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Q96A33 (CCD47_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 47
Gene names
Name:CCDC47
ORF Names:GK001, MSTP041, PSEC0077
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence caution

The sequence AAG39292.1 differs from that shown. Reason: Frameshift at position 306.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Irak1Q99J342EBI-720151,EBI-6117042From a different organism.
IRF7Q929852EBI-720151,EBI-968267
Sarm1Q6PDS32EBI-720151,EBI-6117196From a different organism.
TIRAPP587532EBI-720151,EBI-528644
TMEM173Q86WV62EBI-720151,EBI-2800345

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96A33-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96A33-2)

The sequence of this isoform differs from the canonical sequence as follows:
     458-483: EAALRREQKKLEKKQMKMKQIKVKAM → VRQTYHWGKTTICKDDCLCSVGC

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 483463Coiled-coil domain-containing protein 47
PRO_0000235797

Regions

Transmembrane136 – 15520Helical; Potential
Coiled coil450 – 48334 Potential

Amino acid modifications

Glycosylation1781N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence458 – 48326EAALR…KVKAM → VRQTYHWGKTTICKDDCLCS VGC in isoform 2.
VSP_018478

Experimental info

Sequence conflict464 – 4652EQ → AK in AAF86954. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 2C77CB7359B6A857

FASTA48355,874
        10         20         30         40         50         60 
MKAFHTFCVV LLVFGSVSEA KFDDFEDEED IVEYDDNDFA EFEDVMEDSV TESPQRVIIT 

        70         80         90        100        110        120 
EDDEDETTVE LEGQDENQEG DFEDADTQEG DTESEPYDDE EFEGYEDKPD TSSSKNKDPI 

       130        140        150        160        170        180 
TIVDVPAHLQ NSWESYYLEI LMVTGLLAYI MNYIIGKNKN SRLAQAWFNT HRELLESNFT 

       190        200        210        220        230        240 
LVGDDGTNKE ATSTGKLNQE NEHIYNLWCS GRVCCEGMLI QLRFLKRQDL LNVLARMMRP 

       250        260        270        280        290        300 
VSDQVQIKVT MNDEDMDTYV FAVGTRKALV RLQKEMQDLS EFCSDKPKSG AKYGLPDSLA 

       310        320        330        340        350        360 
ILSEMGEVTD GMMDTKMVHF LTHYADKIES VHFSDQFSGP KIMQEEGQPL KLPDTKRTLL 

       370        380        390        400        410        420 
FTFNVPGSGN TYPKDMEALL PLMNMVIYSI DKAKKFRLNR EGKQKADKNR ARVEENFLKL 

       430        440        450        460        470        480 
THVQRQEAAQ SRREEKKRAE KERIMNEEDP EKQRRLEEAA LRREQKKLEK KQMKMKQIKV 


KAM 

« Hide

Isoform 2 [UniParc].

Checksum: 5312D8D979B50D1C
Show »

FASTA48055,318

References

[1]"A novel gene expressed in human liver cancer tissue."
Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Liver cancer.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Placenta.
[3]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lymph and Ovary.
[6]Liu B., Liu Y.Q., Wang X.Y., Zhao B., Sheng H., Zhao X.W., Liu S., Xu Y.Y., Ye J., Song L., Gao Y., Zhang C.L., Zhang J., Wei Y.J., Cao H.Q., Zhao Y., Liu L.S., Ding J.F. expand/collapse author list , Gao R.L., Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 107-483 (ISOFORM 1).
Tissue: Heart.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF226054 mRNA. Translation: AAF86954.1.
AK027786 mRNA. Translation: BAB55367.1.
AK027844 mRNA. Translation: BAB55407.1.
AK075387 mRNA. Translation: BAC11587.1.
AK314328 mRNA. Translation: BAG36975.1.
CH471109 Genomic DNA. Translation: EAW94279.1.
CH471109 Genomic DNA. Translation: EAW94281.1.
CH471109 Genomic DNA. Translation: EAW94282.1.
BC008905 mRNA. Translation: AAH08905.1.
BC013600 mRNA. Translation: AAH13600.2.
AF113221 mRNA. Translation: AAG39292.1. Frameshift.
CCDSCCDS11643.1. [Q96A33-1]
RefSeqNP_064583.2. NM_020198.2. [Q96A33-1]
XP_005257584.1. XM_005257527.1. [Q96A33-1]
UniGeneHs.202011.

3D structure databases

ProteinModelPortalQ96A33.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121318. 18 interactions.
IntActQ96A33. 12 interactions.
MINTMINT-1375420.
STRING9606.ENSP00000225726.

PTM databases

PhosphoSiteQ96A33.

Polymorphism databases

DMDM74731083.

Proteomic databases

MaxQBQ96A33.
PaxDbQ96A33.
PRIDEQ96A33.

Protocols and materials databases

DNASU57003.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000225726; ENSP00000225726; ENSG00000108588. [Q96A33-1]
ENST00000403162; ENSP00000384888; ENSG00000108588. [Q96A33-1]
ENST00000582252; ENSP00000463577; ENSG00000108588. [Q96A33-2]
GeneID57003.
KEGGhsa:57003.
UCSCuc002jbs.4. human. [Q96A33-1]
uc002jbt.2. human. [Q96A33-2]

Organism-specific databases

CTD57003.
GeneCardsGC17M061822.
HGNCHGNC:24856. CCDC47.
HPAHPA029674.
neXtProtNX_Q96A33.
PharmGKBPA142672164.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG323483.
HOVERGENHBG081033.
InParanoidQ96A33.
OMAEFEHFQD.
OrthoDBEOG7PP577.
PhylomeDBQ96A33.
TreeFamTF314902.

Gene expression databases

BgeeQ96A33.
CleanExHS_CCDC47.
GenevestigatorQ96A33.

Family and domain databases

InterProIPR012879. DUF1682.
[Graphical view]
PANTHERPTHR12883. PTHR12883. 1 hit.
PfamPF07946. DUF1682. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCCDC47. human.
GenomeRNAi57003.
NextBio62739.
PROQ96A33.

Entry information

Entry nameCCD47_HUMAN
AccessionPrimary (citable) accession number: Q96A33
Secondary accession number(s): B2RAS8 expand/collapse secondary AC list , D3DU20, Q96D00, Q96JZ7, Q9H3E4, Q9NRG3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM