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Q96A25

- T106A_HUMAN

UniProt

Q96A25 - T106A_HUMAN

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Protein
Transmembrane protein 106A
Gene
TMEM106A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 106A
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:28288. TMEM106A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei95 – 11521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670755.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Transmembrane protein 106A
PRO_0000242137Add
BLAST

Proteomic databases

MaxQBiQ96A25.
PaxDbiQ96A25.
PRIDEiQ96A25.

PTM databases

PhosphoSiteiQ96A25.

Expressioni

Gene expression databases

ArrayExpressiQ96A25.
BgeeiQ96A25.
CleanExiHS_TMEM106A.
GenevestigatoriQ96A25.

Interactioni

Protein-protein interaction databases

BioGridi125240. 1 interaction.
IntActiQ96A25. 1 interaction.
STRINGi9606.ENSP00000330774.

Structurei

3D structure databases

ProteinModelPortaliQ96A25.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM106 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44552.
HOGENOMiHOG000230966.
HOVERGENiHBG055025.
InParanoidiQ96A25.
OMAiHTKLFVF.
PhylomeDBiQ96A25.

Family and domain databases

InterProiIPR009790. DUF1356_TMEM106.
[Graphical view]
PfamiPF07092. DUF1356. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96A25-1 [UniParc]FASTAAdd to Basket

« Hide

MGKTFSQLGS WREDENKSIL SSKPAIGSKA VNYSSTGSSK SFCSCVPCEG    50
TADASFVTCP TCQGSGKIPQ ELEKQLVALI PYGDQRLKPK HTKLFVFLAV 100
LICLVTSSFI VFFLFPRSVI VQPAGLNSST VAFDEADIYL NITNILNISN 150
GNYYPIMVTQ LTLEVLHLSL VVGQVSNNLL LHIGPLASEQ MFYAVATKIR 200
DENTYKICTW LEIKVHHVLL HIQGTLTCSY LSHSEQLVFQ SYEYVDCRGN 250
ASVPHQLTPH PP 262
Length:262
Mass (Da):28,920
Last modified:December 1, 2001 - v1
Checksum:i306433230D5E8D8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056132 mRNA. Translation: BAB71101.1.
AK290387 mRNA. Translation: BAF83076.1.
BC012139 mRNA. Translation: AAH12139.1.
BC146974 mRNA. Translation: AAI46975.1.
BC146976 mRNA. Translation: AAI46977.1.
BC147023 mRNA. Translation: AAI47024.1.
AC087365 Genomic DNA. No translation available.
AC109326 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60954.1.
BC157892 mRNA. Translation: AAI57893.1.
CCDSiCCDS11462.1.
RefSeqiNP_001278515.1. NM_001291586.1.
NP_659478.1. NM_145041.3.
XP_006721721.1. XM_006721658.1.
UniGeneiHs.536474.

Genome annotation databases

EnsembliENST00000331615; ENSP00000330774; ENSG00000184988.
ENST00000588659; ENSP00000466820; ENSG00000184988.
GeneIDi113277.
KEGGihsa:113277.
UCSCiuc002idn.1. human.

Polymorphism databases

DMDMi74731081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056132 mRNA. Translation: BAB71101.1 .
AK290387 mRNA. Translation: BAF83076.1 .
BC012139 mRNA. Translation: AAH12139.1 .
BC146974 mRNA. Translation: AAI46975.1 .
BC146976 mRNA. Translation: AAI46977.1 .
BC147023 mRNA. Translation: AAI47024.1 .
AC087365 Genomic DNA. No translation available.
AC109326 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60954.1 .
BC157892 mRNA. Translation: AAI57893.1 .
CCDSi CCDS11462.1.
RefSeqi NP_001278515.1. NM_001291586.1.
NP_659478.1. NM_145041.3.
XP_006721721.1. XM_006721658.1.
UniGenei Hs.536474.

3D structure databases

ProteinModelPortali Q96A25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125240. 1 interaction.
IntActi Q96A25. 1 interaction.
STRINGi 9606.ENSP00000330774.

PTM databases

PhosphoSitei Q96A25.

Polymorphism databases

DMDMi 74731081.

Proteomic databases

MaxQBi Q96A25.
PaxDbi Q96A25.
PRIDEi Q96A25.

Protocols and materials databases

DNASUi 113277.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331615 ; ENSP00000330774 ; ENSG00000184988 .
ENST00000588659 ; ENSP00000466820 ; ENSG00000184988 .
GeneIDi 113277.
KEGGi hsa:113277.
UCSCi uc002idn.1. human.

Organism-specific databases

CTDi 113277.
GeneCardsi GC17P041363.
HGNCi HGNC:28288. TMEM106A.
neXtProti NX_Q96A25.
PharmGKBi PA142670755.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44552.
HOGENOMi HOG000230966.
HOVERGENi HBG055025.
InParanoidi Q96A25.
OMAi HTKLFVF.
PhylomeDBi Q96A25.

Miscellaneous databases

GeneWikii TMEM106A.
GenomeRNAii 113277.
NextBioi 78820.
PROi Q96A25.

Gene expression databases

ArrayExpressi Q96A25.
Bgeei Q96A25.
CleanExi HS_TMEM106A.
Genevestigatori Q96A25.

Family and domain databases

InterProi IPR009790. DUF1356_TMEM106.
[Graphical view ]
Pfami PF07092. DUF1356. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Testis.

Entry informationi

Entry nameiT106A_HUMAN
AccessioniPrimary (citable) accession number: Q96A25
Secondary accession number(s): A8K2X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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