Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GDP-fucose transporter 1

Gene

SLC35C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181830-MONOMER.
ReactomeiR-HSA-6787639. GDP-fucose biosynthesis.
R-HSA-727802. Transport of nucleotide sugars.

Protein family/group databases

TCDBi2.A.7.16.1. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-fucose transporter 1
Alternative name(s):
Solute carrier family 35 member C1
Gene namesi
Name:SLC35C1
Synonyms:FUCT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:20197. SLC35C1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 56HelicalSequence analysisAdd BLAST23
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Transmembranei111 – 130HelicalSequence analysisAdd BLAST20
Transmembranei140 – 162HelicalSequence analysisAdd BLAST23
Transmembranei167 – 185HelicalSequence analysisAdd BLAST19
Transmembranei195 – 214HelicalSequence analysisAdd BLAST20
Transmembranei227 – 249HelicalSequence analysisAdd BLAST23
Transmembranei264 – 286HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital disorder of glycosylation 2C (CDG2C)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. The clinical features of CDG2C include mental retardation, short stature, facial stigmata, and recurrent bacterial peripheral infections with persistently elevated peripheral leukocytes. Biochemically, CDG2C is characterized by a lack of fucosylated glycoconjugates, including selectin ligands.
See also OMIM:266265
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012347147R → C in CDG2C. 2 PublicationsCorresponds to variant rs28939087dbSNPEnsembl.1
Natural variantiVAR_012348308T → R in CDG2C. 1 PublicationCorresponds to variant rs28937886dbSNPEnsembl.1

Keywords - Diseasei

Congenital disorder of glycosylation, Disease mutation

Organism-specific databases

DisGeNETi55343.
MalaCardsiSLC35C1.
MIMi266265. phenotype.
OpenTargetsiENSG00000181830.
Orphaneti99843. Leukocyte adhesion deficiency type II.
PharmGKBiPA134930330.

Polymorphism and mutation databases

BioMutaiSLC35C1.
DMDMi20138280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133911 – 364GDP-fucose transporter 1Add BLAST364

Proteomic databases

MaxQBiQ96A29.
PaxDbiQ96A29.
PeptideAtlasiQ96A29.
PRIDEiQ96A29.

PTM databases

iPTMnetiQ96A29.
PhosphoSitePlusiQ96A29.
SwissPalmiQ96A29.

Expressioni

Gene expression databases

BgeeiENSG00000181830.
CleanExiHS_SLC35C1.
ExpressionAtlasiQ96A29. baseline and differential.
GenevisibleiQ96A29. HS.

Organism-specific databases

HPAiHPA064001.

Interactioni

Protein-protein interaction databases

BioGridi120624. 1 interactor.
STRINGi9606.ENSP00000313318.

Structurei

3D structure databases

ProteinModelPortaliQ96A29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1442. Eukaryota.
ENOG410XST0. LUCA.
GeneTreeiENSGT00390000013315.
HOGENOMiHOG000021132.
HOVERGENiHBG051670.
InParanoidiQ96A29.
KOiK15279.
OMAiVVSLYWV.
OrthoDBiEOG091G0CH6.
PhylomeDBiQ96A29.
TreeFamiTF354269.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A29-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRAPLKRSR ILHMALTGAS DPSAEAEANG EKPFLLRALQ IALVVSLYWV
60 70 80 90 100
TSISMVFLNK YLLDSPSLRL DTPIFVTFYQ CLVTTLLCKG LSALAACCPG
110 120 130 140 150
AVDFPSLRLD LRVARSVLPL SVVFIGMITF NNLCLKYVGV AFYNVGRSLT
160 170 180 190 200
TVFNVLLSYL LLKQTTSFYA LLTCGIIIGG FWLGVDQEGA EGTLSWLGTV
210 220 230 240 250
FGVLASLCVS LNAIYTTKVL PAVDGSIWRL TFYNNVNACI LFLPLLLLLG
260 270 280 290 300
ELQALRDFAQ LGSAHFWGMM TLGGLFGFAI GYVTGLQIKF TSPLTHNVSG
310 320 330 340 350
TAKACAQTVL AVLYYEETKS FLWWTSNMMV LGGSSAYTWV RGWEMKKTPE
360
EPSPKDSEKS AMGV
Length:364
Mass (Da):39,809
Last modified:December 1, 2001 - v1
Checksum:i2E659D49C5C5E92E
GO
Isoform 2 (identifier: Q96A29-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Show »
Length:351
Mass (Da):38,235
Checksum:i070ECFC1B614798C
GO

