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Q96A33

- CCD47_HUMAN

UniProt

Q96A33 - CCD47_HUMAN

Protein

Coiled-coil domain-containing protein 47

Gene

CCDC47

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: Ensembl
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. calcium ion homeostasis Source: Ensembl
    2. embryo development Source: Ensembl
    3. ER overload response Source: Ensembl
    4. osteoblast differentiation Source: UniProt
    5. post-embryonic development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 47
    Gene namesi
    Name:CCDC47
    ORF Names:GK001, MSTP041, PSEC0077
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:24856. CCDC47.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672164.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 483463Coiled-coil domain-containing protein 47PRO_0000235797Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ96A33.
    PaxDbiQ96A33.
    PRIDEiQ96A33.

    PTM databases

    PhosphoSiteiQ96A33.

    Expressioni

    Gene expression databases

    BgeeiQ96A33.
    CleanExiHS_CCDC47.
    GenevestigatoriQ96A33.

    Organism-specific databases

    HPAiHPA029674.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Irak1Q99J342EBI-720151,EBI-6117042From a different organism.
    IRF7Q929852EBI-720151,EBI-968267
    Sarm1Q6PDS32EBI-720151,EBI-6117196From a different organism.
    TIRAPP587532EBI-720151,EBI-528644
    TMEM173Q86WV62EBI-720151,EBI-2800345

    Protein-protein interaction databases

    BioGridi121318. 18 interactions.
    IntActiQ96A33. 12 interactions.
    MINTiMINT-1375420.
    STRINGi9606.ENSP00000225726.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96A33.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei136 – 15520HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili450 – 48334Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG323483.
    HOVERGENiHBG081033.
    InParanoidiQ96A33.
    OMAiEFEHFQD.
    OrthoDBiEOG7PP577.
    PhylomeDBiQ96A33.
    TreeFamiTF314902.

    Family and domain databases

    InterProiIPR012879. DUF1682.
    [Graphical view]
    PANTHERiPTHR12883. PTHR12883. 1 hit.
    PfamiPF07946. DUF1682. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96A33-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKAFHTFCVV LLVFGSVSEA KFDDFEDEED IVEYDDNDFA EFEDVMEDSV    50
    TESPQRVIIT EDDEDETTVE LEGQDENQEG DFEDADTQEG DTESEPYDDE 100
    EFEGYEDKPD TSSSKNKDPI TIVDVPAHLQ NSWESYYLEI LMVTGLLAYI 150
    MNYIIGKNKN SRLAQAWFNT HRELLESNFT LVGDDGTNKE ATSTGKLNQE 200
    NEHIYNLWCS GRVCCEGMLI QLRFLKRQDL LNVLARMMRP VSDQVQIKVT 250
    MNDEDMDTYV FAVGTRKALV RLQKEMQDLS EFCSDKPKSG AKYGLPDSLA 300
    ILSEMGEVTD GMMDTKMVHF LTHYADKIES VHFSDQFSGP KIMQEEGQPL 350
    KLPDTKRTLL FTFNVPGSGN TYPKDMEALL PLMNMVIYSI DKAKKFRLNR 400
    EGKQKADKNR ARVEENFLKL THVQRQEAAQ SRREEKKRAE KERIMNEEDP 450
    EKQRRLEEAA LRREQKKLEK KQMKMKQIKV KAM 483
    Length:483
    Mass (Da):55,874
    Last modified:December 1, 2001 - v1
    Checksum:i2C77CB7359B6A857
    GO
    Isoform 2 (identifier: Q96A33-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         458-483: EAALRREQKKLEKKQMKMKQIKVKAM → VRQTYHWGKTTICKDDCLCSVGC

    Show »
    Length:480
    Mass (Da):55,318
    Checksum:i5312D8D979B50D1C
    GO

    Sequence cautioni

    The sequence AAG39292.1 differs from that shown. Reason: Frameshift at position 306.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti464 – 4652EQ → AK in AAF86954. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei458 – 48326EAALR…KVKAM → VRQTYHWGKTTICKDDCLCS VGC in isoform 2. 1 PublicationVSP_018478Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226054 mRNA. Translation: AAF86954.1.
    AK027786 mRNA. Translation: BAB55367.1.
    AK027844 mRNA. Translation: BAB55407.1.
    AK075387 mRNA. Translation: BAC11587.1.
    AK314328 mRNA. Translation: BAG36975.1.
    CH471109 Genomic DNA. Translation: EAW94279.1.
    CH471109 Genomic DNA. Translation: EAW94281.1.
    CH471109 Genomic DNA. Translation: EAW94282.1.
    BC008905 mRNA. Translation: AAH08905.1.
    BC013600 mRNA. Translation: AAH13600.2.
    AF113221 mRNA. Translation: AAG39292.1. Frameshift.
    CCDSiCCDS11643.1. [Q96A33-1]
    RefSeqiNP_064583.2. NM_020198.2. [Q96A33-1]
    XP_005257584.1. XM_005257527.1. [Q96A33-1]
    UniGeneiHs.202011.

