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Q96A11 (G3ST3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galactose-3-O-sulfotransferase 3

Short name=Gal3ST-3
EC=2.8.2.-
Alternative name(s):
Beta-galactose-3-O-sulfotransferase 3
Short name=Gal3ST3
Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3
Gene names
Name:GAL3ST3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc. Ref.1 Ref.2

Cofactor

Magnesium.

Pathway

Protein modification; carbohydrate sulfation.

Subcellular location

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein Probable.

Tissue specificity

Highly expressed in thyroid, brain, kidney, heart and spinal cord. Ref.1 Ref.2

Sequence similarities

Belongs to the galactose-3-O-sulfotransferase family.

Biophysicochemical properties

pH dependence:

Optimum pH is 7.0-8.0.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Galactose-3-O-sulfotransferase 3
PRO_0000085206

Regions

Topological domain1 – 1919Cytoplasmic Potential
Transmembrane20 – 4021Helical; Signal-anchor for type II membrane protein; Potential
Topological domain41 – 431391Lumenal Potential

Amino acid modifications

Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential

Natural variations

Natural variant2211A → D.
Corresponds to variant rs35285455 [ dbSNP | Ensembl ].
VAR_053988
Natural variant4101E → A.
Corresponds to variant rs4565902 [ dbSNP | Ensembl ].
VAR_053989

Sequences

Sequence LengthMass (Da)Tools
Q96A11 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 3E1B8418A72A5EB6

FASTA43148,956
        10         20         30         40         50         60 
MPPILQRLQQ ATKMMSRRKI LLLVLGCSTV SLLIHQGAQL SWYPKLFPLS CPPLRNSPPR 

        70         80         90        100        110        120 
PKHMTVAFLK THKTAGTTVQ NILFRFAERH NLTVALPHPS CEHQFCYPRN FSAHFVHPAT 

       130        140        150        160        170        180 
RPPHVLASHL RFDRAELERL MPPSTVYVTI LREPAAMFES LFSYYNQYCP AFRRVPNASL 

       190        200        210        220        230        240 
EAFLRAPEAY YRAGEHFAMF AHNTLAYDLG GDNERSPRDD AAYLAGLIRQ VEEVFSLVMI 

       250        260        270        280        290        300 
AEYFDESLVL LRRLLAWDLD DVLYAKLNAR AASSRLAAIP AALARAARTW NALDAGLYDH 

       310        320        330        340        350        360 
FNATFWRHVA RAGRACVERE ARELREARQR LLRRCFGDEP LLRPAAQIRT KQLQPWQPSR 

       370        380        390        400        410        420 
KVDIMGYDLP GGGAGPATEA CLKLAMPEVQ YSNYLLRKQK RRGGARARPE PVLDNPPPRP 

       430 
IRVLPRGPQG P 

« Hide

References

« Hide 'large scale' references
[1]"A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization, and its implications in biosynthesis of (SO4-3)Galbeta 1-4(Fucalpha 1-3)GlcNAc."
El-Fasakhany F.M., Uchimura K., Kannagi R., Muramatsu T.
J. Biol. Chem. 276:26988-26994(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Fetal brain.
[2]"Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans."
Suzuki A., Hiraoka N., Suzuki M., Angata K., Misra A.K., McAuliffe J., Hindsgaul O., Fukuda M.
J. Biol. Chem. 276:24388-24395(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Web resources

GGDB

GlycoGene database

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB053232 mRNA. Translation: BAB61900.1.
AY026481 mRNA. Translation: AAK01945.1.
BC113552 mRNA. Translation: AAI13553.1.
BC113554 mRNA. Translation: AAI13555.1.
RefSeqNP_149025.1. NM_033036.2.
UniGeneHs.208343.

3D structure databases

ProteinModelPortalQ96A11.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000308591.

PTM databases

PhosphoSiteQ96A11.

Polymorphism databases

DMDM47116425.

Proteomic databases

PaxDbQ96A11.
PRIDEQ96A11.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312006; ENSP00000308591; ENSG00000175229.
ENST00000527878; ENSP00000434829; ENSG00000175229.
GeneID89792.
KEGGhsa:89792.
UCSCuc001ogv.3. human.

Organism-specific databases

CTD89792.
GeneCardsGC11M065810.
HGNCHGNC:24144. GAL3ST3.
HPAHPA013570.
MIM608234. gene.
neXtProtNX_Q96A11.
PharmGKBPA134864180.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42801.
HOGENOMHOG000232148.
HOVERGENHBG051681.
InParanoidQ96A11.
KOK09676.
OMAMPEVQYS.
OrthoDBEOG7K0ZF1.
PhylomeDBQ96A11.
TreeFamTF314802.

Enzyme and pathway databases

UniPathwayUPA00353.

Gene expression databases

BgeeQ96A11.
CleanExHS_GAL3ST3.
GenevestigatorQ96A11.

Family and domain databases

InterProIPR009729. Gal-3-0_sulfotransfrase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR14647. PTHR14647. 1 hit.
PfamPF06990. Gal-3-0_sulfotr. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

GeneWikiGAL3ST3.
GenomeRNAi89792.
NextBio76281.
PROQ96A11.
SOURCESearch...

Entry information

Entry nameG3ST3_HUMAN
AccessionPrimary (citable) accession number: Q96A11
Secondary accession number(s): Q14D05
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM