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Protein

Protein FAM46B

Gene

FAM46B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM46B
Gene namesi
Name:FAM46B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28273. FAM46B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000158246.
PharmGKBiPA134962922.

Polymorphism and mutation databases

BioMutaiFAM46B.
DMDMi294862433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002599311 – 425Protein FAM46BAdd BLAST425

Proteomic databases

EPDiQ96A09.
MaxQBiQ96A09.
PaxDbiQ96A09.
PeptideAtlasiQ96A09.
PRIDEiQ96A09.

PTM databases

PhosphoSitePlusiQ96A09.

Expressioni

Gene expression databases

BgeeiENSG00000158246.
CleanExiHS_FAM46B.
GenevisibleiQ96A09. HS.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125440. 5 interactors.
IntActiQ96A09. 53 interactors.
MINTiMINT-2878241.
STRINGi9606.ENSP00000289166.

Structurei

3D structure databases

ProteinModelPortaliQ96A09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM46 family.Curated

Phylogenomic databases

eggNOGiKOG3852. Eukaryota.
ENOG410XTG4. LUCA.
GeneTreeiENSGT00500000044785.
HOGENOMiHOG000234733.
HOVERGENiHBG057969.
InParanoidiQ96A09.
OMAiAHSYPTW.
OrthoDBiEOG091G06T9.
PhylomeDBiQ96A09.
TreeFamiTF315239.

Family and domain databases

InterProiView protein in InterPro
IPR012937. DUF1693.
PfamiView protein in Pfam
PF07984. NTP_transf_7. 1 hit.
SMARTiView protein in SMART
SM01153. DUF1693. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96A09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPSESGAER RDRAAAQVGT AAATAVATAA PAGGGPDPEA LSAFPGRHLS
60 70 80 90 100
GLSWPQVKRL DALLSEPIPI HGRGNFPTLS VQPRQIVQVV RSTLEEQGLH
110 120 130 140 150
VHSVRLHGSA ASHVLHPESG LGYKDLDLVF RVDLRSEASF QLTKAVVLAC
160 170 180 190 200
LLDFLPAGVS RAKITPLTLK EAYVQKLVKV CTDSDRWSLI SLSNKSGKNV
210 220 230 240 250
ELKFVDSVRR QFEFSIDSFQ IILDSLLLFG QCSSTPMSEA FHPTVTGESL
260 270 280 290 300
YGDFTEALEH LRHRVIATRS PEEIRGGGLL KYCHLLVRGF RPRPSTDVRA
310 320 330 340 350
LQRYMCSRFF IDFPDLVEQR RTLERYLEAH FGGADAARRY ACLVTLHRVV
360 370 380 390 400
NESTVCLMNH ERRQTLDLIA ALALQALAEQ GPAATAALAW RPPGTDGVVP
410 420
ATVNYYVTPV QPLLAHAYPT WLPCN
Length:425
Mass (Da):46,688
Last modified:April 20, 2010 - v2
Checksum:iA0FD17359AF2C6DD
GO

Sequence cautioni

The sequence AAH12790 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH14160 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI13555 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356390 Genomic DNA. Translation: CAI13555.1. Different initiation.
BC012790 mRNA. Translation: AAH12790.1. Different initiation.
BC014160 mRNA. Translation: AAH14160.1. Different initiation.
CCDSiCCDS294.2.
RefSeqiNP_443175.2. NM_052943.3.
UniGeneiHs.632378.

Genome annotation databases

EnsembliENST00000289166; ENSP00000289166; ENSG00000158246.
GeneIDi115572.
KEGGihsa:115572.
UCSCiuc010ofj.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFA46B_HUMAN
AccessioniPrimary (citable) accession number: Q96A09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 20, 2010
Last modified: June 7, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families