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Q96A37

- RN166_HUMAN

UniProt

Q96A37 - RN166_HUMAN

Protein

RING finger protein 166

Gene

RNF166

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri33 – 7341RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RING finger protein 166
    Gene namesi
    Name:RNF166
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:28856. RNF166.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134915234.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 237237RING finger protein 166PRO_0000245588Add
    BLAST

    Proteomic databases

    MaxQBiQ96A37.
    PaxDbiQ96A37.
    PRIDEiQ96A37.

    PTM databases

    PhosphoSiteiQ96A37.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96A37.
    BgeeiQ96A37.
    CleanExiHS_RNF166.
    GenevestigatoriQ96A37.

    Organism-specific databases

    HPAiHPA042970.

    Interactioni

    Protein-protein interaction databases

    BioGridi125465. 17 interactions.
    IntActiQ96A37. 19 interactions.
    STRINGi9606.ENSP00000326095.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96A37.
    SMRiQ96A37. Positions 32-116, 145-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati221 – 23717UIMAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri33 – 7341RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG149065.
    HOGENOMiHOG000230946.
    HOVERGENiHBG074331.
    InParanoidiQ96A37.
    KOiK17044.
    OMAiNCRARTC.
    OrthoDBiEOG7VDXQ7.
    PhylomeDBiQ96A37.
    TreeFamiTF331012.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR008598. Di19_Zn_binding.
    IPR015880. Znf_C2H2-like.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF05605. zf-Di19. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00355. ZnF_C2H2. 2 hits.
    [Graphical view]
    PROSITEiPS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96A37-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAMFRSLVAS AQQRQPPAGP AGGDSGLEAQ YTCPICLEVY HRPVAIGSCG    50
    HTFCGECLQP CLQVPSPLCP LCRLPFDPKK VDKATHVEKQ LSSYKAPCRG 100
    CNKKVTLAKM RVHISSCLKV QEQMANCPKF VPVVPTSQPI PSNIPNRSTF 150
    ACPYCGARNL DQQELVKHCV ESHRSDPNRV VCPICSAMPW GDPSYKSANF 200
    LQHLLHRHKF SYDTFVDYSI DEEAAFQAAL ALSLSEN 237
    Length:237
    Mass (Da):26,122
    Last modified:December 1, 2001 - v1
    Checksum:i2802E758F4681716
    GO
    Isoform 2 (identifier: Q96A37-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-109: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:128
    Mass (Da):14,408
    Checksum:i5DBB30DA8B718284
    GO
    Isoform 3 (identifier: Q96A37-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         39-119: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:156
    Mass (Da):17,187
    Checksum:i2407DCA260F9C5E5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111A → V in BI911983. (PubMed:15489334)Curated
    Sequence conflicti38 – 381E → K in BI911983. (PubMed:15489334)Curated
    Sequence conflicti175 – 1751S → G in BAB71380. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 109109Missing in isoform 2. 1 PublicationVSP_019750Add
    BLAST
    Alternative sequencei39 – 11981Missing in isoform 3. 1 PublicationVSP_046147Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057106 mRNA. Translation: BAG51865.1.
    AK057201 mRNA. Translation: BAB71380.1.
    AC138028 Genomic DNA. No translation available.
    CH471184 Genomic DNA. Translation: EAW66784.1.
    CH471184 Genomic DNA. Translation: EAW66781.1.
    CH471184 Genomic DNA. Translation: EAW66785.1.
    BC013948 mRNA. Translation: AAH13948.1.
    BC017226 mRNA. Translation: AAH17226.1.
    BI911983 mRNA. No translation available.
    CCDSiCCDS10969.1. [Q96A37-1]
    CCDS54056.1. [Q96A37-2]
    CCDS54057.1. [Q96A37-3]
    RefSeqiNP_001165286.1. NM_001171815.1. [Q96A37-3]
    NP_001165287.1. NM_001171816.1. [Q96A37-2]
    NP_849163.1. NM_178841.3. [Q96A37-1]
    XP_005256335.1. XM_005256278.2. [Q96A37-2]
    UniGeneiHs.513804.

