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Q96A37 (RN166_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RING finger protein 166
Gene names
Name:RNF166
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 RING-type zinc finger.

Contains 1 UIM (ubiquitin-interacting motif) repeat.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96A37-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96A37-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q96A37-3)

The sequence of this isoform differs from the canonical sequence as follows:
     39-119: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237RING finger protein 166
PRO_0000245588

Regions

Repeat221 – 23717UIM
Zinc finger33 – 7341RING-type

Natural variations

Alternative sequence1 – 109109Missing in isoform 2.
VSP_019750
Alternative sequence39 – 11981Missing in isoform 3.
VSP_046147

Experimental info

Sequence conflict111A → V in BI911983. Ref.4
Sequence conflict381E → K in BI911983. Ref.4
Sequence conflict1751S → G in BAB71380. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 2802E758F4681716

FASTA23726,122
        10         20         30         40         50         60 
MAMFRSLVAS AQQRQPPAGP AGGDSGLEAQ YTCPICLEVY HRPVAIGSCG HTFCGECLQP 

        70         80         90        100        110        120 
CLQVPSPLCP LCRLPFDPKK VDKATHVEKQ LSSYKAPCRG CNKKVTLAKM RVHISSCLKV 

       130        140        150        160        170        180 
QEQMANCPKF VPVVPTSQPI PSNIPNRSTF ACPYCGARNL DQQELVKHCV ESHRSDPNRV 

       190        200        210        220        230 
VCPICSAMPW GDPSYKSANF LQHLLHRHKF SYDTFVDYSI DEEAAFQAAL ALSLSEN 

« Hide

Isoform 2 [UniParc].

Checksum: 5DBB30DA8B718284
Show »

FASTA12814,408
Isoform 3 [UniParc].

Checksum: 2407DCA260F9C5E5
Show »

FASTA15617,187

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Small intestine and Synovial cell.
[2]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Brain, Eye and Leukocyte.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057106 mRNA. Translation: BAG51865.1.
AK057201 mRNA. Translation: BAB71380.1.
AC138028 Genomic DNA. No translation available.
CH471184 Genomic DNA. Translation: EAW66784.1.
CH471184 Genomic DNA. Translation: EAW66781.1.
CH471184 Genomic DNA. Translation: EAW66785.1.
BC013948 mRNA. Translation: AAH13948.1.
BC017226 mRNA. Translation: AAH17226.1.
BI911983 mRNA. No translation available.
CCDSCCDS10969.1. [Q96A37-1]
CCDS54056.1. [Q96A37-2]
CCDS54057.1. [Q96A37-3]
RefSeqNP_001165286.1. NM_001171815.1. [Q96A37-3]
NP_001165287.1. NM_001171816.1. [Q96A37-2]
NP_849163.1. NM_178841.3. [Q96A37-1]
XP_005256335.1. XM_005256278.2. [Q96A37-2]
UniGeneHs.513804.

3D structure databases

ProteinModelPortalQ96A37.
SMRQ96A37. Positions 32-116, 145-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125465. 17 interactions.
IntActQ96A37. 19 interactions.
STRING9606.ENSP00000326095.

PTM databases

PhosphoSiteQ96A37.

Polymorphism databases

DMDM74762644.

Proteomic databases

MaxQBQ96A37.
PaxDbQ96A37.
PRIDEQ96A37.

Protocols and materials databases

DNASU115992.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312838; ENSP00000326095; ENSG00000158717. [Q96A37-1]
ENST00000537718; ENSP00000446301; ENSG00000158717. [Q96A37-2]
ENST00000541206; ENSP00000440454; ENSG00000158717. [Q96A37-2]
ENST00000567844; ENSP00000457336; ENSG00000158717. [Q96A37-3]
GeneID115992.
KEGGhsa:115992.
UCSCuc002flk.3. human. [Q96A37-1]

Organism-specific databases

CTD115992.
GeneCardsGC16M088762.
HGNCHGNC:28856. RNF166.
HPAHPA042970.
neXtProtNX_Q96A37.
PharmGKBPA134915234.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149065.
HOGENOMHOG000230946.
HOVERGENHBG074331.
InParanoidQ96A37.
KOK17044.
OMANCRARTC.
OrthoDBEOG7VDXQ7.
PhylomeDBQ96A37.
TreeFamTF331012.

Gene expression databases

ArrayExpressQ96A37.
BgeeQ96A37.
CleanExHS_RNF166.
GenevestigatorQ96A37.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR008598. Di19_Zn_binding.
IPR015880. Znf_C2H2-like.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF05605. zf-Di19. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRNF166. human.
GenomeRNAi115992.
NextBio79721.
PROQ96A37.

Entry information

Entry nameRN166_HUMAN
AccessionPrimary (citable) accession number: Q96A37
Secondary accession number(s): B3KQ03 expand/collapse secondary AC list , D3DX75, H3BTU8, Q96DM0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM