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Protein

Galactose-3-O-sulfotransferase 3

Gene

GAL3ST3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc.2 Publications

Cofactori

pH dependencei

Optimum pH is 7.0-8.0.

Pathwayi: carbohydrate sulfation

This protein is involved in the pathway carbohydrate sulfation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway carbohydrate sulfation and in Protein modification.

GO - Molecular functioni

  • 3'-phosphoadenosine 5'-phosphosulfate binding Source: UniProtKB
  • carbohydrate binding Source: UniProtKB
  • galactose 3-O-sulfotransferase activity Source: UniProtKB
  • galactosylceramide sulfotransferase activity Source: InterPro
  • proteoglycan sulfotransferase activity Source: UniProtKB

GO - Biological processi

  • glycolipid biosynthetic process Source: InterPro
  • monosaccharide metabolic process Source: UniProtKB
  • oligosaccharide metabolic process Source: UniProtKB
  • poly-N-acetyllactosamine metabolic process Source: UniProtKB
  • proteoglycan biosynthetic process Source: UniProtKB
  • sulfur compound metabolic process Source: UniProtKB

Keywordsi

Molecular functionTransferase
LigandMagnesium

Enzyme and pathway databases

UniPathwayiUPA00353

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-3-O-sulfotransferase 3 (EC:2.8.2.-)
Short name:
Gal3ST-3
Alternative name(s):
Beta-galactose-3-O-sulfotransferase 3
Short name:
Gal3ST3
Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3
Gene namesi
Name:GAL3ST3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175229.6
HGNCiHGNC:24144 GAL3ST3
MIMi608234 gene
neXtProtiNX_Q96A11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini41 – 431LumenalSequence analysisAdd BLAST391

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175229
PharmGKBiPA134864180

Polymorphism and mutation databases

BioMutaiGAL3ST3
DMDMi47116425

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000852061 – 431Galactose-3-O-sulfotransferase 3Add BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96A11
PaxDbiQ96A11
PeptideAtlasiQ96A11
PRIDEiQ96A11

PTM databases

iPTMnetiQ96A11
PhosphoSitePlusiQ96A11

Expressioni

Tissue specificityi

Highly expressed in thyroid, brain, kidney, heart and spinal cord.2 Publications

Gene expression databases

BgeeiENSG00000175229
CleanExiHS_GAL3ST3
GenevisibleiQ96A11 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308591

Structurei

3D structure databases

ProteinModelPortaliQ96A11
SMRiQ96A11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIE9 Eukaryota
ENOG4110RXY LUCA
GeneTreeiENSGT00390000013505
HOGENOMiHOG000232148
HOVERGENiHBG051681
InParanoidiQ96A11
KOiK09676
OMAiSYYNQYC
OrthoDBiEOG091G0N28
PhylomeDBiQ96A11
TreeFamiTF314802

Family and domain databases

InterProiView protein in InterPro
IPR009729 Gal-3-0_sulfotransfrase
IPR027417 P-loop_NTPase
PANTHERiPTHR14647 PTHR14647, 1 hit
PfamiView protein in Pfam
PF06990 Gal-3-0_sulfotr, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q96A11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPILQRLQQ ATKMMSRRKI LLLVLGCSTV SLLIHQGAQL SWYPKLFPLS
60 70 80 90 100
CPPLRNSPPR PKHMTVAFLK THKTAGTTVQ NILFRFAERH NLTVALPHPS
110 120 130 140 150
CEHQFCYPRN FSAHFVHPAT RPPHVLASHL RFDRAELERL MPPSTVYVTI
160 170 180 190 200
LREPAAMFES LFSYYNQYCP AFRRVPNASL EAFLRAPEAY YRAGEHFAMF
210 220 230 240 250
AHNTLAYDLG GDNERSPRDD AAYLAGLIRQ VEEVFSLVMI AEYFDESLVL
260 270 280 290 300
LRRLLAWDLD DVLYAKLNAR AASSRLAAIP AALARAARTW NALDAGLYDH
310 320 330 340 350
FNATFWRHVA RAGRACVERE ARELREARQR LLRRCFGDEP LLRPAAQIRT
360 370 380 390 400
KQLQPWQPSR KVDIMGYDLP GGGAGPATEA CLKLAMPEVQ YSNYLLRKQK
410 420 430
RRGGARARPE PVLDNPPPRP IRVLPRGPQG P
Length:431
Mass (Da):48,956
Last modified:December 1, 2001 - v1
Checksum:i3E1B8418A72A5EB6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053988221A → D. Corresponds to variant dbSNP:rs35285455Ensembl.1
Natural variantiVAR_053989410E → A. Corresponds to variant dbSNP:rs4565902Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB053232 mRNA Translation: BAB61900.1
AY026481 mRNA Translation: AAK01945.1
BC113552 mRNA Translation: AAI13553.1
BC113554 mRNA Translation: AAI13555.1
CCDSiCCDS8128.1
RefSeqiNP_149025.1, NM_033036.2
UniGeneiHs.208343

Genome annotation databases

EnsembliENST00000312006; ENSP00000308591; ENSG00000175229
ENST00000527878; ENSP00000434829; ENSG00000175229
GeneIDi89792
KEGGihsa:89792
UCSCiuc001ogv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiG3ST3_HUMAN
AccessioniPrimary (citable) accession number: Q96A11
Secondary accession number(s): Q14D05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome