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Q96A11

- G3ST3_HUMAN

UniProt

Q96A11 - G3ST3_HUMAN

Protein

Galactose-3-O-sulfotransferase 3

Gene

GAL3ST3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc.2 Publications

    Cofactori

    Magnesium.

    pH dependencei

    Optimum pH is 7.0-8.0.

    Pathwayi

    GO - Molecular functioni

    1. 3'-phosphoadenosine 5'-phosphosulfate binding Source: UniProtKB
    2. carbohydrate binding Source: UniProtKB
    3. galactose 3-O-sulfotransferase activity Source: UniProtKB
    4. galactosylceramide sulfotransferase activity Source: InterPro
    5. proteoglycan sulfotransferase activity Source: UniProtKB

    GO - Biological processi

    1. monosaccharide metabolic process Source: UniProtKB
    2. oligosaccharide metabolic process Source: UniProtKB
    3. poly-N-acetyllactosamine metabolic process Source: UniProtKB
    4. proteoglycan biosynthetic process Source: UniProtKB
    5. sulfur compound metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    UniPathwayiUPA00353.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galactose-3-O-sulfotransferase 3 (EC:2.8.2.-)
    Short name:
    Gal3ST-3
    Alternative name(s):
    Beta-galactose-3-O-sulfotransferase 3
    Short name:
    Gal3ST3
    Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3
    Gene namesi
    Name:GAL3ST3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:24144. GAL3ST3.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi cisterna membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134864180.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Galactose-3-O-sulfotransferase 3PRO_0000085206Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ96A11.
    PRIDEiQ96A11.

    PTM databases

    PhosphoSiteiQ96A11.

    Expressioni

    Tissue specificityi

    Highly expressed in thyroid, brain, kidney, heart and spinal cord.2 Publications

    Gene expression databases

    BgeeiQ96A11.
    CleanExiHS_GAL3ST3.
    GenevestigatoriQ96A11.

    Organism-specific databases

    HPAiHPA013570.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000308591.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96A11.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 431391LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42801.
    HOGENOMiHOG000232148.
    HOVERGENiHBG051681.
    InParanoidiQ96A11.
    KOiK09676.
    OMAiRCFGDEP.
    OrthoDBiEOG7K0ZF1.
    PhylomeDBiQ96A11.
    TreeFamiTF314802.

    Family and domain databases

    InterProiIPR009729. Gal-3-0_sulfotransfrase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR14647. PTHR14647. 1 hit.
    PfamiPF06990. Gal-3-0_sulfotr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96A11-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPILQRLQQ ATKMMSRRKI LLLVLGCSTV SLLIHQGAQL SWYPKLFPLS    50
    CPPLRNSPPR PKHMTVAFLK THKTAGTTVQ NILFRFAERH NLTVALPHPS 100
    CEHQFCYPRN FSAHFVHPAT RPPHVLASHL RFDRAELERL MPPSTVYVTI 150
    LREPAAMFES LFSYYNQYCP AFRRVPNASL EAFLRAPEAY YRAGEHFAMF 200
    AHNTLAYDLG GDNERSPRDD AAYLAGLIRQ VEEVFSLVMI AEYFDESLVL 250
    LRRLLAWDLD DVLYAKLNAR AASSRLAAIP AALARAARTW NALDAGLYDH 300
    FNATFWRHVA RAGRACVERE ARELREARQR LLRRCFGDEP LLRPAAQIRT 350
    KQLQPWQPSR KVDIMGYDLP GGGAGPATEA CLKLAMPEVQ YSNYLLRKQK 400
    RRGGARARPE PVLDNPPPRP IRVLPRGPQG P 431
    Length:431
    Mass (Da):48,956
    Last modified:December 1, 2001 - v1
    Checksum:i3E1B8418A72A5EB6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti221 – 2211A → D.
    Corresponds to variant rs35285455 [ dbSNP | Ensembl ].
    VAR_053988
    Natural varianti410 – 4101E → A.
    Corresponds to variant rs4565902 [ dbSNP | Ensembl ].
    VAR_053989

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB053232 mRNA. Translation: BAB61900.1.
    AY026481 mRNA. Translation: AAK01945.1.
    BC113552 mRNA. Translation: AAI13553.1.
    BC113554 mRNA. Translation: AAI13555.1.
    CCDSiCCDS8128.1.
    RefSeqiNP_149025.1. NM_033036.2.
    UniGeneiHs.208343.

    Genome annotation databases

    EnsembliENST00000312006; ENSP00000308591; ENSG00000175229.
    ENST00000527878; ENSP00000434829; ENSG00000175229.
    GeneIDi89792.
    KEGGihsa:89792.
    UCSCiuc001ogv.3. human.

    Polymorphism databases

    DMDMi47116425.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB053232 mRNA. Translation: BAB61900.1 .
    AY026481 mRNA. Translation: AAK01945.1 .
    BC113552 mRNA. Translation: AAI13553.1 .
    BC113554 mRNA. Translation: AAI13555.1 .
    CCDSi CCDS8128.1.
    RefSeqi NP_149025.1. NM_033036.2.
    UniGenei Hs.208343.

    3D structure databases

    ProteinModelPortali Q96A11.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000308591.

    PTM databases

    PhosphoSitei Q96A11.

    Polymorphism databases

    DMDMi 47116425.

    Proteomic databases

    PaxDbi Q96A11.
    PRIDEi Q96A11.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312006 ; ENSP00000308591 ; ENSG00000175229 .
    ENST00000527878 ; ENSP00000434829 ; ENSG00000175229 .
    GeneIDi 89792.
    KEGGi hsa:89792.
    UCSCi uc001ogv.3. human.

    Organism-specific databases

    CTDi 89792.
    GeneCardsi GC11M065810.
    HGNCi HGNC:24144. GAL3ST3.
    HPAi HPA013570.
    MIMi 608234. gene.
    neXtProti NX_Q96A11.
    PharmGKBi PA134864180.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42801.
    HOGENOMi HOG000232148.
    HOVERGENi HBG051681.
    InParanoidi Q96A11.
    KOi K09676.
    OMAi RCFGDEP.
    OrthoDBi EOG7K0ZF1.
    PhylomeDBi Q96A11.
    TreeFami TF314802.

    Enzyme and pathway databases

    UniPathwayi UPA00353 .

    Miscellaneous databases

    GeneWikii GAL3ST3.
    GenomeRNAii 89792.
    NextBioi 76281.
    PROi Q96A11.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96A11.
    CleanExi HS_GAL3ST3.
    Genevestigatori Q96A11.

    Family and domain databases

    InterProi IPR009729. Gal-3-0_sulfotransfrase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR14647. PTHR14647. 1 hit.
    Pfami PF06990. Gal-3-0_sulfotr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization, and its implications in biosynthesis of (SO4-3)Galbeta 1-4(Fucalpha 1-3)GlcNAc."
      El-Fasakhany F.M., Uchimura K., Kannagi R., Muramatsu T.
      J. Biol. Chem. 276:26988-26994(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans."
      Suzuki A., Hiraoka N., Suzuki M., Angata K., Misra A.K., McAuliffe J., Hindsgaul O., Fukuda M.
      J. Biol. Chem. 276:24388-24395(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiG3ST3_HUMAN
    AccessioniPrimary (citable) accession number: Q96A11
    Secondary accession number(s): Q14D05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3