Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q96A33

- CCD47_HUMAN

UniProt

Q96A33 - CCD47_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Coiled-coil domain-containing protein 47

Gene

CCDC47

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. calcium ion homeostasis Source: Ensembl
  2. ER overload response Source: Ensembl
  3. osteoblast differentiation Source: UniProt
  4. post-embryonic development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 47
Gene namesi
Name:CCDC47
ORF Names:GK001, MSTP041, PSEC0077
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:24856. CCDC47.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672164.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 483463Coiled-coil domain-containing protein 47PRO_0000235797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96A33.
PaxDbiQ96A33.
PRIDEiQ96A33.

PTM databases

PhosphoSiteiQ96A33.

Expressioni

Gene expression databases

BgeeiQ96A33.
CleanExiHS_CCDC47.
GenevestigatoriQ96A33.

Organism-specific databases

HPAiHPA029674.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Irak1Q99J342EBI-720151,EBI-6117042From a different organism.
IRF7Q929852EBI-720151,EBI-968267
Sarm1Q6PDS32EBI-720151,EBI-6117196From a different organism.
TIRAPP587532EBI-720151,EBI-528644
TMEM173Q86WV62EBI-720151,EBI-2800345

Protein-protein interaction databases

BioGridi121318. 18 interactions.
IntActiQ96A33. 12 interactions.
MINTiMINT-1375420.
STRINGi9606.ENSP00000225726.

Structurei

3D structure databases

ProteinModelPortaliQ96A33.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei136 – 15520HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili450 – 48334Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG323483.
GeneTreeiENSGT00390000013997.
HOVERGENiHBG081033.
InParanoidiQ96A33.
OMAiEFEHFQD.
OrthoDBiEOG7PP577.
PhylomeDBiQ96A33.
TreeFamiTF314902.

Family and domain databases

InterProiIPR012879. DUF1682.
[Graphical view]
PANTHERiPTHR12883. PTHR12883. 1 hit.
PfamiPF07946. DUF1682. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96A33-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAFHTFCVV LLVFGSVSEA KFDDFEDEED IVEYDDNDFA EFEDVMEDSV
60 70 80 90 100
TESPQRVIIT EDDEDETTVE LEGQDENQEG DFEDADTQEG DTESEPYDDE
110 120 130 140 150
EFEGYEDKPD TSSSKNKDPI TIVDVPAHLQ NSWESYYLEI LMVTGLLAYI
160 170 180 190 200
MNYIIGKNKN SRLAQAWFNT HRELLESNFT LVGDDGTNKE ATSTGKLNQE
210 220 230 240 250
NEHIYNLWCS GRVCCEGMLI QLRFLKRQDL LNVLARMMRP VSDQVQIKVT
260 270 280 290 300
MNDEDMDTYV FAVGTRKALV RLQKEMQDLS EFCSDKPKSG AKYGLPDSLA
310 320 330 340 350
ILSEMGEVTD GMMDTKMVHF LTHYADKIES VHFSDQFSGP KIMQEEGQPL
360 370 380 390 400
KLPDTKRTLL FTFNVPGSGN TYPKDMEALL PLMNMVIYSI DKAKKFRLNR
410 420 430 440 450
EGKQKADKNR ARVEENFLKL THVQRQEAAQ SRREEKKRAE KERIMNEEDP
460 470 480
EKQRRLEEAA LRREQKKLEK KQMKMKQIKV KAM
Length:483
Mass (Da):55,874
Last modified:December 1, 2001 - v1
Checksum:i2C77CB7359B6A857
GO
Isoform 2 (identifier: Q96A33-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-483: EAALRREQKKLEKKQMKMKQIKVKAM → VRQTYHWGKTTICKDDCLCSVGC

Show »
Length:480
Mass (Da):55,318
Checksum:i5312D8D979B50D1C
GO

Sequence cautioni

The sequence AAG39292.1 differs from that shown. Reason: Frameshift at position 306.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti464 – 4652EQ → AK in AAF86954. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei458 – 48326EAALR…KVKAM → VRQTYHWGKTTICKDDCLCS VGC in isoform 2. 1 PublicationVSP_018478Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF226054 mRNA. Translation: AAF86954.1.
AK027786 mRNA. Translation: BAB55367.1.
AK027844 mRNA. Translation: BAB55407.1.
AK075387 mRNA. Translation: BAC11587.1.
AK314328 mRNA. Translation: BAG36975.1.
CH471109 Genomic DNA. Translation: EAW94279.1.
CH471109 Genomic DNA. Translation: EAW94281.1.
CH471109 Genomic DNA. Translation: EAW94282.1.
BC008905 mRNA. Translation: AAH08905.1.
BC013600 mRNA. Translation: AAH13600.2.
AF113221 mRNA. Translation: AAG39292.1. Frameshift.
CCDSiCCDS11643.1. [Q96A33-1]
RefSeqiNP_064583.2. NM_020198.2. [Q96A33-1]
XP_005257584.1. XM_005257527.1. [Q96A33-1]
UniGeneiHs.202011.

