ID T106A_HUMAN Reviewed; 262 AA. AC Q96A25; A8K2X2; B7Z698; DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 24-JAN-2024, entry version 148. DE RecName: Full=Transmembrane protein 106A; GN Name=TMEM106A; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Umbilical cord blood; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the RT human lineage."; RL Nature 440:1045-1049(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Kidney, and Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP FUNCTION, AND TISSUE SPECIFICITY. RX PubMed=29131025; DOI=10.1159/000484495; RA Wu C., Xu J., Wang H., Zhang J., Zhong J., Zou X., Chen Y., Yang G., RA Zhong Y., Lai D., Li X., Tang A.; RT "TMEM106a is a Novel Tumor Suppressor in Human Renal Cancer."; RL Kidney Blood Press. Res. 42:853-864(2017). RN [6] RP FUNCTION, AND TISSUE SPECIFICITY. RX PubMed=30456879; DOI=10.1002/jcb.28057; RA Liu J., Zhu H.; RT "TMEM106A inhibits cell proliferation, migration, and induces apoptosis of RT lung cancer cells."; RL J. Cell. Biochem. 0:0-0(2018). CC -!- FUNCTION: Activates macrophages and polarizes them into M1-like CC macrophages through the activation of the MAPK and NF-kappaB signaling CC pathway. Upon activation, up-regulates the expression of CD80, CD86, CC CD69 and MHC II on macrophages, and induces the release of pro- CC inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide CC (By similarity). May play a role in inhibition of proliferation and CC migration (PubMed:30456879, PubMed:29131025). CC {ECO:0000250|UniProtKB:Q8VC04, ECO:0000269|PubMed:29131025, CC ECO:0000269|PubMed:30456879}. CC -!- INTERACTION: CC Q96A25; O75355-2: ENTPD3; NbExp=3; IntAct=EBI-3915978, EBI-12279764; CC Q96A25; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-3915978, EBI-711490; CC Q96A25; P29033: GJB2; NbExp=3; IntAct=EBI-3915978, EBI-3905204; CC Q96A25; O14653: GOSR2; NbExp=3; IntAct=EBI-3915978, EBI-4401517; CC Q96A25; P24593: IGFBP5; NbExp=3; IntAct=EBI-3915978, EBI-720480; CC Q96A25; Q9BVX2: TMEM106C; NbExp=3; IntAct=EBI-3915978, EBI-2821497; CC Q96A25; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-3915978, EBI-12845616; CC Q96A25; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-3915978, EBI-10694905; CC Q96A25; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-3915978, EBI-2548832; CC Q96A25; Q9H2S6-2: TNMD; NbExp=3; IntAct=EBI-3915978, EBI-12003398; CC Q96A25; O14817: TSPAN4; NbExp=3; IntAct=EBI-3915978, EBI-8652667; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VC04}; CC Single-pass membrane protein {ECO:0000255}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q96A25-1; Sequence=Displayed; CC Name=2; CC IsoId=Q96A25-2; Sequence=VSP_056642; CC -!- TISSUE SPECIFICITY: Expressed in renal cells (at protein level) CC (PubMed:29131025). Expressed in epithelial cells (PubMed:30456879). CC {ECO:0000269|PubMed:29131025, ECO:0000269|PubMed:30456879}. CC -!- SIMILARITY: Belongs to the TMEM106 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK056132; BAB71101.1; -; mRNA. DR EMBL; AK290387; BAF83076.1; -; mRNA. DR EMBL; AK299974; BAH13184.1; -; mRNA. DR EMBL; BC012139; AAH12139.1; -; mRNA. DR EMBL; BC146974; AAI46975.1; -; mRNA. DR EMBL; BC146976; AAI46977.1; -; mRNA. DR EMBL; BC147023; AAI47024.1; -; mRNA. DR EMBL; AC087365; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC109326; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471152; EAW60954.1; -; Genomic_DNA. DR EMBL; BC157892; AAI57893.1; -; mRNA. DR CCDS; CCDS11462.1; -. [Q96A25-1] DR CCDS; CCDS74073.1; -. [Q96A25-2] DR RefSeq; NP_001278515.1; NM_001291586.1. [Q96A25-1] DR RefSeq; NP_001278516.1; NM_001291587.1. [Q96A25-2] DR RefSeq; NP_659478.1; NM_145041.3. [Q96A25-1] DR RefSeq; XP_006721721.1; XM_006721658.2. DR RefSeq; XP_006721722.1; XM_006721659.3. DR RefSeq; XP_016879603.1; XM_017024114.1. DR