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Protein

SLAM family member 9

Gene

SLAMF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the immune response.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
SLAM family member 9
Alternative name(s):
CD2 family member 10
Short name:
CD2F-10
CD84 homolog 1
Short name:
CD84-H1
Gene namesi
Name:SLAMF9
Synonyms:CD2F10
ORF Names:UNQ1938/PRO4421
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18430. SLAMF9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 236218ExtracellularSequence analysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence analysisAdd
BLAST
Topological domaini258 – 28932CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134993219.

Polymorphism and mutation databases

BioMutaiSLAMF9.
DMDMi311033512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 289271SLAM family member 9PRO_0000042233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Disulfide bondi156 ↔ 200PROSITE-ProRule annotation
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96A28.
PeptideAtlasiQ96A28.
PRIDEiQ96A28.

Expressioni

Tissue specificityi

Expression is predominantly restricted in hematopoietic tissues. Expressed in heart, spleen, liver, intestine, muscle and testis. Expressed in immune cells, including monocytes, dendritic, B- and T-cells. No expression was seen in peripheral blood leukocytes. Expressed in the leukocyte cell line THP-1.2 Publications

Gene expression databases

BgeeiQ96A28.
CleanExiHS_SLAMF9.
GenevisibleiQ96A28. HS.

Organism-specific databases

HPAiHPA035153.

Structurei

3D structure databases

ProteinModelPortaliQ96A28.
SMRiQ96A28. Positions 30-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11488Ig-like V-typeAdd
BLAST
Domaini136 – 21075Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ6Y. Eukaryota.
ENOG41113EW. LUCA.
GeneTreeiENSGT00530000063114.
HOGENOMiHOG000013065.
InParanoidiQ96A28.
OMAiALSYTCR.
OrthoDBiEOG77HDFC.
PhylomeDBiQ96A28.
TreeFamiTF334964.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCAFPWLLLL LLLQEGSQRR LWRWCGSEEV VAVLQESISL PLEIPPDEEV
60 70 80 90 100
ENIIWSSHKS LATVVPGKEG HPATIMVTNP HYQGQVSFLD PSYSLHISNL
110 120 130 140 150
SWEDSGLYQA QVNLRTSQIS TMQQYNICVY RWLSEPQITV NFESSGEGAC
160 170 180 190 200
SMSLVCSVEK AGMDMTYSWL SRGDSTYTFH EGPVLSTSWR PGDSALSYTC
210 220 230 240 250
RANNPISNVS SCPIPDGPFY ADPNYASEKP STAFCLLAKG LLIFLLLVIL
260 270 280
AMGLWVIRVQ KRHKMPRMKK LMRNRMKLRK EAKPGSSPA
Length:289
Mass (Da):32,436
Last modified:November 2, 2010 - v2
Checksum:i2BA22CBAC2E7F275
GO
Isoform 2 (identifier: Q96A28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-131: R → H
     132-222: Missing.

Show »
Length:198
Mass (Da):22,584
Checksum:i14BF2C18587DBF39
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti86 – 861V → M.
Corresponds to variant rs34540580 [ dbSNP | Ensembl ].
VAR_032812
Natural varianti127 – 1271I → L.4 Publications
Corresponds to variant rs2789417 [ dbSNP | Ensembl ].
VAR_023580
Natural varianti164 – 1641D → H.
Corresponds to variant rs35438196 [ dbSNP | Ensembl ].
VAR_032813
Natural varianti181 – 1811E → K.
Corresponds to variant rs34884993 [ dbSNP | Ensembl ].
VAR_032814

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei131 – 1311R → H in isoform 2. 1 PublicationVSP_015819
Alternative sequencei132 – 22291Missing in isoform 2. 1 PublicationVSP_015820Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275725 mRNA. Translation: AAK69052.1.
AY034613 mRNA. Translation: AAK61389.1.
AY358801 mRNA. Translation: AAQ89161.1.
AL513485 Genomic DNA. Translation: CAI14607.1.
AL513485 Genomic DNA. Translation: CAI14608.1.
BC074754 mRNA. Translation: AAH74754.1.
CCDSiCCDS1191.1. [Q96A28-1]
CCDS53392.1. [Q96A28-2]
RefSeqiNP_001139644.1. NM_001146172.1. [Q96A28-2]
NP_001139645.1. NM_001146173.1.
NP_254273.2. NM_033438.3. [Q96A28-1]
UniGeneiHs.661712.

