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Protein

39S ribosomal protein L24, mitochondrial

Gene

MRPL24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L24, mitochondrial
Short name:
L24mt
Short name:
MRP-L24
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL24m1 Publication
Gene namesi
Name:MRPL24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14037. MRPL24.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: UniProtKB

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143314.
PharmGKBiPA30954.

Polymorphism and mutation databases

BioMutaiMRPL24.
DMDMi74751733.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 9MitochondrionBy similarity9
ChainiPRO_000027048810 – 21639S ribosomal protein L24, mitochondrialAdd BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96A35.
MaxQBiQ96A35.
PaxDbiQ96A35.
PeptideAtlasiQ96A35.
PRIDEiQ96A35.
TopDownProteomicsiQ96A35.

PTM databases

iPTMnetiQ96A35.
PhosphoSitePlusiQ96A35.
SwissPalmiQ96A35.

Expressioni

Gene expression databases

BgeeiENSG00000143314.
CleanExiHS_MRPL24.
ExpressionAtlasiQ96A35. baseline and differential.
GenevisibleiQ96A35. HS.

Organism-specific databases

HPAiHPA030295.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Protein-protein interaction databases

BioGridi122732. 65 interactors.
IntActiQ96A35. 14 interactors.
MINTiMINT-6942170.
STRINGi9606.ENSP00000354525.

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 34Combined sources6
Beta strandi61 – 64Combined sources4
Turni68 – 71Combined sources4
Beta strandi73 – 80Combined sources8
Turni81 – 84Combined sources4
Beta strandi85 – 88Combined sources4
Beta strandi92 – 99Combined sources8
Beta strandi102 – 104Combined sources3
Beta strandi107 – 112Combined sources6
Beta strandi119 – 123Combined sources5
Turni125 – 127Combined sources3
Beta strandi133 – 137Combined sources5
Beta strandi141 – 150Combined sources10
Beta strandi152 – 154Combined sources3
Helixi179 – 182Combined sources4
Helixi193 – 202Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40V1-216[»]
3J9Melectron microscopy3.50V1-216[»]
ProteinModelPortaliQ96A35.
SMRiQ96A35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 89KOWAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi40 – 43Poly-Arg4

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1708. Eukaryota.
COG0198. LUCA.
GeneTreeiENSGT00390000014542.
HOVERGENiHBG093899.
InParanoidiQ96A35.
KOiK02895.
OMAiPAKSYWY.
OrthoDBiEOG091G0EA2.
PhylomeDBiQ96A35.
TreeFamiTF105984.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiView protein in InterPro
IPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR003256. Ribosomal_L24.
IPR005825. Ribosomal_L24/26_CS.
IPR008991. Translation_prot_SH3-like.
PfamiView protein in Pfam
PF00467. KOW. 1 hit.
PF17136. ribosomal_L24. 1 hit.
SMARTiView protein in SMART
SM00739. KOW. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01079. rplX_bact. 1 hit.
PROSITEiView protein in PROSITE
PS01108. RIBOSOMAL_L24. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96A35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSALLALA SKVTLPPHYR YGMSPPGSVA DKRKNPPWIR RRPVVVEPIS
60 70 80 90 100
DEDWYLFCGD TVEILEGKDA GKQGKVVQVI RQRNWVVVGG LNTHYRYIGK
110 120 130 140 150
TMDYRGTMIP SEAPLLHRQV KLVDPMDRKP TEIEWRFTEA GERVRVSTRS
160 170 180 190 200
GRIIPKPEFP RADGIVPETW IDGPKDTSVE DALERTYVPC LKTLQEEVME
210
AMGIKETRKY KKVYWY
Length:216
Mass (Da):24,915
Last modified:December 1, 2001 - v1
Checksum:i2A1F5C88001557D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109I → V in BAB14929 (PubMed:14702039).Curated1
Sequence conflicti109I → V in BAD96220 (Ref. 3) Curated1
Sequence conflicti119Q → H in BAB14929 (PubMed:14702039).Curated1
Sequence conflicti134E → D in BAB14929 (PubMed:14702039).Curated1
Sequence conflicti142E → Q in BAB14929 (PubMed:14702039).Curated1
Sequence conflicti208R → Q in BAD96786 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024570 mRNA. Translation: BAB14929.1.
CR457329 mRNA. Translation: CAG33610.1.
AK222500 mRNA. Translation: BAD96220.1.
AK223066 mRNA. Translation: BAD96786.1.
AL590666 Genomic DNA. Translation: CAI16343.1.
AL590666 Genomic DNA. Translation: CAI16344.1.
AL590666 Genomic DNA. Translation: CAI16345.1.
AL590666 Genomic DNA. Translation: CAI16346.1.
CH471121 Genomic DNA. Translation: EAW52913.1.
CH471121 Genomic DNA. Translation: EAW52914.1.
BC012440 mRNA. Translation: AAH12440.1.
BC016700 mRNA. Translation: AAH16700.1.
AB051341 Genomic DNA. Translation: BAB54931.2.
CCDSiCCDS1155.1.
RefSeqiNP_078816.2. NM_024540.3.
NP_663781.1. NM_145729.2.
XP_011508283.1. XM_011509981.2.
XP_011508284.1. XM_011509982.2.
UniGeneiHs.418233.

Genome annotation databases

EnsembliENST00000361531; ENSP00000354525; ENSG00000143314.
ENST00000368211; ENSP00000357194; ENSG00000143314.
GeneIDi79590.
KEGGihsa:79590.
UCSCiuc001fpw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024570 mRNA. Translation: BAB14929.1.
CR457329 mRNA. Translation: CAG33610.1.
AK222500 mRNA. Translation: BAD96220.1.
AK223066 mRNA. Translation: BAD96786.1.
AL590666 Genomic DNA. Translation: CAI16343.1.
AL590666 Genomic DNA. Translation: CAI16344.1.
AL590666 Genomic DNA. Translation: CAI16345.1.
AL590666 Genomic DNA. Translation: CAI16346.1.
CH471121 Genomic DNA. Translation: EAW52913.1.
CH471121 Genomic DNA. Translation: EAW52914.1.
BC012440 mRNA. Translation: AAH12440.1.
BC016700 mRNA. Translation: AAH16700.1.
AB051341 Genomic DNA. Translation: BAB54931.2.
CCDSiCCDS1155.1.
RefSeqiNP_078816.2. NM_024540.3.
NP_663781.1. NM_145729.2.
XP_011508283.1. XM_011509981.2.
XP_011508284.1. XM_011509982.2.
UniGeneiHs.418233.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40V1-216[»]
3J9Melectron microscopy3.50V1-216[»]
ProteinModelPortaliQ96A35.
SMRiQ96A35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122732. 65 interactors.
IntActiQ96A35. 14 interactors.
MINTiMINT-6942170.
STRINGi9606.ENSP00000354525.

PTM databases

iPTMnetiQ96A35.
PhosphoSitePlusiQ96A35.
SwissPalmiQ96A35.

Polymorphism and mutation databases

BioMutaiMRPL24.
DMDMi74751733.

Proteomic databases

EPDiQ96A35.
MaxQBiQ96A35.
PaxDbiQ96A35.
PeptideAtlasiQ96A35.
PRIDEiQ96A35.
TopDownProteomicsiQ96A35.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361531; ENSP00000354525; ENSG00000143314.
ENST00000368211; ENSP00000357194; ENSG00000143314.
GeneIDi79590.
KEGGihsa:79590.
UCSCiuc001fpw.2. human.

Organism-specific databases

CTDi79590.
GeneCardsiMRPL24.
HGNCiHGNC:14037. MRPL24.
HPAiHPA030295.
MIMi611836. gene.
neXtProtiNX_Q96A35.
OpenTargetsiENSG00000143314.
PharmGKBiPA30954.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1708. Eukaryota.
COG0198. LUCA.
GeneTreeiENSGT00390000014542.
HOVERGENiHBG093899.
InParanoidiQ96A35.
KOiK02895.
OMAiPAKSYWY.
OrthoDBiEOG091G0EA2.
PhylomeDBiQ96A35.
TreeFamiTF105984.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

GeneWikiiMRPL24.
GenomeRNAii79590.
PROiPR:Q96A35.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143314.
CleanExiHS_MRPL24.
ExpressionAtlasiQ96A35. baseline and differential.
GenevisibleiQ96A35. HS.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiView protein in InterPro
IPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR003256. Ribosomal_L24.
IPR005825. Ribosomal_L24/26_CS.
IPR008991. Translation_prot_SH3-like.
PfamiView protein in Pfam
PF00467. KOW. 1 hit.
PF17136. ribosomal_L24. 1 hit.
SMARTiView protein in SMART
SM00739. KOW. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01079. rplX_bact. 1 hit.
PROSITEiView protein in PROSITE
PS01108. RIBOSOMAL_L24. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM24_HUMAN
AccessioniPrimary (citable) accession number: Q96A35
Secondary accession number(s): D3DVC8
, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96Q70, Q9H7G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.