Q96A47 (ISL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Insulin gene enhancer protein ISL-2
Short name=Islet-2

Gene names

Name:

ISL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox LIM domain Repeat
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of neuron differentiation Inferred from electronic annotation. Source: Compara peripheral nervous system neuron development Traceable author statement PubMed 20096094. Source: BHF-UCL retinal ganglion cell axon guidance Inferred from electronic annotation. Source: Compara spinal cord motor neuron cell fate specification Inferred from electronic annotation. Source: Compara visceral motor neuron differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred by curator PubMed 17091338. Source: BHF-UCL
Molecular_function	DNA binding Inferred from sequence or structural similarity PubMed 17091338. Source: BHF-UCL sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Insulin gene enhancer protein ISL-2		PRO_0000075752
Regions
	Domain	25 – 86	62	LIM zinc-binding 1
	Domain	87 – 149	63	LIM zinc-binding 2
	DNA binding	191 – 250	60	Homeobox
Amino acid modifications
	Modified residue	279	1	Phosphoserine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q96A47 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2162FB3D430EE4BE	FASTA	359	39,768
	10 20 30 40 50 60 MVDIIFHYPF LGAMGDHSKK KPGTAMCVGC GSQIHDQFIL RVSPDLEWHA ACLKCAECSQ 70 80 90 100 110 120 YLDETCTCFV RDGKTYCKRD YVRLFGIKCA KCQVGFSSSD LVMRARDSVY HIECFRCSVC 130 140 150 160 170 180 SRQLLPGDEF SLREHELLCR ADHGLLLERA AAGSPRSPGP LPGARGLHLP DAGSGRQPAL 190 200 210 220 230 240 RPHVHKQTEK TTRVRTVLNE KQLHTLRTCY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ 250 260 270 280 290 300 NKRCKDKKKS ILMKQLQQQQ HSDKTSLQGL TGTPLVAGSP IRHENAVQGS AVEVQTYQPP 310 320 330 340 350 WKALSEFALQ SDLDQPAFQQ LVSFSESGSL GNSSGSDVTS LSSQLPDTPN SMVPSPVET

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[5]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279, MASS SPECTROMETRY. Tissue: Leukemic T-cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001022 mRNA. Translation: BAG50849.1. CH471136 Genomic DNA. Translation: EAW99220.1. BC011967 mRNA. Translation: AAH11967.1. BC012136 mRNA. Translation: AAH12136.1.
IPI	IPI00059240.
RefSeq	NP_665804.1. NM_145805.1.
UniGene	Hs.444677.
3D structure databases
ProteinModelPortal	Q96A47.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000290759.
PTM databases
PhosphoSite	Q96A47.
Polymorphism databases
DMDM	20978495.
Proteomic databases
PaxDb	Q96A47.
PRIDE	Q96A47.
Protocols and materials databases
DNASU	64843.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000290759; ENSP00000290759; ENSG00000159556.
GeneID	64843.
KEGG	hsa:64843.
UCSC	uc002bbw.1. human.
Organism-specific databases
CTD	64843.
GeneCards	GC15P076629.
HGNC	HGNC:18524. ISL2.
MIM	609481. gene.
neXtProt	NX_Q96A47.
PharmGKB	PA38566.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5576.
HOGENOM	HOG000236304.
HOVERGEN	HBG004671.
InParanoid	Q96A47.
KO	K09370.
OMA	RHDSAVQ.
OrthoDB	EOG4G4GQR.
PhylomeDB	Q96A47.
Gene expression databases
ArrayExpress	Q96A47.
Bgee	Q96A47.
CleanEx	HS_ISL2.
Genevestigator	Q96A47.
GermOnline	ENSG00000159556. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit. 2.10.110.10. 2 hits.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF00412. LIM. 2 hits. [Graphical view]
SMART	SM00389. HOX. 1 hit. SM00132. LIM. 2 hits. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	64843.
NextBio	66950.
SOURCE	Search...

Entry information

Entry name

ISL2_HUMAN

Accession

Primary (citable) accession number: Q96A47
Secondary accession number(s): B3KM37

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.