Genome annotation databases

EnsembliENST00000225726; ENSP00000225726; ENSG00000108588. [Q96A33-1]
ENST00000403162; ENSP00000384888; ENSG00000108588. [Q96A33-1]
ENST00000582252; ENSP00000463577; ENSG00000108588. [Q96A33-2]
GeneIDi57003.
KEGGihsa:57003.
UCSCiuc002jbs.4. human. [Q96A33-1]
uc002jbt.2. human. [Q96A33-2]

Polymorphism databases

DMDMi74731083.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF226054 mRNA. Translation: AAF86954.1 .
AK027786 mRNA. Translation: BAB55367.1 .
AK027844 mRNA. Translation: BAB55407.1 .
AK075387 mRNA. Translation: BAC11587.1 .
AK314328 mRNA. Translation: BAG36975.1 .
CH471109 Genomic DNA. Translation: EAW94279.1 .
CH471109 Genomic DNA. Translation: EAW94281.1 .
CH471109 Genomic DNA. Translation: EAW94282.1 .
BC008905 mRNA. Translation: AAH08905.1 .
BC013600 mRNA. Translation: AAH13600.2 .
AF113221 mRNA. Translation: AAG39292.1 . Frameshift.
CCDSi CCDS11643.1. [Q96A33-1 ]
RefSeqi NP_064583.2. NM_020198.2. [Q96A33-1 ]
XP_005257584.1. XM_005257527.1. [Q96A33-1 ]
UniGenei Hs.202011.

3D structure databases

ProteinModelPortali Q96A33.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121318. 18 interactions.
IntActi Q96A33. 12 interactions.
MINTi MINT-1375420.
STRINGi 9606.ENSP00000225726.

PTM databases

PhosphoSitei Q96A33.

Polymorphism databases

DMDMi 74731083.

Proteomic databases

MaxQBi Q96A33.
PaxDbi Q96A33.
PRIDEi Q96A33.

Protocols and materials databases

DNASUi 57003.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225726 ; ENSP00000225726 ; ENSG00000108588 . [Q96A33-1 ]
ENST00000403162 ; ENSP00000384888 ; ENSG00000108588 . [Q96A33-1 ]
ENST00000582252 ; ENSP00000463577 ; ENSG00000108588 . [Q96A33-2 ]
GeneIDi 57003.
KEGGi hsa:57003.
UCSCi uc002jbs.4. human. [Q96A33-1 ]
uc002jbt.2. human. [Q96A33-2 ]

Organism-specific databases

CTDi 57003.
GeneCardsi GC17M061822.
HGNCi HGNC:24856. CCDC47.
HPAi HPA029674.
neXtProti NX_Q96A33.
PharmGKBi PA142672164.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG323483.
GeneTreei ENSGT00390000013997.
HOVERGENi HBG081033.
InParanoidi Q96A33.
OMAi EFEHFQD.
OrthoDBi EOG7PP577.
PhylomeDBi Q96A33.
TreeFami TF314902.

Miscellaneous databases

ChiTaRSi CCDC47. human.
GenomeRNAii 57003.
NextBioi 62739.
PROi Q96A33.

Gene expression databases

Bgeei Q96A33.
CleanExi HS_CCDC47.
Genevestigatori Q96A33.

Family and domain databases

InterProi IPR012879. DUF1682.
[Graphical view ]
PANTHERi PTHR12883. PTHR12883. 1 hit.
Pfami PF07946. DUF1682. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel gene expressed in human liver cancer tissue."
    Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver cancer.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph and Ovary.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 107-483 (ISOFORM 1).
    Tissue: Heart.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCCD47_HUMAN
AccessioniPrimary (citable) accession number: Q96A33
Secondary accession number(s): B2RAS8
, D3DU20, Q96D00, Q96JZ7, Q9H3E4, Q9NRG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM

External Data

Dasty 3