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Q96A35

- RM24_HUMAN

UniProt

Q96A35 - RM24_HUMAN

Protein

39S ribosomal protein L24, mitochondrial

Gene

MRPL24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L24, mitochondrial
    Short name:
    L24mt
    Short name:
    MRP-L24
    Gene namesi
    Name:MRPL24
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14037. MRPL24.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30954.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 99MitochondrionBy similarity
    Chaini10 – 21620739S ribosomal protein L24, mitochondrialPRO_0000270488Add
    BLAST

    Proteomic databases

    MaxQBiQ96A35.
    PaxDbiQ96A35.
    PRIDEiQ96A35.

    PTM databases

    PhosphoSiteiQ96A35.

    Expressioni

    Gene expression databases

    BgeeiQ96A35.
    CleanExiHS_MRPL24.
    GenevestigatoriQ96A35.

    Organism-specific databases

    HPAiHPA030295.

    Interactioni

    Protein-protein interaction databases

    BioGridi122732. 27 interactions.
    IntActiQ96A35. 2 interactions.
    MINTiMINT-6942170.
    STRINGi9606.ENSP00000354525.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96A35.
    SMRiQ96A35. Positions 53-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 8934KOWAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi40 – 434Poly-Arg

    Sequence similaritiesi

    Belongs to the ribosomal protein L24P family.Curated
    Contains 1 KOW domain.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0198.
    HOVERGENiHBG093899.
    InParanoidiQ96A35.
    KOiK02895.
    OMAiGIQETRR.
    OrthoDBiEOG7JQBP1.
    PhylomeDBiQ96A35.
    TreeFamiTF105984.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    InterProiIPR005824. KOW.
    IPR014722. Rib_L2_dom2.
    IPR003256. Ribosomal_L24.
    IPR005825. Ribosomal_L24/26_CS.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR12903. PTHR12903. 1 hit.
    PfamiPF00467. KOW. 1 hit.
    [Graphical view]
    SMARTiSM00739. KOW. 1 hit.
    [Graphical view]
    SUPFAMiSSF50104. SSF50104. 1 hit.
    TIGRFAMsiTIGR01079. rplX_bact. 1 hit.
    PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96A35-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLSALLALA SKVTLPPHYR YGMSPPGSVA DKRKNPPWIR RRPVVVEPIS    50
    DEDWYLFCGD TVEILEGKDA GKQGKVVQVI RQRNWVVVGG LNTHYRYIGK 100
    TMDYRGTMIP SEAPLLHRQV KLVDPMDRKP TEIEWRFTEA GERVRVSTRS 150
    GRIIPKPEFP RADGIVPETW IDGPKDTSVE DALERTYVPC LKTLQEEVME 200
    AMGIKETRKY KKVYWY 216
    Length:216
    Mass (Da):24,915
    Last modified:December 1, 2001 - v1
    Checksum:i2A1F5C88001557D0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti109 – 1091I → V in BAB14929. (PubMed:14702039)Curated
    Sequence conflicti109 – 1091I → V in BAD96220. 1 PublicationCurated
    Sequence conflicti119 – 1191Q → H in BAB14929. (PubMed:14702039)Curated
    Sequence conflicti134 – 1341E → D in BAB14929. (PubMed:14702039)Curated
    Sequence conflicti142 – 1421E → Q in BAB14929. (PubMed:14702039)Curated
    Sequence conflicti208 – 2081R → Q in BAD96786. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024570 mRNA. Translation: BAB14929.1.
    CR457329 mRNA. Translation: CAG33610.1.
    AK222500 mRNA. Translation: BAD96220.1.
    AK223066 mRNA. Translation: BAD96786.1.
    AL590666 Genomic DNA. Translation: CAI16343.1.
    AL590666 Genomic DNA. Translation: CAI16344.1.
    AL590666 Genomic DNA. Translation: CAI16345.1.
    AL590666 Genomic DNA. Translation: CAI16346.1.
    CH471121 Genomic DNA. Translation: EAW52913.1.
    CH471121 Genomic DNA. Translation: EAW52914.1.
    BC012440 mRNA. Translation: AAH12440.1.
    BC016700 mRNA. Translation: AAH16700.1.
    AB051341 Genomic DNA. Translation: BAB54931.2.
    CCDSiCCDS1155.1.
    RefSeqiNP_078816.2. NM_024540.3.
    NP_663781.1. NM_145729.2.
    UniGeneiHs.418233.

