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Protein

RING finger protein 166

Gene

RNF166

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 73RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri98 – 117C2HC RNF-typePROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158717-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 166
Gene namesi
Name:RNF166
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28856. RNF166.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi115992.
OpenTargetsiENSG00000158717.
PharmGKBiPA134915234.

Polymorphism and mutation databases

BioMutaiRNF166.
DMDMi74762644.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455881 – 237RING finger protein 166Add BLAST237

Proteomic databases

MaxQBiQ96A37.
PaxDbiQ96A37.
PeptideAtlasiQ96A37.
PRIDEiQ96A37.

PTM databases

iPTMnetiQ96A37.
PhosphoSitePlusiQ96A37.

Expressioni

Gene expression databases

BgeeiENSG00000158717.
CleanExiHS_RNF166.
ExpressionAtlasiQ96A37. baseline and differential.
GenevisibleiQ96A37. HS.

Organism-specific databases

HPAiHPA042970.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125465. 60 interactors.
IntActiQ96A37. 19 interactors.
STRINGi9606.ENSP00000326095.

Structurei

3D structure databases

ProteinModelPortaliQ96A37.
SMRiQ96A37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini221 – 237UIMCuratedAdd BLAST17

Sequence similaritiesi

Contains 1 C2HC RNF-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 73RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri98 – 117C2HC RNF-typePROSITE-ProRule annotationAdd BLAST20

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIQT. Eukaryota.
ENOG4110WN4. LUCA.
GeneTreeiENSGT00530000063064.
HOGENOMiHOG000230946.
HOVERGENiHBG074331.
InParanoidiQ96A37.
KOiK17044.
OMAiNKVVCPV.
OrthoDBiEOG091G0M3K.
PhylomeDBiQ96A37.
TreeFamiTF331012.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR008598. Di19_Zn_binding_dom.
IPR027370. Znf-RING_LisH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF05605. zf-Di19. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51803. ZF_C2HC_RNF. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A37-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMFRSLVAS AQQRQPPAGP AGGDSGLEAQ YTCPICLEVY HRPVAIGSCG
60 70 80 90 100
HTFCGECLQP CLQVPSPLCP LCRLPFDPKK VDKATHVEKQ LSSYKAPCRG
110 120 130 140 150
CNKKVTLAKM RVHISSCLKV QEQMANCPKF VPVVPTSQPI PSNIPNRSTF
160 170 180 190 200
ACPYCGARNL DQQELVKHCV ESHRSDPNRV VCPICSAMPW GDPSYKSANF
210 220 230
LQHLLHRHKF SYDTFVDYSI DEEAAFQAAL ALSLSEN
Length:237
Mass (Da):26,122
Last modified:December 1, 2001 - v1
Checksum:i2802E758F4681716
GO
Isoform 2 (identifier: Q96A37-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: Missing.

Note: No experimental confirmation available.
Show »
Length:128
Mass (Da):14,408
Checksum:i5DBB30DA8B718284
GO
Isoform 3 (identifier: Q96A37-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-119: Missing.

Note: No experimental confirmation available.
Show »
Length:156
Mass (Da):17,187
Checksum:i2407DCA260F9C5E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11A → V in BI911983 (PubMed:15489334).Curated1
Sequence conflicti38E → K in BI911983 (PubMed:15489334).Curated1
Sequence conflicti175S → G in BAB71380 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0197501 – 109Missing in isoform 2. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_04614739 – 119Missing in isoform 3. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057106 mRNA. Translation: BAG51865.1.
AK057201 mRNA. Translation: BAB71380.1.
AC138028 Genomic DNA. No translation available.
CH471184 Genomic DNA. Translation: EAW66784.1.
CH471184 Genomic DNA. Translation: EAW66781.1.
CH471184 Genomic DNA. Translation: EAW66785.1.
BC013948 mRNA. Translation: AAH13948.1.
BC017226 mRNA. Translation: AAH17226.1.
BI911983 mRNA. No translation available.
CCDSiCCDS10969.1. [Q96A37-1]
CCDS54056.1. [Q96A37-2]
CCDS54057.1. [Q96A37-3]
RefSeqiNP_001165286.1. NM_001171815.1. [Q96A37-3]
NP_001165287.1. NM_001171816.1. [Q96A37-2]
NP_849163.1. NM_178841.3. [Q96A37-1]
XP_016878402.1. XM_017022913.1. [Q96A37-2]
UniGeneiHs.513804.

