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Protein

RING finger protein 166

Gene

RNF166

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 7341RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 166
Gene namesi
Name:RNF166
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:28856. RNF166.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134915234.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237RING finger protein 166PRO_0000245588Add
BLAST

Proteomic databases

MaxQBiQ96A37.
PaxDbiQ96A37.
PRIDEiQ96A37.

PTM databases

PhosphoSiteiQ96A37.

Expressioni

Gene expression databases

BgeeiQ96A37.
CleanExiHS_RNF166.
ExpressionAtlasiQ96A37. baseline and differential.
GenevestigatoriQ96A37.

Organism-specific databases

HPAiHPA042970.

Interactioni

Protein-protein interaction databases

BioGridi125465. 46 interactions.
IntActiQ96A37. 19 interactions.
STRINGi9606.ENSP00000326095.

Structurei

3D structure databases

ProteinModelPortaliQ96A37.
SMRiQ96A37. Positions 32-116, 141-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini221 – 23717UIMCuratedAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 7341RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG149065.
GeneTreeiENSGT00530000063064.
HOGENOMiHOG000230946.
HOVERGENiHBG074331.
InParanoidiQ96A37.
KOiK17044.
OMAiNRSTFVC.
OrthoDBiEOG7VDXQ7.
PhylomeDBiQ96A37.
TreeFamiTF331012.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR008598. Di19_Zn_binding.
IPR015880. Znf_C2H2-like.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF05605. zf-Di19. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96A37-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMFRSLVAS AQQRQPPAGP AGGDSGLEAQ YTCPICLEVY HRPVAIGSCG
60 70 80 90 100
HTFCGECLQP CLQVPSPLCP LCRLPFDPKK VDKATHVEKQ LSSYKAPCRG
110 120 130 140 150
CNKKVTLAKM RVHISSCLKV QEQMANCPKF VPVVPTSQPI PSNIPNRSTF
160 170 180 190 200
ACPYCGARNL DQQELVKHCV ESHRSDPNRV VCPICSAMPW GDPSYKSANF
210 220 230
LQHLLHRHKF SYDTFVDYSI DEEAAFQAAL ALSLSEN
Length:237
Mass (Da):26,122
Last modified:December 1, 2001 - v1
Checksum:i2802E758F4681716
GO
Isoform 2 (identifier: Q96A37-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: Missing.

Note: No experimental confirmation available.

Show »
Length:128
Mass (Da):14,408
Checksum:i5DBB30DA8B718284
GO
Isoform 3 (identifier: Q96A37-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-119: Missing.

Note: No experimental confirmation available.

Show »
Length:156
Mass (Da):17,187
Checksum:i2407DCA260F9C5E5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111A → V in BI911983. (PubMed:15489334)Curated
Sequence conflicti38 – 381E → K in BI911983. (PubMed:15489334)Curated
Sequence conflicti175 – 1751S → G in BAB71380. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 109109Missing in isoform 2. 1 PublicationVSP_019750Add
BLAST
Alternative sequencei39 – 11981Missing in isoform 3. 1 PublicationVSP_046147Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057106 mRNA. Translation: BAG51865.1.
AK057201 mRNA. Translation: BAB71380.1.
AC138028 Genomic DNA. No translation available.
CH471184 Genomic DNA. Translation: EAW66784.1.
CH471184 Genomic DNA. Translation: EAW66781.1.
CH471184 Genomic DNA. Translation: EAW66785.1.
BC013948 mRNA. Translation: AAH13948.1.
BC017226 mRNA. Translation: AAH17226.1.
BI911983 mRNA. No translation available.
CCDSiCCDS10969.1. [Q96A37-1]
CCDS54056.1. [Q96A37-2]
CCDS54057.1. [Q96A37-3]
RefSeqiNP_001165286.1. NM_001171815.1. [Q96A37-3]
NP_001165287.1. NM_001171816.1. [Q96A37-2]
NP_849163.1. NM_178841.3. [Q96A37-1]
XP_005256335.1. XM_005256278.2. [Q96A37-2]
UniGeneiHs.513804.

Genome annotation databases

EnsembliENST00000312838; ENSP00000326095; ENSG00000158717. [Q96A37-1]
ENST00000537718; ENSP00000446301; ENSG00000158717. [Q96A37-2]
ENST00000541206; ENSP00000440454; ENSG00000158717. [Q96A37-2]
ENST00000567844; ENSP00000457336; ENSG00000158717. [Q96A37-3]
GeneIDi115992.
KEGGihsa:115992.
UCSCiuc002flk.3. human. [Q96A37-1]

Polymorphism databases

DMDMi74762644.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057106 mRNA. Translation: BAG51865.1.
AK057201 mRNA. Translation: BAB71380.1.
AC138028 Genomic DNA. No translation available.
CH471184 Genomic DNA. Translation: EAW66784.1.
CH471184 Genomic DNA. Translation: EAW66781.1.
CH471184 Genomic DNA. Translation: EAW66785.1.
BC013948 mRNA. Translation: AAH13948.1.
BC017226 mRNA. Translation: AAH17226.1.
BI911983 mRNA. No translation available.
CCDSiCCDS10969.1. [Q96A37-1]
CCDS54056.1. [Q96A37-2]
CCDS54057.1. [Q96A37-3]
RefSeqiNP_001165286.1. NM_001171815.1. [Q96A37-3]
NP_001165287.1. NM_001171816.1. [Q96A37-2]
NP_849163.1. NM_178841.3. [Q96A37-1]
XP_005256335.1. XM_005256278.2. [Q96A37-2]
UniGeneiHs.513804.

3D structure databases

ProteinModelPortaliQ96A37.
SMRiQ96A37. Positions 32-116, 141-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125465. 46 interactions.
IntActiQ96A37. 19 interactions.
STRINGi9606.ENSP00000326095.

PTM databases

PhosphoSiteiQ96A37.

Polymorphism databases

DMDMi74762644.

Proteomic databases

MaxQBiQ96A37.
PaxDbiQ96A37.
PRIDEiQ96A37.

Protocols and materials databases

DNASUi115992.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312838; ENSP00000326095; ENSG00000158717. [Q96A37-1]
ENST00000537718; ENSP00000446301; ENSG00000158717. [Q96A37-2]
ENST00000541206; ENSP00000440454; ENSG00000158717. [Q96A37-2]
ENST00000567844; ENSP00000457336; ENSG00000158717. [Q96A37-3]
GeneIDi115992.
KEGGihsa:115992.
UCSCiuc002flk.3. human. [Q96A37-1]

Organism-specific databases

CTDi115992.
GeneCardsiGC16M088762.
HGNCiHGNC:28856. RNF166.
HPAiHPA042970.
neXtProtiNX_Q96A37.
PharmGKBiPA134915234.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG149065.
GeneTreeiENSGT00530000063064.
HOGENOMiHOG000230946.
HOVERGENiHBG074331.
InParanoidiQ96A37.
KOiK17044.
OMAiNRSTFVC.
OrthoDBiEOG7VDXQ7.
PhylomeDBiQ96A37.
TreeFamiTF331012.

Miscellaneous databases

ChiTaRSiRNF166. human.
GenomeRNAii115992.
NextBioi79721.
PROiQ96A37.

Gene expression databases

BgeeiQ96A37.
CleanExiHS_RNF166.
ExpressionAtlasiQ96A37. baseline and differential.
GenevestigatoriQ96A37.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR008598. Di19_Zn_binding.
IPR015880. Znf_C2H2-like.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF05605. zf-Di19. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Small intestine and Synovial cell.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain, Eye and Leukocyte.

Entry informationi

Entry nameiRN166_HUMAN
AccessioniPrimary (citable) accession number: Q96A37
Secondary accession number(s): B3KQ03
, D3DX75, H3BTU8, Q96DM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.