    Genome annotation databases

    EnsembliENST00000225726; ENSP00000225726; ENSG00000108588. [Q96A33-1]
    ENST00000403162; ENSP00000384888; ENSG00000108588. [Q96A33-1]
    ENST00000582252; ENSP00000463577; ENSG00000108588. [Q96A33-2]
    GeneIDi57003.
    KEGGihsa:57003.
    UCSCiuc002jbs.4. human. [Q96A33-1]
    uc002jbt.2. human. [Q96A33-2]

    Polymorphism databases

    DMDMi74731083.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226054 mRNA. Translation: AAF86954.1 .
    AK027786 mRNA. Translation: BAB55367.1 .
    AK027844 mRNA. Translation: BAB55407.1 .
    AK075387 mRNA. Translation: BAC11587.1 .
    AK314328 mRNA. Translation: BAG36975.1 .
    CH471109 Genomic DNA. Translation: EAW94279.1 .
    CH471109 Genomic DNA. Translation: EAW94281.1 .
    CH471109 Genomic DNA. Translation: EAW94282.1 .
    BC008905 mRNA. Translation: AAH08905.1 .
    BC013600 mRNA. Translation: AAH13600.2 .
    AF113221 mRNA. Translation: AAG39292.1 . Frameshift.
    CCDSi CCDS11643.1. [Q96A33-1 ]
    RefSeqi NP_064583.2. NM_020198.2. [Q96A33-1 ]
    XP_005257584.1. XM_005257527.1. [Q96A33-1 ]
    UniGenei Hs.202011.

    3D structure databases

    ProteinModelPortali Q96A33.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121318. 18 interactions.
    IntActi Q96A33. 12 interactions.
    MINTi MINT-1375420.
    STRINGi 9606.ENSP00000225726.

    PTM databases

    PhosphoSitei Q96A33.

    Polymorphism databases

    DMDMi 74731083.

    Proteomic databases

    MaxQBi Q96A33.
    PaxDbi Q96A33.
    PRIDEi Q96A33.

    Protocols and materials databases

    DNASUi 57003.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225726 ; ENSP00000225726 ; ENSG00000108588 . [Q96A33-1 ]
    ENST00000403162 ; ENSP00000384888 ; ENSG00000108588 . [Q96A33-1 ]
    ENST00000582252 ; ENSP00000463577 ; ENSG00000108588 . [Q96A33-2 ]
    GeneIDi 57003.
    KEGGi hsa:57003.
    UCSCi uc002jbs.4. human. [Q96A33-1 ]
    uc002jbt.2. human. [Q96A33-2 ]

    Organism-specific databases

    CTDi 57003.
    GeneCardsi GC17M061822.
    HGNCi HGNC:24856. CCDC47.
    HPAi HPA029674.
    neXtProti NX_Q96A33.
    PharmGKBi PA142672164.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323483.
    HOVERGENi HBG081033.
    InParanoidi Q96A33.
    OMAi EFEHFQD.
    OrthoDBi EOG7PP577.
    PhylomeDBi Q96A33.
    TreeFami TF314902.

    Miscellaneous databases

    ChiTaRSi CCDC47. human.
    GenomeRNAii 57003.
    NextBioi 62739.
    PROi Q96A33.

    Gene expression databases

    Bgeei Q96A33.
    CleanExi HS_CCDC47.
    Genevestigatori Q96A33.

    Family and domain databases

    InterProi IPR012879. DUF1682.
    [Graphical view ]
    PANTHERi PTHR12883. PTHR12883. 1 hit.
    Pfami PF07946. DUF1682. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene expressed in human liver cancer tissue."
      Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Liver cancer.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta.
    3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lymph and Ovary.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 107-483 (ISOFORM 1).
      Tissue: Heart.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCCD47_HUMAN
    AccessioniPrimary (citable) accession number: Q96A33
    Secondary accession number(s): B2RAS8
    , D3DU20, Q96D00, Q96JZ7, Q9H3E4, Q9NRG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM

    External Data

    Dasty 3