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Protein

Copine-4

Gene

CPNE4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-4Curated
Alternative name(s):
Copine IVBy similarityImported
Copine-81 Publication
Gene namesi
Name:CPNE4Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:2317. CPNE4.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26834.

Polymorphism and mutation databases

BioMutaiCPNE4.
DMDMi26006702.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Copine-4PRO_0000144841Add
BLAST

Proteomic databases

EPDiQ96A23.
MaxQBiQ96A23.
PaxDbiQ96A23.
PRIDEiQ96A23.
TopDownProteomicsiQ96A23-1. [Q96A23-1]

PTM databases

iPTMnetiQ96A23.
PhosphoSiteiQ96A23.

Expressioni

Tissue specificityi

Widely expressed (PubMed:12670487, PubMed:12949241). Expressed strongly in the brain, heart and prostate (PubMed:12670487, PubMed:12949241). Expressed strongly in peripheral blood leukocytes (PubMed:12949241).2 Publications

Gene expression databases

BgeeiQ96A23.
CleanExiHS_CPNE4.
ExpressionAtlasiQ96A23. baseline and differential.
GenevisibleiQ96A23. HS.

Organism-specific databases

HPAiHPA032036.

Interactioni

Subunit structurei

Interacts (via VWFA domain) with ACTB, BCOR, BICD2, CCDC22, CDC42BPB, CEP162, MYCBP2, NONO, PDCD6, PITPNM2, RDX, SKIL, SKT, SPTBN1, UBE2O and WTAP (PubMed:12522145).1 Publication

Protein-protein interaction databases

BioGridi126267. 42 interactions.
STRINGi9606.ENSP00000411904.

Structurei

3D structure databases

ProteinModelPortaliQ96A23.
SMRiQ96A23. Positions 163-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 130107C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini141 – 246106C2 2PROSITE-ProRule annotationAdd
BLAST
Domaini305 – 507203VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the copine family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327. Eukaryota.
ENOG410XPC8. LUCA.
GeneTreeiENSGT00760000119085.
HOGENOMiHOG000220898.
HOVERGENiHBG066841.
InParanoidiQ96A23.
OMAiFLGAMEC.
OrthoDBiEOG77DJ57.
PhylomeDBiQ96A23.
TreeFamiTF316419.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96A23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKMSNIYES AANTLGIFNS PCLTKVELRV ACKGISDRDA LSKPDPCVIL
60 70 80 90 100
KMQSHGQWFE VDRTEVIRTC INPVYSKLFT VDFYFEEVQR LRFEVHDISS
110 120 130 140 150
NHNGLKEADF LGGMECTLGQ IVSQRKLSKS LLKHGNTAGK SSITVIAEEL
160 170 180 190 200
SGNDDYVELA FNARKLDDKD FFSKSDPFLE IFRMNDDATQ QLVHRTEVVM
210 220 230 240 250
NNLSPAWKSF KVSVNSLCSG DPDRRLKCIV WDWDSNGKHD FIGEFTSTFK
260 270 280 290 300
EMRGAMEGKQ VQWECINPKY KAKKKNYKNS GTVILNLCKI HKMHSFLDYI
310 320 330 340 350
MGGCQIQFTV AIDFTASNGD PRNSCSLHYI HPYQPNEYLK ALVAVGEICQ
360 370 380 390 400
DYDSDKMFPA FGFGARIPPE YTVSHDFAIN FNEDNPECAG IQGVVEAYQS
410 420 430 440 450
CLPKLQLYGP TNIAPIIQKV AKSASEETNT KEASQYFILL ILTDGVITDM
460 470 480 490 500
ADTREAIVHA SHLPMSVIIV GVGNADFSDM QMLDGDDGIL RSPKGEPVLR
510 520 530 540 550
DIVQFVPFRN FKHASPAALA KSVLAEVPNQ VVDYYNGKGI KPKCSSEMYE

SSRTLAP
Length:557
Mass (Da):62,395
Last modified:December 1, 2001 - v1
Checksum:i34AA5F103FE3C7BD
GO
Isoform 2 (identifier: Q96A23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAVEPSSSESIKRRAGRRM

Show »
Length:575
Mass (Da):64,394
Checksum:iFC2685D643DD0AAA
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MAVEPSSSESIKRRAGRRM in isoform 2. 1 PublicationVSP_001214

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465770 mRNA. Translation: AAL74190.1.
AF465771 mRNA. Translation: AAL74191.1.
AK056175 mRNA. Translation: BAB71111.1.
CH471052 Genomic DNA. Translation: EAW79206.1.
CH471052 Genomic DNA. Translation: EAW79207.1.
BC014396 mRNA. Translation: AAH14396.1.
BC075046 mRNA. Translation: AAH75046.1.
CCDSiCCDS3072.1. [Q96A23-1]
CCDS75010.1. [Q96A23-2]
RefSeqiNP_001276041.1. NM_001289112.1. [Q96A23-2]
NP_570720.1. NM_130808.2. [Q96A23-1]
NP_702907.1. NM_153429.1. [Q96A23-2]
XP_011510705.1. XM_011512403.1. [Q96A23-2]
XP_011510706.1. XM_011512404.1. [Q96A23-2]
XP_011510707.1. XM_011512405.1. [Q96A23-2]
UniGeneiHs.199877.

