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Protein

Synapse-associated protein 1

Gene

SYAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Synapse-associated protein 1
Gene namesi
Name:SYAP1
ORF Names:PRO3113
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:16273. SYAP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: HPA
  • nucleoplasm Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38107.

Polymorphism and mutation databases

BioMutaiSYAP1.
DMDMi30580522.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Synapse-associated protein 1PRO_0000072355Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481PhosphothreonineCombined sources
Modified residuei269 – 2691PhosphoserineCombined sources
Modified residuei313 – 3131PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96A49.
MaxQBiQ96A49.
PaxDbiQ96A49.
PeptideAtlasiQ96A49.
PRIDEiQ96A49.

PTM databases

iPTMnetiQ96A49.
PhosphoSiteiQ96A49.

Expressioni

Gene expression databases

BgeeiQ96A49.
CleanExiHS_SYAP1.
GenevisibleiQ96A49. HS.

Organism-specific databases

HPAiHPA000175.
HPA000882.
HPA048047.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
POT1Q9NUX52EBI-10770179,EBI-752420

Protein-protein interaction databases

BioGridi125103. 19 interactions.
IntActiQ96A49. 5 interactions.
STRINGi9606.ENSP00000369500.

Structurei

Secondary structure

1
352
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi134 – 14411Combined sources
Helixi148 – 1514Combined sources
Beta strandi156 – 1583Combined sources
Helixi164 – 17714Combined sources
Helixi179 – 1879Combined sources
Turni188 – 1925Combined sources
Helixi195 – 21521Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X3ANMR-A130-216[»]
ProteinModelPortaliQ96A49.
SMRiQ96A49. Positions 130-217.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96A49.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini158 – 21053BSDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BSD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4310. Eukaryota.
ENOG410ZPSV. LUCA.
GeneTreeiENSGT00390000007662.
HOGENOMiHOG000231677.
HOVERGENiHBG057553.
InParanoidiQ96A49.
OMAiCNLDQED.
OrthoDBiEOG7WDN49.
PhylomeDBiQ96A49.
TreeFamiTF319666.

Family and domain databases

InterProiIPR005607. BSD_dom.
[Graphical view]
PfamiPF03909. BSD. 1 hit.
[Graphical view]
SMARTiSM00751. BSD. 1 hit.
[Graphical view]
PROSITEiPS50858. BSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96A49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRGLSSWLG LQQPVAGGGQ PNGDAPPEQP SETVAESAEE ELQQAGDQEL
60 70 80 90 100
LHQAKDFGNY LFNFASAATK KITESVAETA QTIKKSVEEG KIDGIIDKTI
110 120 130 140 150
IGDFQKEQKK FVEEQHTKKS EAAVPPWVDT NDEETIQQQI LALSADKRNF
160 170 180 190 200
LRDPPAGVQF NFDFDQMYPV ALVMLQEDEL LSKMRFALVP KLVKEEVFWR
210 220 230 240 250
NYFYRVSLIK QSAQLTALAA QQQAAGKEEK SNGREQDLPL AEAVRPKTPP
260 270 280 290 300
VVIKSQLKTQ EDEEEISTSP GVSEFVSDAF DACNLNQEDL RKEMEQLVLD
310 320 330 340 350
KKQEETAVLE EDSADWEKEL QQELQEYEVV TESEKRDENW DKEIEKMLQE

EN
Length:352
Mass (Da):39,933
Last modified:December 1, 2001 - v1
Checksum:i2083636CF7CF75AE
GO

Sequence cautioni

The sequence AAK55531.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261P → L in AAH14657 (PubMed:15489334).Curated
Sequence conflicti96 – 961I → T in BAB55087 (PubMed:14702039).Curated
Sequence conflicti176 – 1761Q → H in AAK55531 (PubMed:11483580).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168955 mRNA. Translation: AAK81893.1.
AF338728 mRNA. Translation: AAK69273.1.
AK027401 mRNA. Translation: BAB55087.1.
CR749849 mRNA. Translation: CAH18697.1.
AL445467 Genomic DNA. Translation: CAI40087.1.
CH471074 Genomic DNA. Translation: EAW98917.1.
BC014657 mRNA. Translation: AAH14657.1.
AF305828 mRNA. Translation: AAK55531.1. Different initiation.
CCDSiCCDS14177.1.
RefSeqiNP_116185.2. NM_032796.3.
UniGeneiHs.744256.

