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Protein

Mitoferrin-2

Gene

SLC25A28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe2+, is then probably delivered to ferrochelatase to catalyze Fe2+ incorporation into protoprophyrin IX to make heme (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

ReactomeiR-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis

Protein family/group databases

TCDBi2.A.29.5.8 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitoferrin-2
Alternative name(s):
Mitochondrial RNA-splicing protein 3/4 homolog
Short name:
MRS3/4
Short name:
hMRS3/4
Mitochondrial iron transporter 2
Solute carrier family 25 member 28
Gene namesi
Name:SLC25A28
Synonyms:MFRN2
ORF Names:NPD016
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000155287.10
HGNCiHGNC:23472 SLC25A28
MIMi609767 gene
neXtProtiNX_Q96A46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei72 – 91Helical; Name=1Sequence analysisAdd BLAST20
Transmembranei133 – 152Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei170 – 189Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei227 – 246Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei261 – 280Helical; Name=5Sequence analysisAdd BLAST20
Transmembranei327 – 346Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81894
OpenTargetsiENSG00000155287
PharmGKBiPA134867966

Polymorphism and mutation databases

BioMutaiSLC25A28
DMDMi74751734

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352551 – 364Mitoferrin-2Add BLAST364

Proteomic databases

EPDiQ96A46
MaxQBiQ96A46
PaxDbiQ96A46
PeptideAtlasiQ96A46
PRIDEiQ96A46

PTM databases

iPTMnetiQ96A46
PhosphoSitePlusiQ96A46

Expressioni

Tissue specificityi

Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiENSG00000155287
CleanExiHS_SLC25A28
ExpressionAtlasiQ96A46 baseline and differential
GenevisibleiQ96A46 HS

Interactioni

Protein-protein interaction databases

BioGridi123626, 5 interactors
STRINGi9606.ENSP00000359526

Structurei

3D structure databases

ProteinModelPortaliQ96A46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati70 – 158Solcar 1Add BLAST89
Repeati168 – 252Solcar 2Add BLAST85
Repeati259 – 352Solcar 3Add BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 47Gly-richAdd BLAST43

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0760 Eukaryota
ENOG410XNT2 LUCA
GeneTreeiENSGT00550000074721
HOGENOMiHOG000038810
HOVERGENiHBG079464
InParanoidiQ96A46
KOiK15113
OMAiEHAVMFP
OrthoDBiEOG091G0PU8
PhylomeDBiQ96A46
TreeFamiTF314118

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELEGRGAGG VAGGPAAGPG RSPGESALLD GWLQRGVGRG AGGGEAGACR
60 70 80 90 100
PPVRQDPDSG PDYEALPAGA TVTTHMVAGA VAGILEHCVM YPIDCVKTRM
110 120 130 140 150
QSLQPDPAAR YRNVLEALWR IIRTEGLWRP MRGLNVTATG AGPAHALYFA
160 170 180 190 200
CYEKLKKTLS DVIHPGGNSH IANGAAGCVA TLLHDAAMNP AEVVKQRMQM
210 220 230 240 250
YNSPYHRVTD CVRAVWQNEG AGAFYRSYTT QLTMNVPFQA IHFMTYEFLQ
260 270 280 290 300
EHFNPQRRYN PSSHVLSGAC AGAVAAAATT PLDVCKTLLN TQESLALNSH
310 320 330 340 350
ITGHITGMAS AFRTVYQVGG VTAYFRGVQA RVIYQIPSTA IAWSVYEFFK
360
YLITKRQEEW RAGK
Length:364
Mass (Da):39,272
Last modified:December 1, 2001 - v1
Checksum:i22049C4F8DD7A577
GO
Isoform 2 (identifier: Q96A46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.

Show »
Length:177
Mass (Da):20,045
Checksum:iE5370283AAF732E3
GO
Isoform 3 (identifier: Q96A46-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-188: Missing.
     189-192: NPAE → MALL

Show »
Length:176
Mass (Da):19,931
Checksum:i4A4831AC572309D4
GO

Sequence cautioni

The sequence AAH47312 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI16900 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0184131 – 188Missing in isoform 3. 2 PublicationsAdd BLAST188
Alternative sequenceiVSP_0184141 – 187Missing in isoform 2. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_018415189 – 192NPAE → MALL in isoform 3. 2 Publications4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327402 mRNA Translation: AAK49519.1
AF327403 mRNA Translation: AAK49520.1
AJ303077 mRNA Translation: CAC27996.1
AJ303078 mRNA Translation: CAC27997.1
AF267854 mRNA Translation: AAG44723.1
AL831943 mRNA Translation: CAH10774.1
AL353719 Genomic DNA Translation: CAI16900.1 Sequence problems.
AL353719 Genomic DNA Translation: CAI16901.1
BC047312 mRNA Translation: AAH47312.1 Different initiation.
BC058937 mRNA Translation: AAH58937.1
BC076399 mRNA Translation: AAH76399.1
BC094821 mRNA Translation: AAH94821.1
CCDSiCCDS41559.1 [Q96A46-1]
RefSeqiNP_112489.3, NM_031212.3 [Q96A46-1]
UniGeneiHs.403790
Hs.736801

Genome annotation databases

EnsembliENST00000370495; ENSP00000359526; ENSG00000155287 [Q96A46-1]
GeneIDi81894
KEGGihsa:81894
UCSCiuc001kpx.3 human [Q96A46-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMFRN2_HUMAN
AccessioniPrimary (citable) accession number: Q96A46
Secondary accession number(s): Q4VBZ0
, Q5T777, Q86VX5, Q969G8, Q9H2J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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