AlphaFoldDB; Q96A25; -. DR BioGRID; 125240; 242. DR IntAct; Q96A25; 12. DR STRING; 9606.ENSP00000483246; -. DR TCDB; 9.B.23.1.5; the tmem106 (tmem106) family. DR iPTMnet; Q96A25; -. DR PhosphoSitePlus; Q96A25; -. DR BioMuta; TMEM106A; -. DR DMDM; 74731081; -. DR jPOST; Q96A25; -. DR MassIVE; Q96A25; -. DR MaxQB; Q96A25; -. DR PaxDb; 9606-ENSP00000483246; -. DR PeptideAtlas; Q96A25; -. DR ProteomicsDB; 6760; -. DR ProteomicsDB; 75896; -. [Q96A25-1] DR Antibodypedia; 61733; 66 antibodies from 19 providers. DR DNASU; 113277; -. DR Ensembl; ENST00000541594.5; ENSP00000439844.1; ENSG00000184988.8. [Q96A25-2] DR Ensembl; ENST00000588659.5; ENSP00000466820.1; ENSG00000184988.8. [Q96A25-1] DR Ensembl; ENST00000612339.4; ENSP00000483246.1; ENSG00000184988.8. [Q96A25-1] DR GeneID; 113277; -. DR KEGG; hsa:113277; -. DR MANE-Select; ENST00000612339.4; ENSP00000483246.1; NM_145041.4; NP_659478.1. DR UCSC; uc002idn.2; human. [Q96A25-1] DR AGR; HGNC:28288; -. DR CTD; 113277; -. DR DisGeNET; 113277; -. DR GeneCards; TMEM106A; -. DR HGNC; HGNC:28288; TMEM106A. DR HPA; ENSG00000184988; Tissue enhanced (kidney). DR neXtProt; NX_Q96A25; -. DR OpenTargets; ENSG00000184988; -. DR PharmGKB; PA142670755; -. DR VEuPathDB; HostDB:ENSG00000184988; -. DR eggNOG; ENOG502RY0I; Eukaryota. DR GeneTree; ENSGT00940000161546; -. DR HOGENOM; CLU_089337_1_0_1; -. DR InParanoid; Q96A25; -. DR OMA; CSYLCHS; -. DR OrthoDB; 5353335at2759; -. DR PhylomeDB; Q96A25; -. DR PathwayCommons; Q96A25; -. DR SignaLink; Q96A25; -. DR BioGRID-ORCS; 113277; 32 hits in 1159 CRISPR screens. DR GeneWiki; TMEM106A; -. DR GenomeRNAi; 113277; -. DR Pharos; Q96A25; Tbio. DR PRO; PR:Q96A25; -. DR Proteomes; UP000005640; Chromosome 17. DR RNAct; Q96A25; Protein. DR Bgee; ENSG00000184988; Expressed in buccal mucosa cell and 169 other cell types or tissues. DR ExpressionAtlas; Q96A25; baseline and differential. DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB. DR GO; GO:0035780; P:CD80 biosynthetic process; ISS:UniProtKB. DR GO; GO:0035781; P:CD86 biosynthetic process; ISS:UniProtKB. DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW. DR GO; GO:0042116; P:macrophage activation; ISS:UniProtKB. DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; ISS:UniProtKB. DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:UniProtKB. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; ISS:UniProtKB. DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB. DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISS:UniProtKB. DR GO; GO:1904407; P:positive regulation of nitric oxide metabolic process; ISS:UniProtKB. DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB. DR Gene3D; 6.20.20.10; -; 1. DR InterPro; IPR009790; TMEM106. DR InterPro; IPR048509; TMEM106_C. DR InterPro; IPR048511; TMEM106_N. DR PANTHER; PTHR28556:SF3; TRANSMEMBRANE PROTEIN 106A; 1. DR PANTHER; PTHR28556; TRANSMEMBRANE PROTEIN 106B; 1. DR Pfam; PF07092; TMEM106; 1. DR Pfam; PF21002; TMEM106_N; 1. DR Genevisible; Q96A25; HS. PE 1: Evidence at protein level; KW Alternative splicing; Cell membrane; Immunity; Innate immunity; Membrane; KW Reference proteome; Transmembrane; Transmembrane helix. FT CHAIN 1..262 FT /note="Transmembrane protein 106A" FT /id="PRO_0000242137" FT TRANSMEM 95..115 FT /note="Helical" FT /evidence="ECO:0000255" FT VAR_SEQ 1..49 FT /note="MGKTFSQLGSWREDENKSILSSKPAIGSKAVNYSSTGSSKSFCSCVPCE -> FT M (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_056642" SQ SEQUENCE 262 AA; 28920 MW; 306433230D5E8D8B CRC64; MGKTFSQLGS WREDENKSIL SSKPAIGSKA VNYSSTGSSK SFCSCVPCEG TADASFVTCP TCQGSGKIPQ ELEKQLVALI PYGDQRLKPK HTKLFVFLAV LICLVTSSFI VFFLFPRSVI VQPAGLNSST VAFDEADIYL NITNILNISN GNYYPIMVTQ LTLEVLHLSL VVGQVSNNLL LHIGPLASEQ MFYAVATKIR DENTYKICTW LEIKVHHVLL HIQGTLTCSY LSHSEQLVFQ SYEYVDCRGN ASVPHQLTPH PP //