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Protein

Coiled-coil domain-containing protein 102A

Gene

CCDC102A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 102A
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28097. CCDC102A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596469.

Polymorphism and mutation databases

BioMutaiCCDC102A.
DMDMi296434412.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Coiled-coil domain-containing protein 102APRO_0000274400Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261PhosphoserineCombined sources
Modified residuei28 – 281PhosphoserineCombined sources
Modified residuei537 – 5371PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96A19.
MaxQBiQ96A19.
PaxDbiQ96A19.
PRIDEiQ96A19.

PTM databases

iPTMnetiQ96A19.
PhosphoSiteiQ96A19.

Expressioni

Gene expression databases

BgeeiQ96A19.
CleanExiHS_CCDC102A.
GenevisibleiQ96A19. HS.

Organism-specific databases

HPAiHPA040598.
HPA040958.

Interactioni

Protein-protein interaction databases

BioGridi124987. 25 interactions.
IntActiQ96A19. 6 interactions.
STRINGi9606.ENSP00000258214.

Structurei

3D structure databases

ProteinModelPortaliQ96A19.
SMRiQ96A19. Positions 360-502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili72 – 16190Sequence analysisAdd
BLAST
Coiled coili263 – 396134Sequence analysisAdd
BLAST
Coiled coili427 – 51892Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 6135Pro-richAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II1J. Eukaryota.
ENOG410XRGB. LUCA.
GeneTreeiENSGT00730000110960.
HOGENOMiHOG000008304.
HOVERGENiHBG080941.
InParanoidiQ96A19.
KOiK16759.
OMAiLKHAGQF.
OrthoDBiEOG79PJP7.
PhylomeDBiQ96A19.
TreeFamiTF320856.

Family and domain databases

InterProiIPR002928. Myosin_tail.
[Graphical view]
PfamiPF01576. Myosin_tail_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96A19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHGPSPRLA ESPQLSKGSL LTILGSPSPE RMGPADSLPP TPPSGTPSPG
60 70 80 90 100
PPPALPLPPA PALLADGDWE SREELRLREL EEARARAAQM EKTMRRWSDC
110 120 130 140 150
TANWREKWSK VRAERNRARE EVRQLRQRLD ALTKELAGAR RERQEAQGEC
160 170 180 190 200
EARGRELARL RGARGVADQT RDGPEPEAER EPVRDVGSER PPGSQELELV
210 220 230 240 250
ESLLKSMPEE SEDCWEARSL GAGGPRGSSG RQERSRLPWE DTAATEEEAS
260 270 280 290 300
KLTALRLRLD ESQKVLLKER EDKLALSRNI EKLEGELSQW KIKYEELSKT
310 320 330 340 350
KQEMLKQLSI LKEAHQDELG RMSEDLEDEL GARSSMDRKM AELRGEMERL
360 370 380 390 400
QAENAAEWGR RERLETEKLG LERENKKLRA QVGDLEEALA RRRRQTASAL
410 420 430 440 450
DCDLRASQAA LFEKNKELAD LKHVHGKLKK QFQEKVAELA HANRRVEQHE
460 470 480 490 500
AEVKKLRLRV EELKKELAQA EDELDEAHNQ ARKLQRSLDE QTEQSENLQV
510 520 530 540 550
QLEHLQSRLR RQQQNAPLFG KIRSARFGTE EAEDGTSDLD EDEDLQIQVA
Length:550
Mass (Da):62,596
Last modified:May 18, 2010 - v2
Checksum:iFB8D693B4B7E580A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961R → W in AAH08285 (PubMed:15489334).Curated
Sequence conflicti96 – 961R → W in AAH09941 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004382 Genomic DNA. No translation available.
BC004307 mRNA. Translation: AAH04307.1.
BC008285 mRNA. Translation: AAH08285.1.
BC009941 mRNA. Translation: AAH09941.1.
CCDSiCCDS10784.1.
RefSeqiNP_149989.2. NM_033212.3.
XP_011521771.1. XM_011523469.1.
UniGeneiHs.644611.

Genome annotation databases

EnsembliENST00000258214; ENSP00000258214; ENSG00000135736.
GeneIDi92922.
KEGGihsa:92922.
UCSCiuc002elw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004382 Genomic DNA. No translation available.
BC004307 mRNA. Translation: AAH04307.1.
BC008285 mRNA. Translation: AAH08285.1.
BC009941 mRNA. Translation: AAH09941.1.
CCDSiCCDS10784.1.
RefSeqiNP_149989.2. NM_033212.3.
XP_011521771.1. XM_011523469.1.
UniGeneiHs.644611.

3D structure databases

ProteinModelPortaliQ96A19.
SMRiQ96A19. Positions 360-502.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124987. 25 interactions.
IntActiQ96A19. 6 interactions.
STRINGi9606.ENSP00000258214.

PTM databases

iPTMnetiQ96A19.
PhosphoSiteiQ96A19.

Polymorphism and mutation databases

BioMutaiCCDC102A.
DMDMi296434412.

Proteomic databases

EPDiQ96A19.
MaxQBiQ96A19.
PaxDbiQ96A19.
PRIDEiQ96A19.

Protocols and materials databases

DNASUi92922.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258214; ENSP00000258214; ENSG00000135736.
GeneIDi92922.
KEGGihsa:92922.
UCSCiuc002elw.4. human.

Organism-specific databases

CTDi92922.
GeneCardsiCCDC102A.
H-InvDBHIX0013076.
HGNCiHGNC:28097. CCDC102A.
HPAiHPA040598.
HPA040958.
neXtProtiNX_Q96A19.
PharmGKBiPA144596469.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II1J. Eukaryota.
ENOG410XRGB. LUCA.
GeneTreeiENSGT00730000110960.
HOGENOMiHOG000008304.
HOVERGENiHBG080941.
InParanoidiQ96A19.
KOiK16759.
OMAiLKHAGQF.
OrthoDBiEOG79PJP7.
PhylomeDBiQ96A19.
TreeFamiTF320856.

Miscellaneous databases

ChiTaRSiCCDC102A. human.
GenomeRNAii92922.
PROiQ96A19.

Gene expression databases

BgeeiQ96A19.
CleanExiHS_CCDC102A.
GenevisibleiQ96A19. HS.

Family and domain databases

InterProiIPR002928. Myosin_tail.
[Graphical view]
PfamiPF01576. Myosin_tail_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Placenta and Uterus.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26 AND SER-28, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26 AND SER-28, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-537, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiC102A_HUMAN
AccessioniPrimary (citable) accession number: Q96A19
Secondary accession number(s): Q9BT74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.