    Genome annotation databases

    EnsembliENST00000312838; ENSP00000326095; ENSG00000158717. [Q96A37-1]
    ENST00000537718; ENSP00000446301; ENSG00000158717. [Q96A37-2]
    ENST00000541206; ENSP00000440454; ENSG00000158717. [Q96A37-2]
    ENST00000567844; ENSP00000457336; ENSG00000158717. [Q96A37-3]
    GeneIDi115992.
    KEGGihsa:115992.
    UCSCiuc002flk.3. human. [Q96A37-1]

    Polymorphism databases

    DMDMi74762644.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057106 mRNA. Translation: BAG51865.1 .
    AK057201 mRNA. Translation: BAB71380.1 .
    AC138028 Genomic DNA. No translation available.
    CH471184 Genomic DNA. Translation: EAW66784.1 .
    CH471184 Genomic DNA. Translation: EAW66781.1 .
    CH471184 Genomic DNA. Translation: EAW66785.1 .
    BC013948 mRNA. Translation: AAH13948.1 .
    BC017226 mRNA. Translation: AAH17226.1 .
    BI911983 mRNA. No translation available.
    CCDSi CCDS10969.1. [Q96A37-1 ]
    CCDS54056.1. [Q96A37-2 ]
    CCDS54057.1. [Q96A37-3 ]
    RefSeqi NP_001165286.1. NM_001171815.1. [Q96A37-3 ]
    NP_001165287.1. NM_001171816.1. [Q96A37-2 ]
    NP_849163.1. NM_178841.3. [Q96A37-1 ]
    XP_005256335.1. XM_005256278.2. [Q96A37-2 ]
    UniGenei Hs.513804.

    3D structure databases

    ProteinModelPortali Q96A37.
    SMRi Q96A37. Positions 32-116, 145-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125465. 17 interactions.
    IntActi Q96A37. 19 interactions.
    STRINGi 9606.ENSP00000326095.

    PTM databases

    PhosphoSitei Q96A37.

    Polymorphism databases

    DMDMi 74762644.

    Proteomic databases

    MaxQBi Q96A37.
    PaxDbi Q96A37.
    PRIDEi Q96A37.

    Protocols and materials databases

    DNASUi 115992.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312838 ; ENSP00000326095 ; ENSG00000158717 . [Q96A37-1 ]
    ENST00000537718 ; ENSP00000446301 ; ENSG00000158717 . [Q96A37-2 ]
    ENST00000541206 ; ENSP00000440454 ; ENSG00000158717 . [Q96A37-2 ]
    ENST00000567844 ; ENSP00000457336 ; ENSG00000158717 . [Q96A37-3 ]
    GeneIDi 115992.
    KEGGi hsa:115992.
    UCSCi uc002flk.3. human. [Q96A37-1 ]

    Organism-specific databases

    CTDi 115992.
    GeneCardsi GC16M088762.
    HGNCi HGNC:28856. RNF166.
    HPAi HPA042970.
    neXtProti NX_Q96A37.
    PharmGKBi PA134915234.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149065.
    HOGENOMi HOG000230946.
    HOVERGENi HBG074331.
    InParanoidi Q96A37.
    KOi K17044.
    OMAi NCRARTC.
    OrthoDBi EOG7VDXQ7.
    PhylomeDBi Q96A37.
    TreeFami TF331012.

    Miscellaneous databases

    ChiTaRSi RNF166. human.
    GenomeRNAii 115992.
    NextBioi 79721.
    PROi Q96A37.

    Gene expression databases

    ArrayExpressi Q96A37.
    Bgeei Q96A37.
    CleanExi HS_RNF166.
    Genevestigatori Q96A37.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR008598. Di19_Zn_binding.
    IPR015880. Znf_C2H2-like.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF05605. zf-Di19. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00355. ZnF_C2H2. 2 hits.
    [Graphical view ]
    PROSITEi PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Small intestine and Synovial cell.
    2. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain, Eye and Leukocyte.

    Entry informationi

    Entry nameiRN166_HUMAN
    AccessioniPrimary (citable) accession number: Q96A37
    Secondary accession number(s): B3KQ03
    , D3DX75, H3BTU8, Q96DM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3