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Protein

Insulin gene enhancer protein ISL-2

Gene

ISL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi191 – 250HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ96A47

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin gene enhancer protein ISL-2
Short name:
Islet-2
Gene namesi
Name:ISL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000159556.9
HGNCiHGNC:18524 ISL2
MIMi609481 gene
neXtProtiNX_Q96A47

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159556
PharmGKBiPA38566

Polymorphism and mutation databases

BioMutaiISL2
DMDMi20978495

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757521 – 359Insulin gene enhancer protein ISL-2Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei154PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei279PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96A47
MaxQBiQ96A47
PaxDbiQ96A47
PeptideAtlasiQ96A47
PRIDEiQ96A47

PTM databases

iPTMnetiQ96A47
PhosphoSitePlusiQ96A47

Expressioni

Gene expression databases

BgeeiENSG00000159556
CleanExiHS_ISL2
ExpressionAtlasiQ96A47 baseline and differential
GenevisibleiQ96A47 HS

Organism-specific databases

HPAiHPA075192

Interactioni

Subunit structurei

Interacts with LHX4.By similarity

Protein-protein interaction databases

BioGridi12231812 interactors.
STRINGi9606.ENSP00000290759

Structurei

3D structure databases

ProteinModelPortaliQ96A47
SMRiQ96A47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 86LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini87 – 149LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni272 – 301LIM-binding domain (LID)By similarityAdd BLAST30

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000236304
HOVERGENiHBG004671
InParanoidiQ96A47
KOiK18492
OMAiRHDSAVQ
OrthoDBiEOG091G09L9
PhylomeDBiQ96A47
TreeFamiTF315442

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q96A47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDIIFHYPF LGAMGDHSKK KPGTAMCVGC GSQIHDQFIL RVSPDLEWHA
60 70 80 90 100
ACLKCAECSQ YLDETCTCFV RDGKTYCKRD YVRLFGIKCA KCQVGFSSSD
110 120 130 140 150
LVMRARDSVY HIECFRCSVC SRQLLPGDEF SLREHELLCR ADHGLLLERA
160 170 180 190 200
AAGSPRSPGP LPGARGLHLP DAGSGRQPAL RPHVHKQTEK TTRVRTVLNE
210 220 230 240 250
KQLHTLRTCY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKKS
260 270 280 290 300
ILMKQLQQQQ HSDKTSLQGL TGTPLVAGSP IRHENAVQGS AVEVQTYQPP
310 320 330 340 350
WKALSEFALQ SDLDQPAFQQ LVSFSESGSL GNSSGSDVTS LSSQLPDTPN

SMVPSPVET
Length:359
Mass (Da):39,768
Last modified:December 1, 2001 - v1
Checksum:i2162FB3D430EE4BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001022 mRNA Translation: BAG50849.1
CH471136 Genomic DNA Translation: EAW99220.1
BC011967 mRNA Translation: AAH11967.1
BC012136 mRNA Translation: AAH12136.1
CCDSiCCDS10290.1
RefSeqiNP_665804.1, NM_145805.2
UniGeneiHs.444677

Genome annotation databases

EnsembliENST00000290759; ENSP00000290759; ENSG00000159556
GeneIDi64843
KEGGihsa:64843
UCSCiuc002bbw.2 human

Similar proteinsi

Entry informationi

Entry nameiISL2_HUMAN
AccessioniPrimary (citable) accession number: Q96A47
Secondary accession number(s): B3KM37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome