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Protein

Coiled-coil domain-containing protein 47

Gene

CCDC47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 47
Gene namesi
Name:CCDC47
ORF Names:GK001, MSTP041, PSEC0077
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108588.13
HGNCiHGNC:24856 CCDC47
neXtProtiNX_Q96A33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei136 – 155HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108588
PharmGKBiPA142672164

Polymorphism and mutation databases

BioMutaiCCDC47
DMDMi74731083

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000023579721 – 483Coiled-coil domain-containing protein 47Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96A33
MaxQBiQ96A33
PaxDbiQ96A33
PeptideAtlasiQ96A33
PRIDEiQ96A33

PTM databases

iPTMnetiQ96A33
PhosphoSitePlusiQ96A33
SwissPalmiQ96A33

Expressioni

Gene expression databases

BgeeiENSG00000108588
CleanExiHS_CCDC47
ExpressionAtlasiQ96A33 baseline and differential
GenevisibleiQ96A33 HS

Organism-specific databases

HPAiHPA029674
HPA072573

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi12131844 interactors.
IntActiQ96A33 40 interactors.
MINTiQ96A33
STRINGi9606.ENSP00000225726

Structurei

3D structure databases

ProteinModelPortaliQ96A33
SMRiQ96A33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili450 – 483Sequence analysisAdd BLAST34

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2357 Eukaryota
ENOG410XREM LUCA
GeneTreeiENSGT00390000013997
HOVERGENiHBG081033
InParanoidiQ96A33
OMAiMLIQLKF
OrthoDBiEOG091G0ERU
PhylomeDBiQ96A33
TreeFamiTF314902

Family and domain databases

InterProiView protein in InterPro
IPR012879 DUF1682
PANTHERiPTHR12883 PTHR12883, 1 hit
PfamiView protein in Pfam
PF07946 DUF1682, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAFHTFCVV LLVFGSVSEA KFDDFEDEED IVEYDDNDFA EFEDVMEDSV
60 70 80 90 100
TESPQRVIIT EDDEDETTVE LEGQDENQEG DFEDADTQEG DTESEPYDDE
110 120 130 140 150
EFEGYEDKPD TSSSKNKDPI TIVDVPAHLQ NSWESYYLEI LMVTGLLAYI
160 170 180 190 200
MNYIIGKNKN SRLAQAWFNT HRELLESNFT LVGDDGTNKE ATSTGKLNQE
210 220 230 240 250
NEHIYNLWCS GRVCCEGMLI QLRFLKRQDL LNVLARMMRP VSDQVQIKVT
260 270 280 290 300
MNDEDMDTYV FAVGTRKALV RLQKEMQDLS EFCSDKPKSG AKYGLPDSLA
310 320 330 340 350
ILSEMGEVTD GMMDTKMVHF LTHYADKIES VHFSDQFSGP KIMQEEGQPL
360 370 380 390 400
KLPDTKRTLL FTFNVPGSGN TYPKDMEALL PLMNMVIYSI DKAKKFRLNR
410 420 430 440 450
EGKQKADKNR ARVEENFLKL THVQRQEAAQ SRREEKKRAE KERIMNEEDP
460 470 480
EKQRRLEEAA LRREQKKLEK KQMKMKQIKV KAM
Length:483
Mass (Da):55,874
Last modified:December 1, 2001 - v1
Checksum:i2C77CB7359B6A857
GO
Isoform 2 (identifier: Q96A33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-483: EAALRREQKKLEKKQMKMKQIKVKAM → VRQTYHWGKTTICKDDCLCSVGC

Show »
Length:480
Mass (Da):55,318
Checksum:i5312D8D979B50D1C
GO

Sequence cautioni

The sequence AAG39292 differs from that shown. Reason: Frameshift at position 306.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti464 – 465EQ → AK in AAF86954 (Ref. 1) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018478458 – 483EAALR…KVKAM → VRQTYHWGKTTICKDDCLCS VGC in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226054 mRNA Translation: AAF86954.1
AK027786 mRNA Translation: BAB55367.1
AK027844 mRNA Translation: BAB55407.1
AK075387 mRNA Translation: BAC11587.1
AK314328 mRNA Translation: BAG36975.1
CH471109 Genomic DNA Translation: EAW94279.1
CH471109 Genomic DNA Translation: EAW94281.1
CH471109 Genomic DNA Translation: EAW94282.1
BC008905 mRNA Translation: AAH08905.1
BC013600 mRNA Translation: AAH13600.2
AF113221 mRNA Translation: AAG39292.1 Frameshift.
CCDSiCCDS11643.1 [Q96A33-1]
RefSeqiNP_064583.2, NM_020198.2 [Q96A33-1]
XP_005257584.1, XM_005257527.2 [Q96A33-1]
UniGeneiHs.202011

Genome annotation databases

EnsembliENST00000225726; ENSP00000225726; ENSG00000108588 [Q96A33-1]
ENST00000403162; ENSP00000384888; ENSG00000108588 [Q96A33-1]
ENST00000582252; ENSP00000463577; ENSG00000108588 [Q96A33-2]
GeneIDi57003
KEGGihsa:57003
UCSCiuc002jbs.5 human [Q96A33-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCD47_HUMAN
AccessioniPrimary (citable) accession number: Q96A33
Secondary accession number(s): B2RAS8
, D3DU20, Q96D00, Q96JZ7, Q9H3E4, Q9NRG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome