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Protein

SLAM family member 9

Gene

SLAMF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the immune response.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
SLAM family member 9
Alternative name(s):
CD2 family member 10
Short name:
CD2F-10
CD84 homolog 1
Short name:
CD84-H1
Gene namesi
Name:SLAMF9
Synonyms:CD2F10
ORF Names:UNQ1938/PRO4421
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162723.9.
HGNCiHGNC:18430. SLAMF9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 236ExtracellularSequence analysisAdd BLAST218
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 289CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi89886.
OpenTargetsiENSG00000162723.
PharmGKBiPA134993219.

Polymorphism and mutation databases

BioMutaiSLAMF9.
DMDMi311033512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000004223319 – 289SLAM family member 9Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 200PROSITE-ProRule annotation
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96A28.
PeptideAtlasiQ96A28.
PRIDEiQ96A28.

Expressioni

Tissue specificityi

Expression is predominantly restricted in hematopoietic tissues. Expressed in heart, spleen, liver, intestine, muscle and testis. Expressed in immune cells, including monocytes, dendritic, B- and T-cells. No expression was seen in peripheral blood leukocytes. Expressed in the leukocyte cell line THP-1.2 Publications

Gene expression databases

BgeeiENSG00000162723.
CleanExiHS_SLAMF9.
GenevisibleiQ96A28. HS.

Organism-specific databases

HPAiHPA035153.

Interactioni

Protein-protein interaction databases

BioGridi124637. 5 interactors.
STRINGi9606.ENSP00000357072.

Structurei

3D structure databases

ProteinModelPortaliQ96A28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 114Ig-like V-typeAdd BLAST88
Domaini136 – 210Ig-like C2-typeAdd BLAST75

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ6Y. Eukaryota.
ENOG41113EW. LUCA.
GeneTreeiENSGT00530000063114.
HOGENOMiHOG000013065.
InParanoidiQ96A28.
OMAiALSYTCR.
OrthoDBiEOG091G0KKU.
PhylomeDBiQ96A28.
TreeFamiTF334964.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCAFPWLLLL LLLQEGSQRR LWRWCGSEEV VAVLQESISL PLEIPPDEEV
60 70 80 90 100
ENIIWSSHKS LATVVPGKEG HPATIMVTNP HYQGQVSFLD PSYSLHISNL
110 120 130 140 150
SWEDSGLYQA QVNLRTSQIS TMQQYNICVY RWLSEPQITV NFESSGEGAC
160 170 180 190 200
SMSLVCSVEK AGMDMTYSWL SRGDSTYTFH EGPVLSTSWR PGDSALSYTC
210 220 230 240 250
RANNPISNVS SCPIPDGPFY ADPNYASEKP STAFCLLAKG LLIFLLLVIL
260 270 280
AMGLWVIRVQ KRHKMPRMKK LMRNRMKLRK EAKPGSSPA
Length:289
Mass (Da):32,436
Last modified:November 2, 2010 - v2
Checksum:i2BA22CBAC2E7F275
GO
Isoform 2 (identifier: Q96A28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-131: R → H
     132-222: Missing.

Show »
Length:198
Mass (Da):22,584
Checksum:i14BF2C18587DBF39
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03281286V → M. Corresponds to variant dbSNP:rs34540580Ensembl.1
Natural variantiVAR_023580127I → L4 PublicationsCorresponds to variant dbSNP:rs2789417Ensembl.1
Natural variantiVAR_032813164D → H. Corresponds to variant dbSNP:rs35438196Ensembl.1
Natural variantiVAR_032814181E → K. Corresponds to variant dbSNP:rs34884993Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015819131R → H in isoform 2. 1 Publication1
Alternative sequenceiVSP_015820132 – 222Missing in isoform 2. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275725 mRNA. Translation: AAK69052.1.
AY034613 mRNA. Translation: AAK61389.1.
AY358801 mRNA. Translation: AAQ89161.1.
AL513485 Genomic DNA. Translation: CAI14607.1.
AL513485 Genomic DNA. Translation: CAI14608.1.
BC074754 mRNA. Translation: AAH74754.1.
CCDSiCCDS1191.1. [Q96A28-1]
CCDS53392.1. [Q96A28-2]
RefSeqiNP_001139644.1. NM_001146172.1. [Q96A28-2]
NP_001139645.1. NM_001146173.1.
NP_254273.2. NM_033438.3. [Q96A28-1]
UniGeneiHs.661712.

Genome annotation databases

EnsembliENST00000368092; ENSP00000357071; ENSG00000162723. [Q96A28-2]
ENST00000368093; ENSP00000357072; ENSG00000162723. [Q96A28-1]
GeneIDi89886.
KEGGihsa:89886.
UCSCiuc001fus.3. human. [Q96A28-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSLAF9_HUMAN
AccessioniPrimary (citable) accession number: Q96A28
Secondary accession number(s): Q5JRQ9, Q5JRR0, Q6UWG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: November 2, 2010
Last modified: October 25, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot