source: UniProtKB
  • glucose homeostasis Source: UniProtKB
  • hormone-mediated signaling pathway Source: UniProtKB
  • leptin-mediated signaling pathway Source: Ensembl
  • negative regulation of cell growth Source: Ensembl
  • negative regulation of epithelial cell migration Source: BHF-UCL
  • negative regulation of epithelial to mesenchymal transition Source: BHF-UCL
  • negative regulation of JAK-STAT cascade Source: BHF-UCL
  • negative regulation of NIK/NF-kappaB signaling Source: BHF-UCL
  • positive regulation of insulin receptor signaling pathway Source: Ensembl
  • positive regulation of JAK-STAT cascade Source: Ensembl
  • regulation of glucose metabolic process Source: UniProtKB
  • regulation of lipid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159346-MONOMER.
ReactomeiR-HSA-163680. AMPK inhibits chREBP transcriptional activation activity.
SIGNORiQ96A54.

Protein family/group databases

TCDBi1.C.113.1.9. 1.c.113 the hly iii (hly iii) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Adiponectin receptor protein 1
Alternative name(s):
Progestin and adipoQ receptor family member I
Gene namesi
Name:ADIPOR1
Synonyms:PAQR11 Publication, TESBP1A
ORF Names:CGI-45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24040. ADIPOR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 136Cytoplasmic1 PublicationAdd BLAST136
Transmembranei137 – 157Helical; Name=11 PublicationAdd BLAST21
Topological domaini158 – 170Extracellular1 PublicationAdd BLAST13
Transmembranei171 – 191Helical; Name=21 PublicationAdd BLAST21
Topological domaini192 – 203Cytoplasmic1 PublicationAdd BLAST12
Transmembranei204 – 224Helical; Name=31 PublicationAdd BLAST21
Topological domaini225 – 234Extracellular1 Publication10
Transmembranei235 – 255Helical; Name=41 PublicationAdd BLAST21
Topological domaini256 – 264Cytoplasmic1 Publication9
Transmembranei265 – 285Helical; Name=51 PublicationAdd BLAST21
Topological domaini286 – 298Extracellular1 PublicationAdd BLAST13
Transmembranei299 – 319Helical; Name=61 PublicationAdd BLAST21
Topological domaini320 – 337Cytoplasmic1 PublicationAdd BLAST18
Transmembranei338 – 358Helical; Name=71 PublicationAdd BLAST21
Topological domaini359 – 375Extracellular1 PublicationAdd BLAST17

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intrinsic component of plasma membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi161 – 167MYFMAPL → SGSSGGS: Decreases activation of AMPK in response to ADIPOQ binding; when associated with 229-G--G-231 and 291-S--S-297. 1 Publication7
Mutagenesisi191H → A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-208; A-337 and A-341. 1 Publication1
Mutagenesisi208D → A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-191; A-337 and A-341. 1 Publication1
Mutagenesisi229 – 231YCS → GGG: Decreases activation of AMPK in response to ADIPOQ binding; when associated with 161-S--S-167 and 291-S--S-297. 1 Publication3
Mutagenesisi291 – 297FVKATTV → SSSGGGS: Decreases activation of AMPK in response to ADIPOQ binding; when associated with 161-S--S-167 and 229-G--G-231. 1 Publication7
Mutagenesisi337H → A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-191; A-208 and A-341. 1 Publication1
Mutagenesisi341H → A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-191; A-208 and A-337. 1 Publication1

Organism-specific databases

DisGeNETi51094.
OpenTargetsiENSG00000159346.
PharmGKBiPA134861801.

Chemistry databases

ChEMBLiCHEMBL3392946.

Polymorphism and mutation databases

BioMutaiADIPOR1.
DMDMi38372248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188271 – 375Adiponectin receptor protein 1Add BLAST375

Proteomic databases

EPDiQ96A54.
MaxQBiQ96A54.
PaxDbiQ96A54.
PeptideAtlasiQ96A54.
PRIDEiQ96A54.

