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Protein

Protein FAM162A

Gene

FAM162A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.1 Publication

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • cellular response to hypoxia Source: UniProtKB
  • neuron apoptotic process Source: Ensembl
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of release of cytochrome c from mitochondria Source: UniProtKB

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM162A
Alternative name(s):
E2-induced gene 5 protein
Growth and transformation-dependent protein
Short name:
HGTD-P
Gene namesi
Name:FAM162A
Synonyms:C3orf28, E2IG5
ORF Names:DC16, FWP001
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114023.15
HGNCiHGNC:17865 FAM162A
MIMi608017 gene
neXtProtiNX_Q96A26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei103 – 120HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000114023
PharmGKBiPA162386916

Polymorphism and mutation databases

BioMutaiFAM162A
DMDMi117949400

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546351 – 154Protein FAM162AAdd BLAST154

Proteomic databases

EPDiQ96A26
MaxQBiQ96A26
PaxDbiQ96A26
PeptideAtlasiQ96A26
PRIDEiQ96A26
TopDownProteomicsiQ96A26

PTM databases

iPTMnetiQ96A26
PhosphoSitePlusiQ96A26
SwissPalmiQ96A26

Expressioni

Inductioni

By 17-beta-estradiol. By hypoxia.1 Publication

Gene expression databases

BgeeiENSG00000114023
CleanExiHS_FAM162A
ExpressionAtlasiQ96A26 baseline and differential
GenevisibleiQ96A26 HS

Organism-specific databases

HPAiHPA035856
HPA058113

Interactioni

Subunit structurei

Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity. Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permability transition.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11769125 interactors.
IntActiQ96A26 4 interactors.
MINTiQ96A26
STRINGi9606.ENSP00000419088

Structurei

3D structure databases

ProteinModelPortaliQ96A26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 102Required for proapoptotic activityAdd BLAST27

Sequence similaritiesi

Belongs to the UPF0389 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1EB Eukaryota
ENOG4111YCK LUCA
GeneTreeiENSGT00640000091497
HOGENOMiHOG000060246
HOVERGENiHBG057006
InParanoidiQ96A26
OMAiTYSHRVP
OrthoDBiEOG091G17FA
PhylomeDBiQ96A26
TreeFamiTF323771

Family and domain databases

InterProiView protein in InterPro
IPR009432 DUF1075
PANTHERiPTHR13674 PTHR13674, 1 hit
PfamiView protein in Pfam
PF06388 DUF1075, 1 hit

Sequencei

Sequence statusi: Complete.

Q96A26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLSGLRLA AGSCFRLCER DVSSSLRLTR SSDLKRINGF CTKPQESPGA
60 70 80 90 100
PSRTYNRVPL HKPTDWQKKI LIWSGRFKKE DEIPETVSLE MLDAAKNKMR
110 120 130 140 150
VKISYLMIAL TVVGCIFMVI EGKKAAQRHE TLTSLNLEKK ARLKEEAAMK

AKTE
Length:154
Mass (Da):17,342
Last modified:October 31, 2006 - v2
Checksum:i3C4457C83044ADD8
GO

Sequence cautioni

The sequence AAF09484 differs from that shown. Reason: Frameshift at position 147.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02884950A → V1 PublicationCorresponds to variant dbSNP:rs17850692Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191020 mRNA Translation: AAF09484.1 Frameshift.
AF201944 mRNA Translation: AAF86880.1
AF107495 mRNA Translation: AAG39275.1
BC010896 mRNA Translation: AAH10896.1
BC015060 mRNA Translation: AAH15060.1
CCDSiCCDS43139.1
RefSeqiNP_055182.3, NM_014367.3
UniGeneiHs.584881

Genome annotation databases

EnsembliENST00000477892; ENSP00000419088; ENSG00000114023
GeneIDi26355
KEGGihsa:26355
UCSCiuc003eez.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF162A_HUMAN
AccessioniPrimary (citable) accession number: Q96A26
Secondary accession number(s): Q9NRN6, Q9UJX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: February 28, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome