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Protein

Insulin gene enhancer protein ISL-2

Gene

ISL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi191 – 250HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding Source: BHF-UCL
  • sequence-specific DNA binding Source: InterPro
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159556-MONOMER.
SIGNORiQ96A47.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin gene enhancer protein ISL-2
Short name:
Islet-2
Gene namesi
Name:ISL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:18524. ISL2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159556.
PharmGKBiPA38566.

Polymorphism and mutation databases

BioMutaiISL2.
DMDMi20978495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757521 – 359Insulin gene enhancer protein ISL-2Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei154PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei279PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96A47.
MaxQBiQ96A47.
PaxDbiQ96A47.
PeptideAtlasiQ96A47.
PRIDEiQ96A47.

PTM databases

iPTMnetiQ96A47.
PhosphoSitePlusiQ96A47.

Expressioni

Gene expression databases

BgeeiENSG00000159556.
CleanExiHS_ISL2.
ExpressionAtlasiQ96A47. baseline and differential.
GenevisibleiQ96A47. HS.

Interactioni

Subunit structurei

Interacts with LHX4.By similarity

Protein-protein interaction databases

BioGridi122318. 10 interactors.
STRINGi9606.ENSP00000290759.

Structurei

3D structure databases

ProteinModelPortaliQ96A47.
SMRiQ96A47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 86LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini87 – 149LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni272 – 301LIM-binding domain (LID)By similarityAdd BLAST30

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000236304.
HOVERGENiHBG004671.
InParanoidiQ96A47.
KOiK18492.
OMAiRHDSAVQ.
OrthoDBiEOG091G09L9.
PhylomeDBiQ96A47.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96A47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDIIFHYPF LGAMGDHSKK KPGTAMCVGC GSQIHDQFIL RVSPDLEWHA
60 70 80 90 100
ACLKCAECSQ YLDETCTCFV RDGKTYCKRD YVRLFGIKCA KCQVGFSSSD
110 120 130 140 150
LVMRARDSVY HIECFRCSVC SRQLLPGDEF SLREHELLCR ADHGLLLERA
160 170 180 190 200
AAGSPRSPGP LPGARGLHLP DAGSGRQPAL RPHVHKQTEK TTRVRTVLNE
210 220 230 240 250
KQLHTLRTCY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKKS
260 270 280 290 300
ILMKQLQQQQ HSDKTSLQGL TGTPLVAGSP IRHENAVQGS AVEVQTYQPP
310 320 330 340 350
WKALSEFALQ SDLDQPAFQQ LVSFSESGSL GNSSGSDVTS LSSQLPDTPN

SMVPSPVET
Length:359
Mass (Da):39,768
Last modified:December 1, 2001 - v1
Checksum:i2162FB3D430EE4BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001022 mRNA. Translation: BAG50849.1.
CH471136 Genomic DNA. Translation: EAW99220.1.
BC011967 mRNA. Translation: AAH11967.1.
BC012136 mRNA. Translation: AAH12136.1.
CCDSiCCDS10290.1.
RefSeqiNP_665804.1. NM_145805.2.
UniGeneiHs.444677.

Genome annotation databases

EnsembliENST00000290759; ENSP00000290759; ENSG00000159556.
GeneIDi64843.
KEGGihsa:64843.
UCSCiuc002bbw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001022 mRNA. Translation: BAG50849.1.
CH471136 Genomic DNA. Translation: EAW99220.1.
BC011967 mRNA. Translation: AAH11967.1.
BC012136 mRNA. Translation: AAH12136.1.
CCDSiCCDS10290.1.
RefSeqiNP_665804.1. NM_145805.2.
UniGeneiHs.444677.

3D structure databases

ProteinModelPortaliQ96A47.
SMRiQ96A47.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122318. 10 interactors.
STRINGi9606.ENSP00000290759.

PTM databases

iPTMnetiQ96A47.
PhosphoSitePlusiQ96A47.

Polymorphism and mutation databases

BioMutaiISL2.
DMDMi20978495.

Proteomic databases

EPDiQ96A47.
MaxQBiQ96A47.
PaxDbiQ96A47.
PeptideAtlasiQ96A47.
PRIDEiQ96A47.

Protocols and materials databases

DNASUi64843.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290759; ENSP00000290759; ENSG00000159556.
GeneIDi64843.
KEGGihsa:64843.
UCSCiuc002bbw.2. human.

Organism-specific databases

CTDi64843.
GeneCardsiISL2.
HGNCiHGNC:18524. ISL2.
MIMi609481. gene.
neXtProtiNX_Q96A47.
OpenTargetsiENSG00000159556.
PharmGKBiPA38566.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000236304.
HOVERGENiHBG004671.
InParanoidiQ96A47.
KOiK18492.
OMAiRHDSAVQ.
OrthoDBiEOG091G09L9.
PhylomeDBiQ96A47.
TreeFamiTF315442.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159556-MONOMER.
SIGNORiQ96A47.

Miscellaneous databases

GenomeRNAii64843.
PROiQ96A47.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159556.
CleanExiHS_ISL2.
ExpressionAtlasiQ96A47. baseline and differential.
GenevisibleiQ96A47. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISL2_HUMAN
AccessioniPrimary (citable) accession number: Q96A47
Secondary accession number(s): B3KM37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.