PTM databases

iPTMnetiQ96A54.
PhosphoSitePlusiQ96A54.

Expressioni

Tissue specificityi

Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337). Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337). Weakly expressed in colon, thymus and small intestine (PubMed:12802337).2 Publications

Gene expression databases

BgeeiENSG00000159346.
CleanExiHS_ADIPOR1.
ExpressionAtlasiQ96A54. baseline and differential.
GenevisibleiQ96A54. HS.

Organism-specific databases

HPAiHPA048306.

Interactioni

Subunit structurei

May form homooligomers and heterooligomers with ADIPOR2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-1632076,EBI-1632076
APPL1Q9UKG16EBI-1632076,EBI-741243

GO - Molecular functioni

  • adiponectin binding Source: UniProtKB
  • protein kinase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi119283. 24 interactors.
DIPiDIP-48622N.
IntActiQ96A54. 9 interactors.
STRINGi9606.ENSP00000341785.

Chemistry databases

BindingDBiQ96A54.

Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi97 – 99Combined sources3
Helixi102 – 104Combined sources3
Helixi121 – 126Combined sources6
Helixi127 – 129Combined sources3
Helixi135 – 157Combined sources23
Helixi169 – 192Combined sources24
Helixi193 – 195Combined sources3
Helixi198 – 227Combined sources30
Turni228 – 230Combined sources3
Helixi232 – 252Combined sources21
Beta strandi257 – 260Combined sources4
Helixi261 – 263Combined sources3
Helixi264 – 275Combined sources12
Helixi276 – 278Combined sources3
Helixi279 – 288Combined sources10
Helixi291 – 295Combined sources5
Helixi305 – 319Combined sources15
Turni320 – 325Combined sources6
Beta strandi329 – 334Combined sources6
Helixi336 – 364Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WXVX-ray2.90A89-375[»]
ProteinModelPortaliQ96A54.
SMRiQ96A54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.1 Publication

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748. Eukaryota.
COG1272. LUCA.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000197115.
HOVERGENiHBG013916.
InParanoidiQ96A54.
KOiK07297.
OMAiEQACPVP.
OrthoDBiEOG091G04EU.
PhylomeDBiQ96A54.
TreeFamiTF313640.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96A54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHKGSVVA QGNGAPASNR EADTVELAEL GPLLEEKGKR VIANPPKAEE
60 70 80 90 100
EQTCPVPQEE EEEVRVLTLP LQAHHAMEKM EEFVYKVWEG RWRVIPYDVL
110 120 130 140 150
PDWLKDNDYL LHGHRPPMPS FRACFKSIFR IHTETGNIWT HLLGFVLFLF
160 170 180 190 200
LGILTMLRPN MYFMAPLQEK VVFGMFFLGA VLCLSFSWLF HTVYCHSEKV
210 220 230 240 250
SRTFSKLDYS GIALLIMGSF VPWLYYSFYC SPQPRLIYLS IVCVLGISAI
260 270 280 290 300
IVAQWDRFAT PKHRQTRAGV FLGLGLSGVV PTMHFTIAEG FVKATTVGQM
310 320 330 340 350
GWFFLMAVMY ITGAGLYAAR IPERFFPGKF DIWFQSHQIF HVLVVAAAFV
360 370
HFYGVSNLQE FRYGLEGGCT DDTLL
Length:375
Mass (Da):42,616
Last modified:December 1, 2001 - v1
Checksum:i1CC0300A7D178EB0
GO

Sequence cautioni

The sequence AAD34040 differs from that shown. Reason: Frameshift at position 369.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti183C → W in BAG50922 (PubMed:14702039).Curated1
Sequence conflicti340F → Y in BAD96223 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424279 mRNA. Translation: AAR08367.1.
AF125179 mRNA. Translation: AAQ13552.1.
AF151803 mRNA. Translation: AAD34040.1. Frameshift.
AK001484 mRNA. Translation: BAG50922.1.
AK222503 mRNA. Translation: BAD96223.1.
CH471067 Genomic DNA. Translation: EAW91450.1.
BC001594 mRNA. Translation: AAH01594.1.
BC010743 mRNA. Translation: AAH10743.1.
CCDSiCCDS1430.1.
RefSeqiNP_001277482.1. NM_001290553.1.
NP_001277486.1. NM_001290557.1.
NP_001277558.1. NM_001290629.1.
NP_057083.2. NM_015999.5.
UniGeneiHs.5298.
Hs.713729.

Genome annotation databases

EnsembliENST00000340990; ENSP00000341785; ENSG00000159346.
GeneIDi51094.
KEGGihsa:51094.
UCSCiuc001gyq.7. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424279 mRNA. Translation: AAR08367.1.
AF125179 mRNA. Translation: AAQ13552.1.
AF151803 mRNA. Translation: AAD34040.1. Frameshift.
AK001484 mRNA. Translation: BAG50922.1.
AK222503 mRNA. Translation: BAD96223.1.
CH471067 Genomic DNA. Translation: EAW91450.1.
BC001594 mRNA. Translation: AAH01594.1.
BC010743 mRNA. Translation: AAH10743.1.
CCDSiCCDS1430.1.
RefSeqiNP_001277482.1. NM_001290553.1.
NP_001277486.1. NM_001290557.1.
NP_001277558.1. NM_001290629.1.
NP_057083.2. NM_015999.5.
UniGeneiHs.5298.
Hs.713729.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WXVX-ray2.90A89-375[»]
ProteinModelPortaliQ96A54.
SMRiQ96A54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119283. 24 interactors.
DIPiDIP-48622N.
IntActiQ96A54. 9 interactors.
STRINGi9606.ENSP00000341785.

Chemistry databases

BindingDBiQ96A54.
ChEMBLiCHEMBL3392946.

Protein family/group databases

TCDBi1.C.113.1.9. 1.c.113 the hly iii (hly iii) family.

PTM databases

iPTMnetiQ96A54.
PhosphoSitePlusiQ96A54.

Polymorphism and mutation databases

BioMutaiADIPOR1.
DMDMi38372248.

Proteomic databases

EPDiQ96A54.
MaxQBiQ96A54.
PaxDbiQ96A54.
PeptideAtlasiQ96A54.
PRIDEiQ96A54.

Protocols and materials databases

DNASUi51094.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340990; ENSP00000341785; ENSG00000159346.
GeneIDi51094.
KEGGihsa:51094.
UCSCiuc001gyq.7. human.

Organism-specific databases

CTDi51094.
DisGeNETi51094.
GeneCardsiADIPOR1.
HGNCiHGNC:24040. ADIPOR1.
HPAiHPA048306.
MIMi607945. gene.
neXtProtiNX_Q96A54.
OpenTargetsiENSG00000159346.
PharmGKBiPA134861801.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0748. Eukaryota.
COG1272. LUCA.
GeneTreeiENSGT00530000062926.
HOGENOMiHOG000197115.
HOVERGENiHBG013916.
InParanoidiQ96A54.
KOiK07297.
OMAiEQACPVP.
OrthoDBiEOG091G04EU.
PhylomeDBiQ96A54.
TreeFamiTF313640.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159346-MONOMER.
ReactomeiR-HSA-163680. AMPK inhibits chREBP transcriptional activation activity.
SIGNORiQ96A54.

Miscellaneous databases

ChiTaRSiADIPOR1. human.
GeneWikiiADIPOR1.
GenomeRNAii51094.
PROiQ96A54.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159346.
CleanExiHS_ADIPOR1.
ExpressionAtlasiQ96A54. baseline and differential.
GenevisibleiQ96A54. HS.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADR1_HUMAN
AccessioniPrimary (citable) accession number: Q96A54
Secondary accession number(s): B3KMB0
, Q53HS7, Q53YY6, Q9Y360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.