Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Coiled-coil domain-containing protein 47

Gene

CCDC47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • calcium ion binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 47
Gene namesi
Name:CCDC47
ORF Names:GK001, MSTP041, PSEC0077
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:24856. CCDC47.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei136 – 155HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108588.
PharmGKBiPA142672164.

Polymorphism and mutation databases

BioMutaiCCDC47.
DMDMi74731083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000023579721 – 483Coiled-coil domain-containing protein 47Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96A33.
MaxQBiQ96A33.
PaxDbiQ96A33.
PeptideAtlasiQ96A33.
PRIDEiQ96A33.

PTM databases

iPTMnetiQ96A33.
PhosphoSitePlusiQ96A33.
SwissPalmiQ96A33.

Expressioni

Gene expression databases

BgeeiENSG00000108588.
CleanExiHS_CCDC47.
ExpressionAtlasiQ96A33. baseline and differential.
GenevisibleiQ96A33. HS.

Organism-specific databases

HPAiHPA029674.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Irak1Q99J342EBI-720151,EBI-6117042From a different organism.
IRF7Q929852EBI-720151,EBI-968267
Sarm1Q6PDS32EBI-720151,EBI-6117196From a different organism.
TIRAPP587532EBI-720151,EBI-528644
TMEM173Q86WV62EBI-720151,EBI-2800345

Protein-protein interaction databases

BioGridi121318. 40 interactors.
IntActiQ96A33. 28 interactors.
MINTiMINT-1375420.
STRINGi9606.ENSP00000225726.

Structurei

3D structure databases

ProteinModelPortaliQ96A33.
SMRiQ96A33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili450 – 483Sequence analysisAdd BLAST34

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2357. Eukaryota.
ENOG410XREM. LUCA.
GeneTreeiENSGT00390000013997.
HOVERGENiHBG081033.
InParanoidiQ96A33.
OMAiIDQKVEP.
OrthoDBiEOG091G0ERU.
PhylomeDBiQ96A33.
TreeFamiTF314902.

Family and domain databases

InterProiIPR012879. DUF1682.
[Graphical view]
PANTHERiPTHR12883. PTHR12883. 1 hit.
PfamiPF07946. DUF1682. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAFHTFCVV LLVFGSVSEA KFDDFEDEED IVEYDDNDFA EFEDVMEDSV
60 70 80 90 100
TESPQRVIIT EDDEDETTVE LEGQDENQEG DFEDADTQEG DTESEPYDDE
110 120 130 140 150
EFEGYEDKPD TSSSKNKDPI TIVDVPAHLQ NSWESYYLEI LMVTGLLAYI
160 170 180 190 200
MNYIIGKNKN SRLAQAWFNT HRELLESNFT LVGDDGTNKE ATSTGKLNQE
210 220 230 240 250
NEHIYNLWCS GRVCCEGMLI QLRFLKRQDL LNVLARMMRP VSDQVQIKVT
260 270 280 290 300
MNDEDMDTYV FAVGTRKALV RLQKEMQDLS EFCSDKPKSG AKYGLPDSLA
310 320 330 340 350
ILSEMGEVTD GMMDTKMVHF LTHYADKIES VHFSDQFSGP KIMQEEGQPL
360 370 380 390 400
KLPDTKRTLL FTFNVPGSGN TYPKDMEALL PLMNMVIYSI DKAKKFRLNR
410 420 430 440 450
EGKQKADKNR ARVEENFLKL THVQRQEAAQ SRREEKKRAE KERIMNEEDP
460 470 480
EKQRRLEEAA LRREQKKLEK KQMKMKQIKV KAM
Length:483
Mass (Da):55,874
Last modified:December 1, 2001 - v1
Checksum:i2C77CB7359B6A857
GO
Isoform 2 (identifier: Q96A33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-483: EAALRREQKKLEKKQMKMKQIKVKAM → VRQTYHWGKTTICKDDCLCSVGC