Genome annotation databases

EnsembliENST00000312838; ENSP00000326095; ENSG00000158717. [Q96A37-1]
ENST00000537718; ENSP00000446301; ENSG00000158717. [Q96A37-2]
ENST00000541206; ENSP00000440454; ENSG00000158717. [Q96A37-2]
ENST00000567844; ENSP00000457336; ENSG00000158717. [Q96A37-3]
GeneIDi115992.
KEGGihsa:115992.
UCSCiuc002flk.3. human. [Q96A37-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057106 mRNA. Translation: BAG51865.1.
AK057201 mRNA. Translation: BAB71380.1.
AC138028 Genomic DNA. No translation available.
CH471184 Genomic DNA. Translation: EAW66784.1.
CH471184 Genomic DNA. Translation: EAW66781.1.
CH471184 Genomic DNA. Translation: EAW66785.1.
BC013948 mRNA. Translation: AAH13948.1.
BC017226 mRNA. Translation: AAH17226.1.
BI911983 mRNA. No translation available.
CCDSiCCDS10969.1. [Q96A37-1]
CCDS54056.1. [Q96A37-2]
CCDS54057.1. [Q96A37-3]
RefSeqiNP_001165286.1. NM_001171815.1. [Q96A37-3]
NP_001165287.1. NM_001171816.1. [Q96A37-2]
NP_849163.1. NM_178841.3. [Q96A37-1]
XP_016878402.1. XM_017022913.1. [Q96A37-2]
UniGeneiHs.513804.

3D structure databases

ProteinModelPortaliQ96A37.
SMRiQ96A37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125465. 60 interactors.
IntActiQ96A37. 19 interactors.
STRINGi9606.ENSP00000326095.

PTM databases

iPTMnetiQ96A37.
PhosphoSitePlusiQ96A37.

Polymorphism and mutation databases

BioMutaiRNF166.
DMDMi74762644.

Proteomic databases

MaxQBiQ96A37.
PaxDbiQ96A37.
PeptideAtlasiQ96A37.
PRIDEiQ96A37.

Protocols and materials databases

DNASUi115992.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312838; ENSP00000326095; ENSG00000158717. [Q96A37-1]
ENST00000537718; ENSP00000446301; ENSG00000158717. [Q96A37-2]
ENST00000541206; ENSP00000440454; ENSG00000158717. [Q96A37-2]
ENST00000567844; ENSP00000457336; ENSG00000158717. [Q96A37-3]
GeneIDi115992.
KEGGihsa:115992.
UCSCiuc002flk.3. human. [Q96A37-1]

Organism-specific databases

CTDi115992.
DisGeNETi115992.
GeneCardsiRNF166.
HGNCiHGNC:28856. RNF166.
HPAiHPA042970.
neXtProtiNX_Q96A37.
OpenTargetsiENSG00000158717.
PharmGKBiPA134915234.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIQT. Eukaryota.
ENOG4110WN4. LUCA.
GeneTreeiENSGT00530000063064.
HOGENOMiHOG000230946.
HOVERGENiHBG074331.
InParanoidiQ96A37.
KOiK17044.
OMAiNKVVCPV.
OrthoDBiEOG091G0M3K.
PhylomeDBiQ96A37.
TreeFamiTF331012.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158717-MONOMER.

Miscellaneous databases

ChiTaRSiRNF166. human.
GenomeRNAii115992.
PROiQ96A37.

Gene expression databases

BgeeiENSG00000158717.
CleanExiHS_RNF166.
ExpressionAtlasiQ96A37. baseline and differential.
GenevisibleiQ96A37. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR008598. Di19_Zn_binding_dom.
IPR027370. Znf-RING_LisH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF05605. zf-Di19. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51803. ZF_C2HC_RNF. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRN166_HUMAN
AccessioniPrimary (citable) accession number: Q96A37
Secondary accession number(s): B3KQ03
, D3DX75, H3BTU8, Q96DM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.