Q96A49 (SYAP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 83.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Synapse-associated protein 1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 352 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Sequence similarities | Contains 1 BSD domain. |
| Sequence caution | The sequence AAK55531.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| PTM | Acetylation Phosphoprotein |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||
Molecule processing | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 352 | 352 | Synapse-associated protein 1 | PRO_0000072355 | ||||||||||||||||||
Regions | ||||||||||||||||||||||
| Domain | 158 – 210 | 53 | BSD | |||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||
| Modified residue | 191 | 1 | N6-acetyllysine Ref.15 | |||||||||||||||||||
| Modified residue | 248 | 1 | Phosphothreonine Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 | |||||||||||||||||||
| Modified residue | 269 | 1 | Phosphoserine Ref.14 | |||||||||||||||||||
| Modified residue | 327 | 1 | Phosphotyrosine Ref.11 | |||||||||||||||||||
Experimental info | ||||||||||||||||||||||
| Sequence conflict | 26 | 1 | P → L in AAH14657. Ref.6 | |||||||||||||||||||
| Sequence conflict | 96 | 1 | I → T in BAB55087. Ref.2 | |||||||||||||||||||
| Sequence conflict | 176 | 1 | Q → H in AAK55531. Ref.7 | |||||||||||||||||||
Secondary structure | ||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||
| Helix | 134 – 144 | 11 | ||||||||||||||||||||
| Helix | 148 – 151 | 4 | ||||||||||||||||||||
| Beta strand | 156 – 158 | 3 | ||||||||||||||||||||
| Helix | 164 – 177 | 14 | ||||||||||||||||||||
| Helix | 179 – 187 | 9 | ||||||||||||||||||||
| Turn | 188 – 192 | 5 | ||||||||||||||||||||
| Helix | 195 – 215 | 21 | ||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "SYAP1, the human homolog of the SAP47 gene of Drosophila melanogaster." Chang Y., Yu Y., Wang N., Xu Y. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix. |
| [4] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin. |
| [7] | "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs." Yu Y., Zhang C., Zhou G., Wu S., Qu X., Wei H., Xing G., Dong C., Zhai Y., Wan J., Ouyang S., Li L., Zhang S., Zhou K., Zhang Y., Wu C., He F. Genome Res. 11:1392-1403(2001) [PubMed: 11483580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 124-352. Tissue: Fetal liver. |
| [8] | "Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [9] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [10] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [11] | "Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248 AND TYR-327, MASS SPECTROMETRY. Tissue: Embryonic kidney. |
| [12] | "Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [13] | "Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248, MASS SPECTROMETRY. Tissue: Platelet. |
| [14] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248 AND SER-269, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [15] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-191, MASS SPECTROMETRY. |
| [16] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| [17] | "Solution structure of the BSD domain of human synapse associated protein 1." RIKEN structural genomics initiative (RSGI) Submitted (JAN-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 130-216. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AF168955 mRNA. Translation: AAK81893.1. AF338728 mRNA. Translation: AAK69273.1. AK027401 mRNA. Translation: BAB55087.1. CR749849 mRNA. Translation: CAH18697.1. AL445467 Genomic DNA. Translation: CAI40087.1. CH471074 Genomic DNA. Translation: EAW98917.1. BC014657 mRNA. Translation: AAH14657.1. AF305828 mRNA. Translation: AAK55531.1. Different initiation. | ||||||||||||
| IPI | IPI00059242. | ||||||||||||
| RefSeq | NP_116185.2. NM_032796.3. | ||||||||||||
| UniGene | Hs.729197. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | Q96A49. | ||||||||||||
| SMR | Q96A49. Positions 130-217. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| STRING | Q96A49. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q96A49. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 30580522. | ||||||||||||
Proteomic databases | |||||||||||||
| PeptideAtlas | Q96A49. | ||||||||||||
| PRIDE | Q96A49. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000380155; ENSP00000369500; ENSG00000169895. | ||||||||||||
| GeneID | 94056. | ||||||||||||
| KEGG | hsa:94056. | ||||||||||||
| UCSC | uc004cxp.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 94056. | ||||||||||||
| GeneCards | GC0XP016737. | ||||||||||||
| H-InvDB | HIX0016676. | ||||||||||||
| HGNC | HGNC:16273. SYAP1. | ||||||||||||
| HPA | HPA000175. | ||||||||||||
| neXtProt | NX_Q96A49. | ||||||||||||
| PharmGKB | PA38107. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| GeneTree | ENSGT00390000007662. | ||||||||||||
| HOGENOM | HBG278505. | ||||||||||||
| HOVERGEN | HBG057553. | ||||||||||||
| InParanoid | Q96A49. | ||||||||||||
| OMA | WVDTNDE. | ||||||||||||
| OrthoDB | EOG473PS3. | ||||||||||||
| PhylomeDB | Q96A49. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q96A49. | ||||||||||||
| Bgee | Q96A49. | ||||||||||||
| CleanEx | HS_SYAP1. | ||||||||||||
| Genevestigator | Q96A49. | ||||||||||||
| GermOnline | ENSG00000169895. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR005607. BSD. [Graphical view] | ||||||||||||
| Pfam | PF03909. BSD. 1 hit. [Graphical view] | ||||||||||||
| SMART | SM00751. BSD. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS50858. BSD. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| NextBio | 78351. | ||||||||||||
Entry information
| Entry name | SYAP1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96A49 Secondary accession number(s): Q68CP1 Q96T20 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

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