Show »
Length:480
Mass (Da):55,318
Checksum:i5312D8D979B50D1C
GO

Sequence cautioni

The sequence AAG39292 differs from that shown. Reason: Frameshift at position 306.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti464 – 465EQ → AK in AAF86954 (Ref. 1) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018478458 – 483EAALR…KVKAM → VRQTYHWGKTTICKDDCLCS VGC in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226054 mRNA. Translation: AAF86954.1.
AK027786 mRNA. Translation: BAB55367.1.
AK027844 mRNA. Translation: BAB55407.1.
AK075387 mRNA. Translation: BAC11587.1.
AK314328 mRNA. Translation: BAG36975.1.
CH471109 Genomic DNA. Translation: EAW94279.1.
CH471109 Genomic DNA. Translation: EAW94281.1.
CH471109 Genomic DNA. Translation: EAW94282.1.
BC008905 mRNA. Translation: AAH08905.1.
BC013600 mRNA. Translation: AAH13600.2.
AF113221 mRNA. Translation: AAG39292.1. Frameshift.
CCDSiCCDS11643.1. [Q96A33-1]
RefSeqiNP_064583.2. NM_020198.2. [Q96A33-1]
XP_005257584.1. XM_005257527.2. [Q96A33-1]
UniGeneiHs.202011.

Genome annotation databases

EnsembliENST00000225726; ENSP00000225726; ENSG00000108588. [Q96A33-1]
ENST00000403162; ENSP00000384888; ENSG00000108588. [Q96A33-1]
ENST00000582252; ENSP00000463577; ENSG00000108588. [Q96A33-2]
GeneIDi57003.
KEGGihsa:57003.
UCSCiuc002jbs.5. human. [Q96A33-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226054 mRNA. Translation: AAF86954.1.
AK027786 mRNA. Translation: BAB55367.1.
AK027844 mRNA. Translation: BAB55407.1.
AK075387 mRNA. Translation: BAC11587.1.
AK314328 mRNA. Translation: BAG36975.1.
CH471109 Genomic DNA. Translation: EAW94279.1.
CH471109 Genomic DNA. Translation: EAW94281.1.
CH471109 Genomic DNA. Translation: EAW94282.1.
BC008905 mRNA. Translation: AAH08905.1.
BC013600 mRNA. Translation: AAH13600.2.
AF113221 mRNA. Translation: AAG39292.1. Frameshift.
CCDSiCCDS11643.1. [Q96A33-1]
RefSeqiNP_064583.2. NM_020198.2. [Q96A33-1]
XP_005257584.1. XM_005257527.2. [Q96A33-1]
UniGeneiHs.202011.

3D structure databases

ProteinModelPortaliQ96A33.
SMRiQ96A33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121318. 40 interactors.
IntActiQ96A33. 28 interactors.
MINTiMINT-1375420.
STRINGi9606.ENSP00000225726.

PTM databases

iPTMnetiQ96A33.
PhosphoSitePlusiQ96A33.
SwissPalmiQ96A33.

Polymorphism and mutation databases

BioMutaiCCDC47.
DMDMi74731083.

Proteomic databases

EPDiQ96A33.
MaxQBiQ96A33.
PaxDbiQ96A33.
PeptideAtlasiQ96A33.
PRIDEiQ96A33.

Protocols and materials databases

DNASUi57003.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225726; ENSP00000225726; ENSG00000108588. [Q96A33-1]
ENST00000403162; ENSP00000384888; ENSG00000108588. [Q96A33-1]
ENST00000582252; ENSP00000463577; ENSG00000108588. [Q96A33-2]
GeneIDi57003.
KEGGihsa:57003.
UCSCiuc002jbs.5. human. [Q96A33-1]

Organism-specific databases

CTDi57003.
GeneCardsiCCDC47.
HGNCiHGNC:24856. CCDC47.
HPAiHPA029674.
neXtProtiNX_Q96A33.
OpenTargetsiENSG00000108588.
PharmGKBiPA142672164.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2357. Eukaryota.
ENOG410XREM. LUCA.
GeneTreeiENSGT00390000013997.
HOVERGENiHBG081033.
InParanoidiQ96A33.
OMAiIDQKVEP.
OrthoDBiEOG091G0ERU.
PhylomeDBiQ96A33.
TreeFamiTF314902.

Miscellaneous databases

ChiTaRSiCCDC47. human.
GenomeRNAii57003.
PROiQ96A33.

Gene expression databases

BgeeiENSG00000108588.
CleanExiHS_CCDC47.
ExpressionAtlasiQ96A33. baseline and differential.
GenevisibleiQ96A33. HS.

Family and domain databases

InterProiIPR012879. DUF1682.
[Graphical view]
PANTHERiPTHR12883. PTHR12883. 1 hit.
PfamiPF07946. DUF1682. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCD47_HUMAN
AccessioniPrimary (citable) accession number: Q96A33
Secondary accession number(s): B2RAS8
, D3DU20, Q96D00, Q96JZ7, Q9H3E4, Q9NRG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.