Genome annotation databases

EnsembliENST00000368092; ENSP00000357071; ENSG00000162723. [Q96A28-2]
ENST00000368093; ENSP00000357072; ENSG00000162723. [Q96A28-1]
GeneIDi89886.
KEGGihsa:89886.
UCSCiuc001fus.3. human. [Q96A28-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275725 mRNA. Translation: AAK69052.1.
AY034613 mRNA. Translation: AAK61389.1.
AY358801 mRNA. Translation: AAQ89161.1.
AL513485 Genomic DNA. Translation: CAI14607.1.
AL513485 Genomic DNA. Translation: CAI14608.1.
BC074754 mRNA. Translation: AAH74754.1.
CCDSiCCDS1191.1. [Q96A28-1]
CCDS53392.1. [Q96A28-2]
RefSeqiNP_001139644.1. NM_001146172.1. [Q96A28-2]
NP_001139645.1. NM_001146173.1.
NP_254273.2. NM_033438.3. [Q96A28-1]
UniGeneiHs.661712.

3D structure databases

ProteinModelPortaliQ96A28.
SMRiQ96A28. Positions 30-210.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiSLAMF9.
DMDMi311033512.

Proteomic databases

PaxDbiQ96A28.
PeptideAtlasiQ96A28.
PRIDEiQ96A28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368092; ENSP00000357071; ENSG00000162723. [Q96A28-2]
ENST00000368093; ENSP00000357072; ENSG00000162723. [Q96A28-1]
GeneIDi89886.
KEGGihsa:89886.
UCSCiuc001fus.3. human. [Q96A28-1]

Organism-specific databases

CTDi89886.
GeneCardsiSLAMF9.
H-InvDBHIX0028587.
HGNCiHGNC:18430. SLAMF9.
HPAiHPA035153.
MIMi608589. gene.
neXtProtiNX_Q96A28.
PharmGKBiPA134993219.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ6Y. Eukaryota.
ENOG41113EW. LUCA.
GeneTreeiENSGT00530000063114.
HOGENOMiHOG000013065.
InParanoidiQ96A28.
OMAiALSYTCR.
OrthoDBiEOG77HDFC.
PhylomeDBiQ96A28.
TreeFamiTF334964.

Miscellaneous databases

ChiTaRSiSLAMF9. human.
GenomeRNAii89886.
PROiQ96A28.
SOURCEiSearch...

Gene expression databases

BgeeiQ96A28.
CleanExiHS_SLAMF9.
GenevisibleiQ96A28. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic approach to insight into the immunobiology of human dendritic cells and identification of CD84-H1, a novel CD84 homologue."
    Zhang W., Wan T., Li N., Yuan Z., He L., Zhu X., Yu M., Cao X.
    Clin. Cancer Res. Suppl. 7:822-829(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT LEU-127.
  2. "CD2F-10: a new member of the CD2 subset of the immunoglobulin superfamily."
    Fennelly J.A., Tiwari B., Davis S.J., Evans E.J.
    Immunogenetics 53:599-602(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT LEU-127.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT LEU-127.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-127.

Entry informationi

Entry nameiSLAF9_HUMAN
AccessioniPrimary (citable) accession number: Q96A28
Secondary accession number(s): Q5JRQ9, Q5JRR0, Q6UWG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: November 2, 2010
Last modified: July 6, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.