Q96A37 (RN166_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RING finger protein 166

Gene names

Name:

RNF166

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 RING-type zinc finger. Contains 1 UIM (ubiquitin-interacting motif) repeat.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96A37-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96A37-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-109: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q96A37-3)

The sequence of this isoform differs from the canonical sequence as follows:
     39-119: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	RING finger protein 166		PRO_0000245588
Regions
	Repeat	221 – 237	17	UIM
	Zinc finger	33 – 73	41	RING-type
Natural variations
	Alternative sequence	1 – 109	109	Missing in isoform 2.		VSP_019750
	Alternative sequence	39 – 119	81	Missing in isoform 3.		VSP_046147
Experimental info
	Sequence conflict	11	1	A → V in BI911983. Ref.4
	Sequence conflict	38	1	E → K in BI911983. Ref.4
	Sequence conflict	175	1	S → G in BAB71380. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2802E758F4681716	FASTA	237	26,122
	10 20 30 40 50 60 MAMFRSLVAS AQQRQPPAGP AGGDSGLEAQ YTCPICLEVY HRPVAIGSCG HTFCGECLQP 70 80 90 100 110 120 CLQVPSPLCP LCRLPFDPKK VDKATHVEKQ LSSYKAPCRG CNKKVTLAKM RVHISSCLKV 130 140 150 160 170 180 QEQMANCPKF VPVVPTSQPI PSNIPNRSTF ACPYCGARNL DQQELVKHCV ESHRSDPNRV 190 200 210 220 230 VCPICSAMPW GDPSYKSANF LQHLLHRHKF SYDTFVDYSI DEEAAFQAAL ALSLSEN
	Isoform 2 [UniParc]. Checksum: 5DBB30DA8B718284	FASTA	128	14,408
	10 20 30 40 50 60 MRVHISSCLK VQEQMANCPK FVPVVPTSQP IPSNIPNRST FACPYCGARN LDQQELVKHC 70 80 90 100 110 120 VESHRSDPNR VVCPICSAMP WGDPSYKSAN FLQHLLHRHK FSYDTFVDYS IDEEAAFQAA LALSLSEN
	Isoform 3 [UniParc]. Checksum: 2407DCA260F9C5E5	FASTA	156	17,187
	10 20 30 40 50 60 MAMFRSLVAS AQQRQPPAGP AGGDSGLEAQ YTCPICLEVQ EQMANCPKFV PVVPTSQPIP 70 80 90 100 110 120 SNIPNRSTFA CPYCGARNLD QQELVKHCVE SHRSDPNRVV CPICSAMPWG DPSYKSANFL 130 140 150 QHLLHRHKFS YDTFVDYSID EEAAFQAALA LSLSEN

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Small intestine and Synovial cell.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain, Eye and Leukocyte.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK057106 mRNA. Translation: BAG51865.1. AK057201 mRNA. Translation: BAB71380.1. AC138028 Genomic DNA. No translation available. CH471184 Genomic DNA. Translation: EAW66784.1. CH471184 Genomic DNA. Translation: EAW66781.1. CH471184 Genomic DNA. Translation: EAW66785.1. BC013948 mRNA. Translation: AAH13948.1. BC017226 mRNA. Translation: AAH17226.1. BI911983 mRNA. No translation available.
IPI	IPI00059215. IPI00647888.
RefSeq	NP_001165286.1. NM_001171815.1. NP_001165287.1. NM_001171816.1. NP_849163.1. NM_178841.3.
UniGene	Hs.513804.
3D structure databases
ProteinModelPortal	Q96A37.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96A37. 19 interactions.
STRING	9606.ENSP00000326095.
PTM databases
PhosphoSite	Q96A37.
Polymorphism databases
DMDM	74762644.
Proteomic databases
PaxDb	Q96A37.
PRIDE	Q96A37.
Protocols and materials databases
DNASU	115992.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312838; ENSP00000326095; ENSG00000158717. ENST00000537718; ENSP00000446301; ENSG00000158717. ENST00000541206; ENSP00000440454; ENSG00000158717. ENST00000567844; ENSP00000457336; ENSG00000158717.
GeneID	115992.
KEGG	hsa:115992.
UCSC	uc002flk.3. human.
Organism-specific databases
CTD	115992.
GeneCards	GC16M088762.
HGNC	HGNC:28856. RNF166.
HPA	HPA042970.
neXtProt	NX_Q96A37.
PharmGKB	PA134915234.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG149065.
HOGENOM	HOG000230946.
HOVERGEN	HBG074331.
InParanoid	Q96A37.
OMA	LVKHCVD.
OrthoDB	EOG4DJJX8.
PhylomeDB	Q96A37.
Gene expression databases
ArrayExpress	Q96A37.
Bgee	Q96A37.
CleanEx	HS_RNF166.
Genevestigator	Q96A37.
GermOnline	ENSG00000158717. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR008598. Di19_RING_finger_144. IPR015880. Znf_C2H2-like. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF05605. Di19. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. SM00355. ZnF_C2H2. 2 hits. [Graphical view]
PROSITE	PS50330. UIM. False negative. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RNF166. human.
GenomeRNAi	115992.
NextBio	79721.

Entry information

Entry name

RN166_HUMAN

Accession

Primary (citable) accession number: Q96A37
Secondary accession number(s): B3KQ03 , D3DX75, H3BTU8, Q96DM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.