Sequence cautioni

The sequence BAA92126 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti258F → L in BAA92126 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05730249W → S.1 PublicationCorresponds to variant rs11538193dbSNPEnsembl.1
Natural variantiVAR_012347147R → C in CDG2C. 2 PublicationsCorresponds to variant rs28939087dbSNPEnsembl.1
Natural variantiVAR_057303240I → V.Corresponds to variant rs7130656dbSNPEnsembl.1
Natural variantiVAR_012348308T → R in CDG2C. 1 PublicationCorresponds to variant rs28937886dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0471161 – 13Missing in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323970 mRNA. Translation: AAK50397.1.
AF326199 mRNA. Translation: AAK51705.1.
AK027394 mRNA. Translation: BAB55080.1.
AK002182 mRNA. Translation: BAA92126.1. Different initiation.
AK315473 mRNA. Translation: BAG37859.1.
AC044839 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68031.1.
BC001427 mRNA. Translation: AAH01427.2.
CCDSiCCDS44575.1. [Q96A29-2]
CCDS7914.1. [Q96A29-1]
RefSeqiNP_001138737.1. NM_001145265.1. [Q96A29-2]
NP_001138738.1. NM_001145266.1. [Q96A29-2]
NP_060859.4. NM_018389.4. [Q96A29-1]
UniGeneiHs.12211.

Genome annotation databases

EnsembliENST00000314134; ENSP00000313318; ENSG00000181830. [Q96A29-1]
ENST00000442528; ENSP00000412408; ENSG00000181830. [Q96A29-2]
GeneIDi55343.
KEGGihsa:55343.
UCSCiuc001nbo.4. human. [Q96A29-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SLC35C1base

SLC35C1 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323970 mRNA. Translation: AAK50397.1.
AF326199 mRNA. Translation: AAK51705.1.
AK027394 mRNA. Translation: BAB55080.1.
AK002182 mRNA. Translation: BAA92126.1. Different initiation.
AK315473 mRNA. Translation: BAG37859.1.
AC044839 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68031.1.
BC001427 mRNA. Translation: AAH01427.2.
CCDSiCCDS44575.1. [Q96A29-2]
CCDS7914.1. [Q96A29-1]
RefSeqiNP_001138737.1. NM_001145265.1. [Q96A29-2]
NP_001138738.1. NM_001145266.1. [Q96A29-2]
NP_060859.4. NM_018389.4. [Q96A29-1]
UniGeneiHs.12211.

3D structure databases

ProteinModelPortaliQ96A29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120624. 1 interactor.
STRINGi9606.ENSP00000313318.

Protein family/group databases

TCDBi2.A.7.16.1. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ96A29.
PhosphoSitePlusiQ96A29.
SwissPalmiQ96A29.

Polymorphism and mutation databases

BioMutaiSLC35C1.
DMDMi20138280.

Proteomic databases

MaxQBiQ96A29.
PaxDbiQ96A29.
PeptideAtlasiQ96A29.
PRIDEiQ96A29.

Protocols and materials databases

DNASUi55343.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314134; ENSP00000313318; ENSG00000181830. [Q96A29-1]
ENST00000442528; ENSP00000412408; ENSG00000181830. [Q96A29-2]
GeneIDi55343.
KEGGihsa:55343.
UCSCiuc001nbo.4. human. [Q96A29-1]

Organism-specific databases

CTDi55343.
DisGeNETi55343.
GeneCardsiSLC35C1.
HGNCiHGNC:20197. SLC35C1.
HPAiHPA064001.
MalaCardsiSLC35C1.
MIMi266265. phenotype.
605881. gene.
neXtProtiNX_Q96A29.
OpenTargetsiENSG00000181830.
Orphaneti99843. Leukocyte adhesion deficiency type II.
PharmGKBiPA134930330.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1442. Eukaryota.
ENOG410XST0. LUCA.
GeneTreeiENSGT00390000013315.
HOGENOMiHOG000021132.
HOVERGENiHBG051670.
InParanoidiQ96A29.
KOiK15279.
OMAiVVSLYWV.
OrthoDBiEOG091G0CH6.
PhylomeDBiQ96A29.
TreeFamiTF354269.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181830-MONOMER.
ReactomeiR-HSA-6787639. GDP-fucose biosynthesis.
R-HSA-727802. Transport of nucleotide sugars.

Miscellaneous databases

GeneWikiiSLC35C1.
GenomeRNAii55343.
PROiQ96A29.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181830.
CleanExiHS_SLC35C1.
ExpressionAtlasiQ96A29. baseline and differential.
GenevisibleiQ96A29. HS.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUCT1_HUMAN
AccessioniPrimary (citable) accession number: Q96A29
Secondary accession number(s): B2RDB2, Q9BV76, Q9NUJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.