Genome annotation databases

EnsembliENST00000380155; ENSP00000369500; ENSG00000169895.
GeneIDi94056.
KEGGihsa:94056.
UCSCiuc004cxp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168955 mRNA. Translation: AAK81893.1.
AF338728 mRNA. Translation: AAK69273.1.
AK027401 mRNA. Translation: BAB55087.1.
CR749849 mRNA. Translation: CAH18697.1.
AL445467 Genomic DNA. Translation: CAI40087.1.
CH471074 Genomic DNA. Translation: EAW98917.1.
BC014657 mRNA. Translation: AAH14657.1.
AF305828 mRNA. Translation: AAK55531.1. Different initiation.
CCDSiCCDS14177.1.
RefSeqiNP_116185.2. NM_032796.3.
UniGeneiHs.744256.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X3ANMR-A130-216[»]
ProteinModelPortaliQ96A49.
SMRiQ96A49. Positions 130-217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125103. 19 interactions.
IntActiQ96A49. 5 interactions.
STRINGi9606.ENSP00000369500.

PTM databases

iPTMnetiQ96A49.
PhosphoSiteiQ96A49.

Polymorphism and mutation databases

BioMutaiSYAP1.
DMDMi30580522.

Proteomic databases

EPDiQ96A49.
MaxQBiQ96A49.
PaxDbiQ96A49.
PeptideAtlasiQ96A49.
PRIDEiQ96A49.

Protocols and materials databases

DNASUi94056.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380155; ENSP00000369500; ENSG00000169895.
GeneIDi94056.
KEGGihsa:94056.
UCSCiuc004cxp.4. human.

Organism-specific databases

CTDi94056.
GeneCardsiSYAP1.
HGNCiHGNC:16273. SYAP1.
HPAiHPA000175.
HPA000882.
HPA048047.
neXtProtiNX_Q96A49.
PharmGKBiPA38107.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4310. Eukaryota.
ENOG410ZPSV. LUCA.
GeneTreeiENSGT00390000007662.
HOGENOMiHOG000231677.
HOVERGENiHBG057553.
InParanoidiQ96A49.
OMAiCNLDQED.
OrthoDBiEOG7WDN49.
PhylomeDBiQ96A49.
TreeFamiTF319666.

Miscellaneous databases

ChiTaRSiSYAP1. human.
EvolutionaryTraceiQ96A49.
GeneWikiiSYAP1.
GenomeRNAii94056.
PROiQ96A49.

Gene expression databases

BgeeiQ96A49.
CleanExiHS_SYAP1.
GenevisibleiQ96A49. HS.

Family and domain databases

InterProiIPR005607. BSD_dom.
[Graphical view]
PfamiPF03909. BSD. 1 hit.
[Graphical view]
SMARTiSM00751. BSD. 1 hit.
[Graphical view]
PROSITEiPS50858. BSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SYAP1, the human homolog of the SAP47 gene of Drosophila melanogaster."
    Chang Y., Yu Y., Wang N., Xu Y.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  7. "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs."
    Yu Y., Zhang C., Zhou G., Wu S., Qu X., Wei H., Xing G., Dong C., Zhai Y., Wan J., Ouyang S., Li L., Zhang S., Zhou K., Zhang Y., Wu C., He F.
    Genome Res. 11:1392-1403(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 124-352.
    Tissue: Fetal liver.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248 AND SER-313, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248 AND SER-313, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  16. "Solution structure of the BSD domain of human synapse associated protein 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JAN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 130-216.

Entry informationi

Entry nameiSYAP1_HUMAN
AccessioniPrimary (citable) accession number: Q96A49
Secondary accession number(s): Q68CP1
, Q96C60, Q96JQ6, Q96T20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.