Genome annotation databases

EnsembliENST00000429747; ENSP00000411904; ENSG00000196353. [Q96A23-1]
ENST00000502818; ENSP00000421646; ENSG00000196353. [Q96A23-2]
ENST00000511604; ENSP00000423811; ENSG00000196353. [Q96A23-1]
ENST00000512055; ENSP00000421705; ENSG00000196353. [Q96A23-1]
ENST00000512332; ENSP00000424853; ENSG00000196353. [Q96A23-2]
ENST00000617767; ENSP00000478878; ENSG00000196353. [Q96A23-2]
GeneIDi131034.
KEGGihsa:131034.
UCSCiuc003eok.5. human. [Q96A23-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF465770 mRNA. Translation: AAL74190.1.
AF465771 mRNA. Translation: AAL74191.1.
AK056175 mRNA. Translation: BAB71111.1.
CH471052 Genomic DNA. Translation: EAW79206.1.
CH471052 Genomic DNA. Translation: EAW79207.1.
BC014396 mRNA. Translation: AAH14396.1.
BC075046 mRNA. Translation: AAH75046.1.
CCDSiCCDS3072.1. [Q96A23-1]
CCDS75010.1. [Q96A23-2]
RefSeqiNP_001276041.1. NM_001289112.1. [Q96A23-2]
NP_570720.1. NM_130808.2. [Q96A23-1]
NP_702907.1. NM_153429.1. [Q96A23-2]
XP_011510705.1. XM_011512403.1. [Q96A23-2]
XP_011510706.1. XM_011512404.1. [Q96A23-2]
XP_011510707.1. XM_011512405.1. [Q96A23-2]
UniGeneiHs.199877.

3D structure databases

ProteinModelPortaliQ96A23.
SMRiQ96A23. Positions 163-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126267. 42 interactions.
STRINGi9606.ENSP00000411904.

PTM databases

iPTMnetiQ96A23.
PhosphoSiteiQ96A23.

Polymorphism and mutation databases

BioMutaiCPNE4.
DMDMi26006702.

Proteomic databases

EPDiQ96A23.
MaxQBiQ96A23.
PaxDbiQ96A23.
PRIDEiQ96A23.
TopDownProteomicsiQ96A23-1. [Q96A23-1]

Protocols and materials databases

DNASUi131034.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000429747; ENSP00000411904; ENSG00000196353. [Q96A23-1]
ENST00000502818; ENSP00000421646; ENSG00000196353. [Q96A23-2]
ENST00000511604; ENSP00000423811; ENSG00000196353. [Q96A23-1]
ENST00000512055; ENSP00000421705; ENSG00000196353. [Q96A23-1]
ENST00000512332; ENSP00000424853; ENSG00000196353. [Q96A23-2]
ENST00000617767; ENSP00000478878; ENSG00000196353. [Q96A23-2]
GeneIDi131034.
KEGGihsa:131034.
UCSCiuc003eok.5. human. [Q96A23-1]

Organism-specific databases

CTDi131034.
GeneCardsiCPNE4.
HGNCiHGNC:2317. CPNE4.
HPAiHPA032036.
MIMi604208. gene.
neXtProtiNX_Q96A23.
PharmGKBiPA26834.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1327. Eukaryota.
ENOG410XPC8. LUCA.
GeneTreeiENSGT00760000119085.
HOGENOMiHOG000220898.
HOVERGENiHBG066841.
InParanoidiQ96A23.
OMAiFLGAMEC.
OrthoDBiEOG77DJ57.
PhylomeDBiQ96A23.
TreeFamiTF316419.

Miscellaneous databases

ChiTaRSiCPNE4. human.
GeneWikiiCPNE4.
GenomeRNAii131034.
NextBioi82854.
PROiQ96A23.
SOURCEiSearch...

Gene expression databases

BgeeiQ96A23.
CleanExiHS_CPNE4.
ExpressionAtlasiQ96A23. baseline and differential.
GenevisibleiQ96A23. HS.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, molecular characterization, and expression analysis of copine 8."
    Maitra R., Grigoryev D.N., Bera T.K., Pastan I.H., Lee B.
    Biochem. Biophys. Res. Commun. 303:842-847(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: Prostate.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif."
    Tomsig J.L., Snyder S.L., Creutz C.E.
    J. Biol. Chem. 278:10048-10054(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ACTB; BCOR; BICD2; CCDC22; CDC42BPB; CEP162; MYCBP2; NONO; PDCD6; PITPNM2; RDX; SKIL; SKT; SPTBN1; UBE2O AND WTAP.
  6. "Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils."
    Cowland J.B., Carter D., Bjerregaard M.D., Johnsen A.H., Borregaard N., Lollike K.
    J. Leukoc. Biol. 74:379-388(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCPNE4_HUMAN
AccessioniPrimary (citable) accession number: Q96A23
Secondary accession number(s): D3DNC5, Q8TEX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.