    Genome annotation databases

    EnsembliENST00000361531; ENSP00000354525; ENSG00000143314.
    ENST00000368211; ENSP00000357194; ENSG00000143314.
    GeneIDi79590.
    KEGGihsa:79590.
    UCSCiuc001fpw.1. human.

    Polymorphism databases

    DMDMi74751733.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024570 mRNA. Translation: BAB14929.1 .
    CR457329 mRNA. Translation: CAG33610.1 .
    AK222500 mRNA. Translation: BAD96220.1 .
    AK223066 mRNA. Translation: BAD96786.1 .
    AL590666 Genomic DNA. Translation: CAI16343.1 .
    AL590666 Genomic DNA. Translation: CAI16344.1 .
    AL590666 Genomic DNA. Translation: CAI16345.1 .
    AL590666 Genomic DNA. Translation: CAI16346.1 .
    CH471121 Genomic DNA. Translation: EAW52913.1 .
    CH471121 Genomic DNA. Translation: EAW52914.1 .
    BC012440 mRNA. Translation: AAH12440.1 .
    BC016700 mRNA. Translation: AAH16700.1 .
    AB051341 Genomic DNA. Translation: BAB54931.2 .
    CCDSi CCDS1155.1.
    RefSeqi NP_078816.2. NM_024540.3.
    NP_663781.1. NM_145729.2.
    UniGenei Hs.418233.

    3D structure databases

    ProteinModelPortali Q96A35.
    SMRi Q96A35. Positions 53-155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122732. 27 interactions.
    IntActi Q96A35. 2 interactions.
    MINTi MINT-6942170.
    STRINGi 9606.ENSP00000354525.

    PTM databases

    PhosphoSitei Q96A35.

    Polymorphism databases

    DMDMi 74751733.

    Proteomic databases

    MaxQBi Q96A35.
    PaxDbi Q96A35.
    PRIDEi Q96A35.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361531 ; ENSP00000354525 ; ENSG00000143314 .
    ENST00000368211 ; ENSP00000357194 ; ENSG00000143314 .
    GeneIDi 79590.
    KEGGi hsa:79590.
    UCSCi uc001fpw.1. human.

    Organism-specific databases

    CTDi 79590.
    GeneCardsi GC01M156707.
    HGNCi HGNC:14037. MRPL24.
    HPAi HPA030295.
    MIMi 611836. gene.
    neXtProti NX_Q96A35.
    PharmGKBi PA30954.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0198.
    HOVERGENi HBG093899.
    InParanoidi Q96A35.
    KOi K02895.
    OMAi GIQETRR.
    OrthoDBi EOG7JQBP1.
    PhylomeDBi Q96A35.
    TreeFami TF105984.

    Miscellaneous databases

    GeneWikii MRPL24.
    GenomeRNAii 79590.
    NextBioi 68600.
    PROi Q96A35.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96A35.
    CleanExi HS_MRPL24.
    Genevestigatori Q96A35.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    InterProi IPR005824. KOW.
    IPR014722. Rib_L2_dom2.
    IPR003256. Ribosomal_L24.
    IPR005825. Ribosomal_L24/26_CS.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR12903. PTHR12903. 1 hit.
    Pfami PF00467. KOW. 1 hit.
    [Graphical view ]
    SMARTi SM00739. KOW. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50104. SSF50104. 1 hit.
    TIGRFAMsi TIGR01079. rplX_bact. 1 hit.
    PROSITEi PS01108. RIBOSOMAL_L24. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adipose tissue.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adipose tissue.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow and Ovary.
    7. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 129-216.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM24_HUMAN
    AccessioniPrimary (citable) accession number: Q96A35
    Secondary accession number(s): D3DVC8
    , Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96Q70, Q9H7G3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3