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Protein

Protein FAM162A

Gene

FAM162A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.1 Publication

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • cellular response to hypoxia Source: UniProtKB
  • neuron apoptotic process Source: Ensembl
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM162A
Alternative name(s):
E2-induced gene 5 protein
Growth and transformation-dependent protein
Short name:
HGTD-P
Gene namesi
Name:FAM162A
Synonyms:C3orf28, E2IG5
ORF Names:DC16, FWP001
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:17865. FAM162A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei103 – 12018HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386916.

Polymorphism and mutation databases

BioMutaiFAM162A.
DMDMi117949400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Protein FAM162APRO_0000254635Add
BLAST

Proteomic databases

EPDiQ96A26.
MaxQBiQ96A26.
PaxDbiQ96A26.
PeptideAtlasiQ96A26.
PRIDEiQ96A26.
TopDownProteomicsiQ96A26.

PTM databases

iPTMnetiQ96A26.
PhosphoSiteiQ96A26.
SwissPalmiQ96A26.

Expressioni

Inductioni

By 17-beta-estradiol. By hypoxia.1 Publication

Gene expression databases

BgeeiENSG00000114023.
CleanExiHS_FAM162A.
ExpressionAtlasiQ96A26. baseline and differential.
GenevisibleiQ96A26. HS.

Organism-specific databases

HPAiHPA035856.
HPA058113.

Interactioni

Subunit structurei

Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity. Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permability transition.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AB1P082383EBI-6123466,EBI-352572
VDAC2P458802EBI-6123466,EBI-354022

Protein-protein interaction databases

BioGridi117691. 21 interactions.
IntActiQ96A26. 3 interactions.
MINTiMINT-2567375.
STRINGi9606.ENSP00000419088.

Structurei

3D structure databases

ProteinModelPortaliQ96A26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni76 – 10227Required for proapoptotic activityAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0389 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1EB. Eukaryota.
ENOG4111YCK. LUCA.
GeneTreeiENSGT00640000091497.
HOGENOMiHOG000060246.
HOVERGENiHBG057006.
InParanoidiQ96A26.
OMAiICYLMIA.
OrthoDBiEOG091G17FA.
PhylomeDBiQ96A26.
TreeFamiTF323771.

Family and domain databases

InterProiIPR009432. DUF1075.
[Graphical view]
PANTHERiPTHR13674. PTHR13674. 1 hit.
PfamiPF06388. DUF1075. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96A26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLSGLRLA AGSCFRLCER DVSSSLRLTR SSDLKRINGF CTKPQESPGA
60 70 80 90 100
PSRTYNRVPL HKPTDWQKKI LIWSGRFKKE DEIPETVSLE MLDAAKNKMR
110 120 130 140 150
VKISYLMIAL TVVGCIFMVI EGKKAAQRHE TLTSLNLEKK ARLKEEAAMK

AKTE
Length:154
Mass (Da):17,342
Last modified:October 31, 2006 - v2
Checksum:i3C4457C83044ADD8
GO

Sequence cautioni

The sequence AAF09484 differs from that shown. Reason: Frameshift at position 147. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501A → V.1 Publication
Corresponds to variant rs17850692 [ dbSNP | Ensembl ].
VAR_028849

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191020 mRNA. Translation: AAF09484.1. Frameshift.
AF201944 mRNA. Translation: AAF86880.1.
AF107495 mRNA. Translation: AAG39275.1.
BC010896 mRNA. Translation: AAH10896.1.
BC015060 mRNA. Translation: AAH15060.1.
CCDSiCCDS43139.1.
RefSeqiNP_055182.3. NM_014367.3.
UniGeneiHs.584881.

Genome annotation databases

EnsembliENST00000477892; ENSP00000419088; ENSG00000114023.
GeneIDi26355.
KEGGihsa:26355.
UCSCiuc003eez.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191020 mRNA. Translation: AAF09484.1. Frameshift.
AF201944 mRNA. Translation: AAF86880.1.
AF107495 mRNA. Translation: AAG39275.1.
BC010896 mRNA. Translation: AAH10896.1.
BC015060 mRNA. Translation: AAH15060.1.
CCDSiCCDS43139.1.
RefSeqiNP_055182.3. NM_014367.3.
UniGeneiHs.584881.

3D structure databases

ProteinModelPortaliQ96A26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117691. 21 interactions.
IntActiQ96A26. 3 interactions.
MINTiMINT-2567375.
STRINGi9606.ENSP00000419088.

PTM databases

iPTMnetiQ96A26.
PhosphoSiteiQ96A26.
SwissPalmiQ96A26.

Polymorphism and mutation databases

BioMutaiFAM162A.
DMDMi117949400.

Proteomic databases

EPDiQ96A26.
MaxQBiQ96A26.
PaxDbiQ96A26.
PeptideAtlasiQ96A26.
PRIDEiQ96A26.
TopDownProteomicsiQ96A26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000477892; ENSP00000419088; ENSG00000114023.
GeneIDi26355.
KEGGihsa:26355.
UCSCiuc003eez.4. human.

Organism-specific databases

CTDi26355.
GeneCardsiFAM162A.
HGNCiHGNC:17865. FAM162A.
HPAiHPA035856.
HPA058113.
MIMi608017. gene.
neXtProtiNX_Q96A26.
PharmGKBiPA162386916.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1EB. Eukaryota.
ENOG4111YCK. LUCA.
GeneTreeiENSGT00640000091497.
HOGENOMiHOG000060246.
HOVERGENiHBG057006.
InParanoidiQ96A26.
OMAiICYLMIA.
OrthoDBiEOG091G17FA.
PhylomeDBiQ96A26.
TreeFamiTF323771.

Miscellaneous databases

ChiTaRSiFAM162A. human.
GenomeRNAii26355.
PROiQ96A26.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114023.
CleanExiHS_FAM162A.
ExpressionAtlasiQ96A26. baseline and differential.
GenevisibleiQ96A26. HS.

Family and domain databases

InterProiIPR009432. DUF1075.
[Graphical view]
PANTHERiPTHR13674. PTHR13674. 1 hit.
PfamiPF06388. DUF1075. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF162A_HUMAN
AccessioniPrimary (citable) accession number: Q96A26
Secondary accession number(s): Q9NRN6, Q9UJX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.